NL1044086A - Combination of Zn, red ginseng, saw palmetto fruit extracts, nicotinamide mononucleotide (NMN) and resveratrol as a food supplement - Google Patents

Combination of Zn, red ginseng, saw palmetto fruit extracts, nicotinamide mononucleotide (NMN) and resveratrol as a food supplement Download PDF

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NL1044086A
NL1044086A NL1044086A NL1044086A NL1044086A NL 1044086 A NL1044086 A NL 1044086A NL 1044086 A NL1044086 A NL 1044086A NL 1044086 A NL1044086 A NL 1044086A NL 1044086 A NL1044086 A NL 1044086A
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nmn
resveratrol
effects
saw palmetto
red ginseng
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Barjaktarovic Jelena
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Dr Jelena Barjaktarovic Md
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract

Zink (Zn) (1) has proven positive effects on immunity, while red ginseng (2) has been proven to improve immune function and healthy blood flow. Saw palmetto fruit extract (3) can help with maintaining prostate health. In a preclinical and clinical studies, nicotine amide mononucleotide (NMN) (4) has been associated with properties such as anti-aging, cardio and brain protection, while animal studies are confirming its potential for lifespan extension. Recent studies of resveratrol (5) have shown its preventive effects for cardiovascular diseases and stroke, potential for lifespan extension and is associated with numerous health benefits. Healthy food supplement, containing a combination of Zinc (Zn) (1), red ginseng (2), saw palmetto extract (3), nicotinamide mononucleotide (NMN) (4) and resveratrol (5) should have strong effects on maintaining prostate health, boosting immunity and maintaining healthy blood flow.

