NL2029953A - Bioaerosol lung deposition experimental model system - Google Patents

Bioaerosol lung deposition experimental model system Download PDF

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NL2029953A
NL2029953A NL2029953A NL2029953A NL2029953A NL 2029953 A NL2029953 A NL 2029953A NL 2029953 A NL2029953 A NL 2029953A NL 2029953 A NL2029953 A NL 2029953A NL 2029953 A NL2029953 A NL 2029953A
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lung
bioaerosol
model
chamber
deposition
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NL2029953A
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Xie Hongwei
Zhang Lei
Li Rong
Guo Haitao
Wang Chao
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Logistics Univ Of Peoples Armed Police
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Abstract

The present disclosure discloses a bioaerosol lung deposition experimental model system. The system comprises a bioaerosol exposure experiment chamber, a lung model, a bioaerosol generating and sampling system, a respiration simulation and monitoring system, and the like. A bioaerosol uniform diffuser, a bioaerosol generator and a bioaerosol sampler are mounted at the top of the bioaerosol exposure experiment chamber, the lung model is fixed in a lung' model seal chamber, and, the lung' model seal chamber is placed, in the middle of the bottonl of the bioaerosol exposure experiment chamber; the lung model comprises a left lung transparent flexible model, a right lung transparent flexible model, a transparent throat, a trachea and second—fourth generation bronchi, which jointly form a respiratory system model conforming to physiological characteristics of a human body, and the respiratory system. model is connected, with the bioaerosol samplers and a simulated respiratory pump.

Description

P838/NLpd
BIOAEROSOL LUNG DEPOSITION EXPERIMENTAL MODEL SYSTEM
TECHNICAL FIELD The present disclosure relates to the technical field of re- search on respiratory tract invasion of pathogenic microorganisms, and in particular to a bioaerosol lung deposition experimental model system.
BACKGROUND ART Entry of pathogenic microorganisms into the trachea, bronchus and even lung of a human body in the form of bioaerosols under the action of respiration is the main route for the outbreak of vari- ous infectious diseases such as influenza and the like, therefore, the research on the characteristics of pathogenic microorganisms entering a respiratory system of the human body is an important means for the prevention and control of various respiratory dis- eases. Traditional animal models cannot fully conform to the human body characteristics, and research results are highly biased. There are significant potential risks in real human experiments, and the cost is relatively high. Therefore, the construction of an in vitro experimental model capable of simulating real human body characteristics to simulate the entry of bioaerosols into the res- piratory system of the human body has received attention, and var- ious in vitro models have been proposed and applied. However, the existing models can be all used for simulating physical aerosols such as atmospheric dust and the like, and are mostly local models of the bronchi, which cannot truly reflect deposition rule of the bioaerosols carrying pathogenic microorganisms in the respiratory system of the human body. None of the existing experimental models involve whole lung models, either local models of the trachea and principal bronchus or enlarged models of a group of alveoli, which have a certain of limitation in application.
SUMMARY An objective of the present disclosure is to provide a bio-
aerosol lung deposition experimental model system to solve the problems in the prior art, which can simulate deposition rule of bioaerosols in the trachea, bronchus, and lung of a respiratory system of a human body under various respiratory modes. To achieve the objective, the present disclosure provides the following solutions: a bioaerosol lung deposition experimental model system pro- vided by the present disclosure comprises a bicaerosol exposure experiment chamber, a bioaerosol generator, a lung model, a lung model seal chamber, a simulated respiratory pump, and a bioaerosol sampler, wherein the bicaerosol exposure experiment chamber is cy- lindrical and is made of a transparent plastic material; an open- ing is formed in the upper end of the bioaerosol exposure experi- ment chamber, and a bioaerosol generator is connected to the open- ing through a pipeline; the other end of the pipeline is connected with a diffuser, and the lower side of the diffuser is connected with a suction inlet bioaerosol sampler through a pipeline; the lung model seal chamber is mounted at the lower part in the bio- aerosol exposure experiment chamber, is connected with the simu- lated respiratory pump through a pipeline, and is connected with a differential pressure gauge; the lung model is placed in the lung model seal chamber, and comprises a left lung cavity and a right lung cavity; the left lung cavity and the right lung cavity are connected together through a trachea, the upper side of the tra- chea is connected with a lung model throat through a throat con- nector, the trachea is connected with the bronchi through bronchus connectors, and the bronchi are arranged in the left lung cavity and the right lung cavity respectively; the left lung cavity is connected with a left lung bioaerosol sampler through a pipeline, and the right lung cavity is connected with a right lung bioaero- sol sampler through a pipeline.
