MXPA99002171A - Pantimedia against the celuli - Google Patents

Abstract

A garment for treating the skin, a method for manufacturing the garment, and a method for using the garment for treating the skin, made of a clothing material, in particular a stocking material to be worn tight against the skin, It has a multiplicity of durable chemical bonding sites. Durable sites that are preferably of the type for making covalent bonds are linked to the binding molecules that form chemical hooks for the clothing material. Each of the chemical hooks has one or more semi-durable chemical binding sites of the type that can chemically bind a molecule of active ingredient to the binding agent, but that breaks down in the presence of skin conditions that are normal, such as normal skin pH, normal skin moisture, and normal skin heat generated by both body heat and heat from the friction of the garment being rubbed against the skin. The active ingredient molecules, such as theophylline molecules or theophylline complexes, bind to the binding agent, and are released into the skin when the press is used.

Description

PANTIMEDIA AGAINST CELLULITE FIELD AND BACKGROUND OF THE INVENTION The present invention relates, in general, to skin treatments using socks or other clothing made from stocking material that is worn tight on the skin, and in particular, to a new and useful product, to a method for manufacturing the product, and a method of treatment using the product, which first chemically bonds an active ingredient to the media material by a semi-durable bond, and then releases the active ingredient to the skin while the material is used on average, breaking the semi-durable bond using skin conditioners, such as pH, humidity, and / or heat. In the preferred embodiment of the invention, the media material is nylon, the active ingredient is theophylline, and the treatment is for cellulite. Cellulite is an accumulation of fatty tissue in the upper layers of the skin, which manifests itself as a "mattress button" defect in the skin. It is known that a class of physiological ingredients known as xanthines, are able to reduce the fatty tissue in the underlying skin if they are applied locally. The most common xanthines are caffeine, theophylline, and theobromine. Theophylline is the most common xanthine used in the treatment of cellulite. The North American Patent Number 4,288,433 to Koulbanis et al. Teaches the use of xanthine compounds, of which theophylline is one (caffeine is another) to treat cellulite. The xanthine compounds are combined with other chemical groups, or radicals, such as alkyls, allyls, propyols, and cyclohexyl. A composition containing xanthine compounds mixed with alpha-hydroxy acid and / or phytic acid to be applied to the areas affected by cellulite, is the subject of United States of America Patents Nos. 5,523,090 and 5,536,499, both to Znaiden et al. The compound is disclosed for direct application to a user's skin. U.S. Patent No. 5,051,449 to Kligman et al. Uses retinoid compounds applied directly to the skin to treat cellulite. The retinoid compound is preferably retinoic acid mixed in a commercial lotion. In U.S. Patent No. 4,086,922 to Henderson, a heated massager is disclosed for use in the treatment of cellulite. Other patents disclose the use of theophylline compounds to treat different medical disorders, such as U.S. Patent Number 3,962,243 to Roldan et al., Which teaches the use of meophylline-theophylline acetate to treat bronchial disorders and relieve the effects of histamine poisoning. The mepyramine is combined with an acetic acid suspension of 7-theophylline to form the claimed compound of the '243 from Roldan. In U.S. Patent No. 4,085,214 to Higuchi et al., A stable form of a theophylline compound is disclosed. Higuchi '224 combines theophylline with a phenylalkenyl group having from 2 to 8 carbon atoms in the alkenyl portion, to provide a theophylline drug useful in the treatment of asthma. U.S. Patent No. 4,241,682 to Konstandt, discloses vessel coating with polyethyleneimine solutions, to improve the movement of vessels through water. Patents on pantyhose or articles of clothing that have cosmetic treatment properties include Patent of the United States of America Number 4,152,784 to McGalliard, for a nylon stocking treated with a microencapsulated epilator. The epilator is released to the skin of a user, while the average is used, when the microcapsules are broken by contact with the hair. European Patent Number EP 009,499 to McGalliard corresponds to the Patent of the United States of North America Number 4,152,784. The Patent of the United States of North America Number 4,829,987 a Ste art, teaches a method for the treatment of cellulite, by wrapping the affected portions of the body of a person with a body wrap soaked in a mineral solution, and then exercising while wearing an exercise suit of vinyl. The mineral solutions of Stewart '987 must be heated, and they must leave a residue on the body of the person when they are used. The mineral solutions are discussed more fully in a book cited in the patent.

