NL1044087A

NL1044087A - Combination of Vitamin C, red ginseng, nicotinamide mononucleotide (NMN) and resveratrol as a healthy functional food (food supplement))

Info

Publication number: NL1044087A
Application number: NL1044087A
Authority: NL
Inventors: Barjaktarovic Jelena
Original assignee: Dr Jelena Barjaktarovic Md
Priority date: 2020-08-12
Filing date: 2021-07-06
Publication date: 2022-04-04
Also published as: NL1044087B1

Abstract

Vitamin C (1) has proven antioxidant properties, while red ginseng (2) has been proven to improve immune function and healthy blood flow. In a preclinical and clinical studies, nicotine amide mononucleotide (NMN) (3) has been associated with properties such as anti-aging, cardio and brain protection, while animal studies are confirming its potential for lifespan extension. Recent studies of resveratrol (4) have shown its preventive effects for cardiovascular diseases and stroke, potential for lifespan extension and is associated with numerous health benefits. Healthy food supplement, containing a combination of Vitamin C, red ginseng, nicotinamide mononucleotide (NMN) and resveratrol should have stronger antioxidant effects and more positive effects on immune function and healthy blood flow compared to each product used separately, and is safe for use.

Description

Combination of Vitamin C, red ginseng, nicotinamide mononucleotide (NMN) and resveratrol as a healthy functional food (food supplement))

= 2 og * Discussion While positive effects of Vitamin C and red ginseng have been known for centuries, NMN and resveratrol are getting in the focus in the last years.

As this is a novel combination, below are presented effects of each of these products individually. Vitamin C (1) Vitamin C is a natural antioxidant and crucial for endothelial and organ protection. Vitamin C plays a role in mediating inflammation through antioxidant activities and is also important [0 as a cothctor/on-substrate for the synthesis of endogenous adrenaline, cortisol, and vasopressin, A growing body of evidence suggesting that vitamin C, prevents neutrophil-induced lipid oxidation ad protects against he loss of the endothelial barrier, Marked improvements in capillary fragility have also been reported with NAM and vitamin C combinations, Consumption of high-dose vitamin C (1250 mg per day) enhances functional and structural properties of serum lipoprotein to improve antioxidant, anti-atheroscleratic, and anti-aging effects via regulation of anti-inflagunatory microRNA.

Benefits of high doses of Vitamin C include attenuating oxidative stress and inflanunalion, improving vasopressor synthesis, enhancing mune cell function, improving endovascular function, and epigenetic immmmologic modifications.

2% Higher intakes of vitamin C and linoleic acid and lower intakes of fats and carbohydrates are assooiated with better skiraging appearance. Promoting healthy dietary behaviors may have additional benefit for skin appearance in addition to other health outcomes in the population.

Red Ginseng (2) Korean red ginseng has been used in traditional Chinese medicine as an overall wellness supplement for centuries, It has been used to: boost the bomune system, improve heart health, treat diabetes, increase energy, decrease stress, treat impotence. Korean FDA has approved it for use for improving inunune function and for maintaining healthy blood How.

NMN {Nicotinamide Mononueleotide) Moleenle (3) NMN naturally exists in avocadoes, tomatoes, cucumber, cabbages, broccoli, and raw beet, In the laboratory, 11 is available as nicotinamide mononucleotide bulk powder.

In the human body, NMN is the principal source of energy within the cells, As we age, cellular energy decreases due to the low levels of nicotinamide mononucleotide and subsequent reduction of NAD. Administering NMN will reverse the process and compensate for the deficit, MMN exists in both alpha (a) and beta (B) forms. However, B-NMN is the most active form. This bioactive nuclentide is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide or NAD. FDA recommends that any human being needs approximately 560 mg of NMN per day.

Human Clinical Trials with NMN - There are 113 ongoing clinical trials in humans that are investigating NAD precursors INMN, NR and Niacin}, majority of them are not completed and only few have results published. The most important study in humans was a study in Japanese man, that showed that the

- single oral administration of NMN up to 500 mg was safe and welltolerated in healthy men without causing any significant deleterious effects. it has demonstrated that the oral administration of NMN is feasible and could be a therapeutic strategy to replenish cellular NAD levels to mitigate aging-related functional disorders in humans. - Trials in humans with results are: 18 o An international collaborative team including researchers from Keio University in Tokyo and Washington University School of Medicine in St, Louis is running a Phase I human clinical study of NMN in Japan.

Clinical trials examining the safety and efficacy of NMN are also currently being run at Washington University, investigating the effect on insulin sensitivity, o endothelial function, lipids, body and liver fat and markers of cardiovascular and metabolic health.