The bronchi are provided with the second-fourth generation bronchi, comprise a left part and a right part, and are made of a transparent hard PC material; the lung model is made of a trans- parent elastic silica gel material, the trachea is made of a transparent hard PC material; and the second-fourth generation bronchi.
The lung model is placed in the lung model seal chamber, a throat part is exposed to the external of the lung model seal chamber; the lung model seal chamber is an airtight cylinder made of a transparent PV material; the bioaerosol samplers are respec- tively connected with the bioaerosol exposure experiment chamber, the lung cavity, and the right lung cavity; and the simulated res- piratory pump is connected with the lung model seal chamber.
The diffuser is a uniform diffuser in which circular holes are uniformly distributed in a cylindrical shape of the bicaero- sols.
An efficient air purifier, a temperature sensor and a humidi- ty sensor are mounted at the side face of the bioaerosol exposure experiment chamber.
The lung model throat, the trachea and the bronchi are con- nected by adopting detachable connectors.
The lung model is of a flexible contractile structure.
The bioaerosol lung deposition experimental model system pro- vided by the present disclosure has the beneficial effects that: a fully transparent respiratory tract and lung experimental model is constructed by adopting real physiological size of a hu- man body, which can simulate the deposition of inhaled bicaerosols inside the respiratory tract and lung of the human body under var- ious respiratory modes; and compared with an existing animal ex- perimental model, the model is more in line with the real physio- logical size of the human body. Existing in vitro experimental models are usually used for simulating physical aerosols without simulating inhalation and humidification of particulate matters. The problem of in vitro simulation and research of the deposition of bioaerosols in the respiratory tract of the human body is solved by the system disclosed by the present disclosure, and re- alistic reproduction of the deposition and diffusion of the bio- aerosols in the respiratory system of the human body is achieved through the control on a temperature, humidity, and a respiratory mode.
A lung experimental model system capable of simulating bio- aerosol deposition is designed in the present disclosure, a bio- aerosol generator, a mixing exposure chamber, and a multi-stage biological sampler are used to achieve an experiment on the over- all deposition rate of a respiratory system, thus solving the problem that the existing models cannot perform experiments on the bicaerosol deposition.
By coating a liquid medium evenly in the respiratory system and then solidifying the same, the bioaerosols are cultivated into plaque visible to naked eyes after depositing in the system; the distribution rule and quantity of the bioaerosols deposited in the respiratory system may be visually known by observing the plague; the problem that the existing model can only measure the overall deposition quantity or the total deposition quantity at a certain part rather than obtaining the deposition distribution is solved for the first time, and the technology has a great novelty.
By adopting a detachable experimental model based on CT scan- ning of an adult respiratory system, the trachea and the secondary bronchi to the quaternary bronchi are designed to be detachable, the original bronchiole and alveoli are simplified into the lung model, the lung model is designed to be of a flexible contractile structure, the real respiration situation of a human body can be simulated, and bioaerosol deposition simulation of the full lung model is achieved.
BRIEF DESCRIPTION OF THE DRAWINGS To describe the technical solutions in the embodiments of the present disclosure or in the prior art more clearly, the accompa- nying drawings required for describing the embodiments are briefly introduced below. Apparently, the accompanying drawings in the following description show merely some embodiments of the present disclosure, and those of ordinary skill in the art may still de- rive other drawings from these accompanying drawings without crea- tive efforts.
FIG. 1 is a structure diagram of a bioaerosol lung deposition experimental model system in accordance with the present disclo- sure; FIG. 2 is a diagram of a lung model of a bioaerosol lung dep- osition experimental model system in accordance with the present disclosure;
In the drawings, l-bicaerosol exposure experiment chamber, 2- efficient air purifier, 3-suction inlet bioaerosol sampler, 4-lung model seal chamber, 5-lung model, 6-right lung bioaerosol sampler, 7-left lung bioaerosol sampler, 8-simulated respiratory pump, 9- 5 differential pressure gauge, l1l0-hygrometer, ll-thermometer, 12- bioaerosol generator, 13-bicaerosol uniform diffuser. 5-1-lung model throat, 5-2-throat connector, 5-3-right lung model, 5-4- bronchus, 5-5-left lung model, 5-6-bronchus connector, 5-7- trachea.
DETAILED DESCRIPTION OF THE EMBODIMENTS The following clearly and completely describes the technical solutions in the embodiments of the present disclosure with refer- ence to the accompanying drawings in the embodiments of the pre- sent disclosure. Apparently, the described embodiments are merely a part rather than all of the embodiments of the present disclo- sure. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments of the present disclosure without creative efforts shall fall within the scope of protection of the present disclosure.
