MXPA99011318A - Liquid antimicrobial cleansing compositions - Google Patents

Abstract

La presente invención se refiere a una composición limpiadora antimicrobiana enjuagable que comprende de alrededor de 0.1%a alrededor de 5%de un activo antimicrobiano, de alrededor de 8%a alrededor de 18%de un agente tensioactivo aniónico, de alrededor de 2%a alrededor de 12%de un agente donador de protón;de alrededor de 1%a alrededor de 30%de un agentehumectante lipofílico de la piel;de alrededor de 0.1%a alrededor de 4%de un estabilizador, y de alrededor de 35%a alrededor de 88.8%de agua;al menos alrededor de 67%del agente tensioactivo aniónico comprende una mezcla de agente tensioactivo de clase A y clase C;la relación de peso del agente tensioactivo de clase A al agente tensioactivo de clase C varía de alrededor de 5:1 a alrededor de 1:2;la composición se ajusta a un pH de alrededor de 3.5 a alrededor de 4.5.

Description

LIQUID ANTIMICROBIAL CLEANING COMPOSITIONS TECHNICAL FIELD The present invention relates to mild, rinseable personal cleansing compositions that provide improved antimicrobial effectiveness. Specifically, the personal cleansing compositions of the invention provide residual effectiveness not previously seen against transient Gram-negative bacteria, improved levels of residual effectiveness against Gram-positive bacteria and improved immediate reduction of germs on the skin with use.

BACKGROUND OF THE INVENTION Human health is impacted by many microbial entities.

Inoculation by viruses and bacteria causes a wide variety of diseases and conditions. Media attention to cases of food poisoning, strep infections, and the like is increasing the public's awareness of microbial issues. It is well known that washing hard surfaces, foods (for example fruits or vegetables) and skin, especially hands, with antimicrobial or non-medicated soap, can remove many viruses and bacteria from washed surfaces. The removal of viruses and bacteria is due to the surfactant activity of the soap and the mechanical action of the washing process. Therefore, it is known and recommended that people wash frequently to reduce the spread of viruses and bacteria. The bacteria found on the skin can be divided into two groups: resident and transient bacteria. The resident bacteria are Gram-positive bacteria that are established as permanent microcolonies on the surface and outer layers of the skin and play an important role, helping to prevent the colonization of other bacteria and more harmful fungi. Transient bacteria are bacteria that are not part of the normal resident flora of the skin, but can be deposited when the contaminated material transported by air lands on the skin or when the contaminated material comes into physical contact with it. Transient bacteria are typically divided into two subclasses: Gram positive and Gram negative. Gram-positive bacteria include pathogens such as Staphylococcus aureus, Streptococcus pyogenes and Clostridium botulinum. Gram-negative bacteria include pathogens such as Salmonella, Escherochia coli, Klebsiella, Hoemophilus, Pseudomonas aeruginosa, Proteus and Shigella dysenteriae. Gram-negative bacteria are generally distinguished from Gram-positive bacteria by an additional protective cell membrane that generally results in Gram-negative bacteria being less susceptible to topical antibacterial actives.

Antimicrobial cleaning products have been marketed in a variety of forms for some time. The forms include deodorant soaps, hard surface cleaners and surgical disinfectants. These traditional rinsing antimicrobial products have been formulated to provide bacteria removal during washing. Antimicrobial soaps have also been shown to provide residual effectiveness against Gram-positive bacteria. Residual effectiveness refers to the fact that the growth of bacteria on a surface is controlled by a pepodo after the washing / rinsing procedure. Liquid antimicrobial cleaners are described in U.S. Patent No. 4,847,072, Bissett et al; issued on July 1, 1989, 4,939,284, Degenhardt, issued July 3, 1990 and 4,829,698, Degenhardt, issued April 11, 1989, which are incorporated herein by reference. The previously marketed formulations of Head & Dandruff Shampoo Shoulders®, marketed in 1994, comprise anionic surfactants, an antibacterial active and citric acid as a pH adjuster. The Head & Shoulders®, controls the fungus Pityrosorum ovale, which causes dandruff. The PCT application WO 92/18100, Keegan et al.; published October 29, 1992 ("Keegan") and the PCT application WO 95/32705, Fijiwara et al; published on December 7, 1995 ("Fujiwara") show liquid skin cleansers comprising mild surfactants, antibacterial agents and acidic compounds to regulate pH, which provides enhanced Germ hostility. However, the use of the low levels of the acidic compounds herein results in compositions that do not provide the disassociated acid required to provide the residual effectiveness against the Gram negative bacteria. The above situation is composed in Keegan and Fujiwara by the preference of mild surfactants, including nonionic surfactants. Some of these antimicrobial products, especially hard surface cleaners and surgical disinfectants, use high levels of alcohol and / or harsh surfactants that have been shown to dry and irritate skin tissues. Ideal personal cleansers should gently cleanse the skin, causing little or no irritation, and not leaving the skin extremely dry after frequent use and preferably should provide a moisturizing benefit to the skin. U.S. Patent No. 3,141, 8121, issued to Compeau, July 21, 1964 and Irgasan DP 300 (Triclosan®) technical literature from Ciba-Giegy, Inc., "Basic Formulation for Hand Disinfection 89/42/01" disclose antibacterial skin cleansing compositions that could provide residual effectiveness against Gram-negative bacteria using certain anionic surfactants, antimicrobial actives and acids. However, the selection, in the present, of highly active surfactants results in personal cleansing compositions that dry and roughen the skin.

Given the high severe health impacts of Gram negative bacteria such as Salmonella, Escherichia coli and Shigella, it would be highly desirable to formulate antimicrobial cleansing compositions that provide improved residual effectiveness against said Gram negative bacteria and which are gentle to the skin. The existing products have been unable to achieve the residual effectiveness and smoothness of the negative Gram. Applicants have discovered that rinsing antimicrobial cleaning compositions that provide such softness and such residual effectiveness against Gram-negative bacteria can be formulated using known antibacterial actives in combination with specific organic and / or inorganic acids as proton donor agents, and specific anionic surfactants , all of which are deposited on the skin. The deposited proton donor agent and the anionic surfactant enhance the selected asset, to provide a new level of hostility to the bacteria that contacts the skin.

BRIEF DESCRIPTION OF THE INVENTION The present invention relates to a rinsable antimicrobial cleaning composition comprising from about 0.1% to about 5.% of an antibacterial active; from about 8% to about 18% anionic surfactant; from about 2% to about 12% of a proton donor agent; from about 1% to about 20% of a lipophilic skin moisturizing agent; from about 0.1% to about 4% of a stabilizer and from about 38% to about 88% water. At least about 67% of an anionic surfactant comprises a mixture of Class A and Class C surfactants, wherein the weight ratio of the class A surfactants to class C surfactants varies from about 5: 1. to around 1: 2. The compositions of the present invention have a pH of around 3.5 to about 4: 5. The present invention also relates to cleaning methods and to reducing the distribution of transient Gram-negative bacteria using the rinse-off antimicrobial cleaning compositions described herein.

DETAILED DESCRIPTION OF THE INVENTION The rinsing antimicrobial compositions of the present invention are very effective in cleaning surfaces, especially the skin, providing a residual antimicrobial effectiveness against transient Gram-negative bacteria and are gentle on the skin. The term "rinseable", as used herein, refers to the compositions of the present invention being used in a context where the composition is rinsed or finally washed from the treated surface (e.g., skin or hard surfaces) after or during the application of the product.

