NL8900119A - Werkwijze voor het afsplitsen van (delta)4-onverzadigd uronzuur in glycosaminoglycaan fragmenten. - Google Patents

Werkwijze voor het afsplitsen van (delta)4-onverzadigd uronzuur in glycosaminoglycaan fragmenten. Download PDF

Info

Publication number
NL8900119A
NL8900119A NL8900119A NL8900119A NL8900119A NL 8900119 A NL8900119 A NL 8900119A NL 8900119 A NL8900119 A NL 8900119A NL 8900119 A NL8900119 A NL 8900119A NL 8900119 A NL8900119 A NL 8900119A
Authority
NL
Netherlands
Prior art keywords
uronic acid
fragments
heparin
glycosaminoglycan
unsaturated uronic
Prior art date
Application number
NL8900119A
Other languages
English (en)
Dutch (nl)
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Priority to NL8900119A priority Critical patent/NL8900119A/nl
Priority to DK90200059.5T priority patent/DK0379239T3/da
Priority to ES90200059T priority patent/ES2071742T3/es
Priority to DE69017235T priority patent/DE69017235T2/de
Priority to AT90200059T priority patent/ATE119168T1/de
Priority to EP90200059A priority patent/EP0379239B1/de
Priority to US07/466,161 priority patent/US5451668A/en
Priority to JP2009462A priority patent/JP2996348B2/ja
Publication of NL8900119A publication Critical patent/NL8900119A/nl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL8900119A 1989-01-19 1989-01-19 Werkwijze voor het afsplitsen van (delta)4-onverzadigd uronzuur in glycosaminoglycaan fragmenten. NL8900119A (nl)

Priority Applications (8)

Application Number Priority Date Filing Date Title
NL8900119A NL8900119A (nl) 1989-01-19 1989-01-19 Werkwijze voor het afsplitsen van (delta)4-onverzadigd uronzuur in glycosaminoglycaan fragmenten.
DK90200059.5T DK0379239T3 (da) 1989-01-19 1990-01-10 Fremgangsmåde til fraspaltning af delta4-umættet uronsyre fra glycosaminoglycaner
ES90200059T ES2071742T3 (es) 1989-01-19 1990-01-10 Proceso para la escision de acido uronico delta4-insaturado a partir de glicosaminoglicanos.
DE69017235T DE69017235T2 (de) 1989-01-19 1990-01-10 Verfahren zum Abspalten von delta-4-ungesättigter Uronsäure aus Glycosaminoglykanen.
AT90200059T ATE119168T1 (de) 1989-01-19 1990-01-10 Verfahren zum abspalten von delta-4-ungesättigter uronsäure aus glycosaminoglykanen.
EP90200059A EP0379239B1 (de) 1989-01-19 1990-01-10 Verfahren zum Abspalten von delta-4-ungesättigter Uronsäure aus Glycosaminoglykanen
US07/466,161 US5451668A (en) 1989-01-19 1990-01-17 Process for splitting off Δ4 -unsaturated uronic acid from glycosaminoglycans
JP2009462A JP2996348B2 (ja) 1989-01-19 1990-01-18 グリコサミノグリカンから△▲上4▼―不飽和ウロン酸を分離するための方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8900119A NL8900119A (nl) 1989-01-19 1989-01-19 Werkwijze voor het afsplitsen van (delta)4-onverzadigd uronzuur in glycosaminoglycaan fragmenten.
NL8900119 1989-01-19

Publications (1)

Publication Number Publication Date
NL8900119A true NL8900119A (nl) 1990-08-16

Family

ID=19853979

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8900119A NL8900119A (nl) 1989-01-19 1989-01-19 Werkwijze voor het afsplitsen van (delta)4-onverzadigd uronzuur in glycosaminoglycaan fragmenten.

