NL7002135A - Process for the manufacture of benzodiazepine derivatives - Google Patents

Process for the manufacture of benzodiazepine derivatives

Info

Publication number
NL7002135A
NL7002135A NL7002135A NL7002135A NL7002135A NL 7002135 A NL7002135 A NL 7002135A NL 7002135 A NL7002135 A NL 7002135A NL 7002135 A NL7002135 A NL 7002135A NL 7002135 A NL7002135 A NL 7002135A
Authority
NL
Netherlands
Prior art keywords
lower alkyl
benzodiazepine
manufacture
chloro
phenyl
Prior art date
Application number
NL7002135A
Other versions
NL149492B (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NL6700785A external-priority patent/NL6700785A/xx
Application filed filed Critical
Priority to NL707002135A priority Critical patent/NL149492B/en
Publication of NL7002135A publication Critical patent/NL7002135A/en
Publication of NL149492B publication Critical patent/NL149492B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C07D239/76—N-oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Preparation of 1,4-benzodiazepine-4-oxides (III), and novel intermediates (I) used in the manufacture thereof. where R3,R4, and R5 each = H, halogen, lower alkyl, lower alkoxy, cyano, CF3 or nitro; R6 and R7 each = lower alkyl or aralkyl; R8 = H, lower alkyl, lower alkenyl, lower alkynyl or lower cycloalkyl-lower alkyl. X = the anionic moiety of an acid addition salt. 'Lower alkyl' above denotes C1-C7 7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide and a (6-chloro-4-phenyl-2-quinazolinylmethyl)-trimethyl-ammonium-3-oxi- de salt whenever prepared by the methods specified. (I) as well as being useful intermediates in the preparation of pharmaceutically useful compounds (III), also possess useful cardioactive and antibacterial properties.
NL707002135A 1966-01-19 1970-02-16 PROCESS FOR THE PREPARATION OF CHINAZOLINE DERIVATIVES. NL149492B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL707002135A NL149492B (en) 1966-01-19 1970-02-16 PROCESS FOR THE PREPARATION OF CHINAZOLINE DERIVATIVES.

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52155166A 1966-01-19 1966-01-19
NL6700785A NL6700785A (en) 1966-01-19 1967-01-18
NL707002135A NL149492B (en) 1966-01-19 1970-02-16 PROCESS FOR THE PREPARATION OF CHINAZOLINE DERIVATIVES.

Publications (2)

Publication Number Publication Date
NL7002135A true NL7002135A (en) 1970-04-22
NL149492B NL149492B (en) 1976-05-17

Family

ID=26644140

Family Applications (1)

Application Number Title Priority Date Filing Date
NL707002135A NL149492B (en) 1966-01-19 1970-02-16 PROCESS FOR THE PREPARATION OF CHINAZOLINE DERIVATIVES.

Country Status (1)

Country Link
NL (1) NL149492B (en)

Also Published As

Publication number Publication date
NL149492B (en) 1976-05-17

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