NL1016247C2 - Heart-lung machine provided with an electrical impedance measurement device for signaling microemboli and / or fibrinogen concentration. - Google Patents
Heart-lung machine provided with an electrical impedance measurement device for signaling microemboli and / or fibrinogen concentration. Download PDFInfo
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- NL1016247C2 NL1016247C2 NL1016247A NL1016247A NL1016247C2 NL 1016247 C2 NL1016247 C2 NL 1016247C2 NL 1016247 A NL1016247 A NL 1016247A NL 1016247 A NL1016247 A NL 1016247A NL 1016247 C2 NL1016247 C2 NL 1016247C2
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- heart
- lung machine
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/367—Circuit parts not covered by the preceding subgroups of group A61M1/3621
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/65—Impedance, e.g. conductivity, capacity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Description
Hart-long machine voorzien van een inrichting voor eleXtrische impedantiemeting ter signalering van microembolïen en/of fibrinogeenconcentratie.Heart-lung machine provided with an electrical impedance measurement device for signaling microembolies and / or fibrinogen concentration.
5 Bijna 1.000.000 mensen in de wereld ondergaan jaarlijks een open hart operatie (OHO) en het grootste deel van deze operaties wordt uitgevoerd met de hart-long machine (HLM). Cerebrale dysfunktie ten gevolge van deze operatie komt voor in meer of mindere mate in ongeveer 6,1 % van 10 alle gevallen. Deze cerebrale problemen vormen niet alleen een oorzaak van meer of mindere mate van blijvende invaliditeit voor de patient, maar zorgen op de korte termijn door het langduriger verblijf in het ziekenhuis en op de langere termijn door de vaak chronische 15 mantelzorg (rehabilitatie ed) voor een belangrijke financiële kostenpost in de gezondheidszorg van de westerse landen. Voorzichtige schattingen gaan uit van een extra kostenpost van tenminste 400 miljoen dollars per jaar voor het extra verblijf in het ziekenhuis en van 20 ongeveer 2 tot 4 miljard dollar voor de mantelzorg na ontslag uit het ziekenhuis.5 Nearly 1,000,000 people in the world undergo an open heart surgery (OHO) every year and most of these operations are performed with the heart-lung machine (HLM). Cerebral dysfunction due to this operation occurs to a greater or lesser extent in approximately 6.1% of all cases. These cerebral problems are not only a cause of a greater or lesser degree of permanent disability for the patient, but in the short term due to a longer stay in the hospital and in the longer term due to the often chronic informal care (rehabilitation etc.) important financial cost item in health care in Western countries. Cautious estimates assume an additional cost of at least 400 million dollars per year for the extra stay in the hospital and of around 2 to 4 billion dollars for informal care after discharge from the hospital.
Het optreden van microembolieen tijdens OHO met HLM wordt als belangrijkste oorzaak gezien van de boven genoemde 25 cerebrale problemen. Het moment van canuleren, manipulatie van het hart en 'declamping' van de aorta zijn de belangrijkste chirurgische bronnen voor het optreden van microembolieen. Ondanks het gebruik van verschillende filters in conjunctie met de HLM blijken 30 nog steeds ook een significant deel van de microembolieen op te treden als gevolg van perfusieproblemen, verband houdende met de hart-long machine. De onderhavige uitvinding is bedoeld om enerzijds het optreden van microembolieen door perfusieproblemen zo snel mogelijk op 35 te sporen en op grond daarvan te behandelen en anderzijds de mate van antistollingtherapie te monitoren bij gebruik van fibrinogeen-verlagende medicatie.The occurrence of microemboli during OHO with HLM is seen as the main cause of the above-mentioned cerebral problems. The moment of cannulation, manipulation of the heart and 'declamping' of the aorta are the most important surgical sources for the occurrence of microembolisms. In spite of the use of different filters in conjunction with the HLM, a significant proportion of the microemboli also appears to occur due to perfusion problems associated with the heart-lung machine. The present invention is intended on the one hand to detect the occurrence of microemboli due to perfusion problems as quickly as possible and to treat them on the basis thereof, and on the other hand to monitor the degree of anticoagulation therapy when using fibrinogen-lowering medication.
22
Op zichzelf is het bekend dat bloed elektrische eigenschappen heeft en dat deze elektrische eigenschappen voor het plasma en de bloedcellen verschillend zijn. Het plasma en het inwendige van de bloedcellen bestaat uit 5 geleidende fluïda met een bepaalde elektrische impedantie en de celmembranen bestaan uit fosfolipiden en proteïnen met d.i.-elektrische eigenschappen. De elektrische impedantie van bloed wordt dus primair bepaald door drie parameters: de plasmaweerstand, de inwendige weerstand in 10 de cel en de capaciteit van de celmembraan. De specifieke weerstand van bloed bevindt zich tussen de 120 en 191 Qcm.It is known per se that blood has electrical properties and that these electrical properties are different for plasma and blood cells. The plasma and the interior of the blood cells consist of conductive fluids with a certain electrical impedance and the cell membranes consist of phospholipids and proteins with d.i. electrical properties. The electrical impedance of blood is thus primarily determined by three parameters: the plasma resistance, the internal resistance in the cell and the capacity of the cell membrane. The specific resistance of blood is between 120 and 191 Qcm.
