NL6502977A - - Google Patents

Info

Publication number
NL6502977A
NL6502977A NL6502977A NL6502977A NL6502977A NL 6502977 A NL6502977 A NL 6502977A NL 6502977 A NL6502977 A NL 6502977A NL 6502977 A NL6502977 A NL 6502977A NL 6502977 A NL6502977 A NL 6502977A
Authority
NL
Netherlands
Application number
NL6502977A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of NL6502977A publication Critical patent/NL6502977A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NL6502977A 1964-03-09 1965-03-09 NL6502977A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US350519A US3392173A (en) 1964-03-09 1964-03-09 Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation

Publications (1)

Publication Number Publication Date
NL6502977A true NL6502977A (fr) 1965-09-10

Family

ID=23377073

Family Applications (1)

Application Number Title Priority Date Filing Date
NL6502977A NL6502977A (fr) 1964-03-09 1965-03-09

Country Status (9)

Country Link
US (1) US3392173A (fr)
BE (1) BE660843A (fr)
CH (1) CH507970A (fr)
DE (3) DE1795823C3 (fr)
ES (1) ES310240A1 (fr)
FR (2) FR1449628A (fr)
GB (1) GB1095833A (fr)
NL (1) NL6502977A (fr)
SE (1) SE330700B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899493A (en) * 1972-12-29 1975-08-12 Richter Gedeon Vegyeszet Chromic acid oxidation of vinblastine sulfate to form vincristine
HU165986B (fr) * 1973-02-16 1974-12-28
US4012390A (en) * 1974-10-16 1977-03-15 Eli Lilly And Company Vinblastinoic acid
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4209443A (en) * 1976-02-13 1980-06-24 Richter Gedeon Vegyeszeti Gyar Rt. Process for separating pharmaceutically active diindole alkaloids
US4143041A (en) * 1977-01-19 1979-03-06 Eli Lilly And Company 4'-Deoxyvincristine and related compounds
HU178084B (en) * 1977-05-31 1982-03-28 Richter Gedeon Vegyeszet New process for the extraction of native vindoline,catharantine,3',4'-anhydrovinblastine,leurosine and,if desired,of other diinodle alkaloids from vinca rosea l.drogue
US4195022A (en) * 1978-03-27 1980-03-25 Eli Lilly And Company 4-Desacetoxy-4α-hydroxyvinblastine and related compounds
US4166810A (en) * 1978-04-20 1979-09-04 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide
HU178706B (en) * 1979-04-23 1982-06-28 Richter Gedeon Vegyeszet Process for preparing bis-indole alkaloids and acid addition salts thereof
FR2461714A1 (fr) 1979-07-17 1981-02-06 Anvar Nouvelle classe de composes bis-indoliques utiles comme medicaments et procede pour leur preparation
GR79898B (fr) * 1983-03-30 1984-10-31 Lilly Industries Ltd
US4522750A (en) * 1984-02-21 1985-06-11 Eli Lilly And Company Cytotoxic compositions of transferrin coupled to vinca alkaloids
HU198074B (en) * 1985-06-12 1989-07-28 Richter Gedeon Vegyeszet Process for producing new bis-indole derivatives and pharmaceutical compositions comprising these compounds
HU193318B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing new bis- indol derivatives
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
ATE427948T1 (de) * 2001-04-24 2009-04-15 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
ES2324708T3 (es) * 2002-05-15 2009-08-13 Endocyte, Inc. Conjugados de vitamina-mitomicina.
US7601332B2 (en) 2003-01-27 2009-10-13 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
EP1789391B1 (fr) 2004-07-23 2017-06-28 Endocyte, Inc. Groupes de liaison bivalents et conjugués de ceux-ci
EP1863816B1 (fr) * 2005-03-16 2014-06-25 Endocyte, Inc. Synthese et purification d'acide pteroique et des conjugues de celui-ci
EP1948241B1 (fr) * 2005-08-19 2014-03-05 Endocyte, Inc. Conjugues de ligand multi medicament
WO2007022493A2 (fr) 2005-08-19 2007-02-22 Endocyte, Inc. Conjugues de ligand d'alcaloides vinca, analogues et derives
US20100104626A1 (en) * 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
AU2008224988A1 (en) * 2007-03-14 2008-09-18 Endocyte, Inc. Binding ligand linked drug delivery conjugates of tubulysins
US9138484B2 (en) 2007-06-25 2015-09-22 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CA2703491C (fr) * 2007-10-25 2017-06-13 Endocyte, Inc. Tubulysines et leurs procedes de preparation
WO2013126797A1 (fr) 2012-02-24 2013-08-29 Purdue Research Foundation Ciblage du récepteur de la cholécystokinine de type b pour imagerie et thérapie
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
SG11201502896XA (en) 2012-10-16 2015-05-28 Endocyte Inc Drug delivery conjugates containing unnatural amino acids and methods for using

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3169968A (en) * 1962-05-08 1965-02-16 Ciba Geigy Corp Esters of ajmaline and related compounds
US3225053A (en) * 1963-01-10 1965-12-21 Lilly Co Eli Quebrachidine and derivatives

Also Published As

Publication number Publication date
DE1545760A1 (de) 1969-11-27
DE1795823B2 (de) 1981-04-30
US3392173A (en) 1968-07-09
DE1545760C3 (de) 1978-10-05
CH507970A (de) 1971-05-31
DE1795763C3 (de) 1978-06-29
BE660843A (fr) 1965-09-09
DE1795823A1 (de) 1976-02-05
ES310240A1 (es) 1965-10-16
SE330700B (fr) 1970-11-30
DE1545760B2 (de) 1978-02-09
FR6668M (fr) 1969-02-03
DE1795823C3 (de) 1982-04-15
DE1795763A1 (de) 1974-11-21
GB1095833A (en) 1967-12-20
FR1449628A (fr) 1966-08-19
DE1795763B2 (de) 1977-11-10

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