Country Status (8)

Country Link
US (1) US5451668A (de)
EP (1) EP0379239B1 (de)
JP (1) JP2996348B2 (de)
AT (1) ATE119168T1 (de)
DE (1) DE69017235T2 (de)
DK (1) DK0379239T3 (de)
ES (1) ES2071742T3 (de)
NL (1) NL8900119A (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1582531A1 (de) * 2004-03-24 2005-10-05 Aventis Pharma S.A. Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
JP2006219767A (ja) * 2005-02-08 2006-08-24 Univ Of Tsukuba 製紙用化学パルプ中の不飽和ウロン酸の除去方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2830931A (en) * 1954-03-19 1958-04-15 Boots Pure Drug Co Ltd Process of removing colored impurities from heparin
US3135660A (en) * 1956-11-09 1964-06-02 Riker Laboratories Inc Method for purifying sulfated carbohydrates with oxidizing agents
US4239664A (en) * 1978-10-31 1980-12-16 Research Corporation Anti-thrombogenic PVP-heparin polymer
US4826827A (en) * 1979-10-05 1989-05-02 Choay S.A. Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs
US4322275A (en) * 1980-01-10 1982-03-30 Ionics Incorporated Fractionation of protein mixtures
US4446314A (en) * 1980-09-30 1984-05-01 Cutter Laboratories, Inc. Fractionation of heparin
DK196986D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
SE8702254D0 (sv) * 1987-05-29 1987-05-29 Kabivitrum Ab Novel heparin derivatives
NL8701342A (nl) * 1987-06-09 1989-01-02 Tno Bifunctionele oligosacchariden alsmede daarvan afgeleide aktieve verbindingen.

Also Published As

Publication number Publication date
DE69017235T2 (de) 1995-06-29
ATE119168T1 (de) 1995-03-15
DE69017235D1 (de) 1995-04-06
EP0379239A1 (de) 1990-07-25
JP2996348B2 (ja) 1999-12-27
DK0379239T3 (da) 1995-06-19
EP0379239B1 (de) 1995-03-01
ES2071742T3 (es) 1995-07-01
US5451668A (en) 1995-09-19
JPH02269102A (ja) 1990-11-02

Similar Documents

Publication Publication Date Title
EP0027089B1 (de) Oligosaccharidfraktionen und Oligosaccharide mit biologischen Eigenschaften, Verfahren zu ihrer Herstellung und ihre Verwendungen als Arzneimittel
Kenne et al. Structural studies of the Vibrio cholerae O-antigen
CA1339925C (fr) Oligosaccharides hepariniques affines pour les facteurs de croissance cellulaires
KR100853585B1 (ko) 헤파린-유래 폴리사카라이드 혼합물, 이의 제조방법 및이를 함유하는 약학 조성물
EP0337327A1 (de) Verfahren zur Herstellung von neuen Oligosaccharid-Fragmenten durch kontrollierte chemische Depolymerisation von Heparin
AU2003300161A1 (en) Heparin-derived polysaccharide mixtures, preparation thereof and pharmaceutical compositions containing same
JP2006206849A (ja) アルキルエステル化されたグリコサミノグリカンの製造方法
US10889656B2 (en) Heparan sulfate having high 3-O-sulfation rate in glucosamine residues
CA2439337A1 (en) Highly sulfated derivatives of k5 polysaccharide and their preparation
Fransson et al. Interaction between heparan sulphate chains I. A gel chromatographic, light-scattering and structural study of aggregating and non-aggregating chains
US8513407B2 (en) Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
US5110918A (en) Process for preparing EDTA-free heparins, heparin fractions and fragments
USRE35770E (en) Oligosaccharides having anti-Xa activity and pharmaceutical compositions containing them
JPH06172375A (ja) オリゴマンヌロン酸を重合度によって分離する方法
NL8900119A (nl) Werkwijze voor het afsplitsen van (delta)4-onverzadigd uronzuur in glycosaminoglycaan fragmenten.
AU2004259111B2 (en) Heparin-derived oligosaccharide mixtures, preparation thereof and pharmaceutical compositions containing said mixtures
CA2489862C (en) Epimerized derivatives of k5 polysaccharide with a very high degree of sulfation
EP0408770B1 (de) Sulfatiertes polysaccharid, dessen pharmazeutisch verträgliche salze, dessen herstellung und medikament, das dieses als wirksstoff enthält
Jansson et al. Evidence for the existence of a multichain proteoglycan of heparan sulphate
EP1694714A2 (de) Niedermolekulare polysaccharide mit antithrombotischer wirkung
WO1994029352A1 (en) Polysaccharides having high antithrombotic and anticoagulant activity
US3179566A (en) Purification of heparin
FR2495935A1 (fr) Fractions mucopolysaccharidiques possedant des proprietes biologiques, leur procede de preparation et leur application en tant que medicaments
RU2333222C2 (ru) Эпимеризованные производные полисахарида к5 с высокой степенью сульфатирования

Legal Events

Date Code Title Description
A1B A search report has been drawn up
BI The patent application has been withdrawn