NL7206145A - Thiocolchicoside prepn - from thiocolchicine in high yield in three stages - Google Patents

Thiocolchicoside prepn - from thiocolchicine in high yield in three stages

Info

Publication number
NL7206145A
NL7206145A NL7206145A NL7206145A NL7206145A NL 7206145 A NL7206145 A NL 7206145A NL 7206145 A NL7206145 A NL 7206145A NL 7206145 A NL7206145 A NL 7206145A NL 7206145 A NL7206145 A NL 7206145A
Authority
NL
Netherlands
Prior art keywords
thiocolchicine
demethyl
thiocolchicoside
prepn
stages
Prior art date
Application number
NL7206145A
Other versions
NL177118C (en
NL177118B (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to NL7206145A priority Critical patent/NL177118C/en
Publication of NL7206145A publication Critical patent/NL7206145A/en
Publication of NL177118B publication Critical patent/NL177118B/en
Application granted granted Critical
Publication of NL177118C publication Critical patent/NL177118C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/248—Colchicine radicals, e.g. colchicosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

3-Glucose-2-yl-3-demethyl-thiocolchicine(thiocolchicoside) and the 2-glucose-2-yl-2-demethyl-deriv. are prepd. by (i) reacting thiocolchicine (T) with BBr3 to give 1,2- and 2,3-bis-demethyl-T (the latter predominating); (ii) reacting with acetobromoglucose in the presence of a tertiary base to give 2- and 3-tetraacetoglucose-2-yl-2,3-bis-demethyl-T and 2-tetraacetoglucose-2-yl-1,2-bis-demethyl-T; (iii) reacting with CH3N2 then a base, and (iv) separating the mixture of the two products obtd. The five named inters. are new.
NL7206145A 1972-05-05 1972-05-05 METHOD FOR PREPARING GLUCOSE-2-YL-DEMETHYLTHIOCOLCHICIN AND METHOD FOR PREPARING OR MANUFACTURING THIS COMPOUND NL177118C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7206145A NL177118C (en) 1972-05-05 1972-05-05 METHOD FOR PREPARING GLUCOSE-2-YL-DEMETHYLTHIOCOLCHICIN AND METHOD FOR PREPARING OR MANUFACTURING THIS COMPOUND

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7206145A NL177118C (en) 1972-05-05 1972-05-05 METHOD FOR PREPARING GLUCOSE-2-YL-DEMETHYLTHIOCOLCHICIN AND METHOD FOR PREPARING OR MANUFACTURING THIS COMPOUND

Publications (3)

Publication Number Publication Date
NL7206145A true NL7206145A (en) 1973-11-07
NL177118B NL177118B (en) 1985-03-01
NL177118C NL177118C (en) 1985-08-01

Family

ID=19815983

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7206145A NL177118C (en) 1972-05-05 1972-05-05 METHOD FOR PREPARING GLUCOSE-2-YL-DEMETHYLTHIOCOLCHICIN AND METHOD FOR PREPARING OR MANUFACTURING THIS COMPOUND

Country Status (1)

Country Link
NL (1) NL177118C (en)

Also Published As

Publication number Publication date
NL177118C (en) 1985-08-01
NL177118B (en) 1985-03-01

Similar Documents

Publication Publication Date Title
BE791243A (en) PROCESS FOR PRODUCING A REDUCING GAS MIXTURE
GB1316760A (en) Phenols and their applications as cross-linking agents
ES433029A1 (en) Vibration-damping material
CA982935A (en) Enriched gas drive recovery process
ZA743741B (en) Process for the production of a methane-containing gas
IT944395B (en) PROCESS FOR THE PRODUCTION OF METHANE
ZA747701B (en) Methane-rich gas process
ZA747700B (en) Methane-rich gas process
YU35966B (en) Process for the preparation of a catalyst for the (co)dimerization of linear olefines
YU35374B (en) Process for obtaining methane-rich gaseous products
FR2112710A5 (en) Thiocolchicoside prepn - from thiocolchicine in high yield in three stages
CA956937A (en) 13-polycarbonalkyl-16-methyl-gona-1,3,5(10)-trienes and 13-polycarbonalkyl-16-methylgon-4-en-3-ones and intermediates for their production
NL7206145A (en) Thiocolchicoside prepn - from thiocolchicine in high yield in three stages
BE783009A (en) Thiocolchicoside prepn - from thiocolchicine in high yield in three stages
AU476625B2 (en) Process forthe production ofa hydrogen-rich gas
ZA742753B (en) Process for producing a methane-containing gas
CA981700A (en) Production of 2-chlorobutadiene-1,3
AU464265B2 (en) Process forthe production of methanol
YU35454B (en) Process for producing flame-resistant laminated pressed materials
IT968603B (en) REDUCING GAS AND PROCESS FOR ITS PRODUCTION
BE777880A (en) OLEFINS OXACYLATION PROCESS IN GAS PHASE
ZA746112B (en) Process for the production of a methane-containing gas
IL41632A (en) Anti-rh typing serum and its production
CA920867A (en) Process for producing a fruit product
BE776497A (en) HYDROPEROXIDE PRODUCTION PROCESS

Legal Events

Date Code Title Description
BB A search report has been drawn up
BC A request for examination has been filed
A85 Still pending on 85-01-01
V1 Lapsed because of non-payment of the annual fee