NL7603491A - N-nicotinoyl-4-amino benzoic acid derivs - in compns for promoting cerebral blood flow esp in the elderly - Google Patents

N-nicotinoyl-4-amino benzoic acid derivs - in compns for promoting cerebral blood flow esp in the elderly

Info

Publication number
NL7603491A
NL7603491A NL7603491A NL7603491A NL7603491A NL 7603491 A NL7603491 A NL 7603491A NL 7603491 A NL7603491 A NL 7603491A NL 7603491 A NL7603491 A NL 7603491A NL 7603491 A NL7603491 A NL 7603491A
Authority
NL
Netherlands
Prior art keywords
blood flow
cerebral blood
nicotinoyl
elderly
compns
Prior art date
Application number
NL7603491A
Other languages
Dutch (nl)
Original Assignee
Malsen Egbert Von
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Malsen Egbert Von filed Critical Malsen Egbert Von
Priority to NL7603491A priority Critical patent/NL7603491A/en
Publication of NL7603491A publication Critical patent/NL7603491A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Therapeutic compsn. is new containing as active constituent a cpd. of formula (I): (where A is (i), (ii) the gp. or (iii) the gp. The gp.(I) is pref used for treatment of elderly patients for promoting cerebral blood flow. p-Nitrobenzoyl chloride is converted into the dimethylamino-isopropyl ester witht the alcohol, the NO2 gp. is reduced to NH2. and the product reacts with nicotinoyl chlrodie hydrochloride to give I (A=(i)). The compsns. are given at 20 mg/day orally or parenterally (pref. i.m.). I(A=(i)) is said to have a nirostatic action as well as promoting cerebral blood flow.
NL7603491A 1976-04-02 1976-04-02 N-nicotinoyl-4-amino benzoic acid derivs - in compns for promoting cerebral blood flow esp in the elderly NL7603491A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7603491A NL7603491A (en) 1976-04-02 1976-04-02 N-nicotinoyl-4-amino benzoic acid derivs - in compns for promoting cerebral blood flow esp in the elderly

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7603491A NL7603491A (en) 1976-04-02 1976-04-02 N-nicotinoyl-4-amino benzoic acid derivs - in compns for promoting cerebral blood flow esp in the elderly

Publications (1)

Publication Number Publication Date
NL7603491A true NL7603491A (en) 1977-10-04

Family

ID=19825935

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7603491A NL7603491A (en) 1976-04-02 1976-04-02 N-nicotinoyl-4-amino benzoic acid derivs - in compns for promoting cerebral blood flow esp in the elderly

Country Status (1)

Country Link
NL (1) NL7603491A (en)

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Legal Events

Date Code Title Description
BV The patent application has lapsed