The term "antimicrobial cleansing composition", as used herein, refers to a composition suitable for application to a surface for the purpose of removing dirt, oil or the like which additionally controls the growth and colonization of transient bacteria. Gram negative Preferred embodiments of the present invention are cleaning compositions suitable for use on human skin. The compositions of the present invention may also be useful for the treatment of acne. As used in the present "acne treatment" it refers to the prevention, delay and / or cancellation of the acne formation process in mammalian skin. The compositions of the invention may also potentially be useful to provide essentially immediate visual (ie, acute) improvement to the appearance of the skin after application of the composition to the skin. More particularly, the compositions of the present invention are useful for regulating skin diseases, including the regulation of visible and / or tactile discontinuities of the skin, including but not limited to visible and / or tactile discontinuities in the texture of the skin and / or color, more specifically discontinuities associated with skin aging. Such discontinuities can be induced or caused by internal and / or external factors. Extrinsic factors include ultraviolet radiation (e.g., from sun exposure), environmental pollution, wind, heat, low humidity, harsh surfactants, abrasives, and the like. Intrinsic factors include chronological aging and other biochemical changes within the skin. The regulation of skin diseases includes regulating the skin disease prophylactically and / or therapeutically. As used herein, prophylactically regulating skin disease includes removing layers, minimizing and / or avoiding visible and / or tactile discontinuities in the skin. As used herein, therapeutically regulating skin disease includes improving, for example, decreasing, minimizing and / or eliminating such discontinuities. The regulation of skin disease involves improving the appearance and / or sensation of the skin, for example, causing a smoother or more uniform appearance and / or feeling. As used herein, regular skin disease includes regular signs of aging. "Regulating Signs of Skin Aging" includes prophylactically and / or therapeutically regulating one or more of such signals (similarly, regulating a given signal of aging of the skin, for example, lines, wrinkles or pores, which includes prophylactically regulating and / or therapeutically regulate said signal). "Signs of skin aging" include, but are not limited to, all visible and tactilely perceptible manifestations as well as any other macro or microefectos due to aging of the skin. These signals may result from procedures that include, but are not limited to, the development of texture discontinuities such as wrinkles, including fine surface wrinkles and coarse deep wrinkles, skin lines, baldness, eruptions, large pores (eg, associated with afnexal structures). as learned of sweat gland, sebaceous gland, or hair follicles), scaly, lamellate consistency and / or other forms of disuniformity or roughness of skin, loss of skin elasticity (loss and / or inactivation of functional skin elastin), softening (including puffiness in the eye area and jaw), loss of skin firmness, loss of skin tension, loss of skin recovery from deformation, discoloration (including circles under the eye), blotching, sallowness, regions hyperpigmented skin such as age spots and freckles, keratosis, abnormal differentiation, hyperkeratinization, elastosis, decomposition collagen and other histological changes in the stratum corneum, dermis, epidermis, the skin tilting system (e.g., telangiectasia or spider vessels), and underlying tissues, especially those close to the skin. All percentages and ratios used herein, unless otherwise indicated, are by weight and all measurements are made at 25 ° C, unless otherwise designated. The invention herein may consist, consist of or consist essentially of the essential as well as optional ingredients and components described therein. 1. - Ingredients The rinsing antimicrobial cleansing compositions of the present invention comprise Triclosan®, an anionic surfactant, a proton donor agent, a lipophilic skin wetting agent, a stabilizer and water. Each of these ingredients is described in detail below.

A. Antimicrobial Active The rinsing antimicrobial cleaning compositions of the present invention comprise from about 0.1% to about 5%, preferably from about 0.1% to about 2%, and more preferably from 0.1% to about 1% of an active antimicrobial. Non-cationic actives are required in order to avoid interaction with the anionic surfactants of the invention. Examples of non-cationic antimicrobial agents that are useful in the present invention are given below. Pyrithiones, especially the zinc complex (ZPT) Octopirox® Dimethyldimethylolhydantoin (Glidant®) Methylchloroisothiazolinone / methylisothiazolinone (Kathon CG®) Sodium sulphite Sodium bisulphite Imidazolidinylurea (Germall 115®) Diazolidinylurea (Germall ll®) Benzyl alcohol 2-Bromo-2 -nitropropane-1,3-dioI (Bronopol®) Formalin (formaldehyde) iodopropenyl Butylcarbamate (Polifase P100®) Chloroacetamide Methanamine Metildibromonitrile-GIutaronitrile (1,2-Dibromo-2,4-dicyanobutane or Tektamer®) Glutaraldehyde 5-bromo- 5-nitro-1, 3-dioxane (Bronidox®) Phenethyl alcohol o-Phenylphenol / sodium o-phenylphenol Sodium hydroxymethylglycan (Suttocide A®) Bicyclic polymethoxyoxazolidine (Nuosept C®) Dimetoxan Timersal Dichlorobenzyl alcohol Captan Chlorphenenesin Dichlorophene Chlorbutanol Glycerylurea Halogenated diphenyl ethers Ether 2,4,4, -trichloro-2, -hydroxy-diphenium (Triclosan® or TCS) 2,2'-Dihydroxy-5,5, -diobromo-d-phenyl ester phenolic compounds phenol 2-methylphenol 3-methylphenol 4-methylphenol 4-ethylphenol 2,4-dimethylphenol 2,5-dimethylphenol 3,4-dimethylphenol 2,6-dimethylphenol 10 4-n-propylphenol 4-n-butylphenol 4-n- Amylphenol 4-tert-Amylphenol 4-n-hexylphenol 15 4-n-Heptyphenol Mono- and poly-alkyl aromatic allophenols p-chlorophenol Methyl p-chlorophenol Ethyl p-chlorophenol 20 n-propyl p-chlorophenol n-butyl p-chlorophenol n -amil p-chlorophenol sec-amyl p-chlorophenol n-hexyl p-chlorophenol Cyclohexyl p-chlorophenol n-heptyl p-chlorophenol n-octyl p-chlorophenol o-chlorophenol Methyl o-chlorophenol Ethyl o-chlorophenol n-propyl o-chlorophenol n-butyl o-chlorophenol 10 n-amyl o-chlorophenol tert-amyl o-chlorophenol n-hexyl o-chlorophenol n-heptyl o-chlorophenol o-benzyl p-chlorophenolo-benzyl-m-methyl p-chlorophenol o-benzyl-m, m-dimethyl p-chlorophenol or phenylethyl p-chlorophenol or phenylethyl-m-methyl p-chlorophenol 3-methyl p-chlorophenol 3,5-dimethyl p-chlorophenol 6-ethyl- 3-methyl p-chlorophenol 6-n-propyl-3-methyl p-chlorophenol 6-iso-propyl-3-methyl p-chlorophenol 2-ethyl-3,5-dimethyl p-chlorophenol 6-sec-butyl-3- methyl p-chlorophenol 2-iso-propyl-3,5-dimethyl p-chlorophenol 6-diethylmethyl-3-metii p-chlorophenol 6-iso-propyl-2-ethyl-3-methyl p-chlorophenol 2-sec-amyl- 3,5-dimethyl p-chlorophenol 2-diethylmethyl-3,5-dimethyl p-chlorophenol 6-sec-octyl-3-methyl p-chlorophenol p-chloro-m-cresol p-bromophenol 10 Methyl p-bromophenol Ethyl p- bromophenol n-propyl p-bromophenol n-butyl p-bromophenol n-amyl p-bromophenol 15 sec-amyl-p-bromophenol n-hexyl p-bromophenol Cyclohexyl p-bromophenol o-bromophenol ter-amyl o-bromophenol 20 n-hexyl o-bromophenol n-propyl-m, m-dimethyl o-bromophenol 2-phenylphenol 4-chloro-2-methylphenol 4-cynor-3-methylphenol 4-chloro-3,5-dimethylphenol 2,4-dichloro-3,5 -dimethylphenol 3,4,5,6-terabromo-2-methylphenol 5-methyl-2-pentylphenol 4-isopropyl-3-methylphenol Para-chloro-meta-xylene (PCMX) Chlorothymol Phenoxyethanol Fenoxisopropanol 5-chloro-2-hydroxydiphenylmethane Resorcinol and its Derivatives Resorcinol methylresorcinol ethylresorcinol n-propyl resorcinol n-butylresorcinol n-amilresorcinol n-hexylresorcinol n-heptilresorcinol n-octilresorcinol n-nonilresorcinol fenilresorcinol Bencilresorcinol Feniletilresorcinol Fenilpropilresorcinol p-clorobencüresorcinol 5-chloro-2 , 4-dihydroxydiphenylmethane 4'-chloro-2,4-dihydroxydiphenyl-methane 5-bromo-2,4-dihydroxydiphenylmethane-4, -bromo-2,4-dihydroxydiphenyl-methane Bisphenol-2,2'-methylene-bis (4-chlorophenol) 2,2'-methylene compounds bis (3,4,6-trichlorophenol) 2,2'-methylene bis (4-chloro-6-bromophenol) bis (2-hydroxy-3,5-dichlorophenyl) sulphide) Bis (2-hydroxy-5-chlorobenzyl) sulphide Benzoic esters (Parabens) Methylparaben Propylparaben Butylparaben Ethylparaben Isopropylparaben Isobutylparaben Benzylparaben Methylparaben sodium Propylparaben sodium CarbanilidesHalogenates 3,4,4'-trichlorcarbanilides (Triclocarban® or TCC) 3-trifluoromethyl-4 , 4'-dichlorocarban 3,3 ', 4-trichlorocarbanilide Another class of antibacterial agents, which are useful in the present invention are the so-called "natural" anticaber assets, referred to as natural essential oils. These assets derive their names from their natural occurrence in plants. Typical natural essential oil antibacterial actives include anise, lemon, orange, rosemary, caulteria, thymus, lavender, clavero, hops, tea tree, citronella, wheat, barley, lemon, cedar leaf, cedar wood, cinnamon oils , grass pulguera, geranium, sandalwood, violet, blueberry, eucalyptus, verbena, pepper, benzoin gum, basil, fennel, fir, balsam, menthol, ocmea origanum, Hydastis carradensis, Berberidaceae daceae, Ratanhiae and Curcuma longa. Also included in this class of natural essential oils are the key chemical components of plant oils that have been found to provide the antimicrobial benefit. These chemicals include, but are not limited to, anethole, catecholane, camphene, carbacola, eugenol, eucalyptol, ferulic acid, farnesol, inoquitiol, propolene, limonene, menthol, methyl salicylate, thymol, terpiniol, verbenone, berberine, ratanhiae extract , cariophelene oxide, citronellic acid, curcumin, nerolidol and genariol.

