NL2032123B1 - Mosla chinensis extract and application thereof - Google Patents
Mosla chinensis extract and application thereof Download PDFInfo
- Publication number
- NL2032123B1 NL2032123B1 NL2032123A NL2032123A NL2032123B1 NL 2032123 B1 NL2032123 B1 NL 2032123B1 NL 2032123 A NL2032123 A NL 2032123A NL 2032123 A NL2032123 A NL 2032123A NL 2032123 B1 NL2032123 B1 NL 2032123B1
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- Prior art keywords
- extract
- mosla chinensis
- chinensis
- mosla
- chinensis extract
- Prior art date
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- 241000717677 Mosla chinensis Species 0.000 title claims abstract description 64
- 239000003814 drug Substances 0.000 claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000706 filtrate Substances 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 9
- 229940079593 drug Drugs 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000010495 camellia oil Substances 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 4
- 206010044008 tonsillitis Diseases 0.000 claims description 4
- 206010068319 Oropharyngeal pain Diseases 0.000 claims description 2
- 201000007100 Pharyngitis Diseases 0.000 claims description 2
- 241001122767 Theaceae Species 0.000 claims description 2
- 229940124350 antibacterial drug Drugs 0.000 claims description 2
- 238000000605 extraction Methods 0.000 abstract description 3
- 238000010992 reflux Methods 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract description 2
- 150000002989 phenols Chemical class 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 abstract description 2
- 239000000341 volatile oil Substances 0.000 abstract description 2
- 230000005764 inhibitory process Effects 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010019345 Heat stroke Diseases 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 241000555676 Malassezia Species 0.000 description 1
- 241000717679 Mosla Species 0.000 description 1
- 206010030124 Oedema peripheral Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000012873 acute gastroenteritis Diseases 0.000 description 1
- 230000000941 anti-staphylcoccal effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 208000034526 bruise Diseases 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 208000011318 facial edema Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000004526 pharmaceutical effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention belongs to the technical field of drug preparation, and particularly relates to aMosla chinensis extract and an application thereof. A method for 5 preparing a Mosla chinensis extract includes the following steps: taking Mosla chinensis, adding a solvent in a 5-60x amount, extracting the Mosla chinensis for 5-120 min, filtering the solution and taking filtrate to obtain the Mosla chinensis extract. Compared with the prior art, the Mosla chinensis extract ofthe present invention features the following advantages: the Mosla chinensis is soaked in a large amount of hot water 10 within a short time, and unstable ingredients in the Mosla chinensis such as essential oil and phenols are maintained as much as possible, so that the function of heat clearing and detoxication is achieved; and reflux extraction is performed on the Mosla chinensis through hot water, and a good antibacterial effect is shown.
Description
MOSLA CHINENSIS EXTRACT AND APPLICATION THEREOF
[01] The present invention belongs to the technical field of drug preparation, and particularly relates to a Mosla chinensis extract and an application thereof.
[02] Mosla chinensis Maxim. (Mosla chinensis for short) is a plant of Mosla genus in Labiatae family. It grows on the grass slope or under the forest at an altitude of up to 1,400 meters and is mainly distributed in the north of Vietnam and China. Resource survey shows that a vast number of Mosla chinensis plants grow in the Gannan region of Jiangxi Province. Mosla chinensis can be used as medicine and food. In Chinese folk use, the whole plant can be used as medicine to treat heatstroke and fever, cold and aversion to cold, stomach pain and vomiting, acute gastroenteritis, dysentery, bruise pain, edema of lower extremity, facial edema, dyspepsia, eczema and skin itch, multiple furuncle swollen, etc. Furthermore, it is an important drug to treat venomous snake bites.
At present, the development of Mosla chinensis has been limited due to few studies on its chemical ingredients and pharmacological actions.
[03] To solve the above-mentioned technical problems, the present invention provides a Mosla chinensis extract for medical use and an application thereof.
[04] AMosla chinensis extract is provided in the present invention, wherein a method for preparing the Mosla chinensis extract includes the following steps: taking Aosla chinensis, adding a solvent in a 30-60x amount, extracting the Mosla chinensis for 5- 120 min, filtering the solution and taking filtrate to obtain the Mosla chinensis extract.
[05] AMosla chinensis extract is provided in the present invention, wherein a method for preparing the Mosla chinensis extract includes the following steps: taking Mosla chinensis, adding a solvent in a 30-60x amount at 80-100°C, soaking and extracting the
Mosla chinensis 1-3 times, 5-20 min each time, filtering the solution and taking filtrate to obtain the Mosla chinensis extract.
[06] AMosla chinensis extract is provided in the present invention, wherein a method for preparing the Mosla chinensis extract includes the following steps: taking Mosta chinensis, adding a solvent in a 30-60x amount at 80-100°C, soaking and extracting the
Mosla chinensis 1-3 times, 5-20 min each time, filtering the solution and taking filtrate, and removing the solvent to obtain the Mosla chinensis extract.
[07] AMosla chinensis extract is provided in the present invention, wherein a method for preparing the Mosla chinensis extract requires that the solvent is water or ethanol solution.
[08] An application of the Mosla chinensis extract is provided in the present invention, wherein the Mosla chinensis extract is used to prepare drugs for treating sphagitis, swollen sore throat and tonsillitis.
[09] A composition containing the Mosla chinensis extract is provided in the present invention, wherein the composition includes the Aosla chinensis extract and camellia oil at a mass ratio of (5-1):1.
[10] An application of the composition containing the Mosla chinensis extract is provided in the present invention, wherein the composition is used to prepare antibacterial drugs. [MI] An application of the Mosla chinensis extract is provided in the present invention, wherein the Mosla chinensis extract 1s used to prepare tea bags or dissolved medicines.
