NL2018302B1 - Composition for use in the treatment and / or prevention of a deficiency of vitamins, minerals and / or trace elements. - Google Patents

Abstract

Composition for use in the treatment and / or prevention of a deficiency of vitamins, minerals and / or trace elements, in particular for muscles, bones and / or teeth, wherein the composition is administered one or more times a day which together form a daily dose, which composition comprises per daily dose: a) a number of vitamins individually in an amount of between 90% and 110% of the recommended daily amount of the vitamin in question, the vitamins being the following: vitamin A, vitamin 81, vitamin 82, vitamin 83, vitamin 85, vitamin 86, vitamin 88, vitamin 811, vitamin 812, vitamin C, vitamin E and vitamin K; b) a number of minerals and trace elements, each individually in an amount of between 10% and 20% of the recommended daily amount of the mineral or trace element concerned, the minerals and trace elements being the following: boron, calcium, chromium, chlorine, phosphorus, iron, iodine, potassium, copper, manganese, molybdenum, sodium, selenium and zinc; c) vitamin 03 in an amount between 175 and 225% of the recommended daily allowance for vitamin 03; and d) magnesium in an amount of between 40 and 60% of the recommended daily amount of magnesium.

Description

DESCRIPTION

The invention relates to a composition for use in the treatment and / or prevention of a deficiency of vitamins, minerals and / or trace elements, in particular for muscles, bones and / or teeth, wherein the composition is used one or more times a day which together form a daily dose, which composition comprises per daily dose:

a. a number of vitamins individually in an amount of between 90% and 110% of the recommended daily amount of the vitamin in question, the vitamins being the following: vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B8, vitamin B11, vitamin B12, vitamin C, vitamin E and vitamin K;

b. a number of minerals and trace elements, each individually in an amount of between 10% and 20% of the recommended daily amount of the mineral or trace element concerned, the minerals and trace elements being the following: boron, calcium, chromium, chlorine, phosphorus, iron, iodine, potassium, copper, manganese, molybdenum, sodium, selenium and zinc;

c. vitamin D3 in an amount of between 175 and 225% of the recommended daily allowance for vitamin D3; and

d. magnesium in an amount of between 40 and 60% of the recommended daily amount of magnesium.

Background

Vitamins and minerals are both indispensable for many processes in the body. They are important for the growth, development and recovery of the body, for the energy level and for the regulation of enzymes and hormones. Vitamins come from living nature and can be made by some plants or animals themselves, while minerals come from dead nature and must be taken up by plants from the earth and by animals from food or water. The body does not or insufficiently produces vitamins and minerals itself.

Vitamins can be subdivided into the fat-soluble vitamins A, D, E, K and the water-soluble vitamins thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (vitamin B6), biotin (B8), folic acid (B11), cobalamin (vitamin B12) and vitamin C. Essential minerals are sodium, potassium, magnesium, calcium, chloride and phosphorus. The essential trace elements are iron, zinc, iodine, selenium, copper, manganese and molybdenum.

The nutritional values in fruit and vegetables have fallen enormously in the last twenty years. The cultivation of fruit and vegetables on a massive scale has exhausted the soil. The amount of minerals in the soil in particular has fallen sharply. As a result, plants extract fewer minerals from the soil, which means they themselves contain fewer vitamins and minerals.

A shortage of vitamins and minerals can have an effect on the total body and the symptoms can be very diverse. General complaints are reduced resistance, fatigue, poor concentration, insomnia and listlessness. In addition, a shortage of certain vitamins or minerals can lead to specific complaints, for example:

A deficiency of Vitamin B1 can lead to memory loss, depression or problems with concentration.

A deficiency of Vitamin B12 can lead to fatigue, lack of appetite or damage to the nerves.

A deficiency of Vitamin D gives an increasing chance of osteoporosis.

Calcium deficiency can lead to muscle weakness, irritability and high cholesterol.

Magnesium deficiency increases the risk of muscle cramps, changing moods and nervousness.

There are certain groups that need something extra. Women over 50, pregnant women and children are advised to use extra Vitamin D. Athletes consume more and therefore automatically need more vitamins and minerals, such as Vitamin D and Magnesium. But because of the Western way of living and eating, and because of the ever-decreasing nutritional values in food, everyone actually benefits from supplementation.

The disadvantage with existing preparations is that they often contain a limited number of vitamins and that the daily recommended dosage is not always adapted to each other for the various components.

