NL6908529A - Benzomorphanes as analgesics and morphine- - autogenists - Google Patents

Benzomorphanes as analgesics and morphine- - autogenists

Info

Publication number
NL6908529A
NL6908529A NL6908529A NL6908529A NL6908529A NL 6908529 A NL6908529 A NL 6908529A NL 6908529 A NL6908529 A NL 6908529A NL 6908529 A NL6908529 A NL 6908529A NL 6908529 A NL6908529 A NL 6908529A
Authority
NL
Netherlands
Prior art keywords
benzomorphanes
morphine
analgesics
autogenists
dimethyl
Prior art date
Application number
NL6908529A
Other versions
NL156047B (en
Inventor
A M Akkerman
P A J Janssen
Original Assignee
Acf Chemiefarma Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acf Chemiefarma Nv filed Critical Acf Chemiefarma Nv
Priority to NL6908529.A priority Critical patent/NL156047B/en
Priority to IL34556A priority patent/IL34556A/en
Priority to IE679/70A priority patent/IE34235B1/en
Priority to US00041079A priority patent/US3764606A/en
Priority to LU61000D priority patent/LU61000A1/xx
Priority to BG014806A priority patent/BG17787A3/en
Priority to GB26345/70A priority patent/GB1299669A/en
Priority to HUCE758A priority patent/HU162223B/hu
Priority to DE19702027077 priority patent/DE2027077A1/en
Priority to FR7020440A priority patent/FR2052930B1/fr
Priority to CH829770A priority patent/CH566989A5/xx
Priority to IT68879/70A priority patent/IT1043829B/en
Priority to CH726873A priority patent/CH546241A/en
Priority to AT495470A priority patent/AT300206B/en
Priority to PL1970141075A priority patent/PL82622B1/pl
Priority to ES380352A priority patent/ES380352A1/en
Priority to NO2165/70A priority patent/NO133496C/no
Priority to DK288270A priority patent/DK132172C/en
Priority to CA084689A priority patent/CA935430A/en
Priority to PH11504A priority patent/PH10082A/en
Priority to RO63549A priority patent/RO59611A/ro
Priority to FI1599/70A priority patent/FI53310C/en
Priority to JP45047674A priority patent/JPS496907B1/ja
Priority to SE7007767A priority patent/SE374368B/xx
Publication of NL6908529A publication Critical patent/NL6908529A/en
Priority to DK135672A priority patent/DK142619B/en
Priority to DK135572A priority patent/DK135586B/en
Priority to DK135472A priority patent/DK130831B/en
Priority to ES407194A priority patent/ES407194A1/en
Priority to ES407195A priority patent/ES407195A1/en
Priority to SE7311827A priority patent/SE400277B/en
Priority to CA181,117A priority patent/CA993876A/en
Priority to US05/543,352 priority patent/US4012392A/en
Priority to NO751399A priority patent/NO137091C/en
Publication of NL156047B publication Critical patent/NL156047B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Substituted 6,7-benzomorphanes of basic structure: in which the two Rs are lower alkyls or together and in combination with the ring carbon atom form a cycloalkane ring. The ring system may be substituted. Optically active form and salts are included. As examples are given e.g. methyl-2,2-dimethyl-4-(p-methoxyphenyl)-acetylacetate; methyl 3-benzylamino-2,2-dimethyl-4-phenyl-butyrate. The compounds are useful pharmaceuticals e.g. as analgesics and morphine-antagonists.
NL6908529.A 1969-06-04 1969-06-04 PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS WITH ANALGETIC AND / OR MORPHINE ANTAGONIST ACTION, FORMED PREPARATIONS AND PROCESS FOR THE PREPARATION OF SUITABLE NEW 6,7-BENZOMORPHANS. NL156047B (en)

Priority Applications (33)