Additional active agents are antibacterial metal salts. This class generally includes salts of metals in groups 3b-7b, 8 and 3a-5a. Specifically, they are the aluminum, zirconium, zinc, silver, gold, copper, lead, tin, mercury, bismuth, seleneo, strontium, ixtium, cerium, praseodymium, neodymium, prometheus, samarium, europium, gadolinium, terbiumium, dysprosium salts. , holmium, erbium, thulium, ytterbium, lutetium and mixtures thereof. Preferred antimicrobial agents for use herein are the broad spectrum active agents selected from the group consisting of Triclosan®, Triclocarban®, Octopirox®, PCMX, ZPT, natural essential oils and their key ingredients, and mixtures thereof. The most preferred antimicrobial active for use in the present invention is Triclosan®.

B. Anionic Surfactant The rinsing antimicrobial cleaning compositions of the present invention comprise from about 8% to about 18%, preferably from about 8% to about 16% and more preferably from 8% to about 12%, by weight of the personal cleansing composition, of an anionic surfactant. Without being limited by theory, it is believed that the anionic surfactant breaks the lipid in the cell membrane of the bacteria. The particular acid used herein reduces the negative charges on the cell wall of the bacteria, traverses through the cell membrane, weakened by the surfactant, and acidifies the cytoplasm of the bacteria. The antimicrobial active can then pass more easily through the weakened cell wall, and more efficiently poison the bacteria. Non-limiting examples of anionic foaming surfactants useful in the compositions of the present invention are described in McCutcheon's, Deterqents and Emulsifiers, North American edition (1990), published by The Manufacturing Confectioner Publishing Co .; McCutcheon's, Functional Materials, North American edition (1992); and in U.S. Patent No. 3,929,678 to Laughlin et al., issued December 30, 1975, all of which are incorporated by reference. A wide variety of anionic surfactants are potentially useful herein. Non-limiting examples of anionic foaming surfactants include those selected from the group consisting of alkyl and alkyl ether sulfatessulphated monoglycerides, sulphonated olefins, alkylarylsulfonates, primary and secondary alkanesulfonates, alkyl sulfosucinates, acryl taurates and acyl isethionates, alkyl glyceryl ether sulphonates, sulfonated methyl esters, sulfonated fatty acids, alkyl phosphates, acyl glutamates, acyl sarcosinates, sulfoacetates alkyl, acylated peptides, ether carboxylates, acyl lactylates, fluoroanionic surfactants, and mixtures thereof. Mixtures of anionic surfactants can be used effectively in the present invention.