The mineral solutions appear to be very different from the THA compounds of the invention. U.S. Patent No. 5,575,012 to Fox et al. Covers a sock that has reduced friction with a user's foot, due to coating or impregnation, inter alia, with a fluoropolymer. U.S. Patent No. 5,051,256 to Barnes, teaches an iodine compound that can be bonded with nylon-4, to provide an antibacterial fabric having a prolonged release of iodine as the active agent. U.S. Patent No. 5,156,843 to Leong et al. Is for a fabric impregnated with coated microspheres to provide a controlled time release of the material used to coat the microspheres. U.S. Patent No. 5,614,212 to D 'Angelo et al. Discloses a transdermal application patch for a drug having the microencapsulated active substance, and combined with a polymeric skin enhancer. The preferred skin enhancer is polyvinylpyrrolidone or PVP. The specification of the British Patent GB No. 1,581,586 to Yamauchi discloses a stocking or pantyhose having a solid sanitary composition including a water-insoluble resin binder having a metal dispersed within the binder. The British Patent Number GB 1,361,289 to Alza Corp., and European Patent Application Number EP 436,729 to Kanebo Ltd., teach both treatment compositions using microcapsules initially attached to a bandage or media to apply the active ingredients to a person's skin. European Patent Number EP 174,108 to Jost discloses a porous patch of two-layer polymeric foam for the transdermal application of medicament to a person. Italian Patent Number 1,191,244 to Alza Corp. corresponds to United Kingdom Patent Number 1,361,289, and United States Patent Number 4,435,180. These patents teach a treatment composition that uses microcapsules initially attached to a media, to apply the active ingredients to a person's skin. The stocking provides a compression force against a person's skin, to make good contact between the composition and the skin. Italian Patent Number 951,409 to Eurand SPA discloses a method for applying microcapsules to textiles, such as underwear or lingerie. The microcapsules contain a fragrance. Italian Patent Number 1,093,259 in the name of Holzmann teaches an injectable composition containing theophylline. The Italian Patents Numbers 1,191,962 to Malesci, 1,217,516 to Caroprese, 1,258,343 to Comi, and 1,263,754, each teach compositions for the treatment of cellulitis. The compositions of these patents are different from the composition of the invention.

SUMMARY OF THE INVENTION It has been found that the compliance and application time of cellulite reduction agents are critical for the effectiveness of the treatment. The present invention provides a product, a method for manufacturing the product, and a treatment using the product, which anticipates compliance and prolonged treatment time in an automatic manner, by incorporating the active treatment ingredient into an article. of narrow fitting clothing, that is, a pledge, and in particular an average. A preferred embodiment of the present invention comprises a pantyhose or nylon stocking having polyethyleneimine (PEI) chemically bonded in a permanent manner by durable chemical bonds, to nylon, and ionically bound by a semi-durable chemical bond to theophylline acetate (THA) ), the active ingredient. Polyethyleneimine provides a durable chemical bond of nylon with theophylline acetate that increases the number of available ionic bond sites by a factor of -3. For the purpose of this description, a durable chemical bond or a binding site, is one that will not be broken by skin conditions, such as the pH of the skin (of about 5.5), the moisture of the skin, or the heat of the skin, due to friction or body heat. The durable link will also not break due to ordinary washing. The ionic or semi-durable bond requires a low pH (less than a pH of 5). Theophylline acetate can complex with a compound known as SILANTRIOL, which is known to improve the passage of chemicals through human skin. The ionic bond is referred to herein as semi-durable which is broken by one or more skin conditions selected from skin pH, skin moisture, and / or skin heat (due to the friction or body heat). However, the semi-durable bond is not broken by washing clothes in a usual manner (ie, with detergent, warm water, and agitation). When pantyhose is used, theophylline acetate is gradually released into the skin of the user of the ionic bond, and the pantyhose, due to a combination of three factors: pH increased above 5 by contact with the skin of the user ( the pH of the skin is about 5.5); moisture of the wearer's skin; and body heat and friction (collectively heat from the skin). Over time, theophylline acetate has ei. effect of reducing cellulite. The pantyhose can be "recharged" by soaking it in a solution of theophylline acetate. Pantyhose is treated chemically in a multi-step process to link polyethyleneimine and theophylline acetate to pantyhose. First, the pantyhose is washed twice in distilled water and dried.

