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Application filed by Signal Pharmaceutical Inc, Novartis Pharma AgfiledCriticalSignal Pharmaceutical Inc
Priority to MYPI20031589priorityCriticalpatent/MY137604A/en
Publication of MY137604ApublicationCriticalpatent/MY137604A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
BENZOPYRANONE COMPOUNDS HAVING THE FOLLOWING STRUCTURE: WHEREIN R1, X, Y AND N ARE AS DEFINED HERE, ARE DISCLOSED. THE COMPOUNDS OF FORMULA (I), WHEREIN R1 IS H, CAN BE PREPARED BY DEMETHYLATION OF THE CORRESPONDING PHENOLIC METHYL ETHER. THE COMPOUNDS ARE USEFUL FOR TREATING A BONE-RESORBING DISEASE, CANCER, ARTHRITIS OR AN ESTROGEN-RELATED CONDITION SUCH AS BREAST CANCER, OSTEOPOROSIS AND ENDOMETRIOSIS, CARDIOVASCULAR DISEASE, HYPERCHOLESTEROLEMIA, PROSTATIC HYPERTROPHY, PROSTATIC CARCINOMAS, OBESITY, HOT FLASHES, SKIN EFFECTS, MOOD SWINGS, MEMORY LOSS, AND OR ADVERSE REPRODUCTIVE EFFECTS ASSOCIATED WITH EXPOSURE TO ENVIRONMENTAL CHEMICALS OR NATURAL HORMONAL IMBALANCES.
MYPI200315892003-04-262003-04-26Benzopyranone compounds, compositions thereof, and methods of treatment therewith
MY137604A
(en)