An objective of the present disclosure is to provide a bio- aerosol lung deposition experimental model system to solve the problems in the prior art, which can achieve simulation of deposi- tion and distribution of bioaerosols in a respiratory system of a human body under different respiratory modes.
To make the above objects, features and advantages of the present invention more apparent and understandable, the present disclosure is further described in detail below with reference to the accompanying drawings and specific embodiments.
Embodiment 1 The present disclosure provides a bioaerosol lung deposition experimental model system, which comprises a bioaerosol exposure experiment chamber, a bioaerosol generator, a lung model, a lung model seal chamber, a simulated respiratory pump, and a bioaerosol sampler, wherein the bioaerosol exposure experiment chamber is cy- lindrical and is made of a transparent plastic material; an open- ing is formed in the upper end of the bioaerosol exposure experi-
ment chamber, and the bicaerosol generator is connected to the opening through a pipeline; the other end of the pipeline is con- nected with a diffuser; the lung model seal chamber is mounted at the lower part in the bioaerosol exposure experiment chamber, is connected with the simulated respiratory pump through a pipeline, and is connected with a differential pressure gauge; the lung mod- el is placed in the lung model seal chamber, and consists of a left lung cavity and a right lung cavity; the left lung cavity and the right lung cavity are connected together through a trachea,
the upper side of the trachea is connected with a lung model throat through a throat connector, the trachea is connected with the bronchi through bronchus connectors, and the bronchi are ar- ranged in the left lung cavity and the right lung cavity respec- tively; the left lung cavity is connected with a left lung bioaer-
osol sampler through a pipeline, and the right lung cavity is con- nected with a right lung bioaerosol sampler through a pipeline; the bronchi are provided with the second-fourth generation bron- chi, comprise a left part and a right part, and are made of a transparent hard PC material; the lung model is made of a trans-
parent elastic silica gel material, the trachea is made of a transparent hard PC material; and the second-fourth generation bronchi.
The lung model is placed in the lung model seal chamber, a throat part is exposed to the external of the lung model seal chamber; the lung model seal chamber is an airtight cylinder made of a transparent PV material; the bioaerosol samplers are respec- tively connected with the bioaerosol exposure experiment chamber, the lung cavity, and the right lung cavity; and the simulated res- piratory pump is connected with the lung model seal chamber.
The diffuser is a uniform diffuser in which circular holes are uni-
formly distributed in a cylindrical shape of the bioaerosols.
An efficient air purifier, a temperature sensor and a humidity sensor are mounted at the side face of the bioaerosol exposure experiment chamber.
The lung model threat, the trachea and the bronchi are connected by adopting detachable connectors.
The lung model is of a flexible contractile structure.
The lower side of the diffuser is connected with a suction inlet bioaerosol sampler through a pipeline.
Embodiment 2 The lung model provided by the present disclosure comprises a throat, a trachea, second-fourth generation bronchi, and the lung, the lung is made of a transparent elastic silica gel material, the throat, the trachea and the bronchi are made of a transparent hard PC material, the size and structure data of the lung, the trachea and the second-fourth generation bronchi are obtained through lung CT scanning of an adult healthy male (34 years old, 170 cm in height and 65 kg in weight), with a scanning layer thickness of
0.3 mm.
In accordance with the present disclosure, the simulation of the overall deposition rate of the bioaerosols and the display of the deposition distribution at various parts can be achieved, with a specific use method comprising: (1) simulation of overall deposition rate of bicaerosols: after the model connection is completed, setting a respirato- ry mode of a respiratory pump, including parameters such as a res- piratory rate, a tidal volume, and the like, turning on the bio- aerosol generator, generating bicaerosols into the bioaerosol ex- posure experiment chamber, uniformly diffusing the bioaerosols in- to the bioaerosol exposure experiment chamber through the bioaero- sol uniform diffuser, turning on the suction inlet bioaerosol sam- pler for sampling, then turning-on the simulated respiratory pump to make the lung model deform under the reciprocating pressure difference change of the simulated respiratory pump, thus simulat- ing a respiratory process of human body; inhaling the bioaerosols in the bioaerosol exposure experiment chamber into the lung model, depositing, then exhaling the bioaerosols out of the model, and turning on the left lung bicaerosol sampler and the right lung bi- oaerosol sampler at the same time to collect the bioaerosols in the lung cavities after deposition, placing a culture dish in a biological culture box for culturing and counting after the bio- aerosols are collected; and computing a bioaerosol deposition rate of the bicaerosols in the lung model according to the change of the quantity collected by the suction inlet bioaerosol sampler, the left lung bioaerosol sampler and the right lung bioaerosol sampler.
