NL7801001A - Antibacterial and antimalarial (2,4)-di:amino-pyrimidine derivs. - prepd. e.g. by reacting (2,4)-di:amino-(5)-hydroxy-pyrimidine and aryl(oxy)-alkyl halide cpds. - Google Patents

Antibacterial and antimalarial (2,4)-di:amino-pyrimidine derivs. - prepd. e.g. by reacting (2,4)-di:amino-(5)-hydroxy-pyrimidine and aryl(oxy)-alkyl halide cpds.

Info

Publication number
NL7801001A
NL7801001A NL7801001A NL7801001A NL7801001A NL 7801001 A NL7801001 A NL 7801001A NL 7801001 A NL7801001 A NL 7801001A NL 7801001 A NL7801001 A NL 7801001A NL 7801001 A NL7801001 A NL 7801001A
Authority
NL
Netherlands
Prior art keywords
amino
pyrimidine
prepd
aryl
cpds
Prior art date
Application number
NL7801001A
Other languages
Dutch (nl)
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Priority to NL7801001A priority Critical patent/NL7801001A/en
Publication of NL7801001A publication Critical patent/NL7801001A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New 2,4-diaminopyridimidine derivs. have formula (I) In the formula, R is H, CH3 or C2H5; X is 1-10C alkylene; Y is O, S or a direct bond; and Ar is aryl. (I) can be used for the treatment of malaria and/or bacterial infections. Absorption after oral is good, and (I) are active against malaria infections which are resistant to other antimalarials. Specific cpds. (I) include 2,4-diamino-6-methyl-5-(4-chloro-2-cyclohexylphenoxypropoxy)-pyri- midine. In an example, this is prepd. from 2,4-diamino-6-methyl-5-hydroxypyrimidine dihydrochloride and 4-chloro-2-cyclohexylphenoxypropyl bromide.
NL7801001A 1978-01-27 1978-01-27 Antibacterial and antimalarial (2,4)-di:amino-pyrimidine derivs. - prepd. e.g. by reacting (2,4)-di:amino-(5)-hydroxy-pyrimidine and aryl(oxy)-alkyl halide cpds. NL7801001A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7801001A NL7801001A (en) 1978-01-27 1978-01-27 Antibacterial and antimalarial (2,4)-di:amino-pyrimidine derivs. - prepd. e.g. by reacting (2,4)-di:amino-(5)-hydroxy-pyrimidine and aryl(oxy)-alkyl halide cpds.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7801001A NL7801001A (en) 1978-01-27 1978-01-27 Antibacterial and antimalarial (2,4)-di:amino-pyrimidine derivs. - prepd. e.g. by reacting (2,4)-di:amino-(5)-hydroxy-pyrimidine and aryl(oxy)-alkyl halide cpds.

Publications (1)

Publication Number Publication Date
NL7801001A true NL7801001A (en) 1979-07-31

Family

ID=19830239

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7801001A NL7801001A (en) 1978-01-27 1978-01-27 Antibacterial and antimalarial (2,4)-di:amino-pyrimidine derivs. - prepd. e.g. by reacting (2,4)-di:amino-(5)-hydroxy-pyrimidine and aryl(oxy)-alkyl halide cpds.

Country Status (1)

Country Link
NL (1) NL7801001A (en)

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Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BV The patent application has lapsed