Then, the pantyhose are immersed in a polyethyleneimine solution for 30 minutes with constant agitation. Following the immersion, the pantyhose are washed twice in nized water and dried. Now the polyethyleneimine is permanently bonded with the nylon of the pantyhose, creating the chemical bond to ionically bind theophylline acetate or other substances. Meanwhile, the theophylline-SILANTRIOL acetate complex is prepared by increasingly adding SILANTRIOL to a theophylline acetate solution, at a pH of 5.5. Then the pH of the theophylline-SILANTRIOL acetate complex is reduced below 5 before the next step. To ionically bind the theophylline-SILANTRIOL acetate complex to the polyethylenimine, the pantyhose with the polyethyleneimine chemical bond are immersed in a solution of the theophylline-SILANTRIOL acetate complex for 3 hours with constant stirring. Then the pantyhose is washed twice in nized water and dried. The resulting chemically treated pantyhose can be stored in the dry state indefinitely without decomposition of any of the chemical compounds or bonds. Accordingly, an object of the present invention is to provide a garment for treating the skin of a wearer with an active ingredient, which comprises a garment material having a multiplicity of durable chemical bonding sites, an agent molecule Chemically linked linkage with each of the durable link sites, each linker molecule having at least one semi-durable chemical binding site that can be broken by at least one of the skin's pH, skin moisture , and the heat of the skin, and a molecule of active ingredient linked to each semi-durable chemical binding site, such that the active ingredient chemically bonds with the garment, when the garment is not worn, and in such a manner that the active ingredient is released into the skin when the garment is worn, and the semi-durable binding sites are exposed to at least one of the pH of the skin, the moisture of the skin, and the heat of the skin, to break the bonds between the active ingredient molecules and the binding agent molecules. Another object of the present invention is to provide a method for manufacturing this garment, and a method for treating the skin with this garment. The different characteristics of novelty characterizing the invention are pointed out with particularity to the claims appended to, and forming a part of, this description. For a better understanding of the invention, its operational advantages, and the specific objects obtained by its use, reference is made to the accompanying drawings and to the descriptive matter, wherein the preferred embodiments of the invention are illustrated.

BRIEF DESCRIPTION OF THE DRAWINGS In the drawings: Figure 1 is a graph illustrating the circumference of the left thigh of a test subject, against time. Figure 2 is a graph similar to Figure 1, which shows the same results for the right thigh. Figures 3A and 3B show the chemical scheme for the preferred embodiment of the present invention. Figure 4 is a schematic illustration of the chemical formation of a product in accordance with the present invention.