Anionic surfactants for use in cleaning compositions include alkyl and alkyl ether sulfates. These materials have the respective formulas R1O-SO3M and R1 (CH2HO) x- O-SO3M, wherein R1 is a saturated or unsaturated, branched or unbranched alkyl group of 8 to 24 carbon atoms, x is 1 to 10, and M is a water-soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. Alkyl sulphates are preferably made by sulfation of monohydric alcohols (having from 8 to 24 carbon atoms) using sulfur trioxide or other known sulfation technique. Alkyl ether sulfates are typically made as condensation products of ethylene oxide and monohydric alcohols (having from 8 to 24 carbon atoms) and then sulfated. These alcohols can be derived from fats, for example, coconut or wood oils, or they can be synthetic. Specific examples of alkyl sulfates that can be used in the cleaning compositions are sodium, ammonium, potassium, magnesium, or TEA salts of lauryl or myristyl sulfate. Examples of alkyl ether sulfates that may be used include ammonium sulfate, sodium sulfate, magnesium, or laureth-3 TEA. Another suitable class of anionic surfactants are the sulphated monoglycerides of the form R 1 CO-O-CH 2 -C (OH) H-CH 2 -O-SO 3 M, wherein R 1 is a saturated or unsaturated, branched or unbranched alkyl group of 8 to 24 carbon atoms, and M is a water-soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. This is typically done by the reaction of glycerin with fatty acids (having from 8 to 24 carbon atoms) to form a monoglyceride and the subsequent sulfation of this monoglyceride with sulfur trioxide. An example of a sulfated monoglyceride is sodium cocomonoglyceride sulfate. Other suitable anionic surfactants include olefin sulfonates of the form R1SO3M, wherein R1 is a mono-olefin having from 12 to 24 carbon atoms, and M is a water-soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine , diethanolamine and monoethanolamine. These compounds can be produced by alpha olefin sulfonation by means of non-complex sulfur trioxide, followed by neutralization of the acid reaction mixture under conditions such that any sultone that has been formed in the reaction is hydrolysed to give the corresponding hydroxyalkanesulfonate. An example of a sulfonated olefin is C1-C6 alpha-olefin sulfonate. Other suitable anionic surfactants are linear sulfoalkylbenzene sulphonates of the form R 1 -C 6 H 4 -S 3? M, wherein R 1 is a saturated or unsaturated, branched or unbranched alkyl group of 8 to 24 carbon atoms, and M is a soluble cation in water such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. These are formed by the sulfonation of linear alkylbenzene with sulfur trioxide. An example of this anionic surfactant is sodium dodecylbenzenesulfonate.

Still other suitable anionic surfactants for this cleaning composition include the primary or secondary alkan sulfonates of the form R 1 S 3 M, wherein R 1 is a saturated or unsaturated, branched or unbranched alkyl chain of 8 to 24 carbon atoms, and M is a water-soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. These are commonly formed by the sulfonation of paraffins using sulfur dioxide in the presence of chlorine and ultraviolet light or another known sulfonating method. Sulfonation can occur in the secondary or primary positions of the alkyl chain. An example of an alkan sulfonate useful herein is the alkali metal or ammonium paraffinsulfonate of C? 3-C? . Other suitable surfactants are alkyl sulfosuccinates, which include disodium N-octadecylsulfosucinamate.; diammonium lauryl sulfosuccinate; N- (1,2-dicarboxyethyl) -N-octadecylsulfosucinate tetrasodium; diamyl ester of sodium sulfosucinic acid; dihexyl ester of sodium sulfosuccinic acid; and dioctyl esters of sodium sulfosuccinic acid. Also useful are taurates that are based on taurine, which is also known as 2-aminoethane-sulphonic acid. Examples of taurates include N-alkyl taurines such as that prepared by reacting dodecylamine with sodium isethionate according to the teaching of U.S. Patent 2,658,072, which is incorporated herein by reference in its entirety. Other examples based on taurine include the acyl taurines formed by the reaction of N-methyltaurine with fatty acids (having from 8 to 24 carbon atoms). Another class of anionic surfactants suitable for use in the cleaning composition are the acyl isethionates. Acyl isethionates typically have the formula R 1 CO-O-CH 2 CH 2 SO 3 M, wherein R 1 is a saturated or unsaturated, branched or unbranched alkyl group having from 10 to 30 carbon atoms, and M is a cation. These are typically formed by the reaction of fatty acids (having from 8 to 30 carbon atoms) with an alkali metal isethionate. Non-limiting examples of these acyl isethionates include cocoyl ammonium isethionate, sodium cocoyl isethionate, sodium laureth isethionate, and mixtures thereof. Still other suitable anionic surfactants are the alkylglyceryl ether sulphonates of the form R1-CH (SO4) -COOH, wherein R1 is a saturated or unsaturated, branched or unbranched alkyl group of 8 to 24 carbon atoms, and M is a water-soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. These can be formed by the reaction of epichlorohydrin and sodium disulfide with fatty alcohols (having from 8 to 24 carbon atoms) or other known methods. An example is sodium co-glyceryl sulphonate ether. Other suitable anionic surfactants include the sulfonated fatty acids of the form R1-CH (SO) -COOH and the sulfonated methyl esters of the form R1-CH (SO) -CO-O-CH3, wherein R1 is an alkyl group saturated or unsaturated, branched or unbranched, from 8 to 24 carbon atoms. These may be formed by the sulfonation of fatty acids or methylalkyl esters (having from 8 to 24 carbon atoms) with sulfur trioxide or by another known sulfonating technique. Examples include aliphatic acid coconut fatty acid and laurimethyl ester. Other anionic materials include phosphates such as monoalkyl, dialkyl, and trialkyl phosphate salts formed by the reaction of phosphorus pentoxide with branched or unbranched monohydric alcohols having from 8 to 24 carbon atoms. These could also be formed by other known phosphating methods. An example of this class of surfactants is sodium monodilauryl phosphate. Other anionic materials include acyl glutamates corresponding to the formula R1CO-N (COOH) -CH2CH2-CO2M, wherein R1 is a saturated or unsaturated, branched or unbranched alkyl or alkenyl group, of 8 to 24 carbon atoms, M is a cation soluble in water. Non-limiting examples of which include sodium lauroylglutamate and sodium cocoylglutamate. Other anionic materials include alkanoyl sarcosinates corresponding to the formula R1CON (CH3) -CH2CH2-C2M wherein R1 is a saturated or unsaturated, branched or unbranched alkyl or alkenyl group, of 10 to 20 carbon atoms, and M is a cation soluble in water. Non-limiting examples of which include sodium lauroyl sarcosinate, sodium cocoyl sarcosinate and lauroyl sarcosinate ammonium. Other anionic materials include the alkyl carboxylate ethers corresponding to the formula R1- (OCH2CH2)? -OCH2-C? 2M, wherein R1 is a saturated or unsaturated alkyl or alkenyl group, branched or unbranched of 8 to 24 carbon atoms, x is 1 to 10, and M is a water soluble cation. Non-limiting examples of which include sodium laurethcarboxylate. Other anionic materials include acyl lactylates corresponding to the formula R1CO- [O-CH (CH3) -CO] x -CO2M, wherein R is a saturated or unsaturated, branched or unbranched alkyl or alkenyl group of 8 to 24 atoms of carbon, x is 3, and M is a water-soluble cation. Non-limiting examples of which include sodium lauroylcarboxylate, sodium cocoylcarboxylate, and ammonium lauroylcaboxylate. The fluoroanionic surfactants can also be used. Any countercation, M, can be used on the anionic surfactant. Preferably the counter cation is selected from the group consisting of sodium, potassium, ammonium, monoethanolamine, diethanolamine, and triethanolamine. More preferably the countercation is ammonium. Although any of said surfactants can be employed in the liquid antimicrobial cleansing compositions herein, at least about 67%, preferably at least about 80% and more preferably at least about 90% of the anionic surfactant present in the Liquid antimicrobial compositions herein comprise a mixture of class A and class C surfactants as defined below. The weight ratio of the class A surfactants to class C surfactants ranges from about 5: 1 to about 1: 2, preferably from about 4: 1 to about 1: 1. The surfactants mainly used in the compositions of the present invention can be grouped into four classes based on their softness and antimicrobial efficacy. The four classes of anionic surfactants are defined below. Class A - The first class of anionic surfactants are those that are considered mild, but which improve antimicrobial efficacy to a minimum. These include the group consisting of alkyl ether sulfates; acyl monoglyceryl sulphates; alkyl glyceryl ether sulfates; acyl isethionates; acyltaurates; alkyl sulfosuccinates; alkylsulfoacetates; sulfonated olefins; alkyl sulfates having a predominant chain length of C8, C10, C16 or C18; and mixtures thereof. Class B - The second class of surfactants are those that are considered mild, but which improve antimicrobial efficacy. These include the group consisting of primary and secondary alcansulfonates, alkyl sulfates having a predominant chain length of C14, and mixtures thereof.

