NL187229C - METHOD FOR MANUFACTURING A SOLID, ORAL, ADMINISTRATIVE PHARMACEUTICAL PREPARATION CONTAINING A MORIGOROUS ALKALOID - Google Patents

METHOD FOR MANUFACTURING A SOLID, ORAL, ADMINISTRATIVE PHARMACEUTICAL PREPARATION CONTAINING A MORIGOROUS ALKALOID

Info

Publication number
NL187229C
NL187229C NLAANVRAGE7909105,A NL7909105A NL187229C NL 187229 C NL187229 C NL 187229C NL 7909105 A NL7909105 A NL 7909105A NL 187229 C NL187229 C NL 187229C
Authority
NL
Netherlands
Prior art keywords
morigorous
alkaloid
oral
solid
manufacturing
Prior art date
Application number
NLAANVRAGE7909105,A
Other languages
Dutch (nl)
Other versions
NL7909105A (en
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of NL7909105A publication Critical patent/NL7909105A/en
Application granted granted Critical
Publication of NL187229C publication Critical patent/NL187229C/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
NLAANVRAGE7909105,A 1978-12-21 1979-12-18 METHOD FOR MANUFACTURING A SOLID, ORAL, ADMINISTRATIVE PHARMACEUTICAL PREPARATION CONTAINING A MORIGOROUS ALKALOID NL187229C (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
CH1301978 1978-12-21
CH1302178 1978-12-21
CH1301978 1978-12-21
CH1302178 1978-12-21
CH56779 1979-01-19
CH56779 1979-01-19
CH56679 1979-01-19
CH56679 1979-01-19

Publications (2)

Publication Number Publication Date
NL7909105A NL7909105A (en) 1980-06-24
NL187229C true NL187229C (en) 1991-07-16

Family

ID=27427929

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7909105,A NL187229C (en) 1978-12-21 1979-12-18 METHOD FOR MANUFACTURING A SOLID, ORAL, ADMINISTRATIVE PHARMACEUTICAL PREPARATION CONTAINING A MORIGOROUS ALKALOID

Country Status (23)

Country Link
AT (1) AT372279B (en)
AU (1) AU534051B2 (en)
CA (1) CA1139222A (en)
CH (1) CH642259A5 (en)
CY (1) CY1330A (en)
DE (1) DE2950154A1 (en)
DK (1) DK154607C (en)
FI (1) FI793888A (en)
FR (1) FR2444463A1 (en)
GB (1) GB2038181B (en)
HK (1) HK37986A (en)
HU (1) HU182577B (en)
IE (1) IE49323B1 (en)
IL (1) IL59003A (en)
IT (1) IT1164029B (en)
KE (1) KE3617D (en)
MY (1) MY8500129A (en)
NL (1) NL187229C (en)
NZ (1) NZ192457A (en)
PH (1) PH25178A (en)
PT (1) PT70614A (en)
SE (1) SE442265B (en)
WO (1) WO1980001242A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0064485B1 (en) * 1981-04-27 1985-07-24 Aktiebolaget Hässle New pharmaceutical preparation
US4366145A (en) * 1981-06-24 1982-12-28 Sandoz, Inc. Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation
HU192050B (en) * 1983-04-22 1987-05-28 Sandoz Ag Process for production of medical preparative containing co-dergocrin and one piridin-dicarbonic acid diesthertype calcium-antagonist
DE3413955A1 (en) * 1983-04-22 1984-10-25 Sandoz-Patent-GmbH, 7850 Lörrach Pharmaceutical product containing co-dergocrine and a calcium antagonist
NL194389C (en) * 1984-06-14 2002-03-04 Novartis Ag Process for preparing a solid dispersion of a pharmaceutically active agent that has low water solubility in a solid matrix of a water-soluble polyalkylene glycol as a carrier.
GB8426922D0 (en) * 1984-10-24 1984-11-28 Sandoz Ltd Galenic formulation
AT388101B (en) * 1985-02-05 1989-05-10 Sandoz Ag Process for the production of a pharmaceutical composition for oral administration with controlled release of active ingredient
CN1003978B (en) * 1987-09-05 1989-04-26 广州陈李济药厂 Preparing process of stomach-solvable type and intestinn-solvable type integsated pill-ready-made traditional chinese medicine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3432593A (en) * 1963-09-18 1969-03-11 Key Pharm Inc Delayed and sustained release type pharmaceutical preparation
DE2528257C2 (en) * 1974-07-04 1986-02-13 Sandoz-Patent-GmbH, 7850 Lörrach New galenic preparation
DE2546577B2 (en) * 1975-10-17 1981-04-02 Sandoz-Patent-GmbH, 7850 Lörrach Solid substances made from polyvinylpyrrolidone and ergot alkaloids

Also Published As

Publication number Publication date
AU5403179A (en) 1980-06-26
NL7909105A (en) 1980-06-24
GB2038181A (en) 1980-07-23
MY8500129A (en) 1985-12-31
PH25178A (en) 1991-03-27
CY1330A (en) 1986-06-27
FI793888A (en) 1980-06-22
FR2444463A1 (en) 1980-07-18
DK529879A (en) 1980-06-22
DK154607B (en) 1988-12-05
ATA803679A (en) 1983-02-15
FR2444463B1 (en) 1983-02-25
DE2950154C2 (en) 1989-05-11
SE7910227L (en) 1980-06-22
DK154607C (en) 1989-06-05
GB2038181B (en) 1983-05-11
WO1980001242A1 (en) 1980-06-26
IE49323B1 (en) 1985-09-18
IE792471L (en) 1980-06-21
AU534051B2 (en) 1984-01-05
IT7951153A0 (en) 1979-12-20
HK37986A (en) 1986-05-30
CH642259A5 (en) 1984-04-13
NZ192457A (en) 1983-06-17
DE2950154A1 (en) 1980-07-10
AT372279B (en) 1983-09-26
CA1139222A (en) 1983-01-11
PT70614A (en) 1980-01-01
IT1164029B (en) 1987-04-08
IL59003A (en) 1982-12-31
HU182577B (en) 1984-02-28
KE3617D (en) 1986-04-18
SE442265B (en) 1985-12-16

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Legal Events

Date Code Title Description
A1A A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
A85 Still pending on 85-01-01
SNR Assignments of patents or rights arising from examined patent applications

Owner name: NOVARTIS AG

V4 Discontinued because of reaching the maximum lifetime of a patent

Free format text: 19991218