NL7308083A - Disteroidal ethers - oral and parenteral oestrogens with prolonged activity - Google Patents
Disteroidal ethers - oral and parenteral oestrogens with prolonged activityInfo
- Publication number
- NL7308083A NL7308083A NL7308083A NL7308083A NL7308083A NL 7308083 A NL7308083 A NL 7308083A NL 7308083 A NL7308083 A NL 7308083A NL 7308083 A NL7308083 A NL 7308083A NL 7308083 A NL7308083 A NL 7308083A
- Authority
- NL
- Netherlands
- Prior art keywords
- ethers
- mono
- disteroidal
- oestrogens
- parenteral
- Prior art date
Links
Landscapes
- Steroid Compounds (AREA)
Abstract
The ethers are of formula (I): where R = H, 1-8C mono- or di-carboxylic acid residue, or a 1-9C (cyclo)aliphatic, or aromatic residue; R1 = H or Me; R4 = H or Me; R5 = Me or Et; Y = H, F, or Cl; X = H, beta-OH or O; Q = A = H, 1-8C mono- or di-carboxylic acid residue, or lower alkoxyalkyl; B = H or opt. unsatd. 1-3C alkyl; R2 = H, OH, or a 1-8C mono- or di-carboxylic O-acyl residue; R3 = H, OH, or 1-4C acyloxy; and rings A+B = where R6 = H, SMe, or SAc. (I) are prepd. by condensing a 3-protected-3,17-dihydroxy-estratriene, with an appropriately activated 3-ketosteroid, in the presence of an acid catalyst. Activated functions are pref. enol ethers, esters, or acetals, and the configuration and unsatn. rings A and B in the ketone determines the AB ring system of (I).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7308083A NL7308083A (en) | 1973-06-08 | 1973-06-08 | Disteroidal ethers - oral and parenteral oestrogens with prolonged activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7308083A NL7308083A (en) | 1973-06-08 | 1973-06-08 | Disteroidal ethers - oral and parenteral oestrogens with prolonged activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7308083A true NL7308083A (en) | 1974-12-10 |
Family
ID=19819041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7308083A NL7308083A (en) | 1973-06-08 | 1973-06-08 | Disteroidal ethers - oral and parenteral oestrogens with prolonged activity |
Country Status (1)
| Country | Link |
|---|---|
| NL (1) | NL7308083A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7067504B2 (en) | 2004-01-15 | 2006-06-27 | Warner Chilcott Company, Inc. | Di-steroidal prodrugs of ethinyl estradiol |
| US7067505B2 (en) | 2004-01-15 | 2006-06-27 | Warner Chilcott Company, Inc. | Di-steroidal prodrugs of estradiol |
| US7795241B2 (en) | 2005-07-12 | 2010-09-14 | Warner Chilcott Company, Llc | Derivative prodrugs of ethinyl estradiol |
-
1973
- 1973-06-08 NL NL7308083A patent/NL7308083A/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7067504B2 (en) | 2004-01-15 | 2006-06-27 | Warner Chilcott Company, Inc. | Di-steroidal prodrugs of ethinyl estradiol |
| US7067505B2 (en) | 2004-01-15 | 2006-06-27 | Warner Chilcott Company, Inc. | Di-steroidal prodrugs of estradiol |
| US7795241B2 (en) | 2005-07-12 | 2010-09-14 | Warner Chilcott Company, Llc | Derivative prodrugs of ethinyl estradiol |
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