NL7216969A - Blood coagulation complex - by extraction of plasma with sephadex - Google Patents

Blood coagulation complex - by extraction of plasma with sephadex

Info

Publication number
NL7216969A
NL7216969A NL7216969A NL7216969A NL7216969A NL 7216969 A NL7216969 A NL 7216969A NL 7216969 A NL7216969 A NL 7216969A NL 7216969 A NL7216969 A NL 7216969A NL 7216969 A NL7216969 A NL 7216969A
Authority
NL
Netherlands
Prior art keywords
plasma
sephadex
extraction
mixt
blood coagulation
Prior art date
Application number
NL7216969A
Other versions
NL158703B (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to NL7216969A priority Critical patent/NL158703B/en
Publication of NL7216969A publication Critical patent/NL7216969A/en
Publication of NL158703B publication Critical patent/NL158703B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A storage stable mixt. of coagulation Factors II, VII, IX and X in non-activated form, in the same proportions as in natural human plasma and free of thrombin activated Factor X, depressor activity and anti-complement activity, is prepared by selective absorption from Effluent I, prepared by Cohn method 6 from natural human plasma, onto an ion exchanger. This ion exchanger consists of cross-linked dextran substituted by diethylaminoethyl gps. The mixt of factors is then eluted with a soln of a volatile salt. The product is used for treating coagulation disorders, e.g. for haemophilia.
NL7216969A 1972-12-14 1972-12-14 METHOD OF PREPARING A CONCENTRATE FROM HUMAN PLASMA BY ADSORING AND THEN ELUTING FROM A FRACTION OF HUMAN PLASMA SOLID FACTORS TO AN ANION EXCHANGER. NL158703B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7216969A NL158703B (en) 1972-12-14 1972-12-14 METHOD OF PREPARING A CONCENTRATE FROM HUMAN PLASMA BY ADSORING AND THEN ELUTING FROM A FRACTION OF HUMAN PLASMA SOLID FACTORS TO AN ANION EXCHANGER.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7216969A NL158703B (en) 1972-12-14 1972-12-14 METHOD OF PREPARING A CONCENTRATE FROM HUMAN PLASMA BY ADSORING AND THEN ELUTING FROM A FRACTION OF HUMAN PLASMA SOLID FACTORS TO AN ANION EXCHANGER.

Publications (2)

Publication Number Publication Date
NL7216969A true NL7216969A (en) 1974-06-18
NL158703B NL158703B (en) 1978-12-15

Family

ID=19817537

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7216969A NL158703B (en) 1972-12-14 1972-12-14 METHOD OF PREPARING A CONCENTRATE FROM HUMAN PLASMA BY ADSORING AND THEN ELUTING FROM A FRACTION OF HUMAN PLASMA SOLID FACTORS TO AN ANION EXCHANGER.

Country Status (1)

Country Link
NL (1) NL158703B (en)

Also Published As

Publication number Publication date
NL158703B (en) 1978-12-15

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Legal Events

Date Code Title Description
NL80 Abbreviated name of patent owner mentioned of already nullified patent

Owner name: CUTTER

V4 Lapsed because of reaching the maxim lifetime of a patent