NL6908528A - Benzomorphanes as analgesics and morphine- - autogenists - Google Patents

Benzomorphanes as analgesics and morphine- - autogenists

Info

Publication number
NL6908528A
NL6908528A NL6908528A NL6908528A NL6908528A NL 6908528 A NL6908528 A NL 6908528A NL 6908528 A NL6908528 A NL 6908528A NL 6908528 A NL6908528 A NL 6908528A NL 6908528 A NL6908528 A NL 6908528A
Authority
NL
Netherlands
Prior art keywords
benzomorphanes
morphine
analgesics
autogenists
dimethyl
Prior art date
Application number
NL6908528A
Other versions
NL158787B (en
Inventor
A M Akkerman
P A J Janssen
Original Assignee
Acf Chemiefarma Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acf Chemiefarma Nv filed Critical Acf Chemiefarma Nv
Priority to NL6908528A priority Critical patent/NL158787B/en
Priority to IE412/73A priority patent/IE34236B1/en
Priority to IE679/70A priority patent/IE34235B1/en
Priority to BE750985D priority patent/BE750985A/en
Priority to LU61000D priority patent/LU61000A1/xx
Priority to US00041079A priority patent/US3764606A/en
Priority to GB2273672A priority patent/GB1299670A/en
Priority to GB26345/70A priority patent/GB1299669A/en
Priority to HUCE000870 priority patent/HU164208B/hu
Priority to DE19702027077 priority patent/DE2027077A1/en
Priority to DK288270A priority patent/DK132172C/en
Priority to FR7020440A priority patent/FR2052930B1/fr
Priority to ES380352A priority patent/ES380352A1/en
Priority to CH726873A priority patent/CH546241A/en
Priority to AT697371A priority patent/AT306719B/en
Priority to CH829770A priority patent/CH566989A5/xx
Priority to NO2165/70A priority patent/NO133496C/no
Priority to IT68879/70A priority patent/IT1043829B/en
Priority to PL1970141075A priority patent/PL82622B1/pl
Priority to SE7007767A priority patent/SE374368B/xx
Priority to JP45047674A priority patent/JPS496907B1/ja
Priority to PH11504A priority patent/PH10082A/en
Priority to FI1599/70A priority patent/FI53310C/en
Priority to CA084689A priority patent/CA935430A/en
Publication of NL6908528A publication Critical patent/NL6908528A/en
Priority to JP771372A priority patent/JPS5420503B1/ja
Priority to DK135572A priority patent/DK135586B/en
Priority to DK135472A priority patent/DK130831B/en
Priority to DK135672A priority patent/DK142619B/en
Priority to ES407195A priority patent/ES407195A1/en
Priority to ES407194A priority patent/ES407194A1/en
Priority to SE7311827A priority patent/SE400277B/en
Priority to CA181,117A priority patent/CA993876A/en
Priority to US05/543,352 priority patent/US4012392A/en
Priority to NO751399A priority patent/NO137091C/en
Publication of NL158787B publication Critical patent/NL158787B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Substituted 6,7-benzomorphanes of basic structure: in which the two Rs are lower alkyls or together and in combination with the ring carbon atom form a cycloalkane ring. The ring system may be substituted. Optically active form and salts are included. As examples are given e.g. methyl-2,2-dimethyl-4-(p-methoxyphenyl)-acetylacetate; methyl 3-benzylamino-2,2-dimethyl-4-phenyl-butyrate. The compounds are useful pharmaceuticals e.g. as analgesics and morphine-antagonists.
NL6908528A 1969-06-04 1969-06-04 PROCESS FOR PREPARING SUBSTITUTED 2-BENZYL-4-PIPERIDONES AND 2-BENZYL-4-PIPERIDINOLS AND SALTS OF THESE COMPOUNDS. NL158787B (en)

Priority Applications (34)