Class C - The third class of cationic surfactants are those that are considered rough but generally improve antimicrobial efficacy. These include the group consisting of alkylarylsulfonates, alkylsulfocarboxylates, sulfonated fatty acids, alkyl phosphates, alkylsulfates having to have a predominant chain length of C12, and mixtures thereof. Specific examples of harsh surfactants are lauryl phosphate, laurylbenzenesulfonate, monolaryl phosphate and lauryl sulfocarboxylate. Class D - The fourth class of surfactants consists of surfactants having a pka greater than 4.0. It has been found that such surfactants are generally mild and very effective. These include the group consisting of acyl sarcosinates, acylglutamates, alkyl ether carboxylates and mixtures thereof. It has been discovered that the nonionic surfactants of the group consisting of nonionic surfactants, cationic surfactants, amphoteric surfactants and mixtures thereof, inhibit the residual effectiveness benefits when used with anionic surfactants at high levels. The foregoing is more evident in the case of cationic and amphoteric agents, where it is believed that said amphoteric agents interfere with the ability of the anionic surfactant to interrupt the lipid in the cell membrane (charge-charge interaction). The ratio of the amount of said non-anionic surfactants to the amount of the anionic surfactant should be less than 1: 1, preferably less than 1: 2, and more preferably less than 1: 4 in the compositions herein. The rinsing antimicrobial cleaning compositions of the present invention preferably do not comprise hydrotropic sulfonates, particularly terpenoid salts, or mono- or binuclear aromatic compounds such as camphor sulfonate, toluene, xylene, eumeno and naphthene.

C. Proton donor agent The rinse antimicrobial cleaning compositions of the present invention comprise from about 2% to about 12%, more preferably from about 2% to about 10%, more preferably from about 2% to about 9%, and more preferably from about 4% to about 9% based on the weight of the personal cleansing composition, of a proton donor agent. "Proton donor agent" refers to any acid compound or mixture thereof, which results in an acid dissociated on the skin after use. The proton donor agents may be organic acids, including polymeric acids, mineral acids or mixtures thereof.

Organic Acids The proton donor agents that are organic acids remain at least partially dissociated in the pure composition and remain when the compositions are diluted during washing and rinsing. The proton donor agent of organic acid must have at least a pka value of less than 5.5. Such organic proton donor agents can be added directly to the composition in the acid form or can be formed by the addition of the conjugate base of the desired acid and a sufficient amount of a separate acid sufficiently strong to form the acid disassociated from the base . organic acid biological activity index Preferred organic proton donor agents are selected based on their biological activity. This activity is represented by an index of biological activity, Z, which is defined as: Z = 1 + 0.25pKa1 + 0.42logP The index of biological activity combines the characteristics of dissociation and hydrophobicity of the acid. It is important that the non-dissociated proton donating agent of the composition is deposited on the skin to reduce the negative charge on the cell wall. The acid dissociation constant, pKai, is indicative of the chemical's proton donor capacity in relation to the pH of the medium to which it is incorporated. Although the non-dissociated acid is the most preferred in the composition, acids with higher pKas are generally more preferred for a given pH product. The octanol-water partition coefficient, P, represents the tendency of materials in solution to prefer oils or water. Essentially it is a measure of the hydrophobic nature of a material in solution: the higher the division coefficient, the more soluble in oil, and less soluble in water. Although it is desired that the acids dissolved in the compositions arise from aqueous cleaner on application, are deposited on the oil-based skin and remain during rinsing, organic acids with higher octanol-water cleavage coefficients are most preferred. Preferred organic proton donor agents of the rinsing antimicrobial cleansing compositions of the present invention have a biological activity index greater than about 0.75, preferably greater than about 1.0 more preferably greater than about 1.5 and more preferably greater than 2.0.

Mineral acids The proton donor agents that are mineral acids will not remain dissociated in the pure composition. Despite this, it has been discovered that mineral acids can be effective proton donors for use herein. Without being limited by theory, it is believed that the strong mineral acid acidifies the carboxylic and phosphatidyl groups in proteins of the skin cells, thereby providing acid not dissociated in situ. These proton donor agents can only be added directly to the composition in the acid form. pH It is critical to achieve the benefits of the invention that the acid not disassociated from the proton donor agent (deposited or formed in situ) remains on the skin in the protonated form. Therefore, the pH of the non-rinsing antimicrobial compositions of the present invention must be adjusted to a sufficiently low level in order to form or deposit substantially non-destructive acid on the skin. The pH of the compositions should be adjusted and preferably regulated in the range from about 3.0 to about 6.0, preferably from about 3.5 to about 5.0 and more preferably from about 3.5 to about 4.5. A non-exclusive list of examples of organic acids that can be used as the proton donor agent are adipic acid, tartaric acid, citric acid, maleic acid, malic acid, succinic acid, glycolic acid, glutaric acid, benzoic acid, malonic acid , salicylic acid, gluconic acid, polyacrylic acid, its salts, and mixtures thereof. Especially preferred organic proton donor agents are the group consisting of malic acid, malonic acid, citric acid, succinic acid, and lactic acid, a non-exclusive list of examples of mineral acid to be used herein are hydrochloric, phosphoric, sulfuric and mixtures thereof.

