MY101443A - Analogs of mevalonolactone and derivatives thereof, processes of their production, pharmaceutical compositions containing them and their use as pharmaceuticals - Google Patents
Analogs of mevalonolactone and derivatives thereof, processes of their production, pharmaceutical compositions containing them and their use as pharmaceuticalsInfo
- Publication number
- MY101443A MY101443A MYPI87001949A MYPI19871949A MY101443A MY 101443 A MY101443 A MY 101443A MY PI87001949 A MYPI87001949 A MY PI87001949A MY PI19871949 A MYPI19871949 A MY PI19871949A MY 101443 A MY101443 A MY 101443A
- Authority
- MY
- Malaysia
- Prior art keywords
- mevalonolactone
- pharmaceuticals
- analogs
- hydrogen
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
COMPOUNDS OF FORMULA I ( FORMULA I ) WHEREIN ONE OF R AND R0 IS ( FORMULA 2 ) AND THE OTHER IS PRIMARY OF SECONDARY C1-6 ALKYL, C3-6 CYCLOALKYL OR PHENYL- (CH2) M-, WHEREIN R4 IS HYDROGEN, C1-4 ALKYL, C1-4 ALKOXY, (EXCEPT T-BUTOXY),TRIFLUOROMETHYL, FLUORO, CHLORO, PHENOXY OR BENZYLOXY, R5 IS HYDROGEN, C1-3 ALKYL, C1-3 ALKOXY, TRIFLUOROMETHYL, FLUORO, CHLORO, PHENOXY OR BENZYLOXY, R5A IS HYDROGEN, C1-2 ALKYL, C1-2 ALKOXY , FLUORO OR CHLORO, AND M IS 1, 2 OR 3, WITH THE- PROVISOS THAT BOTH R5 AND R5A MUST BE HYDROGEN WHEN R4 IS HYDROGEN, R5A MUST BE HYDROGEN WHEN R5 IS HYDROGEN, NOT MORE THAN ONE OF R4 AND R5 IS TRIFLUOROMETHYL, NOT MORE THAN ONE OF R4 AND R5 IS PHENOXY AND NOT MORE THAN ONE OF R4 AND R5 IS BENZYLOXY.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44366882A | 1982-11-22 | 1982-11-22 | |
| EP83810548A EP0114027B1 (en) | 1982-11-22 | 1983-11-22 | Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY101443A true MY101443A (en) | 1991-11-18 |
Family
ID=23761739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI87001949A MY101443A (en) | 1982-11-22 | 1987-09-25 | Analogs of mevalonolactone and derivatives thereof, processes of their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS60500015A (en) |
| KR (1) | KR900009006B1 (en) |
| ES (1) | ES8506622A1 (en) |
| MY (1) | MY101443A (en) |
| PH (1) | PH23486A (en) |
| PT (1) | PT77694B (en) |
| ZA (1) | ZA838718B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0532737U (en) * | 1991-10-11 | 1993-04-30 | 日産自動車株式会社 | Gas turbine ceramic structure |
| ES2304140T3 (en) * | 2001-08-03 | 2008-09-16 | Ciba Holding Inc. | FLUVASTATINE SODIUM CRYSTAL FORMS. |
| CN100400510C (en) * | 2003-04-24 | 2008-07-09 | 大赛璐化学工业株式会社 | Method of separating optically active dihydroxy-heptenoic acid esters |
| CA2585623C (en) | 2004-10-27 | 2012-06-05 | Daiichi Sankyo Company Limited | Ortho-substituted benzene derivatives |
| US20090203701A1 (en) | 2006-06-29 | 2009-08-13 | Kowa Co., Ltd | Prophylactic and/or therapeutic agent for rheumatoid arthritis |
| CA2685054C (en) | 2007-04-27 | 2014-11-04 | Kyushu University, National University Corporation | Agent for treatment of pulmonary disease |
| JP2011121949A (en) | 2009-12-14 | 2011-06-23 | Kyoto Univ | Pharmaceutical composition for preventing and treating amyotrophic lateral sclerosis |
| JP6536871B2 (en) | 2013-12-02 | 2019-07-03 | 国立大学法人京都大学 | Preventive and therapeutic agent for FGFR3 disease and method of screening the same |
| US20210290598A1 (en) | 2018-05-08 | 2021-09-23 | National University Corporation Okayama University | Medicament useful for cardiovascular disease |
| JP7224001B2 (en) | 2018-12-21 | 2023-02-17 | 国立大学法人京都大学 | Lubricin-localized cartilage-like tissue, method for producing the same, and composition for treating articular cartilage injury containing the same |
| SG11202109928WA (en) | 2019-03-13 | 2021-10-28 | National Univ Corporation Hamamatsu Univ School Of Medicine | Pharmaceutical composition for treating aortic aneurysm |
| EP4108260A4 (en) | 2020-02-21 | 2024-03-06 | Jsr Corp | Composition for alleviating pulmonary hypertension, method for predicting prognosis of pulmonary hypertension, method for assisting in determining severity of pulmonary hypertension, and method for assisting in diagnosing pulmonary hypertension |
-
1983
- 1983-11-18 JP JP58503754A patent/JPS60500015A/en active Granted
- 1983-11-18 PH PH29858A patent/PH23486A/en unknown
- 1983-11-21 ES ES527428A patent/ES8506622A1/en not_active Expired
- 1983-11-21 PT PT77694A patent/PT77694B/en unknown
- 1983-11-22 ZA ZA838718A patent/ZA838718B/en unknown
- 1983-11-22 KR KR1019830005533A patent/KR900009006B1/en not_active IP Right Cessation
-
1987
- 1987-09-25 MY MYPI87001949A patent/MY101443A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES527428A0 (en) | 1985-08-01 |
| PT77694B (en) | 1986-04-17 |
| JPH0246031B2 (en) | 1990-10-12 |
| PH23486A (en) | 1989-08-16 |
| ES8506622A1 (en) | 1985-08-01 |
| ZA838718B (en) | 1985-08-28 |
| PT77694A (en) | 1983-12-01 |
| KR840007221A (en) | 1984-12-06 |
| KR900009006B1 (en) | 1990-12-17 |
| JPS60500015A (en) | 1985-01-10 |
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