NL2032301B1 - Preparation method of blood-activating stasis-removing pills - Google Patents
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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Abstract
The present invention belongs to the technical field of preparation of medicinal materials, and 5 particularly discloses a preparation method of blood - activating stasis - removing pills. Specific components in the preparation method of the blood - activating stasis - removing pills include by parts: 16 - 26 parts of Angelica sinensis, 16 - 26 parts of Rehmannia glutinosa, 19 - 29 parts of Paeoniae radix rubra, 16 - 26 parts of Carthamus tinctorius, 23 - 33 parts of Semen pruni persicae, 9 - 19 parts of Fructus aurantii fried with bran, 5 - 15 parts of Ligusticum chuanxiong hon‘, 65 - 75 10 parts of Radix bup/euri, 65 - 75 parts of Glycyrrhiza, 16 - 26 parts of Achyranthes bidentata and 5 - 15 parts of Platycodon grandiflorus. The preparation method of the blood - activating stasis - removing pills includes specific steps: step 1: taking 16 - 26 parts of Angelica sinensis, 16 - 26 parts of Rehmannia glutinosa, 9 - 19 parts of Fructus aurantii fried with bran, 16 - 26 parts of Achyranthes bidentata, 5 - 15 parts of Platycodon grandiflorus, 19 - 29 parts of Paeoniae radix 15 rubra and 65 - 75 parts of Glycyrrhiza; removing impurities; placing the components in a container; adding excessive clear water; repeatedly cleaning the components; and washing dust and silt off a surface. The preparation method is simple in operation; high preparation cost is not needed; and the prepared blood - activating stasis - removing pills have excellent treatment effects.
Description
PREPARATION METHOD OF BLOOD - ACTIVATING STASIS - REMOVING PILLS Technical Field The present invention relates to the technical field of preparation of medicinal materials, and particularly discloses a preparation method of blood - activating stasis - removing pills. Background Pill is a traditional dosage form. Due to the rapid development of modern science and technology, pharmaceutical machinery and equipment have been constantly upgraded.
Appearance of novel pill making machines and wide application of new ingredients inject young blood for such an old dosage form, i.e., traditional Chinese medicine pills. The traditional prejudice that the traditional pill is “black, big and thick” is changed. The produced pills have the advantages of fast drug release, high bioavailability, accurate fractional dose, convenience to take and carry and attractive appearance.
Blood - activating stasis - removing pills are a kind of drug, have effects of activating blood and removing stasis, promoting qi circulation and relieving pain, and are mainly used for treating blood stasis stagnation induced headache or chest pain, internal - heat depression, insomnia and dreaminess, palpitation, impatience and irritability. An existing preparation method of the blood - activating stasis - removing pills is relatively complicated in preparation process; and the prepared blood - activating stasis - removing pills have poor curative effects.
Summary The purpose of the present invention is to provide a preparation method of blood - activating stasis - removing pills, for solving problems proposed in the above background that an existing preparation method of the blood - activating stasis - removing pills is relatively complicated in preparation process and the prepared blood - activating stasis - removing pills have poor curative effects.
To achieve the above purpose, technical solutions of the present invention are as follows: according to the preparation method of blood - activating stasis - removing pills, specific components in the preparation method of the blood - activating stasis - removing pills include in weight parts: 16 - 26 parts of Angelica sinensis, 16 - 26 parts of Rehmannia glutinosa, 19 - 29 parts of Paeoniae radix rubra, 16 - 26 parts of Carthamus tinctorius, 23 - 33 parts of Semen pruni persicae, 9 - 19 parts of Fructus aurantii fried with bran, 5 - 15 parts of Ligusticum chuanxiong hort, 65 - 75 parts of Radix bupleuri, 65 - 75 parts of Glycyrrhiza, 16 - 26 parts of Achyranthes bidentata and 5 - 15 parts of Platycodon grandiflorus.