Description

Short Title Combination of Zn, red ginseng, saw palmetto fruit extracts, nicotinamide mononucleotide (NMN) and resveratrol as a food supplement
Discussion While positive effects of Zine (Zn) (1), red ginseng (2), saw palmetto fruit extracts (3) have been known for centuries, NMN (4) and resveratrol (5) are getting in the focus in the last years.
As this is a novel combination, below are presented effects of each of these products individually. Zinc (Zn) (1) Zinc is a nutrient that plays many vital roles in human body. Because body doesn’t naturally produce zinc, we must obtain it through food or supplements.
Zinc is essential for cell growth and division, immune function, enzyme reactions, DNA synthesis and protein production.
Zinc helps keep your immune system strong. Because it is necessary for immune cell function and cell signalling, a deficiency can lead to a weakened immune response. Zinc supplements stimulate particular immune cells and reduce oxidative stress.
A review of seven studies demonstrated that 80-92 mg per day of zinc may reduce the length of the common cold by up to 33%. What’s more, zinc supplements significantly reduce the risk of infections and promote immune response in older adults.
Red Ginseng (2) Korean red ginseng has been used in traditional Chinese medicine as an overall wellness supplement for centuries. It has been used to: boost the immune system, improve heart health, treat diabetes, increase energy, decrease stress, treat impotence.
Korean FDA has approved it for use for improving immune function and for maintaining healthy blood flow.
Saw palmetto fruit extracts (3) Saw palmetto (Serenoa repens) is a type of palm native to the south-eastern United States. The berries of the plant are commonly used in supplements to improve prostate health, balance hormone levels, and prevent hair loss in men. It’s also associated with other benefits, including decreased inflammation and improved urinary function.
Saw palmetto may improve urinary symptoms associated with benign prostate hyperplasia (BPH) — a condition that causes an enlargement of the prostate gland and results in decreased urine flow. One 12-week study in 92 men showed that taking two capsules daily of Prostataplex, a mix of herbal supplements that include saw palmetto, helped improve urinary tract symptoms associated with BPH. Similarly, another study in 85 men over the age of 45 found that treatment with 160 mg of saw palmetto twice daily reduced lower urinary tract symptoms, increased urine flow, and improved overall quality of life after 6 months.
Some research suggests that saw palmetto could support prostate health and may aid in preventing issues like BPH and prostate cancer. According to one test-tube study, saw palmetto berry extract was able to decrease the growth of prostate cancer cells.
Another test-tube study showed that saw palmetto blocked the spread and growth of prostate cancer cells by deactivating specific receptors involved in cancer development. NMN (Nicotinamide Mononucleotide) Molecule (4) NMN naturally exists in avocadoes, tomatoes, cucumber, cabbages, broccoli, and raw beef. In the laboratory, it is available as nicotinamide mononucleotide bulk powder.
In the human body, NMN is the principal source of energy within the cells. As we age, cellular energy decreases due to the low levels of nicotinamide mononucleotide and subsequent reduction of NAD. Administering NMN will reverse the process and compensate for the deficit.
NMN exists in both alpha (a) and beta (B) forms. However, B-NMN is the most active form. This bioactive nucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide or NAD. FDA recommends that any human being needs approximately 560 mg of NMN per day.
Human Clinical Trials with NMN There are 113 ongoing clinical trials in humans that are investigating NAD precursors (NMN, - NR and Niacin), majority of them are not completed and only few have results published. The most important study in humans was a study in Japanese man, that showed that the single oral administration of NMN up to 500 mg was safe and well-tolerated in healthy men without causing any significant deleterious effects. It has demonstrated that the oral administration of NMN is feasible and could be a therapeutic strategy to replenish cellular - NAD" levels to mitigate aging-related functional disorders in humans.
- Trials in humans with results are: o An international collaborative team including researchers from Keio University in Tokyo and Washington University School of Medicine in St. Louis is running a Phase | human clinical study of NMN in Japan.
o Clinical trials examining the safety and efficacy of NMN are also currently being run at Washington University, investigating the effect on insulin sensitivity, endothelial function, lipids, body and liver fat and markers of cardiovascular and metabolic health.
o Arandomized, double-blind, three-arm crossover pharmacokinetic study in 12 human subjects showed that NR raises NAD+ by as much as 2.7-fold in human blood with a single oral dose of 1000 mg.
o Researchers at the University of Washington have completed a clinical trial with 140 participants showing that orally administered NR gives a dose dependent increase in NAD+ from 250-1000 mg/d plateauing at a 2-fold increase in NAD+ at day nine.
o Researchers have also reported positive effects of NR on vascular endothelial function in healthy middle-aged and older adults, with further investigations of motor and cognitive changes to come.
o Recently, researchers have found that a resveratrol analog called pterostilbene combined with NR seemed to help ALS/Lou Gehrig's patients.
o Most recently, a placebo-controlled study assessing 500 mg of NR, taken twice daily by 70- to 80-year olds, showed increases in NAD+ in blood (but not muscle.) Inflammation fell and, unexpectedly, mitochondrial activity did too.
o Multiple other studies are now underway assessing the effects of NR on muscie mitochondrial function, cognition, immune function, kidney function, traumatic brain injury, brown fat activity, lipid accumulation, energy metabolism, cardiovascular risk, body composition, and acetylcarnitine levels.
Clinical trials results should be available in the new few years. What we can claim with certainly at this moment, based on clinical research data is that NMN is safe and well-tolerated in healthy men and that it is able to successfully replenish cellular NAD+ levels. And we know that decline in NAD levels is associated with aging.
NMN Animal Studies - Animal studies are confirming that the pharmacological activities of NMN include its role in cellular biochemical functions, cardio protection, diabetes, Alzheimer’s disease, and complications associated with obesity. The recent groundbreaking discovery of anti-ageing activities of this chemical moiety has added a valuable essence in the research involving this molecule.
- Studies confirmed that manipulation of mitochondrial NAD levels by NMN results in metabolic changes that protect mitochondria against reactive oxygen species and excessive fragmentation, offering therapeutic approaches for pathophysiologic stress conditions.
Resveratrol (5) Resveratrol is a nutrient found abundantly in the skin of red grapes that is known to have robust antioxidant and anti-inflammatory properties.
The efficacy, safety, and pharmacokinetics of Resveratrol have been documented in over 244 clinical trials, with an additional 27 clinical trials currently ongoing.
Resveratrol has various biochemical and physiological effects such as anti-inflammatory, antioxidative, antiproliferative and chemo-preventive effects.
Recent studies have shown its positive effects especially on cardiovascular diseases, cancer, type 2 diabetes and neurological disorders.
Resveratrol is reported to potentially improve the therapeutic outcome in patients suffering from diabetes mellitus, obesity, colorectal cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Alzheimer's disease, stroke, cardiovascular diseases, kidney diseases, inflammatory
5 diseases, and rhinopharyngitis.
It was also proven that it mimics caloric restriction, which has numerous positive effects.
Resveratrol is reported to be safe at doses up to 5 g/d. when used either alone or as a combination therapy. /

Claims (1)

