NL9001387A - Werkwijze ter modificering van de eigenschappen van een substraatoppervlak door kovalente koppeling van een verbinding aan het oppervlak alsmede membraan gemodificeerd volgens de werkwijze. - Google Patents

Werkwijze ter modificering van de eigenschappen van een substraatoppervlak door kovalente koppeling van een verbinding aan het oppervlak alsmede membraan gemodificeerd volgens de werkwijze. Download PDF

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Publication number
NL9001387A
NL9001387A NL9001387A NL9001387A NL9001387A NL 9001387 A NL9001387 A NL 9001387A NL 9001387 A NL9001387 A NL 9001387A NL 9001387 A NL9001387 A NL 9001387A NL 9001387 A NL9001387 A NL 9001387A
Authority
NL
Netherlands
Prior art keywords
compound
membrane
heparin
substrate surface
physiologically active
Prior art date
Application number
NL9001387A
Other languages
English (en)
Dutch (nl)
Original Assignee
Holland Biomaterials Group B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holland Biomaterials Group B V filed Critical Holland Biomaterials Group B V
Priority to NL9001387A priority Critical patent/NL9001387A/nl
Priority to DE69127710T priority patent/DE69127710D1/de
Priority to CA 2085979 priority patent/CA2085979A1/en
Priority to PCT/NL1991/000103 priority patent/WO1991019521A1/en
Priority to EP91912431A priority patent/EP0595805B1/de
Publication of NL9001387A publication Critical patent/NL9001387A/nl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
NL9001387A 1990-06-19 1990-06-19 Werkwijze ter modificering van de eigenschappen van een substraatoppervlak door kovalente koppeling van een verbinding aan het oppervlak alsmede membraan gemodificeerd volgens de werkwijze. NL9001387A (nl)

Priority Applications (5)

Application Number Priority Date Filing Date Title
NL9001387A NL9001387A (nl) 1990-06-19 1990-06-19 Werkwijze ter modificering van de eigenschappen van een substraatoppervlak door kovalente koppeling van een verbinding aan het oppervlak alsmede membraan gemodificeerd volgens de werkwijze.
DE69127710T DE69127710D1 (de) 1990-06-19 1991-06-19 Verfahren zur modifizierung der oberfläche eines substrates durch kovalente bindung einer verbindung an diesem substrat, und durch diesem verfahren modifizierte membran
CA 2085979 CA2085979A1 (en) 1990-06-19 1991-06-19 Method of modifying the properties of a substrate surface by covalent bonding of a compound to the surface, and membrane modified according to this method
PCT/NL1991/000103 WO1991019521A1 (en) 1990-06-19 1991-06-19 Method of modifying the properties of a substrate surface by covalent bonding of a compound to the surface, and membrane modified according to this method
EP91912431A EP0595805B1 (de) 1990-06-19 1991-06-19 Verfahren zur modifizierung der oberfläche eines substrates durch kovalente bindung einer verbindung an diesem substrat, und durch diesem verfahren modifizierte membran

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL9001387 1990-06-19
NL9001387A NL9001387A (nl) 1990-06-19 1990-06-19 Werkwijze ter modificering van de eigenschappen van een substraatoppervlak door kovalente koppeling van een verbinding aan het oppervlak alsmede membraan gemodificeerd volgens de werkwijze.

Publications (1)

Publication Number Publication Date
NL9001387A true NL9001387A (nl) 1992-01-16

Family

ID=19857271

Family Applications (1)

Application Number Title Priority Date Filing Date
NL9001387A NL9001387A (nl) 1990-06-19 1990-06-19 Werkwijze ter modificering van de eigenschappen van een substraatoppervlak door kovalente koppeling van een verbinding aan het oppervlak alsmede membraan gemodificeerd volgens de werkwijze.

Country Status (5)

Country Link
EP (1) EP0595805B1 (de)
CA (1) CA2085979A1 (de)
DE (1) DE69127710D1 (de)
NL (1) NL9001387A (de)
WO (1) WO1991019521A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217743A (en) * 1992-02-07 1993-06-08 Paradigm Biotechnologies Partnership Biomaterials of enhanced biocompatibility
US6262255B1 (en) * 1995-04-05 2001-07-17 Biomm, Inc. Non-immunogenic, biocompatible macromolecular membrane compositions, and methods for making them
US5855618A (en) 1996-09-13 1999-01-05 Meadox Medicals, Inc. Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin
US6306165B1 (en) 1996-09-13 2001-10-23 Meadox Medicals ePTFE small caliber vascular grafts with significant patency enhancement via a surface coating which contains covalently bonded heparin
US5877263A (en) * 1996-11-25 1999-03-02 Meadox Medicals, Inc. Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
US6248127B1 (en) 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3071275D1 (en) * 1980-09-01 1986-01-16 Teijin Ltd Heparin derivative, its production and methods for imparting antithrombotic activity to biomedical materials
SE8200751L (sv) * 1982-02-09 1983-08-10 Olle Larm Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter
EP0336964B1 (de) * 1986-12-03 1993-08-04 Terumo Kabushiki Kaisha Antithrombotische arzneimittel und deren herstellung
NL8701337A (nl) * 1987-06-09 1989-01-02 Sentron V O F Substraat voorzien van een bloedcompatibel oppervlak, verkregen door koppeling aan het oppervlak van een fysiologisch aktieve stof met remmende invloed op de vorming van bloedstolsels en/of in staat om gevormde bloedstolsels af te breken, alsmede werkwijze ter vervaardiging van het substraat.

Also Published As

Publication number Publication date
CA2085979A1 (en) 1991-12-20
WO1991019521A1 (en) 1991-12-26
DE69127710D1 (de) 1997-10-23
EP0595805A1 (de) 1994-05-11
EP0595805B1 (de) 1997-09-17

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