NL9301515A - Material and method for the treatment of urine incontinence. - Google Patents

Material and method for the treatment of urine incontinence. Download PDF

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Publication number
NL9301515A
NL9301515A NL9301515A NL9301515A NL9301515A NL 9301515 A NL9301515 A NL 9301515A NL 9301515 A NL9301515 A NL 9301515A NL 9301515 A NL9301515 A NL 9301515A NL 9301515 A NL9301515 A NL 9301515A
Authority
NL
Netherlands
Prior art keywords
substances
suspension
treatment
tcp
aiming device
Prior art date
Application number
NL9301515A
Other languages
Dutch (nl)
Original Assignee
Claus Jurgen Timmermans
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Claus Jurgen Timmermans filed Critical Claus Jurgen Timmermans
Priority to NL9301515A priority Critical patent/NL9301515A/en
Publication of NL9301515A publication Critical patent/NL9301515A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0004—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse
    • A61F2/0031—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse for constricting the lumen; Support slings for the urethra
    • A61F2/0036—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse for constricting the lumen; Support slings for the urethra implantable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02—Holding devices, e.g. on the body
    • A61M25/04—Holding devices, e.g. on the body in the body, e.g. expansible
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3403—Needle locating or guiding means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00646—Type of implements
    • A61B2017/0065—Type of implements the implement being an adhesive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/02—Devices for expanding tissue, e.g. skin tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The invention relates to the use of bioactive substances such as, for example, hydroxylapatite ceramic for strengthening weakened tissue structures, as well as an instrument and a method for simple and safe administration of corrective substances, notably for the treatment of urine incontinence. Weakening of tissue structures, resulting in loss of function, can in a number of cases be treated by local injection of substances. The materials in use at present migrate or are resorbed. Disappearance of substances after local injection can be prevented by use of bioactive material such as tricalcium phosphate ceramics (TCP) and hydroxylapatite (HA). The invention relates to the choice of the bioactive material TCP and HA, the preparation of an injectable suspension of TCP and HA by means of a plasma expander and a targeting device for a safe injection method. The targeting device and the application thereof are described.

Description

M^ter iaalenme thodet er _behandeXing_van_urine~inconti_nenti_eM ^ ter iaalenme thodet er _behandeXing_van_urine ~ inconti_nenti_e

De uitvinding heeft betrekking op het gebruik van bioaktieve substanties zoals b.v. hydroxy lapat iet keramiek ter versteviging van verslapte weefselstructuren, alsmede een instrument en een methode voor een eenvoudige en veilige toediening van corrigerende substanties, met name voor de behandeling van urine~incontinent ie. De verslapping van weefselstructuren, met als gevolg functieverlies, kan in een aantal gevallen door locale inspuiting van kunststoffen (b.v. teflon en silicone) of biopolimeren (b.v. collageen) worden behandeld. Zo kunnen heesheid, veroorzaakt door verslapping van de stembanden, urine-incontinentie, veroorzaakt door verslapping van de bekkenbodemspieren en vesico~ureterale reflux door locale inspuiting met teflon, silicone of collageen worden behandeld. Deze substanties zijn biocompatibel, maar niet bioactief, hetgeen betekent, dat zij op de duur de plaats van inspuiting verlaten. Teflon en silicone migreren naar andere organen. Collageen wordt geresorbeerd. Door toepassing van bioaktief keramisch materiaal, zoals triclacium phosphaat keramiek (TCP en hydroxylapatiet), kan deze verdwijning van substanties na locale inspuitingen worden voorkomen.The invention relates to the use of bioactive substances such as e.g. Hydroxy lapatite ceramics for strengthening weakened tissue structures, as well as an instrument and a method for the simple and safe administration of corrective substances, in particular for the treatment of urinary incontinence. The weakening of tissue structures, resulting in loss of function, can in some cases be treated by local injection of plastics (e.g. Teflon and silicone) or biopolimers (e.g. Collagen). For example, hoarseness caused by vocal cord relaxation, urinary incontinence caused by pelvic floor muscle relaxation and vesicoureteral reflux by local injection can be treated with Teflon, silicone or collagen. These substances are biocompatible, but not bioactive, which means that they eventually leave the injection site. Teflon and silicone migrate to other organs. Collagen is absorbed. By using bioactive ceramic material, such as triclacium phosphate ceramics (TCP and hydroxylapatite), this disappearance of substances after local injections can be prevented.

