MY110182A - Novel phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism - Google Patents

Novel phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism

Info

Publication number
MY110182A
MY110182A MYPI93001059A MYPI19931059A MY110182A MY 110182 A MY110182 A MY 110182A MY PI93001059 A MYPI93001059 A MY PI93001059A MY PI19931059 A MYPI19931059 A MY PI19931059A MY 110182 A MY110182 A MY 110182A
Authority
MY
Malaysia
Prior art keywords
pharmaceutical compositions
abnormal calcium
novel
methods
treating abnormal
Prior art date
Application number
MYPI93001059A
Inventor
Michael Janusz John
David Francis Marion
George Anthony Nelson Dennis
Vincent Bayless Allan
Hallock Ebetino Frank
Mary Dansereau Susan (Nee Kaas)
Original Assignee
Procter & Gamble Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/055,809 external-priority patent/US5731299A/en
Application filed by Procter & Gamble Pharmaceuticals Inc filed Critical Procter & Gamble Pharmaceuticals Inc
Publication of MY110182A publication Critical patent/MY110182A/en

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Abstract

THE PRESENT INVENTION RELATES TO PHOSPHONSULFONATES AND PHARMACEUTICALLY-ACCEPTABLE SALTS AND ESTERS THEREOF, WHICH ARE USEFUL IN THE TREATMENT OF PREVENTION OF METABOLIC BONE DISORDERS CHARACTERIZED BY ABNORMAL CALCIUM AND PHOSPHATE METABOLISMS. THE COMPOUNDS OF THE PRESENT INVENTION HAVE PO3H2 AND SO3R GROUPS ATTACHED TO THE SAME CARBON ATOMS. R IS SELECTED FROM HYDROGEN, LOWER ALKYL, LOWER ACYLOXYALKYL, AMINOCARBONYLOXYALKYL, PIVALOYLOXYMETHYL, LACTONYL, LOWER ALKOXYACYLOXYALKYL, ALKOXYALKYL, CHOLINE AND ACYLAMINO ALKYL. ONE OF THE OTHER SUBSTITUENTS TO THE CARBON ATOM IS HYDROGEN, HALOGEN, MERCAPTO OR A DERIVATIVE THEREOF, A MERCAPTO-CONTAINING GROUP, AMINOHYDROXY OR SUBSTITUTED OR UNSUBSTITUTED ALKYL OF FROM 1 TO 8 CARBON ATOMS. THE REMAINING GROUP ATTACHED TO THE CENTRAL CARBON ATOM MAY BE ANY ONE OF A WIDE VARIETY OF ORGANIC MOIETIES.THE INVENTION ALSO INCLUDES PHARMACEUTICAL COMPOSITIONS SUITABLE FOR EXAMPLE IN TREATMENT OF OSTEOPOROSIS.
MYPI93001059A 1992-05-29 1993-05-28 Novel phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism MY110182A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US89088692A 1992-05-29 1992-05-29
US89149092A 1992-05-29 1992-05-29
US89130992A 1992-05-29 1992-05-29
US08/055,809 US5731299A (en) 1992-05-29 1993-05-07 Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism

Publications (1)

Publication Number Publication Date
MY110182A true MY110182A (en) 1998-02-28

Family

ID=80001990

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI93001059A MY110182A (en) 1992-05-29 1993-05-28 Novel phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism

Country Status (1)

Country Link
MY (1) MY110182A (en)

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