MY140860A - Novel substituted 1,2,4- trioxanes, useful as antimalarial agents, and a process for the preparation thereof - Google Patents

Novel substituted 1,2,4- trioxanes, useful as antimalarial agents, and a process for the preparation thereof

Info

Publication number
MY140860A
MY140860A MYPI20031149A MYPI20031149A MY140860A MY 140860 A MY140860 A MY 140860A MY PI20031149 A MYPI20031149 A MY PI20031149A MY PI20031149 A MYPI20031149 A MY PI20031149A MY 140860 A MY140860 A MY 140860A
Authority
MY
Malaysia
Prior art keywords
trioxanes
preparation
phenyl
useful
antimalarial
Prior art date
Application number
MYPI20031149A
Inventor
Singh Chandan
Tiwari Pallavi
Puri Sunil Kumar
Original Assignee
Council Scient Ind Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council Scient Ind Res filed Critical Council Scient Ind Res
Publication of MY140860A publication Critical patent/MY140860A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/04—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

IN THE PRESENT INVENTION RELATES TO A NOVEL SERIES OF ANTIMALARIAL 1,2,4-TRIOXANES ANALOGUES OF GENERAL FORMULA 7, WHEREIN R REPRESNTS CYCLOALKYL GROUPS SELECTED FROM THE GROUPS CONSISTING OF CYCLOPENTYL, CYCLOHEXYL, CYCLOHEPTYL AND CYCLOOCTYL OR ARYL GROUPS SELECTED FROM PHENYL, 4-BROMOPHENYL AND 4-CHLOROPHENYL, R1 AND R2 REPRESENT HYDROGEN, ALKYL GROUP SELECTED FROM METHYL, ETHYL, PROPYL AND DECYL, ARYL SELECTED FROM PHENYL OR PARTS OF A CYCLIC SYSTEMS SUCH AS CYCLOPENTANE, CYCLOHEXANE, SUBSTITUTED CYCLOHEXANE, CYCLOHEPTANE BICYCLE (2.2.1) HEPTANE, ADAMANTINE AND ITS PREPARATION THEREOF; SEVERAL OF THESE NOVEL COMPOUNDS SHOW PROMISING ANTIMALARIAL ACTIVITY AGAINST MULTIDRUG RESISTANT MALARIA IN MICE.
MYPI20031149A 2002-03-28 2003-03-28 Novel substituted 1,2,4- trioxanes, useful as antimalarial agents, and a process for the preparation thereof MY140860A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2002/000093 WO2003082852A1 (en) 2002-03-28 2002-03-28 Novel substituted 1,2,4-trioxanes useful as antimalarial agents and a process for the preparation thereof

Publications (1)

Publication Number Publication Date
MY140860A true MY140860A (en) 2010-01-29

Family

ID=28460467

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI20031149A MY140860A (en) 2002-03-28 2003-03-28 Novel substituted 1,2,4- trioxanes, useful as antimalarial agents, and a process for the preparation thereof

Country Status (8)

Country Link
KR (1) KR100932997B1 (en)
CN (1) CN100455577C (en)
AU (1) AU2002249561A1 (en)
BR (1) BR0205828A (en)
MX (1) MXPA03002817A (en)
MY (1) MY140860A (en)
PE (1) PE20040604A1 (en)
WO (1) WO2003082852A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007077479A1 (en) 2005-12-30 2007-07-12 Council Of Scientific And Industrial Research Spiro-1,2,4-trioxanes as antimalarial agents
WO2008038299A1 (en) * 2006-09-29 2008-04-03 Council Of Scientific & Industrial Research Substituted 6-(1-aryl ethyl)-i, 2, 4-trioxanes
WO2008099415A1 (en) * 2007-02-13 2008-08-21 Council Of Scientific & Industrial Research Novel substituted bis-1, 2, 4-trioxanes and a process for preparation thereof
WO2009118747A1 (en) * 2008-03-26 2009-10-01 Council Of Scientific & Industrial Research Novel hydroxy functionalized 1, 2, 4-trioxanes as antimalarial agents and a process for the preparation thereof
EP2505583A1 (en) * 2011-03-29 2012-10-03 Centre National de la Recherche Scientifique Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200001642B (en) * 1999-12-28 2000-10-03 Council Scient Ind Res Novel substituted 1,2,4-trioxanes as antimalarial agents and a process of producing the substituted 1,2,4-trioxanes.

Also Published As

Publication number Publication date
CN1487930A (en) 2004-04-07
MXPA03002817A (en) 2004-05-17
KR100932997B1 (en) 2009-12-21
WO2003082852A1 (en) 2003-10-09
PE20040604A1 (en) 2004-09-18
CN100455577C (en) 2009-01-28
KR20040094597A (en) 2004-11-10
AU2002249561A1 (en) 2003-10-13
BR0205828A (en) 2004-06-29

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