MY140860A - Novel substituted 1,2,4- trioxanes, useful as antimalarial agents, and a process for the preparation thereof - Google Patents
Novel substituted 1,2,4- trioxanes, useful as antimalarial agents, and a process for the preparation thereofInfo
- Publication number
- MY140860A MY140860A MYPI20031149A MYPI20031149A MY140860A MY 140860 A MY140860 A MY 140860A MY PI20031149 A MYPI20031149 A MY PI20031149A MY PI20031149 A MYPI20031149 A MY PI20031149A MY 140860 A MY140860 A MY 140860A
- Authority
- MY
- Malaysia
- Prior art keywords
- trioxanes
- preparation
- phenyl
- useful
- antimalarial
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
- C07D323/04—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
IN THE PRESENT INVENTION RELATES TO A NOVEL SERIES OF ANTIMALARIAL 1,2,4-TRIOXANES ANALOGUES OF GENERAL FORMULA 7, WHEREIN R REPRESNTS CYCLOALKYL GROUPS SELECTED FROM THE GROUPS CONSISTING OF CYCLOPENTYL, CYCLOHEXYL, CYCLOHEPTYL AND CYCLOOCTYL OR ARYL GROUPS SELECTED FROM PHENYL, 4-BROMOPHENYL AND 4-CHLOROPHENYL, R1 AND R2 REPRESENT HYDROGEN, ALKYL GROUP SELECTED FROM METHYL, ETHYL, PROPYL AND DECYL, ARYL SELECTED FROM PHENYL OR PARTS OF A CYCLIC SYSTEMS SUCH AS CYCLOPENTANE, CYCLOHEXANE, SUBSTITUTED CYCLOHEXANE, CYCLOHEPTANE BICYCLE (2.2.1) HEPTANE, ADAMANTINE AND ITS PREPARATION THEREOF; SEVERAL OF THESE NOVEL COMPOUNDS SHOW PROMISING ANTIMALARIAL ACTIVITY AGAINST MULTIDRUG RESISTANT MALARIA IN MICE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IN2002/000093 WO2003082852A1 (en) | 2002-03-28 | 2002-03-28 | Novel substituted 1,2,4-trioxanes useful as antimalarial agents and a process for the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MY140860A true MY140860A (en) | 2010-01-29 |
Family
ID=28460467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MYPI20031149A MY140860A (en) | 2002-03-28 | 2003-03-28 | Novel substituted 1,2,4- trioxanes, useful as antimalarial agents, and a process for the preparation thereof |
Country Status (8)
Country | Link |
---|---|
KR (1) | KR100932997B1 (en) |
CN (1) | CN100455577C (en) |
AU (1) | AU2002249561A1 (en) |
BR (1) | BR0205828A (en) |
MX (1) | MXPA03002817A (en) |
MY (1) | MY140860A (en) |
PE (1) | PE20040604A1 (en) |
WO (1) | WO2003082852A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007077479A1 (en) | 2005-12-30 | 2007-07-12 | Council Of Scientific And Industrial Research | Spiro-1,2,4-trioxanes as antimalarial agents |
WO2008038299A1 (en) * | 2006-09-29 | 2008-04-03 | Council Of Scientific & Industrial Research | Substituted 6-(1-aryl ethyl)-i, 2, 4-trioxanes |
WO2008099415A1 (en) * | 2007-02-13 | 2008-08-21 | Council Of Scientific & Industrial Research | Novel substituted bis-1, 2, 4-trioxanes and a process for preparation thereof |
WO2009118747A1 (en) * | 2008-03-26 | 2009-10-01 | Council Of Scientific & Industrial Research | Novel hydroxy functionalized 1, 2, 4-trioxanes as antimalarial agents and a process for the preparation thereof |
EP2505583A1 (en) * | 2011-03-29 | 2012-10-03 | Centre National de la Recherche Scientifique | Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA200001642B (en) * | 1999-12-28 | 2000-10-03 | Council Scient Ind Res | Novel substituted 1,2,4-trioxanes as antimalarial agents and a process of producing the substituted 1,2,4-trioxanes. |
-
2002
- 2002-03-28 WO PCT/IN2002/000093 patent/WO2003082852A1/en not_active Application Discontinuation
- 2002-03-28 CN CNB028025237A patent/CN100455577C/en not_active Expired - Fee Related
- 2002-03-28 MX MXPA03002817A patent/MXPA03002817A/en active IP Right Grant
- 2002-03-28 KR KR1020037004606A patent/KR100932997B1/en not_active IP Right Cessation
- 2002-03-28 BR BR0205828-6A patent/BR0205828A/en not_active Application Discontinuation
- 2002-03-28 AU AU2002249561A patent/AU2002249561A1/en not_active Abandoned
-
2003
- 2003-03-28 PE PE2003000318A patent/PE20040604A1/en not_active Application Discontinuation
- 2003-03-28 MY MYPI20031149A patent/MY140860A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1487930A (en) | 2004-04-07 |
MXPA03002817A (en) | 2004-05-17 |
KR100932997B1 (en) | 2009-12-21 |
WO2003082852A1 (en) | 2003-10-09 |
PE20040604A1 (en) | 2004-09-18 |
CN100455577C (en) | 2009-01-28 |
KR20040094597A (en) | 2004-11-10 |
AU2002249561A1 (en) | 2003-10-13 |
BR0205828A (en) | 2004-06-29 |
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