NL7002135A - Process for the manufacture of benzodiazepine derivatives - Google Patents
Process for the manufacture of benzodiazepine derivativesInfo
- Publication number
- NL7002135A NL7002135A NL7002135A NL7002135A NL7002135A NL 7002135 A NL7002135 A NL 7002135A NL 7002135 A NL7002135 A NL 7002135A NL 7002135 A NL7002135 A NL 7002135A NL 7002135 A NL7002135 A NL 7002135A
- Authority
- NL
- Netherlands
- Prior art keywords
- lower alkyl
- benzodiazepine
- manufacture
- chloro
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
- C07D239/76—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Preparation of 1,4-benzodiazepine-4-oxides (III), and novel intermediates (I) used in the manufacture thereof. where R3,R4, and R5 each = H, halogen, lower alkyl, lower alkoxy, cyano, CF3 or nitro; R6 and R7 each = lower alkyl or aralkyl; R8 = H, lower alkyl, lower alkenyl, lower alkynyl or lower cycloalkyl-lower alkyl. X = the anionic moiety of an acid addition salt. 'Lower alkyl' above denotes C1-C7 7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide and a (6-chloro-4-phenyl-2-quinazolinylmethyl)-trimethyl-ammonium-3-oxi- de salt whenever prepared by the methods specified. (I) as well as being useful intermediates in the preparation of pharmaceutically useful compounds (III), also possess useful cardioactive and antibacterial properties.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL707002135A NL149492B (en) | 1966-01-19 | 1970-02-16 | PROCESS FOR THE PREPARATION OF CHINAZOLINE DERIVATIVES. |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52155166A | 1966-01-19 | 1966-01-19 | |
NL6700785A NL6700785A (en) | 1966-01-19 | 1967-01-18 | |
NL707002135A NL149492B (en) | 1966-01-19 | 1970-02-16 | PROCESS FOR THE PREPARATION OF CHINAZOLINE DERIVATIVES. |
Publications (2)
Publication Number | Publication Date |
---|---|
NL7002135A true NL7002135A (en) | 1970-04-22 |
NL149492B NL149492B (en) | 1976-05-17 |
Family
ID=26644140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL707002135A NL149492B (en) | 1966-01-19 | 1970-02-16 | PROCESS FOR THE PREPARATION OF CHINAZOLINE DERIVATIVES. |
Country Status (1)
Country | Link |
---|---|
NL (1) | NL149492B (en) |
-
1970
- 1970-02-16 NL NL707002135A patent/NL149492B/en unknown
Also Published As
Publication number | Publication date |
---|---|
NL149492B (en) | 1976-05-17 |
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