Application Number Priority Date Filing Date Title
NL6908529.A NL156047B (en) 1969-06-04 1969-06-04 PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS WITH ANALGETIC AND / OR MORPHINE ANTAGONIST ACTION, FORMED PREPARATIONS AND PROCESS FOR THE PREPARATION OF SUITABLE NEW 6,7-BENZOMORPHANS.
IL34556A IL34556A (en) 1969-06-04 1970-05-19 6,7-benzomorphan derivatives and methods for the preparation thereof
IE679/70A IE34235B1 (en) 1969-06-04 1970-05-26 6,7-benzomorphans and their preparation
US00041079A US3764606A (en) 1969-06-04 1970-05-27 9,9-di-substituted -6,7-benzomorphans
LU61000D LU61000A1 (en) 1969-06-04 1970-05-27
BG014806A BG17787A3 (en) 1969-06-04 1970-05-28 METHOD FOR OBTAINING NEW 6,7-BENZOMORPHENE COMPOUNDS
GB26345/70A GB1299669A (en) 1969-06-04 1970-06-01 6,7-benzomorphans and their preparation
HUCE758A HU162223B (en) 1969-06-04 1970-06-01
DE19702027077 DE2027077A1 (en) 1969-06-04 1970-06-02 6,7-Benzomorphans, process for their preparation and their use
DK288270A DK132172C (en) 1969-06-04 1970-06-03 ANALOGICAL PROCEDURE FOR THE PREPARATION OF 6,7-BENZOMORPHANES OR SALTS THEREOF
CH829770A CH566989A5 (en) 1969-06-04 1970-06-03
IT68879/70A IT1043829B (en) 1969-06-04 1970-06-03 PROCEDURE FOR THE PREPARATION OF 6.7 BENZOHORFANI
CH726873A CH546241A (en) 1969-06-04 1970-06-03 PROCESS FOR THE PREPARATION OF 6,7-BENZOMORPHANES.
AT495470A AT300206B (en) 1969-06-04 1970-06-03 Process for the preparation of new 6,7-benzomorphans
PL1970141075A PL82622B1 (en) 1969-06-04 1970-06-03
ES380352A ES380352A1 (en) 1969-06-04 1970-06-03 9,9-di-substituted -6,7-benzomorphans
NO2165/70A NO133496C (en) 1969-06-04 1970-06-03
FR7020440A FR2052930B1 (en) 1969-06-04 1970-06-03
FI1599/70A FI53310C (en) 1969-06-04 1970-06-04 FOERFARANDE FOER FRAMSTAELLNING AV ANALGETISKT OCH / ELLER MORFINANTAGONISTISKT VERKANDE 9,9-DISUBSTITUERADE 6,7-BENSOMORFANER SAMT DESSAS OPTISKA ENANTIOMERER OCH TERAPEUTISKT GODTAGBARA SYRAADDITION
SE7007767A SE374368B (en) 1969-06-04 1970-06-04
PH11504A PH10082A (en) 1969-06-04 1970-06-04 New 6,7-benzomorphan derivatives and pharmaceutical compositions thereof
RO63549A RO59611A (en) 1969-06-04 1970-06-04
CA084689A CA935430A (en) 1969-06-04 1970-06-04 Benzomorphans
JP45047674A JPS496907B1 (en) 1969-06-04 1970-06-04
DK135672A DK142619B (en) 1969-06-04 1972-03-22 Substituted 2-benzyl-4-piperidones for use as intermediates in the preparation of benzomorphans, and process for their preparation.
DK135572A DK135586B (en) 1969-06-04 1972-03-22 Substituted 2-benzyl-4-piperidinols for use as intermediates in the preparation of benzomorphans.
DK135472A DK130831B (en) 1969-06-04 1972-03-22 Substituted 2-benzyl-4-piperidones for use as intermediates in the preparation of benzomorphans, and process for their preparation.
ES407194A ES407194A1 (en) 1969-06-04 1972-09-30 9,9-di-substituted -6,7-benzomorphans
ES407195A ES407195A1 (en) 1969-06-04 1972-09-30 9,9-di-substituted -6,7-benzomorphans
SE7311827A SE400277B (en) 1969-06-04 1973-08-30 NEW SUBSTITUTED 2-BENZYL-4-PIPERIDE COMPOUNDS, INTENDED AS INTERMEDIATE PRODUCTS IN THE MANUFACTURE OF NEW 6,7-BENZOMORPHENE DERIVATIVES, WHICH ARE TO BE USED AS ANALGETICS
CA181,117A CA993876A (en) 1969-06-04 1973-09-14 Substituted 2-benzyl-4-piperidine compounds
US05/543,352 US4012392A (en) 1969-06-04 1975-01-23 2-Benzyl-4-piperidones useful as intermediates in the production of 6,7-benzomorphan derivatives
NO751399A NO137091C (en) 1969-06-04 1975-04-18 SUBSTITUTED 2-BENZYL-4-PIPERIDONES FOR USE AS INTERMEDIATE PRODUCTS IN THE MANUFACTURE OF THERAPEUTIC ACTIVITIES 6,7-BENZOMORPHANS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL6908529.A NL156047B (en) 1969-06-04 1969-06-04 PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS WITH ANALGETIC AND / OR MORPHINE ANTAGONIST ACTION, FORMED PREPARATIONS AND PROCESS FOR THE PREPARATION OF SUITABLE NEW 6,7-BENZOMORPHANS.

Publications (2)

Publication Number Publication Date
NL6908529A true NL6908529A (en) 1970-12-08
NL156047B NL156047B (en) 1978-03-15

Family

ID=19807109

Family Applications (1)

Application Number Title Priority Date Filing Date
NL6908529.A NL156047B (en) 1969-06-04 1969-06-04 PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS WITH ANALGETIC AND / OR MORPHINE ANTAGONIST ACTION, FORMED PREPARATIONS AND PROCESS FOR THE PREPARATION OF SUITABLE NEW 6,7-BENZOMORPHANS.

Country Status (6)

Country Link
AT (1) AT300206B (en)
BG (1) BG17787A3 (en)
HU (1) HU162223B (en)
IL (1) IL34556A (en)
NL (1) NL156047B (en)
RO (1) RO59611A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268673A (en) * 1975-02-25 1981-05-19 Acf Chemiefarma N.V. 5-Unsubstituted-9,9-dimethyl-6,7-benzomorphans

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268673A (en) * 1975-02-25 1981-05-19 Acf Chemiefarma N.V. 5-Unsubstituted-9,9-dimethyl-6,7-benzomorphans

Also Published As

Publication number Publication date
NL156047B (en) 1978-03-15
HU162223B (en) 1973-01-29
IL34556A (en) 1974-09-10
RO59611A (en) 1976-07-15
AT300206B (en) 1972-07-25
BG17787A3 (en) 1973-12-25

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Legal Events

Date Code Title Description
V1 Lapsed because of non-payment of the annual fee
V1 Lapsed because of non-payment of the annual fee
NL80 Information provided on patent owner name for an already discontinued patent

Owner name: ACF