Resume

It is an object of the invention to provide a composition for use in the treatment and / or prevention of a deficiency of vitamins, minerals and / or trace elements, in particular for muscles, bones and / or teeth. The present invention solves this problem by providing a particularly balanced assembly that contains all necessary vitamins, minerals and trace elements in such a dosage that all vitamins are present in a dose of approximately 100% of the RDA, and all minerals and trace elements present in a dose about 15% of the RDA; with the exception of vitamins D3 and magnesium, which are in need of additional support during periods of fatigue. Normally a user would have to make separate compositions for this in order to arrive at a desired dosage. However, it is difficult for the average user to calculate the desired dosage regime for this and compliance with such a regime is difficult to maintain. The present invention solves this problem by offering a fully balanced composition.

This object is achieved by a composition for use, wherein the composition is administered one or more times a day which together form a daily dose, which composition comprises per daily dose:

a. a number of vitamins individually in an amount of between 90% and 110% of the recommended daily amount of the vitamin in question, the vitamins being the following: vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B8, vitamin B11, vitamin B12, vitamin C, vitamin E and vitamin K;

b. a number of minerals and trace elements, each individually in an amount of between 10% and 20% of the recommended daily amount of the mineral or trace element concerned, the minerals and trace elements being the following: boron, calcium, chromium, chlorine, phosphorus, iron, iodine, potassium, copper, manganese, molybdenum, sodium, selenium and zinc;

c. vitamin D3 in an amount of between 175 and 225% of the recommended daily allowance for vitamin D3; and

d. magnesium in an amount of between 40 and 60% of the recommended daily amount of magnesium.

Definitions

The following definitions are used in the current description and the claims. Other terms not mentioned here have the generally accepted meaning in the field.

"ADH" as used in the current description means "the recommended daily dose for adults according to Regulation (EU) Nr. 1169/2011 of the European Parliament and of the Council. The daily reference intakes for vitamins and minerals are included in the following description as the RDA. The daily reference intakes for vitamins and minerals for adults according to the Annex XIII of the Regulation (EU) Nr. 1169/2011 are shown in Table 1.

Table 1

Vitamin or Mineral Quantity of RDA Vitamin A 800 pg Vitamin D 5 pg Vitamin E 12 mg Vitamin K 75 pg Vitamin C 80 mg Thiamine (Vitamin B1) 1.1 mg Riboflavin (Vitamin B2) 1.4 mg Niacin (Vitamin B3) 16 mg Vitamin B6 1.4 mg Folic acid (Vitamin B11) 200 pg Vitamin B12 2.5 pg Biotin (Vitamin B8) 50 mg Pantothenic acid (Vitamin B5) 6 mg Potassium 2000 mg Chloride 800 mg Calcium 800 mg Phosphorus 700 mg Magnesium 375 mg Iron 14 mg Zinc 10 mg Buyer 1 mg Manganese 2 mg Fluoride 3.5 mg Selenium 55 pg Chrome 40 pg Molybdenum 50 pg Iodine 150 pg

Further description of the invention

Various embodiments of the invention are described below. However, the invention is not limited thereto. The invention is only limited to the claims. One or more of the aforementioned embodiments ensures that one or more of the objectives is achieved.

The invention relates to a composition for use in the treatment and / or prevention of a deficiency of vitamins, minerals and / or trace elements, in particular for muscles, bones and / or teeth, wherein the composition is used one or more times a day which together form a daily dose, which composition comprises per daily dose:

a. a number of vitamins individually in an amount of between 90% and 110% of the recommended daily amount of the vitamin in question, the vitamins being the following: vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B8, vitamin B11, vitamin B12, vitamin C, vitamin E and vitamin K;

b. a number of minerals and trace elements, each individually in an amount of between 10% and 20% of the recommended daily amount of the mineral or trace element concerned, the minerals and trace elements being the following: boron, calcium, chromium, chlorine, phosphorus, iron, iodine, potassium, copper, manganese, molybdenum, sodium, selenium and zinc;

c. vitamin D3 in an amount of between 175 and 225% of the recommended daily allowance for vitamin D3; and

d. magnesium in an amount of between 40 and 60% of the recommended daily amount of magnesium.

In one embodiment, the deficiency is a magnesium deficiency.

In another embodiment, the composition for use according to the invention per daily dose comprises between 150 and 225 mg of magnesium.

Magnesium is good for the functioning of the muscles, maintains strong bones, contributes to mental resilience and supports the normal functioning of the nervous system.

The composition for use may include, for example:

between 750 and 850 pg of vitamin A;

between 0.80 and 1.20 mg of vitamin B1;

between 1.10 and 1.70 mg of vitamin B2;

between 12.50 and 19.00 mg of vitamin B3;

between 4.50 and 7.50 mg of vitamin B5;

between 1.10 and 1.70 mg of vitamin B6;

between 40 and 60 mg of vitamin B8;

between 150 and 250 pg of vitamin B11;

between 2 and 3 pg of vitamin B12;

between 65 and 95 mg of vitamin C;

between 8 and 12 pg of vitamin D3;

between 9.50 and 14.50 mg of vitamin E; and between 60 and 90 pg of vitamin K.