CONCLUSIES Zink (Zn) (1) heeft bewezen positieve effecten op de immuniteit, terwijl van rode ginseng (2) is bewezen dat het de immuunfunctie en een gezonde doorbloeding verbetert. Saw Palmetto-fruitextract (3) kan helpen bij het handhaven van de gezondheid van de prostaat.CONCLUSIONS Zinc (Zn) (1) has been shown to have positive effects on immunity, while red ginseng (2) has been shown to improve immune function and healthy blood flow. Saw Palmetto fruit extract (3) can help maintain prostate health. In preklinische en klinische studies is nicotine-amide-mononucleotide (NMN) (4) in verband gebracht met eigenschappen zoals antiveroudering, cardio- en hersenbescherming, terwijl dierstudies het potentieel voor levensduurverlenging bevestigen. Het heeft antiverouderingseigenschappen omdat het cellulaire NAD + -niveaus aanvult om verouderinggerelateerde functionele stoornissen bij mensen te verminderen; Het helpt bij het verminderen van ontstekingen, het verhogen van energie door het verhogen van de mitochondriale activiteit en het beschermen van mitochondriën tegen reactieve zuurstofsoorten en overmatige fragmentatie, en biedt therapeutische benaderingen voor pathofysiologische stresscondities. Het verbetert het energiemetabolisme en de lichaamssamenstelling en heeft cardio- en hersenbeschermende effecten. Andere mogelijke effecten van NMN zijn: verlenging van de levensduur van elk dier waarop het tot nu toe is getest; Het schaadt de cognitieve functie, stemming en slaap; het heeft een sterk effect op het verhogen van de vruchtbaarheid van vrouwen. Het is effectief bij het verminderen van depressie en gewichtsverlies.In preclinical and clinical studies, nicotinic amide mononucleotide (NMN) (4) has been associated with properties such as anti-aging, cardio- and brain protection, while animal studies confirm the potential for lifespan extension. It has anti-aging properties as it replenishes cellular NAD+ levels to reduce aging-related functional impairment in humans; It aids in reducing inflammation, increasing energy by increasing mitochondrial activity and protecting mitochondria from reactive oxygen species and excessive fragmentation, and provides therapeutic approaches to pathophysiological stress conditions. It improves energy metabolism and body composition and has cardio- and brain-protective effects. Other possible effects of NMN include: extending the lifespan of any animal it has been tested on to date; It impairs cognitive function, mood and sleep; it has a strong effect on increasing female fertility. It is effective in reducing depression and weight loss. Recente studies van resveratrol (5) hebben de preventieve effecten aangetoond voor hart- en vaatziekten en beroertes, verlenging van de levensduur, verbetering van het vetmetabolisme en de algehele gezondheid. Het vermindert het energieverbruik en verbetert de stofwisseling, vasculaire functie, verlaagt de stofwisseling, vermindert vet in de lever, verlaagt de bloeddruk en verlaagt de bloedsuikerspiegel. Het is effectief voor het herstel van het libido omdat het testosteron verhoogt zonder dat de testis wordt afgesloten.Recent studies of resveratrol (5) have shown its preventive effects for cardiovascular disease and stroke, extending lifespan, improving fat metabolism and overall health. It reduces energy expenditure and improves metabolism, vascular function, decreases metabolism, reduces fat in liver, lowers blood pressure and lowers blood sugar. It is effective for restoring libido as it increases testosterone without shutting down the testis. Een gezond voedingssupplement, dat een combinatie van Zink (Zn) (1), rode ginseng (2), zaagpalmetto-fruitextract (3), nicotinamide-mononucleotide (NMN) (4) en resveratrol (5) bevat, zou sterke effecten moeten hebben op het behoud van de gezondheid van de prostaat, het versterken van de immuniteit en het behouden van een gezonde bloedstroom.A healthy dietary supplement containing a combination of Zinc (Zn) (1), red ginseng (2), saw palmetto fruit extract (3), nicotinamide mononucleotide (NMN) (4) and resveratrol (5) should have strong effects on maintaining prostate health, strengthening immunity and maintaining healthy blood flow. I Opmerking: alle verwijzingen naar de uitspraken in dit document zijn op verzoek verkrijgbaar.I Note: All references to statements in this document are available upon request.
NL1044086A 2020-08-12 2021-07-06 Combination of Zn, red ginseng, saw palmetto fruit extracts, nicotinamide mononucleotide (NMN) and resveratrol as a food supplement NL1044086B1 (en)

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