The preparation method of the blood - activating stasis - removing pills includes specific steps:
step 1: taking 16 - 26 parts of Angelica sinensis, 16 - 26 parts of Rehmannia glutinosa, 9 - 19 parts of Fructus aurantii fried with bran, 16 - 26 parts of Achyranthes bidentata, 5 - 15 parts of Platycodon grandiflorus, 19 - 29 parts of Paeoniae radix rubra and 65 - 75 parts of Glycyrrhiza, removing impurities; placing the components in a container, adding excessive clear water; repeatedly cleaning the components; washing dust and silt off the surface; controlling temperature at 10 - 20°C during water draining; placing the components in a drying device; regulating temperature of the drying device at 70 - 80°C; and continuously drying the traditional Chinese medicinal materials for 20 - 24 hours for later use; step 2: taking 16 - 26 parts of Carthamus tinctorius and 23 - 33 parts of Semen pruni persicae; sorting Carthamus tinctorius and Semen pruni persicae on a sorting table; removing non - medicinal parts; mixing and grinding the Carthamus tinctorius and Semen pruni persicae with the traditional Chinese medicinal materials prepared in step 1; and sieving the prepared powder by a sieve of 80 meshes for later use; step 3: cleaning 5 - 15 parts of Ligusticum chuanxiong hort and 65 - 75 parts of Radix bupleuri, washing silt and impurities from the surface with running water; placing the components inside the drying device again; regulating the temperature of the drying device at 30 - 40°C; continuously drying the components for 5 - 7 hours; grinding the components after drying; and sieving the components by a sieve of 80 meshes for later use; step 4: mixing the traditional Chinese medicinal material mixtures prepared in the steps 1, 2 and 3 in a three - dimensional mixer for 120 minutes to fully and uniformly mix all the materials; step 5: pouring the traditional Chinese medicinal material mixture prepared in the step 4 into the same container; adding honey water; and mixing and stirring the mixture by a stirring device until the components are fully and uniformly mixed, thereby obtaining the blood - activating stasis - removing pills.
Preferably, in the step 1, when water in the traditional Chinese medicinal materials is drained at a room temperature, the temperature is kept at 10 - 20°C.
Preferably, in the steps 1, 2 and 3, the powder prepared from the traditional Chinese medicinal materials needs to pass through a sieve of 80 meshes.
Preferably, weight of every 60 prepared blood - activating stasis - removing pills is 6 g.
Compared with the prior art, the present invention has beneficial effects as follows: The blood - activating stasis - removing pills are prepared from the traditional Chinese medicinal materials such as Angelica sinensis, Rehmannia glutinosa, Paeoniae radix rubra, Carthamus tinctorius, Semen pruni persicae, Fructus aurantii fried with bran, Ligusticum chuanxiong hort, Radix bupleuri, Glycyrrhiza, Achyranthes bidentata and Platycodon grandiflorus; the preparation method is simple in operation; high preparation cost is not needed; and the prepared blood - activating stasis - removing pills have excellent treatment effects.
Description of Drawings Fig. 1 is a flow chart of specific production steps of blood - activating stasis - removing pills.
Detailed Description The technical solutions in the embodiments of the present invention will be clearly and fully described below in combination with the drawings in the embodiments of the present invention.
Apparently, the described embodiments are merely part of the embodiments of the present invention, not all of the embodiments.
Based on the embodiments in the present invention, all other embodiments obtained by those ordinary skilled in the art without contributing creative labour will belong to the protection scope of the present invention.
It should be understood in the description of the present invention that terms such as “upper”, “lower”, “front”, “rear”, “left”, “right”, “top”, “bottom”, “inner”, “outer”, etc. indicate direction or position relationships shown based on the drawings, and are only intended to facilitate the description of the present invention and the simplification of the description rather than to indicate or imply that the indicated device or element must have a specific direction or constructed and operated in a specific direction, and therefore, shall not be understood as a limitation to the present invention.
By referring to Fig. 1, the present invention provides a technical solution: a preparation method of blood - activating stasis - removing pills is provided, which comprises specific components by parts: 16 - 26 parts of Angelica sinensis, 16 - 26 parts of Rehmannia glutinosa, 19 - 29 parts of Paeoniae radix rubra, 16 - 26 parts of Carthamus tinctorius, 23 - 33 parts of Semen pruni persicae, 9 - 19 parts of Fructus aurantii fried with bran, 5 - 15 parts of Ligusticum chuanxiong hort, 65 - 75 parts of Radix bupleuri, 65 - 75 parts of Glycyrrhiza, 16 - 26 parts of Achyranthes bidentata and 5 - 15 parts of Platycodon grandiflorus.