(2) Deposition distribution of bioaerosols at various parts: before model connection, disassembling the left lung cavity, the right lung cavity, the throat, the trachea and the secondary bronchus to the quaternary bronchus in the lung model, pouring a molten agar culture medium into the parts, uniformly coating the culture medium on the inner walls of the parts, carrying out model connection after cooling and solidification, then connecting the whole system; setting the respiratory mode of the respiratory pump, including parameters such as a respiratory rate and a tidal volume, turning on the bicaerosol generator, generating bioaero- sols into the bioaerosol exposure experiment chamber, uniformly diffusing the bioaerosols into the bioaerosol exposure experiment chamber through the bioaerosol uniform diffuser, turning on the suction inlet bioaerosol sampler for sampling, then turning on the simulated respiratory pump to make the lung model deform under the reciprocating pressure difference change of the simulated respira- tory pump, thus simulating a respiratory process of the human body; inhaling the bioaerosols in the bioaerosol exposure experi- ment chamber into the lung model, depositing, then exhaling the bicaerosols out of the model, wherein the bioaerosols are attached to an agar culture medium on the inner wall after deposition; and after the experiment is finished, removing the lung model, disas- sembling or putting the whole into a biological incubator to be cultured for a period of time, taking out the lung model, enabling the deposited bicaerosols to grow into plague on the culture medi- um, and observing and counting through a transparent outer wall of the model, thus drawing a deposition distribution diagram.
Principles and the embodiments of the present disclosure are set forth by applying specific examples in the present disclosure, and the above embodiments are only used to help understand the methods of the present disclosure and core ideas thereof; at the same time, for the those of ordinary skill in the art, changes may be made in terms of specific embodiments and scope of application in accordance with the idea of the present disclosure.
In conclu- sion, the description should not be construed as limiting the pre- sent disclosure.

Claims (7)

CONCLUSIESCONCLUSIONS 1. Experimenteel modelsysteem voor afzetting van bicaerosol in de longen, omvattende een experimentkamer voor blootstelling aan bioaerosol, een generator voor bioaerosol, een longmodel, een af- dichtingskamer voor het longmodel, een gesimuleerde ademhalings- pomp en een bio-aerosolmonsternemer, waarbij de experimentkamer voor blootstelling aan bioaerosol cilindrisch is en is gemaakt van een transparante kunststof; een opening wordt gevormd in het bo- venste uiteinde van de experimentkamer voor blootstelling aan bioaerosol en de generator voor bioaerosol via een pijpleiding met de opening is verbonden; het andere uiteinde van de pijpleiding is verbonden met een diffusor, en de onderkant van de diffusor via een pijpleiding is verbonden met een bio-aerosolmonsternemer met zuiginlaat; waarbij de afdichtingskamer voor het longmodel is ge- monteerd in het onderste deel van de experimentkamer voor bloot- stelling aan bio-aerosol, is verbonden via een pijpleiding met de gesimuleerde ademhalingspomp en is verbonden met een drukverschil- meter; waarbij het longmodel in de afdichtingskamer voor het long- model wordt geplaatst en bestaat uit een linker longholte en een rechter longholte; waarbij de linker longholte en de rechter long- holte met elkaar zijn verbonden via een luchtpijp, de bovenzijde van de luchtpijp is verbonden met een longmodel keel via een keel- connector, de luchtpijp is verbonden met bronchiën via bronchus- connectoren, en de bronchiën zijn gerangschikt in respectievelijk de linker longholte en de rechter longholte; waarbij de linker- longholte via een pijpleiding is verbonden met een bio- aerosolmonsternemer van de linkerlong en de rechterlongholte via een pijpleiding is verbonden met een bio-aerosolmonsternemer van de rechterlong.An experimental model system for bicaerosol deposition in the lung, comprising an experimental chamber for bioaerosol exposure, a bioaerosol generator, a lung model, a sealing chamber for the lung model, a simulated breathing pump, and a bioaerosol sampler, wherein the experimental chamber for exposure to bioaerosol is cylindrical and made of a transparent plastic; an opening is formed in the upper end of the bioaerosol exposure chamber and the bioaerosol generator is piped to the opening; the other end of the pipeline is connected to a diffuser, and the bottom of the diffuser is connected via a pipeline to a bio-aerosol sampler with suction inlet; wherein the sealing chamber