NL2031296B1 - Application of aronia melanocarpa leaf polyphenol extract in preparing antidepressants - Google Patents
Application of aronia melanocarpa leaf polyphenol extract in preparing antidepressants Download PDFInfo
- Publication number
- NL2031296B1 NL2031296B1 NL2031296A NL2031296A NL2031296B1 NL 2031296 B1 NL2031296 B1 NL 2031296B1 NL 2031296 A NL2031296 A NL 2031296A NL 2031296 A NL2031296 A NL 2031296A NL 2031296 B1 NL2031296 B1 NL 2031296B1
- Authority
- NL
- Netherlands
- Prior art keywords
- aronia melanocarpa
- polyphenol extract
- leaf
- depression
- mice
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Claims (9)
1. Toepassing van polyfenol-extract van aronia melanocarpa-blad bij het bereiden van medicijnen, functionele voedingsmiddelen of supplementen voor het voorkomen, reguleren of behandelen van de- pressie, waarbij het polyfenol-extract van aronia melanocarpa-blad bestaat uit rutine, chlorogeenzuur en isomeer, 3-0- caffeoylquininezuur, duercetine en derivaat quercetine 3-0-0-L arabinopyranosyl-{(1-+6}) B-D-glucopyranoside, cafeïnezuur en deri- vaat hyperoside.
2. Toepassing volgens conclusie 1, waarbij de toedieningsdosis van het polyfenol extract van aronia melanocarpa blad 15 tot 25 ml/kg lichaamsgewicht is.
3. Toepassing volgens conclusie 1, waarbij het polyfenolextract van aronia melanocarpa-blad effectief de relatieve overvloed van sommige schadelijke bacteriën in darmmicroben kan verminderen, de darmmicro-omgeving kan reguleren en de diversiteit en rijkdom van de darmflora op een normaal niveau kan houden.
4. Toepassing volgens conclusie 1, waarbij het polyfenol-extract van aronia melanocarpa-blad de florastructuur van de darmmicro- omgeving kan reguleren en het BDNF-expressieniveau in de hippocam- pus van de hersenen van depressieve muizen aanzienlijk kan verbe- teren.
5. Toepassing van het polyfenolextract van aronia melanocarpa-blad volgens conclusie 1, waarbij het polyfenol-extract van aronia me- lanocarpa-blad wordt toegepast in antidepressiva.
6. Toepassing van het polyfenolextract van aronia melanocarpa-blad volgens conclusie 1, waarbij het polyfenol-extract van aronia me- lanocarpa-blad wordt toegepast in functionele voedingsmiddelen en supplementen tegen depressie.
7. Toepassing volgens een van de conclusies 5 tot 6, waarbij een aanvaardbare drager wordt toegevoegd aan de medicijnen, functione- le voedingsmiddelen of supplementen.
8. Toepassing volgens een van de conclusies 5 tot 6, waarbij een acceptabel hulpmateriaal of hulpbestanddeel wordt toegevoegd aan de medicijnen, functionele voedingsmiddelen of supplementen tegen depressie.
9. Toepassing volgens een van de conclusies 5 tot 6, waarbij de doseringsvorm van de medicijnen, functionele voedingsmiddelen of supplementen tegen depressie elke farmaceutische doseringsvorm kan zijn.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111653865 | 2021-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL2031296B1 true NL2031296B1 (en) | 2023-07-05 |
Family
ID=81851470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL2031296A NL2031296B1 (en) | 2021-12-30 | 2022-03-15 | Application of aronia melanocarpa leaf polyphenol extract in preparing antidepressants |
Country Status (1)
| Country | Link |
|---|---|
| NL (1) | NL2031296B1 (nl) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112190618A (zh) * | 2020-11-02 | 2021-01-08 | 山东理工大学 | 黑果腺肋花楸叶多酚提取物在制备抗抑郁药物中的应用 |
-
2022
- 2022-03-15 NL NL2031296A patent/NL2031296B1/en active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112190618A (zh) * | 2020-11-02 | 2021-01-08 | 山东理工大学 | 黑果腺肋花楸叶多酚提取物在制备抗抑郁药物中的应用 |
Non-Patent Citations (3)
| Title |
|---|
| EFTIMOV MIROSLAV ET AL: "ANTIDEPRESSANT-LIKE EFFECT oF ARoNIA MELANoCARPA FRUIT JUICE APPLIED SUBCHRoNICALLY To RATS INTRoDUCTIoN", SCRIPTA SCIENTIFIC MEDICA, vol. 45, no. Suppl 6, 1 January 2013 (2013-01-01), pages 7 - 11, XP055959658, Retrieved from the Internet <URL:https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1012.7561&rep=rep1&type=pdf> * |
| MIRKO TOMIĆ ET AL: "Reduction of anxiety-like and depression-like behaviors in rats after one month of drinking Aronia melanocarpa berry juice", FOOD & FUNCTION, vol. 7, no. 7, 1 January 2016 (2016-01-01), GB, pages 3111 - 3120, XP055392348, ISSN: 2042-6496, DOI: 10.1039/C6FO00321D * |
| SZOPA AGNIESZKA ET AL: "Comparative analysis of different groups of phenolic compounds in fruit and leaf extracts ofAroniasp.:A. melanocarpa, A. arbutifolia, andA. xprunifoliaand their antioxidant activities", EUROPEAN FOOD RESEARCH AND TECHNOLOGY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 243, no. 9, 27 March 2017 (2017-03-27), pages 1645 - 1657, XP036299693, ISSN: 1438-2377, [retrieved on 20170327], DOI: 10.1007/S00217-017-2872-8 * |
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