The preparation method of the blood - activating stasis - removing pills includes specific steps: step 1: taking 16 - 26 parts of Angelica sinensis, 16 - 26 parts of Rehmannia glutinosa, 9 - 19 parts of Fructus aurantii fried with bran, 16 - 26 parts of Achyranthes bidentata, 5 - 15 parts of Platycodon grandiflorus, 19 - 29 parts of Paeoniae radix rubra and 65 - 75 parts of Glycyrrhiza, removing impurities; placing the components in a container; adding excessive clear water; repeatedly cleaning the components; washing dust and silt off the surface; controlling temperature at 10 - 20°C during water draining; placing the components in a drying device; regulating temperature of the drying device at 70 - 80°C; and continuously drying the traditional Chinese medicinal materials for 20 - 24 hours for later use; step 2: taking 16 - 26 parts of Carthamus tinctorius and 23 - 33 parts of Semen pruni persicae; sorting Carthamus tinctorius and Semen pruni persicae on a sorting table; removing non - medicinal parts; mixing and grinding the Carthamus tinctorius and Semen pruni persicae with the traditional Chinese medicinal materials prepared in step 1; and sieving the prepared powder by a sieve of 80 meshes for later use; step 3: cleaning 5 - 15 parts of Ligusticum chuanxiong hort and 65 - 75 parts of Radix bupleuri; washing silt and impurities from the surface with running water; placing the components inside the drying device again; regulating the temperature of the drying device at 30 - 40°C; continuously drying the components for 5 - 7 hours; grinding the components after drying; and sieving the components by a sieve of 80 meshes for later use; step 4: mixing the traditional Chinese medicinal material mixtures prepared in the steps 1, 2 and 3 in a three - dimensional mixer for 120 minutes to fully and uniformly mix all the materials; step 5: pouring the traditional Chinese medicinal material mixture prepared in the step 5 into the same container; adding honey water; and mixing and stirring the mixture by a stirring device until the components are fully and uniformly mixed, thereby obtaining the blood - activating stasis - removing pills.
In the step 1, when water in the traditional Chinese medicinal materials is drained at a room temperature, the temperature needs to be controlled at 10 - 20°C.
In the steps 1, 2 and 3, the powder prepared from the traditional Chinese medicinal materials needs to pass through a sieve of 80 meshes.
Weight of every 60 prepared blood - activating stasis - removing pills is 6 g.
Embodiment 1: The preparation method of the blood - activating stasis - removing pills includes specific steps: step 1: taking 16 parts of Angelica sinensis, 16 parts of Rehmannia glutinosa, 9 parts of Fructus aurantii fried with bran, 16 parts of Achyranthes bidentata, 5 parts of Plalycodon grandifiorus, 19 parts of Paeoniae radix rubra and 65 parts of Glycyrrhiza; removing impurities; placing the components in a container; adding excessive clear water; repeatedly cleaning the components; washing dust and silt off the surface; controlling temperature at 10°C during water draining; placing the components in a drying device; regulating temperature of the drying device at 70°C; and continuously drying the traditional Chinese medicinal materials for 20 hours for later use; step 2: taking 16 parts of Carthamus tinctorius and 23 parts of Semen pruni persicae; sorting Carthamus tinctorius and Semen pruni persicae on a sorting table; removing non - medicinal parts; mixing and grinding the Carthamus tinctorius and Semen pruni persicae with the traditional Chinese medicinal materials prepared in step 1; and sieving the prepared powder by a sieve of 80 meshes for later use; step 3: cleaning 5 parts of Ligusticum chuanxiong hort and 65 parts of Radix bupleuri; washing silt and impurities from the surface with running water; placing the components inside the drying device again; regulating the temperature of the drying device at 30°C; continuously drying the components for 5 hours; grinding the components after drying; and sieving the components by a sieve of 80 meshes for later use; step 4: mixing the traditional Chinese medicinal material mixtures prepared in the steps 1, 2 and 3 in a three - dimensional mixer for 120 minutes to fully and uniformly mix all the materials; 5 step 5: pouring the traditional Chinese medicinal material mixture prepared in the step 5 into the same container; adding honey water; and mixing and stirring the mixture by a stirring device until the components are fully and uniformly mixed, thereby obtaining the blood - activating stasis - removing pills.
Embodiment 2: The preparation method of the blood - activating stasis - removing pills includes specific steps: step 1: taking 21 parts of Angelica sinensis, 21 parts of Rehmannia glutinosa, 14 parts of Fructus aurantii fried with bran, 21 parts of Achyranthes bidentata, 10 parts of Platycodon grandiforus, 24 parts of Paeoniae radix rubra and 70 parts of Glycyrrhiza; removing impurities; placing the components in a container; adding excessive clear water, repeatedly cleaning the components; washing dust and silt off the surface; controlling temperature at 15°C during water draining; placing the components in a drying device; regulating temperature of the drying device at 75°C; and continuously drying the traditional Chinese medicinal materials for 22 hours for later use; step 2: taking 21 parts of Carthamus tinctorius and 28 parts of Semen pruni persicae; sorting Carthamus tinctorius and Semen pruni persicae on a sorting table; removing non - medicinal parts; mixing and grinding the Carthamus tinctorius and Semen pruni persicae with the traditional Chinese medicinal materials prepared in step 1; and sieving the prepared powder by a sieve of 80 meshes for later use; step 3: cleaning 10 parts of Ligusticum chuanxiong hort and 70 parts of Radix bupleuri, washing silt and impurities from the surface with running water; placing the components inside the drying device again; regulating the temperature of the drying device at 35°C; continuously drying the components for 6 hours; grinding the components after drying; and sieving the components by a sieve of 80 meshes for later use; step 4: mixing the traditional Chinese medicinal material mixtures prepared in the steps 1, 2 and 3 in a three - dimensional mixer for 120 minutes to fully and uniformly mix all the materials; step 5: pouring the traditional Chinese medicinal material mixture prepared in the step 5 into the same container; adding honey water; and mixing and stirring the mixture by a stirring device until the components are fully and uniformly mixed, thereby obtaining the blood - activating stasis - removing pills.
