NL1044090B1 - Combination of vitamin B6, ginseng, green tea extract, Ganoderma lucidum, black cohosh root, nicotinamide mononucleotide (NMN) and resveratrol as a healthy functional food (food supplement) - Google Patents
Combination of vitamin B6, ginseng, green tea extract, Ganoderma lucidum, black cohosh root, nicotinamide mononucleotide (NMN) and resveratrol as a healthy functional food (food supplement) Download PDFInfo
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- NL1044090B1 NL1044090B1 NL1044090A NL1044090A NL1044090B1 NL 1044090 B1 NL1044090 B1 NL 1044090B1 NL 1044090 A NL1044090 A NL 1044090A NL 1044090 A NL1044090 A NL 1044090A NL 1044090 B1 NL1044090 B1 NL 1044090B1
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
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- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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Abstract
Vitamin B6 (1) is necessary for utilization of proteins and amino acids, while green tea extract (2) has strong antioxidant activity. Ginseng (3) has proven to be effective for fatigue relief, and Ganoderma lucidum (4) is very effective for maintaining healthy blood flow. Black cohosh root (5) extract is very effective for alleviating menopause symptoms. In a preclinical and clinical studies, nicotine amide mononucleotide (NMN) (6) has been associated with properties such as anti-aging, cardio and brain protection, while animal studies are confirming its potential for lifespan extension. Recent studies of resveratrol (7) have shown very good effects on libido recovery. Healthy food supplement, containing a combination of combination of vitamin B6 (1), ginseng (2), green tea extract (3), ganoderma lucidum (4), black cohosh root (5), nicotinamide mononucleotide (NMN) (6) and resveratrol (7) should have stronger effects on addressing issues of women menopause compared to each product used separately, and is safe for use. 1044090
Description
Short Title Combination of vitamin B6, ginseng, green tea exiract, Ganoderma lucidum, black cohosh root, nicotinamide mononucleotide (NMN) and resveratrol as a healthy functional food (food supplement)
- & © 2 o Discussion While positive effects of of vitamin B6 {1}, ginseng (2), green tea extract (3), ganoderma lucidum (4) and black cohosh root {5}, have been known for centuries, NMN (6) and resveratrol {7} are getting in the focus in the last years.
As this is a novel combination, below are presented effects of each of these products individaally. Bo {1} Vitamin Bö, also known as pyridoxine, is a water-soluble vitamin that body needs for several Hy Tanctions, I's significant to protein, fat and carbohydrate metabolism and the creation of red blood cells and neurolransnufters. Body cannot produce vitamin BS, so vou must obtain it from foods or supplements, Vitamin BE, also known as pyridoxine, is a water-soluble vitamin that your body needs for several functions, It's significant to protein, fat and carbohydrate metabolism and the creation of reg blood cells and neuratransmitters. Our body cannot produce vitamin B6, so you must obtain # from foods or supplements, Most people get enough vitamin B6 through their diet, but certain populations may be at risk for deficiency. Consuming adequate amounts of vitamin BS is important for optimal health and may even prevent and treat chronic diseases.
Low levels of vitamin B6 in older adults have been linked to depression, but research has not shown that BS is an effective treatment for mood disorders.
Vitamin B6 may prevent a decline in brain function by decreasing homocysteine levels that have been associated with Alzheimer’s disease and memory impairments. However, studies have not proven the effectivenscss of BS in improving brain health, Gingeng (2) Ginseng has been used in traditional Chinese medicine for centuries, Ginseng has been shown fo benefit mental functions, feelings of calmness and mood in both healthy people and those with Alzheimer's disease.
{rinseng may help fight fatigue and enhance physical activity by lowering oxidative damage and increasing energy production in cells, Furthermore, a review of over 155 studies suggested that ginseng supplements may not only help reduce fatigue but also enhance physical activity.
Green Tea Extract {3} Green tea is touted to be one of the healthiest beverages on the planet, It's fosded with antioxidants that have many health benefits, which may inclode: improved brain function, fat loss, protecting against cancer and lowering the risk of heart disease.
Ganoderma Lucidum {4) The reishi mushroom, also known as Ganoderma lucidum and Hagzhi, is a fungus that grows in various hot and humid locations in Asia. For many years, this fungus has been a staple in Eastern medicine, Reisht mushroom can enhance immune fonction through its effects on white blood cells, which help fight infection and cancer, This may occur primarily in those who are ill, as mixed results have been seen in those who are healthy.
Some preliminary studies have shown that reishi mushroom could decrease anxiety and depression ag well as improve quality of life in those with certain medical conditions.
Black Cohosh Root {5} Alleviating menopause symptoms is the reason most people use black cohosh, and it’s one of the uses that has the most compelling evidence to support it.
In one study in 80 menopausal women who were experiencing hot flashes, those who supplemented with 20 mg of black cohosh daily for 8 weeks reported significantly fewer and less severe hot flashes than before they started the supplement, Black cohosh is also used for a number of other purposes related to women’s health, However, the evidence supporting these benefits is not as strong as the evidence supporting its benefits for Black cohosh may have some beneficial effects on mental health, particularly in menopausal women. Although there’s little evidence that black cohosh can improve sleep, it may help reduce symploms that are causing sleep disturbances in menopausal women, such as hot flashes.