D. Lipophilic Skin Moisturizing Agent The liquid rinseable, antimicrobial personal cleansing compositions herein comprise from about 1% to about 30%, preferably from about 3% to about 25%, more preferably about 5%. % to about 25% of a lipophilic skin moisturizing agent. It has been found that compositions containing a lipophilic skin moisturizing agent have improved their antibacterial efficacy compared to compositions that do not contain a lipophilic skin moisturizing agent. In addition, the lipophilic moisturizing agent of the skin provides a wetting benefit to the user of the personal cleansing product when the lipophilic moisturizing agent of the skin is deposited on the wearer's skin. Two types of rheological parameters are used to define the lipophilic moisturizing agent of the skin used herein. The viscosity of the lipophilic wetting agent of the skin is represented by the consistency (k) and shear rate (n). The lipophilic skin moisturizing agents for use herein typically have a consistency (k) ranging from about 5 to about 5000 poises, preferably from about 10 to about 3000 poises, more preferably about 50. to about 2000 poises, as measured by the consistency method (k) described later in the analytical methods section. The lipophilic skin moisturizing agents suitable for use herein also have a shear rate (n) ranging from about 0.1 to about 0.9, preferably from about 0.1 to about 0.5, more preferably around from 0.2 to around 0.5, as measured by the shear index method described later in the analytical methods section. Although not limited by theory, it is believed that lipophilic skin moisturizing agents have rheological properties different from those defined herein that are emulsified very easily and therefore do not deposit, or are too "rigid" to adhere or deposit to the skin and provide a moisturizing benefit. In addition, the rheological properties of the lipophilic wetting agent of the skin are also important for the user's perception. Some lipophilic moisturizing agents of the skin, when deposited on the skin, are considered very sticky and are not preferred by the user. In some cases, the lipophilic skin moisturizing agent may desirably be defined in terms of its solubility parameter, as defined by Vaughan in Cosmetics and Toiletries, Vol. 103, p. 47-69, October 1988. A lipophilic skin moisturizing agent having a Vaughan solubility parameter (VSP) of from 5 to 10, preferably from 5.5. to 9 is suitable for use in the present antimicrobial compositions. A wide variety of lipid type materials and mixtures of materials are suitable for use in the rinsing antimicrobial cleaning compositions of the present invention. Preferably, the lipophilic skin conditioning agent is selected from the group consisting of hydrocarbon oils and waxes, silicones, fatty acid derivatives, cholesterol, cholesterol derivatives, di-and tri-glycerides, vegetable oils, vegetable oil derivatives, liquid non-digestible oils, such as those described in US Patents 3,600,186 to Mattson; issued on August 17, 1971 and 4,005,195 and 4,005,196 to Jadacek et al; both issued on January 25, 1977, which are incorporated herein by reference, or mixtures of digestible or non-digestible liquid oils with solid polyol polyesters such as those described in U.S. Patent 4,797,300 to Jandacek; Issued on January 10, 1989; U.S. Patents 5,306,514 and 5,306,516 and 5,306,515 to Letton; all issued on April 26, 1994, which are incorporated herein by reference, and acetoglyceride esters, alkyl esters, alkenyl esters, lanolin and its derivatives, milk triglycerides, wax esters, beeswax derivatives , esterales, phospholipids and mixtures thereof. Grade acids, fatty acid soaps and water soluble polyols are specifically excluded from our definition of a lipophilic skin moisturizing agent. Oils and waxes of hydrocarbon: Some examples are petrolatum, microcrystalline waxes of mineral oil, polyalkenes, (hydrogenated and non-hydrogenated polybutene and polydecene), paraffin, wax, ozokerite, polyethylene and peridrosqualene. Hydrogenated and non-hydrogenated high molecular weight petrolatum and polybutene mixtures in which the ratio of petrolatum to polybutene is in the range of 90:10 to 40:60 are also suitable for use as the lipid skin wetting agent in the present compositions . Silicone Oils: Some examples are dimethicone copolyol, dimethyl polysiloxane, diethyl polysiloxane, high molecular weight dimethicone, mixed C 1 -C 30 alkyl polysiloxane, phenyl dimethicone, dimethiconol and mixtures thereof. More preferred are the non-volatile silicones selected from dimethicone, dimethiconol, mixed C 1 -C 30 alkyl polysiloxane, and mixtures thereof. Non-limiting examples of silicones useful herein are described in U.S. Patent No. 5,01,1681 to Ciotti et al., Issued April 30, 1991, which is incorporated by reference. Di- and Tri-glycerides: Some examples are castor oil, soybean oil, derived soybean oils such as maleated soybean oil, sunflower oil, cottonseed oil, corn oil, hazelnut oil, peanut oil, olive oil, cod liver oil, almond oil, avocado oil, palm oil and sesame oil, vegetable oils and vegetable oil derivatives; coconut oil and derived coconut oil, cottonseed oil and derived cottonseed oil, jojoba oil, cocoa butter, and the like. The acetoglyceride esters are used and one example is acetylated monoglycerides. Lanolin and its derivatives are preferred and some examples are lanolin, lanolin oil, lanolin wax, lanolin alcohols, lanolin fatty acids, isopropyl lanolate, acetylated lanolin, acetylated lanolin alcohols, lanolin alcohol linoleate, alcohol riconeleate of lanolin. It is most preferred when at least 75% of the lipophilic skin conditioning agent consists of lipids selected from the group consisting of: petrolatum, mixtures of petrolatum and high molecular weight polybutene, mineral oil, liquid non-digestible oils (octaesters of cottonseed sucrose) liquid) or mixtures of liquid digestible or non-digestible oils with solid polyol polyesters (for example sucrose octaesters prepared from C22 fatty acids) in which the ratio of digestible or non-digestible liquid oil to solid polyol polyester is in the scale from 96: 4 to 80:20, hydrogenated or non-hydrogenated polybutene, microcrystalline wax, polylakene, paraffin, waxen, ozokerite, polyethylene, perhydrosqualene; dimethicones, alkyl siloxane, polymethylsiloxane, methylphenylpolysiloxane and mixtures thereof. When as a mixture of petrolatum and other lipids is used, the ratio of petrolatum to the other selected lipids (polybutene or hydrogenated or non-hydrogenated polydecene or mineral oil) is preferably from 10: 1 to 1: 2., more preferably from 5: 1 to 1: 1. Stabilizers When a lipophilic skin moisturizing agent is used as the softness improver in the present antimicrobial compositions, a stabilizer may also be included at a level in the range of 0.1% 10%, preferably from 0.1% to 8%, more preferably from 0.1% to 5% by weight of the non-rinsing antimicrobial composition. The stabilizer is used to form a crystallizing stabilizing network in the liquid composition which prevents the drops of the lipophilic skin wetting agent from coalescing and separating the phase in the product. The network exhibits viscosity recovery that depends on the time after the shear (for example, thixotropy). The stabilizers used herein are not surfactants. The stabilizers provide improved shelf stability and tension, but allow the liquid personal cleansing composition to separate in the foaming, and thus provide for the increased deposition of the lipophilic skin moisturizing agent in the skin. The above is particularly true when the cleaning emulsions of the present invention are used in conjunction with an increase in sponge with polymer diamond mesh as described in Campagnoli; patent of E: U.A. ,144,744; Issued on September 8, 1992, incorporated herein by reference. In one embodiment of the present invention, the stabilizer employed is the personal cleansing compositions herein comprising a crystalline, hydroxyl-containing stabilizer said stabilizer can be a fatty acid containing hydroxyl, fatty ester or fatty soap in the substances similar to the Wax insoluble in water or similar.