Some of the properties of these vitamins are the following:

Vitamin A helps to keep the skin healthy.

Vitamin B1 has a beneficial effect on the heart.

Vitamin B2 is good for the nervous system.

Vitamin B3 contributes to fitness.

Vitamin B5 contributes to extra energy in fatigue.

Vitamin B6 contributes to the regulation of hormonal activity.

Vitamin B8 contributes to a normal metabolism of carbohydrates, fat and proteins.

Vitamin B11 contributes to the growth of the fetus / unborn child / child during pregnancy.

Vitamin B12 is good for memory and concentration.

Vitamin C contributes to good resistance.

Vitamin D3 increases the absorption of calcium in the bones.

Vitamin E helps protect against the effects of pollution and sunlight.

Vitamin K supports blood clotting.

In one embodiment, the composition for use according to the invention comprises between 8 and 12 pg of vitamin D3.

In addition, the composition for application may include:

between 30 and 45 pg boron;

between 95 and 145 mg of calcium;

between 4.50 and 7.50 pg of chromium;

between 95 and 185 mg of chlorine;

between 85 and 125 mg of phosphorus;

between 1.50 and 2.50 mg of iron;

between 18 and 28 pg of iodine;

between 250 and 350 mg of potassium;

between 120 and 180 pg copper;

between 150 and 225 mg of magnesium;

between 250 and 350 pg of manganese;

between 6 and 9 pg molybdenum;

between 120 and 180 pg of sodium;

between 6.50 and 9.50 pg selenium; and between 1.20 and 1.80 mg of zinc.

Some properties of these minerals are the following:

Boron helps to maintain calcium levels.

Calcium maintains strong bones.

Chromium supports normal (fat) metabolism.

Chlorine contributes to the normal functioning of digestion in the stomach.

Phosphorus is important for strong teeth.

Iron contributes to the normal formation of red blood cells and hemoglobin.

Iodine contributes to the normal functioning of the thyroid gland.

Potassium has a beneficial effect on maintaining normal blood pressure.

Copper contributes to normal pigmentation of the hair and skin.

Magnesium is good for the functioning of the muscles.

Manganese is good for the production / build-up of cartilage in the joints.

Molybdenum contributes to the normal sulfur amino acid metabolism

Sodium has a beneficial effect on blood pressure.

Selenium has a positive influence on the immune system.

Zinc contributes to the normal fertility of both men and women.

In one embodiment, the composition for use according to the invention is for use by oral administration, for example, for sublingual administration or for buccal administration.

The composition for use according to the invention can be administered once or twice a day, preferably twice, the daily dosage as mentioned in this description being the dosage per two units (e.g., tablets or capsules).

In one embodiment, the composition for use according to the invention is administered in a solid dosage form; such as, for example, a tablet or a capsule.

In another embodiment, the composition for use according to the invention is administered twice a day.

The present composition can be in the form of a tablet, capsule, powder, granulate, suspension, and other suitable dosage forms. In case a tablet is used, the tablet may or may not be provided with an enteric, for example, acid-resistant coating. In the case that a capsule is used, it can be a hard capsule (e.g., hard gel) or a soft capsule (soft gel). Such soft capsules are usually made from a composition comprising gelatin and are filled with, for example, a solid (powdered / granulate) or liquid (e.g., oil) filling with active ingredient / active ingredients. A sachet with a powder or granulate can also be used, which can for instance be used directly orally or after suspension / solution thereof in water. The composition may also be in the form of a suspension in a pharmaceutically acceptable carrier, such as water, with one or more excipients.

The composition of the invention may comprise one or more pharmaceutically acceptable carriers and excipients, such as one or more fillers, one or more binders, one or more disintegrating agents, one or more lubricants, one or more solubilizing agents, one or more suspending agents, one or more preservatives, one or more extension agents, and other conventional carriers and excipients.

Example

The present invention is further elucidated on the basis of a specific, non-limiting example, which is only added by way of illustration.

Tablets were made according to the composition of the present invention. The dosage regimen of these tablets is twice a day. The amount of vitamins and minerals intake based on two units, for example tablets, per day is shown in Table 2.