NMN (Nicotinamide Mononucleotide) Molecule (6) NMN naturally exists in avocadoes, tomatoes, cucumber, cabbages, broccoli, and raw beef. In the laboratory, it is available as menopause and fertility. nicotinamide mononucleotide bulk powder.
In the human body, NMN is the principal source of energy within the cells. As we age, cellular energy decreases due to the low levels of nicotinamide mononucleotide and subsequent reduction of NAD. Administering NMN will reverse the process and compensate for the deficit.
NMN exists in both alpha (0) and beta (B) forms. However, B-NMN is the most active form. This bioactive nucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide or NAD. FDA recommends that any human being needs approximately 560 mg of NMN per day.
Human Clinical Trials with NMN There are 113 ongoing clinical trials in humans that are investigating NAD precursors (NMN, - NR and Niacin}, majority of them are not completed and only few have results published. The most important study in humans was a study in Japanese man, that showed that the single oral administration of NMN up to 500 mg was safe and well-tolerated in healthy men without causing any significant deleterious effects. It has demonstrated that the oral administration of NMN is feasible and could be a therapeutic strategy to replenish cellular 33 NADT levels tom itigate aging-related functional disorders in humans.
- Trials in humans with results are: oa An international collaborative team including researchers from Keie University in Tokyo and Washington University School of Medicine in St. Louis is running a Phase | human clinical study of NMN in Japan.
o Clinical trials examining the safety and efficacy of NMN are also currently being run at Washington University, investigating the effect on insulin sensitivity, endothelial function, lipids, body and liver fat and markers of cardiovascular and metabolic health.
oA randomized, double-blind, three-arm crossover pharmacokinetic study in 19 {2 human subjects showed that NR raises NAD+ by as much as 2.7-fold In human blood with a single oral dose of 1000: mg.
o Ressarchers at the University of Washington have completed a clinical trial with 140 participants showing that orally administerad NR gives a dose dependent increase in NAD+ from 250-1000 mg/d plateauing at a 2-fold increase in NAD+ at IN] day nine.
o Researchers have also reported positive effects of NR on vascular endothelial function in healthy middle-aged and older adults, with further investigations of motor and cognitive changes to came, o Recently, researchers have found that a resveratrol analog called pterastijbene conthined with NR seemed to help ALS Lou Gehrig's patients.
> Mos recently, a placebo controlled study assessing 500 mg of NR, taken twice daily by 70- to 80-vear olds, showed increases in NAD+ in blood {hut not muscle.) inflammation fell and, unexpectedly, mitochondrial activity did too. Multiple other studies are now underway assessing the effects of NB on muscle mitochondrial function, cognition, immune function, kidney function, traumatic o brain injury, brown fat activity, lipid accumulation, energy metabolism, cardiovascular risk, body composition, and acelylcarnitine levels. Clinical trials results should be available in the new few years, What we can claim with certainly at this moment, based on clinical research data is that NMN is safe and 36 o well tolerated in healthy men and that it is able to successfully replenish vellgiar NAD+ levels, And we know that dezijns In NAD levels is associated with aging. NMN Anhnal Studies - Animal studies are confirming that the pharmacological activities of NMN include its role in cellular biochemical functions, cardio protection, diabetes, Alzhelmer's disease, and complications associated with obesity, The recent groundbreaking discovery of anti-ageing activities of this chemical moisty has added a valuable gssence in the research involving this molecule. - Studies confirmed that manipulation of mitochondrial NAD levels by NMN results in
5 metabolic changes that protect mitochondria against reactive oxygen species and excessive fragmentation, offering therapeutic approaches for pathophysiologic stress conditions. Resveratrol (7) Resveratrol is a nutrient found abundantly in the skin of red grapes that is known to have robust antioxidant and anti-inflammatory properties. The efficacy, safety, and pharmacokinetics of Resveratrol have been documented in over 244 clinical trials, with an additional 27 clinical trials currently ongoing.
Resveratrol has various biochemical and physiological effects such as anti-inflammatory, antioxidative, antiproliferative and chemo-preventive effects.
Recent studies have shown its positive effects especially on cardiovascular diseases, cancer, type 2 diabetes and neurological disorders.
Resveratrol is reported to potentially improve the therapeutic outcome in patients suffering from diabetes mellitus, obesity, colorectal cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Alzheimer's disease, stroke, cardiovascular disgases, kidney diseases, inflammatory diseases, and rhinopharyngitis.
It was also proven that it mimics caloric restriction, which has numerous positive effects, Resveratrol is reported to be safe at doses up to 5 g/d, when used either alone or as a combination therapy.
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NL1044090A NL1044090B1 (en) | 2020-08-12 | 2021-07-06 | Combination of vitamin B6, ginseng, green tea extract, Ganoderma lucidum, black cohosh root, nicotinamide mononucleotide (NMN) and resveratrol as a healthy functional food (food supplement) |
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US20010039296A1 (en) * | 2000-03-23 | 2001-11-08 | Debasis Bagchi | Method and composition for preventing or reducing the symptoms of menopause |
US20050129783A1 (en) * | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
CN109350653A (en) * | 2018-05-25 | 2019-02-19 | 泓博元生命科技(深圳)有限公司 | The composition of improvement menopause symptom containing NMN, preparation and the preparation method and application thereof |
JPWO2020054795A1 (en) * | 2018-09-14 | 2021-08-30 | めぐみ 田中 | Anti-aging agents and anti-aging methods |
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