De uitvinding heeft betrekking op het vervaardigen van een door een injectienaald verspuitbare biokeramiek houdende suspensie. Voor dit doel werd een zeer fijn biokeramisch granulaat (hydroxy1apatiet) in verschillende volumeverhoudingen met gelvormige oplossingen en suspensies van polymeren in water en glycerine gemengd en als injectiemedium toegepast.. Gebruikt werden verschillende plasmaexpanders, zoals b.v. polyvinyl-pyrolidon of biopolymeren zoals b.v. collageen, chitosan en alginaten en mengsels van deze polymeren. Doel van deze uitvinding is de toepassing van biokeramisch materiaal door middel van een suspensie en het realiseren van een methode voor een eenvoudige en veilige inspuiting van genoemde biokeramieksuspensie, met name voor de behandeling van urine-incontinentie met behulp van een richtapparaat, dat de eenvoudige en veilige injectie mogelijk maakt.The invention relates to the production of a suspension containing bioceramics that can be sprayed by a syringe. For this purpose, a very fine bioceramic granulate (hydroxyapatite) in various volume proportions was mixed with gel-like solutions and suspensions of polymers in water and glycerine and used as injection medium. Various plasma expanders, such as e.g. polyvinylpyrolidone or biopolymers such as e.g. collagen, chitosan and alginates and mixtures of these polymers. The object of this invention is the use of bioceramics by means of a suspension and the realization of a method for a simple and safe injection of said bioceramics suspension, in particular for the treatment of urinary incontinence with the aid of a straightening device, which safe injection.

De uitvinding wordt in het navolgende aan de hand van een tekening verduidelijkt:The invention is explained below with reference to a drawing:

Fig. 1 Een buis 1 is uitgerust met een handvat 2 en een klemschroef 3. In het dikkere gedeelte van het. handvat is onder een hoek een konische boring 4 aangebracht. De buis 1 wordt via de urethra 5 in de blaas 6 geschoven. De symphyse 7 alsmede de vagina 8 en de uterus 9 worden in de figuur aangegeven.Fig. 1 A tube 1 is equipped with a handle 2 and a clamping screw 3. In the thicker part of the. The handle has a conical bore 4 arranged at an angle. The tube 1 is pushed into the bladder 6 via the urethra 5. The symphysis 7 as well as the vagina 8 and the uterus 9 are indicated in the figure.

Fig. 2 Door de buis wordt een baloncatheter 10 in de. blaas geschoven.Fig. 2 A balloon catheter 10 is inserted through the tube into the. bladder pushed.

Fig. 3 De balon 11 van de catheter wordt op gebruikelijke wijze met behulp van een injectiespuit 12 gevuld.Fig. 3 The balloon 11 of the catheter is filled in the usual manner with the aid of a syringe 12.

Fig. 4 De balloncatheter 10 wordt teruggetrokken tot dat de ballon 11 op het uiteinde van de buis 1 rust. Nu wordt de balloncatheter 10 met behulp van de klemschroef 3 in de buis gefixeerd.Fig. The balloon catheter 10 is withdrawn until the balloon 11 rests on the end of the tube 1. The balloon catheter 10 is now fixed in the tube with the aid of the clamping screw 3.

Fig. 5 De buis 1 wordt zo veel mogelijk naar buiten getrokken, totdat de bal on 11 op de blaashals rust.Fig. The tube 1 is pulled out as much as possible, until the ball on 11 rests on the bladder neck.

Fig. 6 door de schuine conus 4 van het handvat 2 wordt een voor dit doel geschikte venencanule 13 met voernaald 14 zo diep mogelijk ingebracht. De ligging van de punt van de venencanule even buiten de blaashals is nu exact bepaald door de ligging van de buis 1.Fig. 6 through the oblique cone 4 of the handle 2, a vein cannula 13 with feed needle 14 suitable for this purpose is inserted as deep as possible. The location of the tip of the vein cannula just outside the bladder neck is now exactly determined by the location of the tube 1.

Fig. 7 Na verwijdering van de voernaald wordt een spuit met biokeramische keramieksuspensie 15 op de venencanule geplaatst. Door inspuiting van de keramieksuspensie wordt de substantie 16 aangebracht tussen urethraepitheel en sluitspieren van de blaasuitgang.Fig. 7 After removal of the feed needle, a syringe with a ceramic ceramic suspension 15 is placed on the vein cannula. By injecting the ceramic suspension, the substance 16 is placed between urethral epithelium and sphincter muscles of the bladder outlet.

Fig. 8 Hier worden drie inspuitplaatsen aangegeven, die een optimaal resultaat van de behandeling verzekeren.Fig. 8 Three injection sites are indicated here, which ensure an optimal result of the treatment.