Table 2

Ingredient Quantity % RDA Vitamin A 800 pg 100 Vitamin B1 1.1 mg 100 Vitamin B2 1.4 mg 100 Vitamin B3 16 mg 100 Vitamin B5 6 mg 100 Vitamin B6 1.4 mg 100 Vitamin B8 50 mg 100 Vitamin B11 200 pg 100 Vitamin B12 2.5 pg 100 Vitamin C 80 mg 100 Vitamin D3 10 pg 200 Vitamin E 12 mg 100 Vitamin K 75 pg 100 Boron 37.5 pg 15 Calcium 120 mg 15 Chrome 6 pg 15 Chloride 120 mg 15 Phosphorus 105 mg 15 Iron 2.1 mg 15 Iodine 22.5 pg 15 Potassium 300 mg 15 Buyer 150 pg 15 Magnesium 188 mg 50 Manganese 300 pg 15 Molybdenum 7.5 pg 15 Sodium 150 pg 15 Selenium 8.25 pg 15 Zinc 1.5 mg 15

The composition according to the invention contributes to a healthy lifestyle and provides all necessary vitamins per day.

The invention is further elucidated with reference to the following claims.

Claims (9)

CONCLUSIONS 1 - 2, wherein the composition per daily dose comprises: • between 750 and 850 pg of vitamin A; • between 0.80 and 1.20 mg of vitamin B1; • between 1.10 and 1.70 mg of vitamin B2; • between 12.50 and 19.00 mg of vitamin B3; • between 4.50 and 7.50 mg of vitamin B5; between 1.10 and 1.70 mg of vitamin B6; between 40 and 60 mg of vitamin B8; between 150 and 250 pg of vitamin B11; between 2 and 3 pg of vitamin B12; between 65 and 95 mg of vitamin C; between 8 and 12 pg of vitamin D3; between 9.50 and 14.50 mg of vitamin E; between 60 and 90 pg of vitamin K; between 30 and 45 pg boron; between 95 and 145 mg of calcium; between 4.50 and 7.50 pg of chromium; between 95 and 185 mg of chlorine; between 85 and 125 mg of phosphorus; between 1.50 and 2.50 mg of iron; between 18 and 28 pg of iodine; between 250 and 350 mg of potassium; between 120 and 180 pg copper; between 150 and 225 mg of magnesium; between 250 and 350 pg of manganese; between 6 and 9 pg molybdenum; between 120 and 180 pg of sodium; between 6.50 and 9.50 pg selenium; and between 1.20 and 1.80 mg of zinc. Composition for use in the treatment and / or prevention of a deficiency of vitamins, minerals and / or trace elements, in particular for muscles, bones and / or teeth, the composition being administered one or more times a day which together daily dosage form, which composition comprises per daily dosage: a. a number of vitamins individually in an amount of between 90% and 110% of the recommended daily amount of the vitamin in question, the vitamins being the following: vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B8, vitamin B11, vitamin B12, vitamin C, vitamin E and vitamin K; b. a number of minerals and trace elements, each individually in an amount of between 10% and 20% of the recommended daily amount of the mineral or trace element concerned, the minerals and trace elements being the following: boron, calcium, chromium, chlorine, phosphorus, iron, iodine, potassium, copper, manganese, molybdenum, sodium, selenium and zinc; c. vitamin D3 in an amount of between 175 and 225% of the recommended daily allowance for vitamin D3; and d. magnesium in an amount of between 40 and 60% of the recommended daily amount of magnesium. The composition for use according to claim 1, wherein the deficiency is a magnesium deficiency. The composition for use according to claim 1 or 2, wherein the composition comprises between 150 and 225 mg of magnesium per daily dose. Composition for use according to one or more of claims 1 to 3, wherein the composition comprises between 8 and 12 pg of vitamin D3 per daily dose. Composition for use according to one or more of the claims 6 - 7, wherein the composition is administered in a solid dosage form. A composition for use according to one or more of the preceding claims by oral administration, for sublingual administration or for buccal administration. The composition for use according to claim 6, wherein the composition is administered twice a day. Composition for use according to one or more of the claims The composition for use according to claim 8, wherein the composition is in a solid dosage form, a tablet or a capsule. YOU IT EXTRACT Composition for use in the treatment and / or prevention of a deficiency of vitamins, minerals and / or trace elements, in particular for muscles, bones and / or teeth, wherein the composition is administered one or more times a day which together form a daily dose , which composition comprises per daily dose: a) a number of vitamins individually in an amount of between 90% and 110% of the recommended daily amount of the vitamin in question, the vitamins being the following: vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B8, vitamin B11, vitamin B12, vitamin C, vitamin E and vitamin K; b) a number of minerals and trace elements, each individually in an amount of between 10% and 20% of the recommended daily amount of the mineral or trace element concerned, the minerals and trace elements being the following: boron, calcium, chromium, chlorine, phosphorus, iron, iodine, potassium, copper, manganese, molybdenum, sodium, selenium and zinc; c) vitamin D3 in an amount between 175 and 225% of the recommended daily allowance for vitamin D3; and d) magnesium in an amount of between 40 and 60% of the recommended daily amount of magnesium.