for the lung model is mounted in the lower part of the bio-aerosol exposure experiment chamber, is piped to the simulated breathing pump and is connected to a differential pressure gauge; wherein the lung model is placed in the lung model sealing chamber and consists of a left lung cavity and a right lung cavity; wherein the left lung cavity and the right lung cavity are connected to each other via a trachea, the top of the trachea is connected to a lung model throat via a throat connector, the trachea is connected to bronchi via bronchus connectors, and the bronchi are arranged in the left lung cavity and the right lung cavity, respectively; wherein the left lung cavity is pipelined to a left lung bioaerosol sampler and the right lung cavity is pipelined to a right lung bioaerosol sampler. 2. Experimenteel modelsysteem voor afzetting van bioaerosol in de longen volgens conclusie 1, waarbij de bronchiën zijn voorzien van tweede-vierde generatie bronchiën, een linkerdeel en een rechter- deel omvatten, en zijn gemaakt van een transparant hard PC- materiaal; waarbij het longmodel is gemaakt van transparant elas-The experimental model system for bioaerosol deposition in the lung according to claim 1, wherein the bronchi are provided with second-fourth generation bronchi, comprising a left part and a right part, and are made of a transparent hard PC material; where the lung model is made of transparent elastane tisch silicagelmateriaal, de luchtpijp is gemaakt van transparant hard PC-materiaal; de bronchiën van de tweede-vierde generatie.tic silica gel material, the trachea is made of transparent hard PC material; second-fourth-generation bronchi. 3. Experimenteel modelsysteem voor afzetting van bicaerosol in de longen volgens conclusie 1, waarbij het longmodel in de afdich- tingskamer van het longmodel wordt geplaatst, en een keelgedeelte wordt blootgesteld aan de buitenkant van de afdichtingskamer van het longmodel; waarbij de afdichtingskamer van het longmodel een luchtdichte cilinder is die is gemaakt van transparant PV- materiaal; waarbij de bio-aerosolmonsternemers respectievelijk zijn verbonden met de experimentkamer voor blootstelling aan bioaerosol, de linker longholte en de rechter longholte; en de ge- simuleerde beademingspomp is verbonden met de afdichtingskamer voor het longmodel.The experimental model system for bicaerosol deposition in the lung according to claim 1, wherein the lung model is placed in the sealing chamber of the lung model, and a throat portion is exposed to the outside of the sealing chamber of the lung model; wherein the sealing chamber of the lung model is an airtight cylinder made of transparent PV material; wherein the bioaerosol samplers are connected to the bioaerosol exposure experiment chamber, the left lung cavity and the right lung cavity, respectively; and the simulated breathing pump is connected to the sealing chamber for the lung model. 4. Experimenteel modelsysteem voor afzetting van bioaerosol in de longen volgens conclusie 1, waarbij de diffusor een uniforme dif- fusor is waarin cirkelvormige gaten uniform zijn verdeeld in een cilindrische vorm van de bioaerosolen.The experimental model system for bioaerosol deposition in the lungs according to claim 1, wherein the diffuser is a uniform diffuser in which circular holes are uniformly distributed in a cylindrical shape of the bioaerosols. 5. Experimenteel modelsysteem voor afzetting van bioaerosol in de longen volgens conclusie 1, waarbij een efficiënte luchtreiniger, een temperatuursensor en een vochtigheidssensor zijn gemonteerd aan de zijkant van de experimentkamer voor blootstelling aan bioaerosol.The experimental model system for bioaerosol deposition in the lungs according to claim 1, wherein an efficient air purifier, a temperature sensor and a humidity sensor are mounted on the side of the experiment chamber for bioaerosol exposure. 6. Experimenteel modelsysteem voor afzetting van bioaerosol in de longen volgens conclusie 1, waarbij de keel van het longmodel, de luchtpijp en de bronchiën zijn verbonden door middel van losneem- bare connectoren.The experimental model system for bioaerosol deposition in the lungs according to claim 1, wherein the throat of the lung model, the trachea and the bronchi are connected by detachable connectors. 7. Experimenteel modelsysteem voor afzetting van bioaerosol in de longen volgens conclusie 1, waarbij het longmodel een flexibele contractiele structuur heeft.The experimental model system for bioaerosol deposition in the lung according to claim 1, wherein the lung model has a flexible contractile structure.
NL2029953A 2021-11-29 2021-11-29 Bioaerosol lung deposition experimental model system NL2029953B1 (en)

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