[12] Compared to the prior art, the Mosla chinensis extract of the present invention features the following advantages: the Mosla chinensis is soaked in a large amount of hot water within a short time, and unstable constituents in the AMosla chinensis such as essential oil and phenols are maintained as much as possible, so that the function of heat clearing and detoxication is achieved; and a reflux extraction is performed on the Mosla chinensis through hot water, and a good antibacterial effect is shown.
[13] The Mosla chinensis extract and the application thereof of the present invention are described further in combination with the specific embodiments, but the protection scope of the present invention is not limited to such embodiments.
[14] Example 1
[15] 5g of Mosla chinensis was taken, water in a 50x amount at 95°C was added, the
Mosla chinensis was soaked and extracted 2 times, 5 min each time, the solution was filtered, and filtrate was taken and merged to obtain the Afosia chinensis extract.
[16] Example 2
[17] 5g of Mosla chinensis was taken, water in a 10x amount at 100°C was added, the Mosla chinensis was heated, reflux extraction was performed 2 times, 120 min each time, the solution was filtered, and filtrate was taken and merged to obtain the AMosla chinensis extract.
[18] Verification of pharmaceutical effect
[19] Treatment of tonsillitis: 27 patients with mild tonsillitis were collected between the beginning of 2020 and the end of 2021. Based on the patients’ will, the patients were treated with example | and warm water at intervals in the order of collecting time as much as possible. Among them, 16 patients were treated with example 1, and 11 patients were controlled with warm water. The patients’ conditions were asked by daily phone calls and the cure time was counted. The results were shown as follows: the cure time for 16 patients treated with example 1 was 2.3+0.6 days, and the cure time for 11 patients treated with warm water as a control was 3.8+1.3 days.
[20] Anti-staphylococcus aureus effect: 1 ml of Mosla chinensis extract with a concentration of 0.5 g/ml crude drug was taken, and 0.1 g of camellia oil was added to obtain a composition; 72 ml of medium was poured into 3 culture dishes, three parallel experiments were performed, about 20 ml for each experiment, and the medium was placed for 30 min; 0.4 ml of staphylococcus aureus suspension with a McFarland concentration of 0.46 was added to 200 ml of medium, the solution was mixed, 5 ml was added to each of these culture dishes, and the solution was shaken well; 1 Oxford cup was placed at each corner of the culture dish and labeled as Groups A, B, C and D, the composition was added in Groups A and B, normal saline was added in Groups C and
D, these groups were placed for 30 min and then put into the incubator, and the inhibition zone was observed. The inhibition zone of the composition was 4.6+1.2 mm and no inhibition zone was observed in the normal saline.
[21] Anti-malassezia effect: 1 ml of Mosla chinensis extract with a concentration of 0.5 g/ml crude drug was taken, and 0.1 g of camellia oil was added to obtain a composition, 72 ml of medium was poured into 3 culture dishes, three parallel experiments were performed, about 20 ml for each experiment, and the medium was placed for 30 min; 0.4 ml of malassezia suspension with a McFarland concentration of 0.46 was added to 200 ml of medium, the solution was mixed, 5 ml was added to each of these culture dishes, and the solution was shaken well; 1 Oxford cup was placed at each corner of the culture dish and labeled as Groups A, B, C and D, the composition was added in Groups A and B, normal saline was added in Groups C and D, these groups were placed for 30 min and then put into the incubator, and the inhibition zone was observed. The inhibition zone of the composition was 3.3+0.8 mm and no inhibition zone was observed in the normal saline.
Claims (8)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2032123A NL2032123B1 (en) | 2022-06-10 | 2022-06-10 | Mosla chinensis extract and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2032123A NL2032123B1 (en) | 2022-06-10 | 2022-06-10 | Mosla chinensis extract and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL2032123B1 true NL2032123B1 (en) | 2023-12-18 |
Family
ID=82404347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL2032123A NL2032123B1 (en) | 2022-06-10 | 2022-06-10 | Mosla chinensis extract and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| NL (1) | NL2032123B1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001031516A (en) * | 1999-07-15 | 2001-02-06 | Murata Makoto | Antibacterial, deodorizing and antioxidation composition produced by using component originated from mosla chinensis maxim. and its processed product |
| CN107617023A (en) * | 2016-07-13 | 2018-01-23 | 江西雾源生态农业有限公司 | The application of camellia seed oil |
| CN111166805A (en) * | 2020-03-20 | 2020-05-19 | 任秀江 | Preparation method and application of plant extract for treating tonsillitis and pharyngolaryngitis |
-
2022
- 2022-06-10 NL NL2032123A patent/NL2032123B1/en active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001031516A (en) * | 1999-07-15 | 2001-02-06 | Murata Makoto | Antibacterial, deodorizing and antioxidation composition produced by using component originated from mosla chinensis maxim. and its processed product |
| CN107617023A (en) * | 2016-07-13 | 2018-01-23 | 江西雾源生态农业有限公司 | The application of camellia seed oil |
| CN111166805A (en) * | 2020-03-20 | 2020-05-19 | 任秀江 | Preparation method and application of plant extract for treating tonsillitis and pharyngolaryngitis |
Non-Patent Citations (2)
| Title |
|---|
| DATABASE TCM / SIPO [online] 19 May 2020 (2020-05-19), REN XIUJIANG ET AL: "A method for preparing plant extracting solution for treating tonsillitis and pharyngolaryngitis and application thereof", XP093012649, Database accession no. CN111166805 A 20200519 * |
| TEIXEIRA ANA MARGARIDA ET AL: "A Review on the Biological Activity of Camellia Species", MOLECULES, vol. 26, no. 8, 9 April 2021 (2021-04-09), pages 2178, XP093012534, DOI: 10.3390/molecules26082178 * |
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