Embodiment 3: The preparation method of the blood - activating stasis - removing pills includes specific steps:
step 1: taking 26 parts of Angelica sinensis, 26 parts of Rehmannia glutinosa, 19 parts of Fructus aurantii fried with bran, 26 parts of Achyranthes bidentata, 15 parts of Platycodon grandiflorus, 29 parts of Paeoniae radix rubra and 75 parts of Glycyrrhiza; removing impurities; placing the components in a container; adding excessive clear water; repeatedly cleaning the components; washing dust and silt off the surface; controlling temperature at 20°C during water draining; placing the components in a drying device; regulating temperature of the drying device at 80°C; and continuously drying the traditional Chinese medicinal materials for 24 hours for later use; step 2: taking 26 parts of Carthamus tinctorius and 33 parts of Semen pruni persicae; sorting Carthamus tinctorius and Semen pruni persicae on a sorting table; removing non - medicinal parts; mixing and grinding the Carthamus tinctorius and Semen pruni persicae with the traditional Chinese medicinal materials prepared in step 1; and sieving the prepared powder by a sieve of 80 meshes for later use; step 3: cleaning 15 parts of Ligusticum chuanxiong hort and 75 parts of Radix bupleuri, washing silt and impurities from the surface with running water; placing the components inside the drying device again; regulating the temperature of the drying device at 30 - 40°C; continuously drying the components for 7 hours; grinding the components after drying; and sieving the components by a sieve of 80 meshes for later use; step 4: mixing the traditional Chinese medicinal material mixtures prepared in the steps 1, 2 and 3 in a three - dimensional mixer for 120 minutes to fully and uniformly mix all the materials; step 5: pouring the traditional Chinese medicinal material mixture prepared in the step 5 into the same container; adding honey water; and mixing and stirring the mixture by a stirring device until the components are fully and uniformly mixed, thereby obtaining the blood - activating stasis - removing pills.
The above shows and describes the basic principle and main features of the present invention and the advantages of present invention. For those skilled in the art, apparently, the present invention is not limited to details of the above demonstrative embodiments. Moreover, the present invention can be realized in other specific farms without departing from the spirit or basic feature of the present invention. Therefore, in all respects, the embodiments shall be regarded to be demonstrative and non-restrictive. The scope of the present invention is defined by appended claims, rather than the above description. Therefore, the present invention is intended to include all changes falling into the meaning and the scope of equivalent elements of claims within the present invention. Any drawing mark in claims shall not be regarded to limit the concerned claims.
Although the embodiments of the present invention have been shown and described, it will be appreciated that various variations, amendments, replacements and modifications can be made by those ordinary skilled in the art without departing from the principle and spirit of the present invention, and the scope of the present invention is limited by the appended claims and the equivalents thereof.
Claims (4)
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CN1524567A (en) * | 2003-09-12 | 2004-09-01 | 北京同仁堂医药科技发展有限公司 | Xuefu Zhuyu soft capsule and its preparation method |
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CN1524567A (en) * | 2003-09-12 | 2004-09-01 | 北京同仁堂医药科技发展有限公司 | Xuefu Zhuyu soft capsule and its preparation method |
Non-Patent Citations (2)
Title |
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CHEN ET AL: "Effect of Radix Platycodonis and Radix Cyathulae in Xuefu Zhuyu Tang on tissue distribution of paeoniflorin in blood-stasis mice by HPLC: Experimental evidence on Shi ingredients in traditional formula compatibility", INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE, NATIONAL INSTITUTE OF SCIENCE COMMUNICATION AND INFORMATION RESOURCES, NEW DELHI - INDIA, vol. 18, no. 3, 1 July 2019 (2019-07-01), pages 516 - 524, XP018030427 * |
LU CHUNG-YEN ET AL: "Utilization trends in traditional Chinese medicine for acute myocardial infarction", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER IRELAND LTD, IE, vol. 241, 15 September 2019 (2019-09-15), XP085730545, ISSN: 0378-8741, [retrieved on 20190605], DOI: 10.1016/J.JEP.2019.112010 * |
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