NL190871C - Werkwijze ter bereiding van 21-hydroxypregna-4,16-dieen-3,20-dionderivaten, alsmede van daarbij te gebruiken tussenprodukten. - Google Patents
Werkwijze ter bereiding van 21-hydroxypregna-4,16-dieen-3,20-dionderivaten, alsmede van daarbij te gebruiken tussenprodukten.Info
- Publication number
- NL190871C NL190871C NL7903975A NL7903975A NL190871C NL 190871 C NL190871 C NL 190871C NL 7903975 A NL7903975 A NL 7903975A NL 7903975 A NL7903975 A NL 7903975A NL 190871 C NL190871 C NL 190871C
- Authority
- NL
- Netherlands
- Prior art keywords
- hydroxypregna
- diene
- intermediates
- preparation
- used therewith
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/34—Separation; Purification; Stabilisation; Use of additives
- C07C41/40—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation
- C07C41/42—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation by distillation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/909,349 US4216159A (en) | 1978-05-25 | 1978-05-25 | Synthesis of 16-unsaturated pregnanes from 17-keto steroids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NL7903975A NL7903975A (nl) | 1979-11-27 |
| NL190871B NL190871B (nl) | 1994-05-02 |
| NL190871C true NL190871C (nl) | 1994-10-03 |
Family
ID=25427088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7903975A NL190871C (nl) | 1978-05-25 | 1979-05-21 | Werkwijze ter bereiding van 21-hydroxypregna-4,16-dieen-3,20-dionderivaten, alsmede van daarbij te gebruiken tussenprodukten. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4216159A (cs) |
| JP (1) | JPS54154751A (cs) |
| CH (1) | CH644872A5 (cs) |
| DE (1) | DE2920290A1 (cs) |
| FR (3) | FR2434176A1 (cs) |
| GB (1) | GB2022590B (cs) |
| HU (2) | HU182607B (cs) |
| IT (1) | IT1116876B (cs) |
| NL (1) | NL190871C (cs) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4357279A (en) * | 1981-05-18 | 1982-11-02 | The Upjohn Company | Preparation of corticoids from 17-keto steroids |
| US4451404A (en) * | 1983-02-09 | 1984-05-29 | The Upjohn Company | 16β-Methyl steroid process |
| US4500461A (en) * | 1984-02-03 | 1985-02-19 | The Upjohn Company | Cyanohydrin process |
| US4585590A (en) * | 1984-02-03 | 1986-04-29 | The Upjohn Company | Cyanohydrin process |
| US4831131A (en) * | 1984-02-03 | 1989-05-16 | The Upjohn Company | 11β,17α-Dihydroxy-17β-cyano-androstanes |
| US4548748A (en) * | 1984-02-03 | 1985-10-22 | The Upjohn Company | Cyanohydrin process |
| US4530795A (en) * | 1984-02-27 | 1985-07-23 | The Upjohn Company | Process for preparation of 16 α-methyl corticoids from Δ16 -steroids |
| US4600538A (en) * | 1984-08-02 | 1986-07-15 | The Upjohn Company | Corticosteroids from 17-keto steroids via 20-cyano-Δ17 (20)-pregnanes |
| US5169966A (en) * | 1987-09-11 | 1992-12-08 | Nippon Zeon Co., Ltd | Process for producing an α-acyloxy-α, β-unsaturated carbonyl compound and a 20-acyloxy-17(20)-methylen-21-al-steroid compound |
| EP0306969B1 (en) * | 1987-09-11 | 1994-11-30 | Nippon Zeon Co., Ltd. | A process for producing an alpha-acyloxy-alpha beta-unsaturated carbonyl compound and a 20-acyl-oxy-17(20)-methylen-21-al-steroid compound |
| US5068368A (en) * | 1990-05-10 | 1991-11-26 | Cyprus Foote Mineral Company | Stabilized lithium acetylide and reactions therewith |
| FR2676740B1 (fr) * | 1991-05-23 | 1993-11-05 | Roussel Uclaf | Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires. |
| FR2677028B1 (fr) * | 1991-05-23 | 1994-01-21 | Roussel Uclaf | Nouveaux derives sterouides du pregna-4,9(11),17(20)-trien-3-one. |
| FR2677029B1 (fr) * | 1991-05-23 | 1994-01-21 | Roussel Uclaf | Nouveaux derives sterouides de l'andostra-4,9(11),16-trien-3-one. |