DESCRIPTION OF THE PREFERRED MODALITIES The product of the present invention is a garment that is made of a clothing material of the type to be used tightly against the skin of a wearer, in particular a stocking, pantyhose, other underwear, or clothing similar, made from a wide variety of clothing material, again in particular a stocking material that closely fits against the skin, such as natural, synthetic, and semi-synthetic materials, including cotton (a cellulose fiber made from certain materials). plants), silk '(a fibroin scleroprotein, which contains glycine and alanine, secreted by the silkworm), rayon (a semi-synthetic fibrous cellulose), Dacron (a trademark of DuPont for a polyester fiber made of polyethylene terephthalate), and nylon (polyamide polymers characterized by the presence of a Amida group-CONH). The requirement of the present invention is that, regardless of the clothing material selected, a durable chemical bonding site, such as the regular amide groups along the nylon chain, or the regular ester locations throughout must be present. of the Dacron chain. Similar durable chemical bond sites can be identified and used in the case of other clothing fibers, such as rayon, silk, and cotton. The preferred durable bond is a covalent bond. The importance for the invention is that a binding agent molecule is chemically linked at one of these durable chemical bonding sites by a durable chemical bond, and that the binding agent itself provides one or more semi-durable bonds, such as as an ionic bond, to bind the active ingredient molecules in a material that can decompose in the presence of normal skin conditions, such as the pH of the skin, the moisture of the skin, and / or the heat of the skin. skin, including body heat and heat due to frictional movement of the garment against the skin. The binding agent can be thought of as the hook that binds the active ingredient to the clothing in a manner in which the active ingredient can be disconnected by breaking the semi-durable bond, due to the presence of one or more of the skin conditions. , to release the active ingredient towards the skin. To the knowledge of the applicant, this technique has never been used before to release active ingredients into the skin. The method for manufacturing the garment of the present invention involves chemically binding the binding agent molecules to the durable bond sites, and then, under conditions that are different from skin conditions, chemically binding the active ingredient molecules to the Semi-durable link agent binding sites. Although it is contemplated that multiplicities of durable and semi-durable chemical bond sites will be provided, it is not essential that each of the durable link sites receive one of the binding agent molecules, nor that each of the binding sites Semi-durable receive a molecule of active ingredient. It is sufficient that there are sufficient active ingredient molecules present to treat the skin, either cosmetically or physiologically, by releasing the active ingredient molecules towards the skin. Accordingly, it is understood that there may be many more durable and semi-durable chemical bond sites present, but, for the present description, only those to which the linking agent is attached, and which in turn the active ingredient molecule. The term "active ingredient molecule" also means that it includes both cosmetic substances and physiological substances. For example, skin moisturizers can be qualified as the active ingredient, as well as chemicals that can alleviate skin conditions, such as rashes, and also anti-cellulite ingredients, such as those disclosed in connection with the modality. preferred of the present invention. Turning now to Figure 3A, the chemical scheme of the present invention is disclosed. Compound [1] is the nylon chain that has been treated with polyethylenimine (PEI), to connect polyethyleneimine through durable chemical bonds, at the nitrogen sites along the nylon chain, at a pH of 10.3. The resulting treated nylon is combined with the active ingredient molecule [2], theophylline acetate (THA), as shown in Figure 3B, and at a pH of 2.5, to create the chain [3], where the theophylline acetate is bound in the ionic bonds, forming semi-durable bonds along the nylon chain.

Polyethyleneimine (PEI) is a weak polybasic aliphatic amine that, among all synthetic polymers, shows the highest concentration of amino groups per unit. Polyethylenimine is used to coat on the nylon support of socks, in order to prepare pantyhose with a lipolytic activity. The polyethyleneimine dissolved in distilled water shows an alkaline pH (10.3), and is strongly absorbed by the nylon by means of electrostatic bonds and H-bonds between the carbonyl groups of the nylon structure and the amine groups of the polyethylenimine. In the acid solution (pH of 2.5), polyethyleneimine has positive charges that can be coupled by ionic bonds with theophylline acetate. The present invention uses a complex of theophylline and silantriol chemically linked through the linking compound (polyethyleneimine) with nylon, which has been manufactured in a pantyhose. The theophylline-silantriol complex is released from the bond, or the linking compound, by a combination of water and pH. The nylon can be reloaded with theophylline as often as desired. Nylon is a linear compound that contains one nitrogen atom in every six carbon atoms. Figure 4 schematically illustrates a nylon 10 chain. Using a compound known as polyethylene imine (PEI) (10), it is possible to make a direct bond with the nylon at specific durable chemical sites 12. The bond of polyethyleneimine to nylon provides three sites of additional binding for the binding of theophylline. Theophylline is used not as a plain theophylline, but as theophylline acetate (THA). The presence of the acetate molecule allows the binding of theophylline with polyethyleneimine in a ratio of one molecule of polyethyleneimine to three molecules of theophylline acetate 18 at the 14 bonds.