Een voorkeursuitvoeringsvorm van de uitvinding omvat 2 15 buitenste stroomelektrodes en 2 binnenste meetelektrodes in de perfusieslang, direct na de oorsprong uit de hart-longmachine (zie figuur 1). De elektrodes zijn bij voorkeur circulair en van platina. Teneinde een homogeen elektrisch veld te verkrijgen zijn de afstanden tussen de 20 elektrodes gekozen als meer dan 2x de doorsnede van de perfusieslang, welke uit de hart-longmachine komt. Door middel van het opwekken van een lage wisselstroom (ΙΟμΑ -ImA) met frequentie tussen de 4 kHz en 5000 kHz via de 2 buitenste elektrodes zal via de meetelektrodes continu 25 een impedantie (ZO) gemeten kunnen worden van het bloed, dat de meetelektrodes passeert. Eveneens kan een continue registratie plaatsvinden van de verandering van het impedantiesignaal (delta Z).A preferred embodiment of the invention comprises 2 outer flow electrodes and 2 inner measurement electrodes in the perfusion tube, immediately after the origin from the heart-lung machine (see Figure 1). The electrodes are preferably circular and made of platinum. In order to obtain a homogeneous electric field, the distances between the electrodes have been selected as more than 2x the cross-section of the perfusion tube coming from the heart-lung machine. By means of generating a low alternating current (ΙΟμΑ -ImA) with a frequency between 4 kHz and 5000 kHz via the 2 outer electrodes, it will be possible to continuously measure an impedance (ZO) of the blood passing through the measuring electrodes via the measuring electrodes. . A continuous recording of the change in the impedance signal (delta Z) can also take place.
Kleine partikels (< 100 micron) met een andere impedantie 30 dan bloed, zullen zich manifesteren in een plotselinge verandering van het impedantiesignaal (Figuur 2). Deze veranderingen zijn met name te zien in het deltaZ signaal en de grootte van deze verandering hangt af van het verschil in specifieke weerstand tussen dat van de 35 partikel en dat van bloed. Bij passeren van luchtpartikels zal een grote uitslag plaatsvinden in het deltaZ signaal gezien de duidelijk hogere specifieke weerstand van lucht ten opzichte van bloed. Deze uitslag 3 van het deltaZ signaal zal minder groot zijn bij passeren van partikels met andere consistentie, zoals wanneer sprake is van kleine stolsels, waarvan de specifieke weerstand in mindere mate verschilt van de specifieke 5 weerstand van bloed. De uitslag van het impedantiesignaal zal daarom niet alleen aangeven of er wel of niet kleine partikels passeren zoals microembolieen, maar zal ook door middel van de karakteristieken van de impedantie bij verschillende frequenties inzicht geven in de Ί0 consistentie van deze partikels, m.a.w. of er sprake is van luchtembolien door bijv. lekkage in het perfusiesysteem of van microembolieen van trombotisch materiaal. In beide gevallen zal de behandeling van het probleem zeer verschillend zijn. Bij aanwijzingen voor 15 kleine trombi zal de antistolling moeten worden aangepast en bij aanwezigheid van lucht zal naar lekkage in het perfusiesysteem gezocht moeten worden.Small particles (<100 microns) with an impedance other than blood will manifest in a sudden change in the impedance signal (Figure 2). These changes can be seen in particular in the delta Z signal and the magnitude of this change depends on the difference in specific resistance between that of the particle and that of blood. When passing air particles, a large result will occur in the deltaZ signal, given the clearly higher specific resistance of air to blood. This result 3 of the delta Z signal will be less large when passing particles with other consistency, such as when small clots are involved, the specific resistance of which differs to a lesser extent from the specific resistance of blood. The result of the impedance signal will therefore not only indicate whether or not small particles pass through, such as microembolisms, but will also provide insight into the Ί0 consistency of these particles, ie whether there is any question, through the characteristics of the impedance at different frequencies of air embolism due to, for example, leakage into the perfusion system or of microembolisms of thrombotic material. In both cases the treatment of the problem will be very different. With indications for small thrombi, the anticoagulation will have to be adjusted and in the presence of air leakage in the perfusion system will have to be sought.