The crystalline, hydroxy-containing stabilizer is selected from the group consisting of: where OR R2 is R1 or H R3 is R1 or H R is alkyl of Co-20 R5 is alkyl of Co-20, Re is alkyl of Co-20 R4 + R5 + W% - C10-22 and where 1 = x + y < 4; (I) OR II R7-c-OM where R7 is -F ^ (CHIH) xR5 (CHOH) and R6 M is Na +, k + or Mg ++, or H; and iii) mixing thereof. Some preferred hydroxyl-containing stabilizers include 12-hydroxystearic acid, 9-10-hydroxystearic acid, tri- 9, 10-dihydroxystearin and tri-12-hydroxystearin (hydrogenated resin oil is mostly tri-12-Hydroxystearin). Tri-12-hydroxystearin is most preferred for use in the emulsion compositions herein. When such crystalline, hydroxyl-containing stabilizers are used in the personal cleansing compositions herein they are typically present from about 0.1% to 10%, preferably from 0.1% to 8%, more preferably from 0.1% about 5% of the liquid personal cleansing compositions. The stabilizer is insoluble in water under an environment close to environmental conditions. Alternatively, the stabilizer employed in the personal cleansing compositions herein may comprise a polymeric thickener. When polymeric thickeners are like the stabilizer in personal cleansing compositions herein, typically it is included in an amount of about 0.1% about 5%, preferably about 0.3% about 3% by weight. the composition. The polymeric thickener is preferably an anionic, nonionic, cationic or hydrophobically modifying polymer selected from the group consisting of cationic polysaccharides of the cationic guar gum class with molecular weights of 1,000 to 3,000,000, anionic homopolymers, cationic and nonionic derivatives of acrylic and / or methacrylic acid, anionic, cationic and nonionic cellulose resins, cationic copolymers of dimethylalkylmonium chloride, acrylic acid, cationic homopolymers of dimethylalkylammonium chloride, cationic polyalkylene and ethoxypolyalkylene, polyethylene glycol of molecular weight from 100,000 to 4,000,000 , and mixtures thereof. Preferably, the polymer is selected from the group consisting of sodium polyacrylate, hydroxyethylcellulose, cetylhydroxyethylcellulose, and polyquaternium 10. Alternatively, the stabilizer employed in personal cleansing compositions herein may comprise fatty acid esters of C 10 -C 22 ethylene glycol. . The C10-C22 ethylene glycol fatty acid esters can also be desirably used in combination with the polymeric thickeners described above. The ester is preferably a diester, more preferably a C 14 -C 18 diester, more preferably ethylene glycol distearate. When the C10-C22 ethylene glycol fatty acid esters are used as the stabilizer in the personal cleansing compositions herein, typically about 3% are present around 10%, preferably about 5% around 8%, more preferably about 6% about 8% of the personal cleansing compositions. Another class of stabilizer that can be employed in the personal cleansing compositions of the present invention comprises dispersed amorphous silica selected from the group consisting of fumed silica and precipitated silica and mixtures thereof. As used herein, the term "dispersed amorphous silica" refers to small silica, finely divided non-crystalline having an average agglomerated particle size of less than 100 microns. Fuming silica, which is also known as ground silica, is produced by the hydrolysis of the vapor phase of silicon tetrachloride in a hydrogen-oxygen flame. It is believed that the combustion process creates silicon dioxide molecules that condense to form particles. The particles collide, adhere and concretize together. The result of this procedure is a three-dimensional branched chain aggregate. Once the aggregate cools below the melting point of the silica, which is about 1710 ° C, additional collisions result in the mechanical entanglement of the chains to form agglomerates. The precipitated silicas and the silica gels are generally made in aqueous solution. See, Cabot Tehcnical Data Pamphiet TD-100 entitled "CAB-O-SIL® Untreated Furnace Silica Properties and Functions", October 1993, and Cabot Technical Dat Pamphiet TD-104 entitled "CABO-SIL® Funded Silica in Cosmetic and Personal Care Products ", March 1992, both of which are incorporated herein by reference. The fumed silica preferably has an average agglomerate particle size on the scale of 0.1 micron to 100 micron, preferably 1 micron to 50 micron, and more preferably 10 micron to 30 micron. The agglomerates are composed of aggregates having an average particle size in the range of 0.01 microns to 15 microns, preferably 0.05 microns to 10 microns, more preferably 0.1 microns to 5 microns and more preferably 0.2 microns to 0.3 microns. The silica preferably has a surface area greater than 50 sq. m / gram, more preferably greater than 130 m2 / gram, more preferably greater than 180 m2 / gram. When amorphous silicas are used as the stabilizer herein, they are typically included in the non-rinsing compositions at levels on the scale of from about 0.1% to about 10%, preferably from about 0.25% to about 8%, more preferably from around 0.5% to around 5%. A fourth class of stabilizer that can be used in the non-rinsing antimicrobial compositions of the present invention consists of dispersed smectite clay selected from the group consisting of bentonite and ectorite and mixtures thereof. Bentonite is a colloidal aluminum clay sulfate. See Merck Index, Eleventh Edition, 1989, entry 1062, p. 164, which is incorporated by reference. Ectorite is a clay that contains sodium, magnesium, lithium, silica, oxygen, hydrogen and fluorine. See Merck Index, eleveth Edition, 1989, entry 4538, p. 729, which is incorporated herein by reference. When smectite clay is used as the stabilizer in the non-rinsing compositions of the present invention, it is typically included in amounts ranging from about 0.1% to about 10%, preferably from about 0.25% to about 8%, and more preferably from about 0.5% to about 5%. Other known stabilizers, such as fatty acids and fatty alcohols, can also be used in the present compositions. Palmitic acid and lauric acid are especially preferred for use herein.

F. Water The rinsing antimicrobial cleansing compositions of the present invention comprise from about 35% to about 88.8%, preferably from about 45% to about 80%, more preferably from about 55% to about 75%. Water. The rinsing antimicrobial cleaning compositions of the present invention have an apparent or pure viscosity of about 500 cps at about 60000 cps at 26.7 ° C, preferably at 5000 to 3000 cps. The term "viscosity", as used herein, refers to viscosity as measured by a Brookfield RVTDCP with a CP-41 spinner at 1 RPM for 3 minutes, unless otherwise indicated. The "pure" viscosity is the viscosity of the undiluted liquid cleaner.

G. PREFERRED OPTIONAL INGREDIENTS Softness Enhancers In order to achieve the required smoothness of the present invention, optional ingredients may be added to improve softness to the skin. These ingredients include cationic and non-ionic polymers, co-surfactants, humectants and mixtures thereof. The polymers useful herein include polyethylene glycols, polypropylene glycols, hydrolyzed bound proteins, hydrolyzed milk proteins, hydrolyzed keratin proteins, guar hydroxypropyltrimonium chloride, polyquats, silicone polymers and mixtures thereof. Polymers, preferably cationic polymers, are preferably included in the compositions herein at a level of from about 0.1% to about 10% of the composition. Surfactant coagents useful herein include nonionic surfactants such as the Genapol® 24 series of ethoxylated alcohols, POE (20) sorbitan monooleate (Tween® 80), polyethylene glycol cocoate and Pluronic® propylene oxide / ethylene oxide block polymers. , and amphoteric surfactants such as alkylbetaines and alkylsultains. Surfactant coagents are typically included in the compositions herein at a level ranging from about 2% to about 70% by weight of the anionic surfactant.

H.- Other optional ingredients The compositions of the present invention may consist of a wide range of optional ingredients. CTFA International Cosmetic Inqredient Dictionarv, Sixth Edition, 1995, which is incorporated by reference herein in its entirety, discloses a wide variety of non-limiting cosmetic and pharmaceutical ingredients commonly used in the skin care industry, which are suitable for use in the compositions of the present invention. Non-limiting examples of functional classes of ingredients are described on page 537 of this reference. Examples of those functional classes include: abrasives, anti-acne agents, cake antiforming agents, antioxidants, mixers, biological additives, volumetric agents, chelating agents, chemical additives, colorants, cosmetic astringents, cosmetic bioisides, denaturants, drug astringents, emulsifiers, external analgesics, film formers, fragrance components, humectants, oating agents, plastisers, preservatives, propellants, reducing agents, skin whitening agents, skin conditioning agents, (emollients, humectants, various, and occlusives) , skin protectants, solvents, foam boosters, hydrotropes, solubilizing agents, suspending agents (non-surfactants), sunscreen agents, ultraviolet light absorbers, and agents to increase viscosity (aqueous and non-aqueous). Examples of other functional classes of materials useful herein that are well known to one skilled in the art include solubilizing, sequestering, and keratolytic agents, and the like.