Theophylline Acetate Complex with Silantriol: Silantriol is a silica-based compound that has been shown to increase the penetration of certain chemical compounds that do not easily pass into the skin. Silantriol can complex with theophylline acetate at a pH of 5. The method involves adding the silantriol in increments to a theophylline acetate solution, and adjusting the pH to 5.5. After adding the silantriol, the pH must again be adjusted to a lower level in order to bind the theophylline-silantriol acetate to the nylon.

Linking the Ingredients to Nylon: Step One The pantyhose are washed in distilled water twice, and dried (centrifugation). Step Two They are then placed in a polyethylenimine solution for 30 minutes with constant stirring at a pH of 10.3. "They are removed, washed twice in deionized water, and dried Step Three Then they are placed in a solution of the acetate complex of theophylline-silantriol for 3 hours at pH 2.5 with constant stirring, stirring, washing twice in deionized water, and drying.The compound is stable indefinitely in the dry state.

Release of the Nylon Theophylline-Silantriol Acetate Complex: Part of this invention refers to the release mechanism for releasing the theophylline-silantriol acetate complex from the pantyhose to reach the skin. The nylon binding molecule is permanently fixed to nylon in the pantyhose. The bond between polyethyleneimine and theophylline acetate is a pH-sensitive bond, which will break when the pH rises. The pH of the skin is 5.5, which is higher than the pH needed to bind the theophylline acetate to the nylon, so that it will be released slowly on the skin. This is a controlled release, and it is a critical part of the invention. Since the nylon is stretched with the user's movement, more theophylline acetate complex is released. The three elements that combine to release the theophylline acetate complex are (1) the pH of the skin, (2) the moisture of the skin, (3) the heat of the skin (due to friction and / or body heat) .

The distinctions and advantages of the invention include; 1. A compound with a permanent chemical bond is attached to the media material, which allows other active ingredients to be applied. This is called the "chemical hook". 2. The active ingredient is attached to the chemical hook, and not to the media material, for example nylon by itself. 3. The chemical hook allows an amplification of the available sites for the link. For example, a hook will bind three molecules of theophylline acetate complex. . The chemical hook allows linking many possible active ingredients.

. The chemical hook can be loaded with active material, such as theophylline acetate complex, as desired. 6. The release of this active substance is controlled by a combination of pH, humidity, and heat induced by friction.

Summary of Experimental Data; We have approximately 12 individuals who have used the pantyhose with good results. A person documented with photographs, ultrasound, and clinical evaluation was studied, and showed a reduction in the diameter of the thigh by 2.54 centimeters in 30 days. The evaluation of the binding of the theophylline complex and release has been done extensively, to demonstrate that the release is controlled. The active compound remains on the pantyhose for a minimum of 3 days, with a continuous sustained release. The pantyhose can be released at home with a simple rinsing or washing solution.

The keys to understanding the present invention are: The nylon is not chemically altered, but is supplied with an amplification compound to which physiologically active compounds can be added. The system allows a controlled release of the active substance by using specific pH values. The pantyhose can be recharged to taste. This is not a mechanical or compressed spray application or particle. It is a specific chemical bond of a controlled release mechanism that binds to nylon, and that is active bound to the release mechanism.

Product Description Against Tested Cellulite: The nylon thread is woven into a standard pair of pantyhose, and dyed. Then the pantyhose is washed in water at room temperature with moderate agitation, rinsed, and washed again. After centrifugation drying, the wet pantyhose is placed in a 1 percent polyethylenimine aqueous solution (PEI) for 30 minutes with continuous agitation and at a pH of 10.3, which was found to be critical. After removing the pantyhose from polyethyleneimine, it is rinsed twice in water, and dried by centrifugation. The moist pantyhose to which the binding agent or polyethyleneimine hook is durably linked by covalent bonds is placed in a 0.2 percent solution of 1,3-dimethyl-xanthine containing 0.1 percent to 0.5 percent silantriol for 3 hours with shaking. At the end of 3 hours, the panty hose is rinsed twice and dried in a forced hot air dryer. Theophylline is chemically linked by ionic bonding as the semi-durable bond, to polyethylene imine, which binds to nylon. All the test products were prepared at the same time.