| CN105622699A (zh) * | 2015-12-25 | 2016-06-01 | 湖南成大生物科技有限公司 | 醋酸四烯物及其衍生物的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3281415A (en) * | 1963-08-30 | 1966-10-25 | Upjohn Co | Steroidal delta16-20 (alpha and beta)-hydroperoxides |
| US3541082A (en) * | 1966-09-26 | 1970-11-17 | Upjohn Co | Steroidal delta**16-20(alpha and beta)-hydroperoxide 21-ethers |
| US3493563A (en) * | 1968-02-23 | 1970-02-03 | Squibb & Sons Inc | Process for the production of intermediates for triamcinolone and related compounds |
| US3631076A (en) * | 1969-05-14 | 1971-12-28 | Merck & Co Inc | Process for preparing 16-unsaturated steroids |
| BE795243A (fr) * | 1972-02-11 | 1973-08-09 | Schering Ag | Procede de preparation de steroides insatures en 16,17 |
| DE2236115A1 (de) * | 1972-07-20 | 1974-02-07 | Schering Ag | Verfahren zur herstellung von delta hoch 4.9(11).16 -3.20diketosteroiden |
| US4076737A (en) * | 1975-02-20 | 1978-02-28 | Ciba-Geigy Corporation | Aldehydes of the pregnane series and derivatives thereof |
| DE2521231A1 (de) * | 1975-05-09 | 1976-11-18 | Schering Ag | Verfahren zur herstellung von 21- hydroxy-16-pregnen-20-on-derivaten |
| US4041055A (en) * | 1975-11-17 | 1977-08-09 | The Upjohn Company | Process for the preparation of 17α-hydroxyprogesterones and corticoids from androstenes |
| DE2603266A1 (de) * | 1976-01-29 | 1977-08-11 | Hoechst Ag | 17-hydroxyacetylsteroide und verfahren zu ihrer herstellung |
| DE2655104A1 (de) * | 1976-12-04 | 1978-06-08 | Hoechst Ag | Verfahren zur herstellung von 17alpha-hydroxy-21-acetoxy-progesteron |
-
1978
- 1978-05-25 US US05/909,349 patent/US4216159A/en not_active Expired - Lifetime
-
1979
- 1979-05-18 CH CH470079A patent/CH644872A5/de not_active IP Right Cessation
- 1979-05-18 GB GB7917445A patent/GB2022590B/en not_active Expired
- 1979-05-18 DE DE19792920290 patent/DE2920290A1/de active Granted
- 1979-05-21 NL NL7903975A patent/NL190871C/xx not_active IP Right Cessation
- 1979-05-23 IT IT49147/79A patent/IT1116876B/it active
- 1979-05-23 FR FR7913089A patent/FR2434176A1/fr active Granted
- 1979-05-24 HU HU801392A patent/HU182607B/hu not_active IP Right Cessation
- 1979-05-24 HU HU79UO156A patent/HU182615B/hu not_active IP Right Cessation
- 1979-05-25 JP JP6489479A patent/JPS54154751A/ja active Granted
- 1979-11-28 FR FR7929277A patent/FR2433539A1/fr active Granted
- 1979-11-28 FR FR7929278A patent/FR2433538A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2433539B1 (cs) | 1983-02-25 |
| GB2022590B (en) | 1982-09-29 |
| IT1116876B (it) | 1986-02-10 |
| FR2434176B1 (cs) | 1983-04-15 |
| US4216159A (en) | 1980-08-05 |
| FR2434176A1 (fr) | 1980-03-21 |
| DE2920290A1 (de) | 1979-12-06 |
| HU182615B (en) | 1984-02-28 |
| NL7903975A (nl) | 1979-11-27 |
| FR2433538B1 (cs) | 1983-04-15 |
| HU182607B (en) | 1984-02-28 |
| JPS6340198B2 (cs) | 1988-08-10 |
| JPS54154751A (en) | 1979-12-06 |
| DE2920290C2 (cs) | 1989-12-28 |
| FR2433538A1 (fr) | 1980-03-14 |
| GB2022590A (en) | 1979-12-19 |
| CH644872A5 (de) | 1984-08-31 |
| FR2433539A1 (fr) | 1980-03-14 |
| NL190871B (nl) | 1994-05-02 |
| IT7949147A0 (it) | 1979-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| BK | Erratum |
Free format text: PAT.BUL.19/94 HEADING P,SECTION 2,PAGE 3401;IN THE TITLE OF THE INVENTION THE WORD 20-DIONDERIVANTEN SHOULD BE MODIFIED INTO:20-DIONDERIVATEN |
|
| TNT | Modifications of names of proprietors of patents or applicants of examined patent applications |
Owner name: PHARMACIA & UPJOHN COMPANY |
|
| V1 | Lapsed because of non-payment of the annual fee |
Effective date: 19981201 |