NL7512120A - Werkwijze ter bereiding van nieuwe derivaten van vinblastine, vincristine en leurosidine. - Google Patents
Werkwijze ter bereiding van nieuwe derivaten van vinblastine, vincristine en leurosidine.Info
- Publication number
- NL7512120A NL7512120A NL7512120A NL7512120A NL7512120A NL 7512120 A NL7512120 A NL 7512120A NL 7512120 A NL7512120 A NL 7512120A NL 7512120 A NL7512120 A NL 7512120A NL 7512120 A NL7512120 A NL 7512120A
- Authority
- NL
- Netherlands
- Prior art keywords
- leurosidine
- vinblastine
- vincristine
- new derivatives
- preparing new
- Prior art date
Links
- JXLYSJRDGCGARV-PJXZDTQASA-N Leurosidine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-PJXZDTQASA-N 0.000 title 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 title 1
- JXLYSJRDGCGARV-KSNABSRWSA-N ac1l29ym Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-KSNABSRWSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical class C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 title 1
- 229960004528 vincristine Drugs 0.000 title 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/515,134 US4012390A (en) | 1974-10-16 | 1974-10-16 | Vinblastinoic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7512120A true NL7512120A (nl) | 1976-04-21 |
Family
ID=24050111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7512120A NL7512120A (nl) | 1974-10-16 | 1975-10-15 | Werkwijze ter bereiding van nieuwe derivaten van vinblastine, vincristine en leurosidine. |
Country Status (19)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4096148A (en) * | 1976-12-06 | 1978-06-20 | Eli Lilly And Company | Oxazolidinedione derivatives of Vinca alkaloids |
| US4558053A (en) * | 1983-12-21 | 1985-12-10 | Eli Lilly And Company | Naphthalene-1,5-disulfonate salts of dimeric indole-dihydroindole alkaloids |
| AU1374601A (en) * | 1999-11-12 | 2001-05-30 | Angiotech International Ag | Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors |
| DE60331367D1 (de) | 2002-12-30 | 2010-04-01 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3392173A (en) * | 1964-03-09 | 1968-07-09 | Lilly Co Eli | Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation |
| US3352868A (en) * | 1964-04-01 | 1967-11-14 | Lilly Co Eli | Dihydrovinblastine |
| US3387001A (en) * | 1964-10-19 | 1968-06-04 | Lilly Co Eli | Novel aminoacyl esters of desacetyl vincaleukoblastine |
-
1974
- 1974-10-16 US US05/515,134 patent/US4012390A/en not_active Expired - Lifetime
-
1975
- 1975-01-01 AR AR260695A patent/AR208330A1/es active
- 1975-10-06 CA CA237,066A patent/CA1061785A/en not_active Expired
- 1975-10-07 IL IL48257A patent/IL48257A/xx unknown
- 1975-10-07 DE DE19752544843 patent/DE2544843A1/de not_active Withdrawn
- 1975-10-08 AU AU85562/75A patent/AU8556275A/en not_active Expired
- 1975-10-10 FR FR7531159A patent/FR2287905A1/fr active Granted
- 1975-10-10 BE BE1006943A patent/BE834364A/xx unknown
- 1975-10-10 IE IE2215/75A patent/IE42132B1/en unknown
- 1975-10-13 GB GB41775/75A patent/GB1521053A/en not_active Expired
- 1975-10-13 ZA ZA756424A patent/ZA756424B/xx unknown
- 1975-10-13 JP JP50123730A patent/JPS5186500A/ja active Pending
- 1975-10-15 NL NL7512120A patent/NL7512120A/xx not_active Application Discontinuation
- 1975-10-15 HU HU75EI652A patent/HU174569B/hu unknown
- 1975-10-15 DK DK464275A patent/DK464275A/da unknown
- 1975-10-15 DD DD188873A patent/DD122538A5/xx unknown
- 1975-10-15 CH CH1338075A patent/CH618983A5/de not_active IP Right Cessation
- 1975-10-15 SE SE7511570A patent/SE7511570L/xx unknown
- 1975-10-16 ES ES441860A patent/ES441860A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE42132L (en) | 1976-04-16 |
| DE2544843A1 (de) | 1976-04-29 |
| SE7511570L (sv) | 1976-04-20 |
| CA1061785A (en) | 1979-09-04 |
| IL48257A (en) | 1979-01-31 |
| IL48257A0 (en) | 1975-12-31 |
| IE42132B1 (en) | 1980-06-04 |
| FR2287905A1 (fr) | 1976-05-14 |
| US4012390A (en) | 1977-03-15 |
| DD122538A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-10-12 |
| FR2287905B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1978-11-10 |
| ES441860A1 (es) | 1977-08-16 |
| JPS5186500A (en) | 1976-07-29 |
| AR208330A1 (es) | 1976-12-20 |
| ZA756424B (en) | 1977-05-25 |
| AU8556275A (en) | 1977-04-21 |
| HU174569B (hu) | 1980-02-28 |
| BE834364A (fr) | 1976-04-12 |
| GB1521053A (en) | 1978-08-09 |
| CH618983A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-08-29 |
| DK464275A (da) | 1976-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BV | The patent application has lapsed |