Niet alleen kan het impedantiesignaal inzicht geven in de wel of niet aanwezigheid en consistentie van partikels 20 met andere impedantie dan bloed, maar bij kennis van de continue stroomsnelheid door de perfusieslangen zal de totale tijd van verandering van het impedantiesignaal iets zeggen over de doorsnede van het partikel, evenwijdig aan de lijn tussen de meetelektrodes (zie 25 Figuur 3).Not only can the impedance signal provide insight into the presence and consistency of particles with impedance other than blood, but when the continuous flow rate through the perfusion tubes is known, the total time of changing the impedance signal will say something about the cross-section of the impedance signal. particle parallel to the line between the measuring electrodes (see Figure 3).
Een andere methode van monitoring van de stolling gedurende OHO met HLM door middel van on-line bioimpedantie metingen doet zich voor bij het gebruik van fibrinogeen verlagende middelen in plaats van heparine 30 als antistollingstherapie. Vergelijkend onderzoek heeft aangetoond, dat de kans op trombotische complicaties enerzijds en hemorragische complicaties anderzijds tijdens open hartoperatie voor heparine en een fibrinogeen verlagende medicatie als Ancrod niet 35 significant verschillend is. Eerder in-vitro bioimpedantie-onderzoek heeft aangetoond, dat er een sterke correlatie bestaat tussen de gemeten impedantie van bloed en de aanwezige concentratie fibrinogeen en dus 4 tussen de impedantie en de viscositeit van het bloed. De impedantie van bloed neemt af bij lager worden van de viscositeit en fibrinogeenconcentratie; andere factoren, die de impedantie beïnvloeden, zoals met name hematocriet 5 en temperatuur dienen constant te worden gehouden. Bij een streefconcentratie van fibrinogeen tijdens OHO door middel van bijvoorbeeld Ancrod kan de dosering van de Ancrod getitreerd worden aan de hand van continue impedantiemetingen. De impedantie kan weer gemeten worden 10 door middel van dezelfde opstelling van 4 elektrodes (2 stroomelektrodes en 2 meetelektrodes) in de perfusieslang (zie figuur 1). De impedantiewaarden, die het best korreleren met de fibrinogeenconcentratie, zijn de Rp en Cm. Deze kunnen berekend worden door middel van het 15 achtereenvolgens binnen enkele seconden meten van de impedantie bij tenminste 3 verschillende stroomfrequenties (bijv. 4 kHz, 512 kHz en 2000 kHz).Another method of monitoring coagulation during OHO with HLM by means of on-line bioimpedance measurements occurs with the use of fibrinogen-lowering agents instead of heparin as anticoagulation therapy. Comparative research has shown that the risk of thrombotic complications on the one hand and hemorrhagic complications on the other during open heart surgery for heparin and a fibrinogen-lowering medication such as Ancrod is not significantly different. Earlier in vitro bioimpedance studies have shown that there is a strong correlation between the measured impedance of blood and the concentration of fibrinogen present and thus 4 between the impedance and the viscosity of the blood. The impedance of blood decreases as the viscosity and fibrinogen concentration decrease; other factors that influence the impedance, such as hematocrit and temperature in particular, must be kept constant. At a target concentration of fibrinogen during OHO by means of, for example, Ancrod, the dosage of the Ancrod can be titrated on the basis of continuous impedance measurements. The impedance can again be measured by means of the same arrangement of 4 electrodes (2 current electrodes and 2 measuring electrodes) in the perfusion tube (see figure 1). The impedance values, which correlate best with the fibrinogen concentration, are the Rp and Cm. These can be calculated by measuring the impedance successively within a few seconds at at least 3 different current frequencies (e.g. 4 kHz, 512 kHz and 2000 kHz).
Claims (13)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL1016247A NL1016247C2 (en) | 2000-09-22 | 2000-09-22 | Heart-lung machine provided with an electrical impedance measurement device for signaling microemboli and / or fibrinogen concentration. |
PCT/NL2001/000701 WO2002025277A1 (en) | 2000-09-22 | 2001-09-24 | Heart-lung machine provided with a device for electrical impedance measurement, and method therefore |
AU2002214386A AU2002214386A1 (en) | 2000-09-22 | 2001-09-24 | Heart-lung machine provided with a device for electrical impedance measurement, and method therefore |
Applications Claiming Priority (2)
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NL1016247A NL1016247C2 (en) | 2000-09-22 | 2000-09-22 | Heart-lung machine provided with an electrical impedance measurement device for signaling microemboli and / or fibrinogen concentration. |
NL1016247 | 2000-09-22 |
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NL1016247C2 true NL1016247C2 (en) | 2002-03-25 |
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NL1016247A NL1016247C2 (en) | 2000-09-22 | 2000-09-22 | Heart-lung machine provided with an electrical impedance measurement device for signaling microemboli and / or fibrinogen concentration. |
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AU (1) | AU2002214386A1 (en) |
NL (1) | NL1016247C2 (en) |
WO (1) | WO2002025277A1 (en) |
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AU2002214386A1 (en) | 2002-04-02 |
WO2002025277A1 (en) | 2002-03-28 |
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