II. METHODS OF MANUFACTURING NON-RINSING ANTIMICROBIAL COMPOSITIONS The non-rinsing antimicrobial compositions of the present invention are made by art-recognized techniques for the various non-rinsing product forms. III. Methods for using the non-enisable antimicrobial composition The non-rinsable antimicrobial compositions of the present invention are useful for reducing the number of germs on the skin and controlling the dispersion of gram-negative and gram-positive bacteria over time. Typically, an appropriate or effective amount of the composition is applied to the area to be treated. Alternatively, a suitable amount of the topical composition can be applied through intermediate application to a fabric, sponge, pad, cotton ball, cushion or other application device. Generally, an effective amount of product to be used will depend on the needs and habits of use of the individual. Typical amounts of the present compositions useful for cleaning are in the range from about 0.1 mg / cm2 to about 10 mg / cm2, preferably from about 0.6 mg / cm2 to about 5 mg / cm2 of skin area to be cleaned.

ANALYTICAL TEST METHODS Consistency (k) and shear rate (n) of lipophilic wetting agent of the skin The tension-controlled rheometer Carrimed CSL 100 was used to determine the shear rate, n, and the consistency, k, of the lipophilic wetting agent of the skin used in the present. The determination was carried out at 35 ° C with the 2 ° cone measuring system of 4 cm typically established with an arrow of 51 microns and was carried out by the programmed application of a shear stress (typically around 0.6 dynes / square centimeter around 5,000 dynes / square centimeter) for a period. If said tension results in a deformation of the sample, that is to say the measurement geometry of at least 10-4 rad / sec, then said velocity of saber would be reported as a shear rate. These data were used to create a viscosity μ Vs. Shear rate? in flow curve for the material. Said flow curve could then be molded in order to provide a mathematical expression that describes the behavior of the material within the specific limits of the shear stress and shear velocity. These results were set with the following well-accepted energy law model (see for example: Chemical Engineering, by Coulson and Richardson, Pergamon, 1982 or Transport Phenomena by Bird, Stewart and Lightfoot, Wiley, 1960): Viscosity, μ k (? ') 1 n-l VISCOSITY OF THE LIQUID COMPOSITION OF PERSONAL CLEANING The Wells-Brookfield viscometer DV-II + plate model was used to determine the viscosity of the liquid personal cleansing compositions herein. The determination was carried out at 25 ° C with the cone measurement system of 2.4 cm ° (Spindle CP-41) with a gap of 0.013 mm between the two small pins in the respective cone and plate. The measurement was carried out by injecting 0.5 ml of the sample that was to be analyzed between the cone and the plate and the rotation of the cone at a fixed speed of 1 rpm. The resistance to rotation of the cone produced a torque that is proportional to the shear stress of the liquid sample. The amount of torque was read and computed by the discometer in units of absolute centipoises (mPa's) based on the geometric constants of the cone, the rotation speed, and the tension related to the torque.

EXAMPLES The following examples further describe and demonstrate embodiments within the scope of the present invention. In the following examples, all the ingredients were enlisted at an active level. The examples are given only for the purpose of illustration and are not limited to the present invention, just as many variations thereof are possible without departing from the spirit and scope of the invention. The ingredients are identified by the chemical name or CTFA.

Procedure to make hand soaps and gels for shower bath 1. - Examples 1 and 2 of hand soap and examples 2 and 3 of gel for shower bath All the ingredients except petrolatum, active and perfume and heat were added to the point necessary for the fusion of the stabilizer (approximately 87.7 ° C for trihydroxystearin). The cooling was below 46.1 ° C and active, petrolatum and perfume were added. The final pH was adjusted using NaOH or salt regulated in its pH. The remaining water was added to complete the product. 2. Example 1 shower gel for shower. Wetting oils and surfactant coagents and heat ingredients were added at 54.4-60 ° C until dissolved. In another container, primary surfactants, acid, pH regulated salt, preservatives, viscosity detergent builder (salt) and polymer were added. Heat was added at 54.4-60 ° C until dissolved. The mixtures were combined (no single mixture was used if oils were not present), when both were found at 54.4-60 ° C then cooling was started. When the mixture was below 46.1 ° C, antibacterial active and perfume were added. The final pH was adjusted using NaOH or salt regulated in its remaining pH. The remaining water was added to complete the product.

Claims (5)

NOVELTY OF THE INVENTION CLAIMS

1. - A rinsing antimicrobial cleaning composition comprising: a. from 0.1% to 1% of an antimicrobial active; b. from 8% to 18% of an anionic surfactant; c. from 2% to 12% of a proton donor agent; d. from 1% to 30% of a lipophilic skin moisturizing agent; and. from 0.1% to 4% of a stabilizer; and f. from 35% to 88.8% water; characterized in that at least 67% of the anionic surfactant comprises a mixture of class A surfactants and class C surfactants and wherein the weight ratio of the class A surfactants to class C surfactants varies from 5: 1. to 1: 2 and where the composition is adjusted to a pH of 3.5 to 4.5.

2. A rinsing antimicrobial cleaning composition comprising: a. from 0.1% to 1% of an antimicrobial active; b. from 8% to 18% of an anionic surfactant; c. from 0.15% to 2% salicylic acid; d. from 1% to 30% of a lipophilic skin moisturizing agent; and. from 0.1% to 4% of a stabilizer; and f. from 45% to 90.65% water; further characterized in that at least 67% of the anionic surfactant comprises a mixture of class A surfactants and class C surfactants wherein the weight ratio of the class A surfactants to class C surfactants varies from 5: 1. to 1: 2 and where the composition is adjusted to a pH of 3.0 to 5.5.

3. The rinsing antimicrobial cleaning composition according to any of the preceding claims, further characterized in that the antimicrobial active comprises Triclosan®.

4. A rinsable antimicrobial cleaning composition according to any of the preceding claims further comprising from 0.1% to 10% of a polymer selected from the group consisting of cationic polymers, non-ionic polymers and mixtures thereof.

5. A rinsing antimicrobial cleaning composition according to any of the preceding claims which additionally comprises from 20% to 70% by weight of the anionic surfactant of the mildness enhancing surfactant coagent selected from the group consisting of betaines, lauroamfoacetate and mixtures thereof. same. 6 .- The rinsing antimicrobial cleaning composition according to any of the preceding claims, further characterized in that the proton donor is an organic acid that has a biological activity index, Z, greater than 0.75. 7. The rinsing antimicrobial cleaning composition according to any of the preceding claims, further characterized in that the ratio of the amount of non-anionic surfactants to the amount of anionic surfactant is less than 1: 1. 8. The rinsing antimicrobial cleaning composition according to any of the preceding claims, further characterized in that the lipophilic wetting agent of the skin comprises petrolatum. 9. The rinsing antimicrobial cleaning composition according to any of the preceding claims, further characterized in that the stabilizer comprises 0.1% to 1.0% of crystalline tri-12-hydroxystearin and 0.5% to 2.0% of a stabilizer selected from the group that It consists of lauric acid, lauric alcohol and mixtures thereof. 10. A method for providing residual effectiveness against Gram-negative bacteria comprising the use of a safe and effective amount of a composition according to any of the preceding claims on human skin. 1. The method for treating acne comprising the use of a safe and effective amount of the composition according to any of the preceding claims on human skin.