Test Procedure: A woman with moderate to severe cellulitis was instructed to use the pantyhose against the treated cellulite for 8 hours a day. The pantyhose was loaded every fourth day, and a new pair was supplied, so that each pair represented 3 full days of use. Each night, the pantyhose was washed in light detergent and water. The person reported to the laboratory every week, for the circumferential measurements of his thighs, three photographs of sight, that is, anterior, posterior, and lateral. Ultrasound measurements and clinical evaluation were also made. Results; The results show a decrease of 2.54 centimeters in the circumference of both the right and left thighs during 4 weeks. The study continued for a total of 12 weeks, with an additional decrease in thigh circumference of approximately 1.27 cen. Figures 1 and 2 are graphs of observed thigh circumferences. The thighs appeared smoother, there was irregularity in the surface. The person stated that his previously tight jeans "felt pouchy and loose". The photographs showed a decrease in the diameter of the buttocks with less fat tissue in the hip. The skin felt firmer and smoother. Conclusions: Based on this initial study, the following conclusions can be drawn: 1. The pantyhose against cellulite is effective to reduce the circumference of the thighs by 2.54 centimeters in 4 weeks. 2. The pantyhose against cellulite is effective to reduce fatty deposits around the buttocks. 3. The pantyhose against cellulite is effective to reduce the irregular surface of the thighs. 4. The pantyhose against cellulite is effective to produce smoother and firmer thighs. 5. The pantyhose against cellulite is effective to reconfigure the appearance of the thighs and buttocks. Although the specific embodiments of the invention have been demonstrated and described in detail to illustrate the application of the principles of the invention, it will be understood that the invention can be incorporated in another manner without departing from these principles.

Claims (27)

NOVELTY OF THE INVENTION Having described the above invention, it is considered as a novelty, and therefore, the content of the following is claimed as property: CLAIMS

1. A garment for treating the skin of a wearer with an active ingredient, which comprises: a clothing material adapted to be worn tight against the skin, and having a multiplicity of durable chemical bonding sites; a linker molecule chemically linked to each of the durable link sites, each linker molecule having at least one semi-durable chemical binding site that can be broken by at least one of the pH of the skin, the moisture of the skin, and the heat of the skin; and a molecule of active ingredient linked to each semi-durable chemical binding site, such that the active ingredient chemically binds to clothing when clothing is not worn, and in such a manner that the active ingredient is released towards the skin when the clothing is worn and the semi-durable binding sites exposed to at least one of the pH of the skin, the moisture of the skin, and the heat of the skin, to break the bonds between the molecules of active ingredient and the binding agent molecules.

2. A garment in accordance with claim 1, characterized in that the binding agent molecules are linked by covalent bonds at the durable chemical bonding sites.

3. A garment in accordance with claim 2, characterized in that the active ingredient molecules are linked to the binding agent molecules by ionic bonds, which form the semi-durable chemical bonding sites. .

A garment in accordance with claim 3, characterized in that the garment material is an average material.

5. A garment in accordance with claim 4, characterized in that the media material is selected from the group consisting of nylon, Dacron, rayon, silk, and cotton.

6. A garment in accordance with claim 5, characterized in that the binding agent is polyethylene imine.

7. A garment in accordance with claim 6, characterized in that the active ingredient is theophylline.

8. A garment in accordance with claim 7, characterized in that theophylline is theophylline acetate.

9. A garment as claimed in claim 8, characterized in that the active ingredient molecule includes silantriol bound to theophylline acetate.