A randomized, double-blind, three-arm crossover pharmacokinetic study in 12 human subjects showed that NR raises NAD+ by as much as 2.7-fold in human blood with a single oral dose of 1000 mg.

o endothelial function, lipids, body and liver fat and markers of cardiovascular and metabolic health.

o Researchers at the University of Washington have completed a clinical trial! with 140 participants showing that orally administered NR gives a dose dependent increase in NAD+ from 250-1000 mg/d plateauing at a 2-fold increase in NAD+. at day nine.

Researchers have also reported positive effects of NR on vascular endothelial Function o in healthy middle-aged and older adults, with further investigations of motor and cognitive changes to come.

o Recently, researchers have found that a resveratrol analog called plerostilbene combined with NR seemed to help ALS/Lou Gehrig's patients.® o Most recently, a placebo-controlled study assessing 500 mg of NR, taken twice daily by 70- to 80-year olds, showed increases in NAD+ in blood {but not muscle.) Inflammation fell and, unexpectedly, mitochondrial activity did toa. Multiple other studies are now underway assessing the effects of NR on muscle mitochondria! function, cognition, immune function, kidney function,

o Traumatic brain injury, brown fal activity, lipid accumulation, energy metabolism, cardiovascular risk, body composition, and acetylcarnitine levels, Clinical trials results should be available in the new few years, What we can claim with certainly at this moment, based on clinical research data is that NMN is safe and well- tolerated in healthy men and that it is able to successfully replenish cellular NAD+ levels, And we know that decline in NAD levels is associated with aging.

NMN Animal Studies - Animal studies are confirming that the pharmacological activities of NMN include its role in cellular biochemical functions, cardio protection, diabetes, Alzheimer's disease, and complications associated with obesity. The recent - The recent groundbreaking discovery of anti-ageing activities of this chemical molety has added a valuable essence in the research involving this molecule, - Studies confirmed that manipulation of mitochondrial NAD levels by NMN results in metabolic changes that protect mitochondria against reactive oxygen species and excessive fragmentation, offering therapeutic approaches for pathophysiologic stress condition Resveratrol {4) Resveratrol is a nutrient found abundantly in the skin of red grapes that is known to have robust antioxidant and asti-inflammatory properties. The efficacy, safety, and pharmacokinetics of Resveratrol have been documented in over 244 clinical trials, with an additional 27 clinical trials currently ongoing.

Resveratrol has various biochemical and physiological effects such as antiinflammatory, antioxidative, antiprofiferative and chemo-preventive effects. Recent studies have shown its positive effects especially on cardiovascular diseases, cancer, type 2 diabetes and neurological disorders. Resveratrol is reported to potentially improve the therapeutic outcome in patients suffering from diabetes mellitus, obesity, colorectal cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Alzheimer's disease, stroke, cardiovascular diseases, kidney diseases, inflammatory diseases, and rhinopharyngitis. It was also proven that it mimics caloric restriction, which has numerous positive effects. Resveratrol is reported to be safe at doses up to 5 g/d, when used either alone or as a combination therapy.

Claims

5 Human clinical trial data suggest that vitamin €1} has proven antioxidant properties, while rade ginseng {2} has been shown to improve immune function and healthy blood flow. In preclinical and clinical studies, nicotinic amide mononucleotide {NMN) {3} has been associated with properties such as anti-aging, cardio- and brain protection, while animal studies confirm the potential for lifespan extension. : It has anti-aging properties as it boosts cellular NAD+ levels to reduce aging-related functional impairment in humans; It aids in reducing inflammation, increasing energy by increasing mitochondrial activity and protecting mitochondria from reactive oxygen species and excessive fragmentation, and provides therapeutic approaches to pathophysiological stress conditions.

It improves energy metabolism and body composition and has cardio- and brain-protective effects. Other possible effects of NMN include: extending the lifespan of any animal it has been tested on to date; It impairs cognitive function, mood and sleep; it has a strong effect on increasing female fertility, It is effective in reducing depression and weight loss, Recent studies of resverairol {4} have shown its preventive effects for cardiovascular disease and stroke, prolonging lifespan, improving fat metabolism and overall health.

It reduces energy expenditure and improves metabolism, vascular function, decreases metabolism, decreases fat in liver, lowers blood pressure and lowers blood sugar.

It is effective for restoring libido as it increases testosterone without shutting down the testis. A healthy dietary supplement, which combines vitamin C {1}, red ginseng (2). nicotinamide mononucleotide [NMN} (3) and resveratrol (4) should have stronger antioxidant effects and more positive effects on immune function and healthy blood flow compared to any product used alone, and is safe to use.

Note: All references to statements in this document are available upon request.