Application Number Priority Date Filing Date Title
NL6908528A NL158787B (en) 1969-06-04 1969-06-04 PROCESS FOR PREPARING SUBSTITUTED 2-BENZYL-4-PIPERIDONES AND 2-BENZYL-4-PIPERIDINOLS AND SALTS OF THESE COMPOUNDS.
IE412/73A IE34236B1 (en) 1969-06-04 1970-05-26 2-benzyl-4-piperidine compounds
IE679/70A IE34235B1 (en) 1969-06-04 1970-05-26 6,7-benzomorphans and their preparation
BE750985D BE750985A (en) 1969-06-04 1970-05-27 Benzomorphanes as analgesics and morphine- - autogenists
LU61000D LU61000A1 (en) 1969-06-04 1970-05-27
US00041079A US3764606A (en) 1969-06-04 1970-05-27 9,9-di-substituted -6,7-benzomorphans
GB2273672A GB1299670A (en) 1969-06-04 1970-06-01 2-benzyl-4-piperidine compounds
GB26345/70A GB1299669A (en) 1969-06-04 1970-06-01 6,7-benzomorphans and their preparation
HUCE000870 HU164208B (en) 1969-06-04 1970-06-01
DE19702027077 DE2027077A1 (en) 1969-06-04 1970-06-02 6,7-Benzomorphans, process for their preparation and their use
IT68879/70A IT1043829B (en) 1969-06-04 1970-06-03 PROCEDURE FOR THE PREPARATION OF 6.7 BENZOHORFANI
FR7020440A FR2052930B1 (en) 1969-06-04 1970-06-03
ES380352A ES380352A1 (en) 1969-06-04 1970-06-03 9,9-di-substituted -6,7-benzomorphans
CH726873A CH546241A (en) 1969-06-04 1970-06-03 PROCESS FOR THE PREPARATION OF 6,7-BENZOMORPHANES.
AT697371A AT306719B (en) 1969-06-04 1970-06-03 Process for the preparation of new 2-benzyl-4-piperidinols and their salts
CH829770A CH566989A5 (en) 1969-06-04 1970-06-03
NO2165/70A NO133496C (en) 1969-06-04 1970-06-03
DK288270A DK132172C (en) 1969-06-04 1970-06-03 ANALOGICAL PROCEDURE FOR THE PREPARATION OF 6,7-BENZOMORPHANES OR SALTS THEREOF
PL1970141075A PL82622B1 (en) 1969-06-04 1970-06-03
FI1599/70A FI53310C (en) 1969-06-04 1970-06-04 FOERFARANDE FOER FRAMSTAELLNING AV ANALGETISKT OCH / ELLER MORFINANTAGONISTISKT VERKANDE 9,9-DISUBSTITUERADE 6,7-BENSOMORFANER SAMT DESSAS OPTISKA ENANTIOMERER OCH TERAPEUTISKT GODTAGBARA SYRAADDITION
CA084689A CA935430A (en) 1969-06-04 1970-06-04 Benzomorphans
JP45047674A JPS496907B1 (en) 1969-06-04 1970-06-04
PH11504A PH10082A (en) 1969-06-04 1970-06-04 New 6,7-benzomorphan derivatives and pharmaceutical compositions thereof
SE7007767A SE374368B (en) 1969-06-04 1970-06-04
JP771372A JPS5420503B1 (en) 1969-06-04 1972-01-21
DK135572A DK135586B (en) 1969-06-04 1972-03-22 Substituted 2-benzyl-4-piperidinols for use as intermediates in the preparation of benzomorphans.
DK135472A DK130831B (en) 1969-06-04 1972-03-22 Substituted 2-benzyl-4-piperidones for use as intermediates in the preparation of benzomorphans, and process for their preparation.
DK135672A DK142619B (en) 1969-06-04 1972-03-22 Substituted 2-benzyl-4-piperidones for use as intermediates in the preparation of benzomorphans, and process for their preparation.
ES407195A ES407195A1 (en) 1969-06-04 1972-09-30 9,9-di-substituted -6,7-benzomorphans
ES407194A ES407194A1 (en) 1969-06-04 1972-09-30 9,9-di-substituted -6,7-benzomorphans
SE7311827A SE400277B (en) 1969-06-04 1973-08-30 NEW SUBSTITUTED 2-BENZYL-4-PIPERIDE COMPOUNDS, INTENDED AS INTERMEDIATE PRODUCTS IN THE MANUFACTURE OF NEW 6,7-BENZOMORPHENE DERIVATIVES, WHICH ARE TO BE USED AS ANALGETICS
CA181,117A CA993876A (en) 1969-06-04 1973-09-14 Substituted 2-benzyl-4-piperidine compounds
US05/543,352 US4012392A (en) 1969-06-04 1975-01-23 2-Benzyl-4-piperidones useful as intermediates in the production of 6,7-benzomorphan derivatives
NO751399A NO137091C (en) 1969-06-04 1975-04-18 SUBSTITUTED 2-BENZYL-4-PIPERIDONES FOR USE AS INTERMEDIATE PRODUCTS IN THE MANUFACTURE OF THERAPEUTIC ACTIVITIES 6,7-BENZOMORPHANS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL6908528A NL158787B (en) 1969-06-04 1969-06-04 PROCESS FOR PREPARING SUBSTITUTED 2-BENZYL-4-PIPERIDONES AND 2-BENZYL-4-PIPERIDINOLS AND SALTS OF THESE COMPOUNDS.

Publications (2)

Publication Number Publication Date
NL6908528A true NL6908528A (en) 1970-12-08
NL158787B NL158787B (en) 1978-12-15

Family

ID=19807108

Family Applications (1)

Application Number Title Priority Date Filing Date
NL6908528A NL158787B (en) 1969-06-04 1969-06-04 PROCESS FOR PREPARING SUBSTITUTED 2-BENZYL-4-PIPERIDONES AND 2-BENZYL-4-PIPERIDINOLS AND SALTS OF THESE COMPOUNDS.

Country Status (2)

Country Link
AT (1) AT306719B (en)
NL (1) NL158787B (en)

Also Published As

Publication number Publication date
NL158787B (en) 1978-12-15
AT306719B (en) 1973-04-25

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Legal Events

Date Code Title Description
V1 Lapsed because of non-payment of the annual fee
V1 Lapsed because of non-payment of the annual fee
NL80 Abbreviated name of patent owner mentioned of already nullified patent

Owner name: ACF