A method for manufacturing a garment for treating the skin of a wearer with an active ingredient, becoming the garment of a clothing material having a multiplicity of durable chemical bonding sites, and which is for a tight fitting garment that remains against the skin, comprising the method: chemically bonding to durable chemical bonding sites, binding agent molecules, with each binding agent molecule having at least one semi-durable chemical binding site that can be broken by a condition of the skin that understands at least one of the pH of the skin, the moisture of the skin, and the heat of the skin; and chemically bonding to the semi-durable binding sites, active ingredient molecules under conditions other than skin conditions, such that the active ingredient is chemically linked to the garment when the garment is not worn, and in such a manner that the active ingredient is released into the skin when the garment is worn, and the semi-durable binding sites are exposed to at least one of the pH of the skin, the moisture of the skin, and the heat of the skin, to break the links between the active ingredient molecules and the binding agent molecules.

11. A method according to claim 10, characterized in that it includes linking the binding agent molecules to the clothing material by covalent bonds., forming the durable link sites.

12. A method according to claim 11, characterized in that it includes linking the active ingredient molecules to the active ingredient molecules by ionic bonds, forming the semi-durable binding sites.

13. A method according to claim 112, characterized in that it includes chemically binding the active ingredient molecule to the semi-durable binding sites under a pH lower than a pH of 5, comprising the condition of the skin to break the ionic link a pH of at least a pH of 5.

14. A method according to claim 13, characterized in that it includes providing a media material as the clothing material selected from the group consisting of r and on , Dacron, rayon, silk, or cotton.

15. A method according to claim 14, characterized in that it includes providing nylon as the media material, providing polyethylene imine as the binding agent, and providing theophylline as the active ingredient.

16. A method according to claim 15, characterized in that it includes providing theophylline acetate as the active ingredient.

17. A method according to claim 16, characterized in that it includes providing theophylline acetate bound with silantriol as the active ingredient.

18. A method according to claim 17, characterized in that it includes chemically linking the binding agent molecules to the durable chemical binding sites, at a pH of about 4.2.

19. A method for treating the skin with an active ingredient, using a garment made of material having a multiplicity of durable chemical bonding sites, a molecule of bonding agent chemically linked to each of the durable bonding sites, each linker molecule having at least one semi-durable chemical binding site that can be broken by at least one of the pH of the skin, skin moisture, and skin heat, and a molecule of active ingredient linked to each semi-durable chemical bond site, in such a way. that the active ingredient is chemically bound to the garment when the garment is not worn, the method comprising: covering the skin tightly with the garment to expose the garment to the pH of the skin, to the moisture of the skin, and to the heat of the skin; and keep the skin covering for a sufficient time, in such a way that the active ingredient is released to the skin through the semi-durable binding sites that are exposed to at least one of the pH of the skin, the moisture of the skin , and the heat of the skin, to break the bonds between the active ingredient molecules and the binding agent molecules, and to release the active ingredient towards the skin.

20. A method according to claim 19, characterized in that it includes reloading the garment with active ingredient molecules, by chemical bonding of additional active ingredient molecules to the semi-durable chemical bonding sites, under different conditions of at least one of the pH of the skin, the moisture of the skin, and the heat of the skin, after an initial treatment of the use of the garment, and an initial release of the active ingredients towards the skin.

21. A method according to claim 20, characterized in that it includes providing a media material such as clothing material, selected from the group consisting of nylon, Dacron, rayon, silk, and cotton.

22. A method according to claim 21, characterized in that it includes treating cellulite, the linking agent being polyethylene imine, and the active ingredient being theophylline.

23. A method according to claim 22, characterized in that the active ingredient is theophylline acetate.

24. A method according to claim 23, characterized in that the active ingredient is theophylline-silantriol acetate.

25. A method according to claim 24, characterized in that it includes breaking the semi-durable binding sites by a skin pH of at most a pH of 5.

26. A method in accordance with that claimed in claim 25, characterized in that the garment comprises an average, the method including covering at least one user's legs with the average.

27. A method according to claim 26, characterized in that the garment comprises a pantyhose.