De uitvinding heeft betrekking op een keramieksuspensie, waarvan slechts de draagsubstantie (max. 50%) wordt geresorbeerd en het aandeel van biokeramiek over een lange periode onaangetast blijft. De uitvinding heeft vervolgens betrekking op een richtapparaat met behulp waarvan de biokeramiek op eenvoudige en veilige wijze en op de juiste plaats kan worden aangebracht.The invention relates to a ceramic suspension, of which only the carrier substance (max. 50%) is absorbed and the proportion of bioceramics remains unaffected over a long period of time. The invention then relates to a straightening device with the aid of which the bioceramics can be applied in a simple and safe manner and in the correct place.

Claims (5)

1. Suspensie van biokeramisch materiaal voor de behandeling van verslapte weefselstructuren, bij voorkeur voor de behandeling van urine-incontinentie. Richtapparaat. voor het snel en veilig uitvoeren van periurthrale injecties van bedoelde suspensies.1. Suspension of bioceramics for the treatment of weakened tissue structures, preferably for the treatment of urinary incontinence. Aiming device. for the quick and safe performance of periurthral injections of said suspensions. 2. Suspensie als onder conclusie 1, daardoor gekenmerkt, dat het biokeramisch materiaal bij voorkeur bestaat uit triclaciumphosphaat keramiek (TCP, hydroxylapatiet).Suspension as claimed in claim 1, characterized in that the bioceramic material preferably consists of triclacium phosphate ceramic (TCP, hydroxylapatite). 3. Suspensie als onder de conclusies 1 en 2, daardoor gekenmerkt, dat als suspenderend medium gelvormige oplossingen van polymeren zoals polyvinylpyrolidon en biopolymeren zoals collageen, alginaten en chitosanen worden gebruikt.Suspension as claimed in claims 1 and 2, characterized in that the suspension medium used is gel solutions of polymers such as polyvinylpyrolidone and biopolymers such as collagen, alginates and chitosans. 4. Richtapparaat als onder conclusie 1, daardoor gekenmerkt, dat met behulp van een balloncatheter de ligging van het uiteinde van de buis van het richtapparaat in de blaashals kan worden bepaald.Aiming device as claimed in claim 1, characterized in that the position of the end of the tube of the aiming device in the bladder neck can be determined with the aid of a balloon catheter. 5. Richtapparaat als onder de conclusies 1 en 4, daardoor gekenmerkt, dat via een op de buis bevestigd handvat een boring als houder voor een venencanule dient en na plaatsen van de canule, de ligging van de punt van de canule even buiten de urethra en de blaashals kan worden bepaald.Aiming device as under Claims 1 and 4, characterized in that a bore serves as a holder for a vein cannula via a handle mounted on the tube and, after insertion of the cannula, the position of the tip of the cannula just outside the urethra and the bladder neck can be determined.
NL9301515A 1993-09-01 1993-09-01 Material and method for the treatment of urine incontinence. NL9301515A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL9301515A NL9301515A (en) 1993-09-01 1993-09-01 Material and method for the treatment of urine incontinence.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL9301515A NL9301515A (en) 1993-09-01 1993-09-01 Material and method for the treatment of urine incontinence.
NL9301515 1993-09-01

Publications (1)

Publication Number Publication Date
NL9301515A true NL9301515A (en) 1995-04-03

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Application Number Title Priority Date Filing Date
NL9301515A NL9301515A (en) 1993-09-01 1993-09-01 Material and method for the treatment of urine incontinence.

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0678009A1 (en) * 1993-09-14 1995-10-25 C.R. Bard, Inc. Apparatus and method for implanting prostheses within periurethral tissues
CN104363845A (en) * 2012-04-24 2015-02-18 于罗吉尼有限责任公司 Bulking agent applicator for treating female urinary incontinence

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0678009A1 (en) * 1993-09-14 1995-10-25 C.R. Bard, Inc. Apparatus and method for implanting prostheses within periurethral tissues
EP0678009A4 (en) * 1993-09-14 1996-05-08 Bard Inc C R Apparatus and method for implanting prostheses within periurethral tissues.
CN104363845A (en) * 2012-04-24 2015-02-18 于罗吉尼有限责任公司 Bulking agent applicator for treating female urinary incontinence
CN104363845B (en) * 2012-04-24 2017-09-01 于罗吉尼有限责任公司 Filler applicator for treating female urinary incontinence
US9775622B2 (en) 2012-04-24 2017-10-03 Urogyn B.V. Bulking agent applicator for treating female urinary incontinence

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