MXPA99000968A - Cleaning patch, developer of the state of the p - Google Patents

Abstract

The present invention. refers to a patch able to rid the skin of the impurities they present, which comprises, on a support, a polymeric matrix containing at least one active, the surface of the patch intended to come into contact with the adhesive skin, characterized in that it comprises a colored layer to be able to visu, quantify and / or qualify the impurities whose release can be favored by the active, and detached by said adhesive surface.

Description

CLEANING PATCH, DEVELOPER OF THE STATE OF THE SKIN DESCRIPTION OF THE INVENTION The present invention relates to a cleaning action patch. In addition to the cleansing action, the patch can perform other actions, in particular by the regulated release on the epidermis of one or more compounds pharmaceutically, cosmetically or chemically active der. Such patches are particularly effective in removing impurities present on the surface of the skin. Such impurities may comprise residues linked to environmental contamination, dead skin cells, sebum plugs, black spots, perspiration residues, etc. It is already known to use patches that allow, by transdermia, to penetrate active compounds. Such patches generally have a structure comprising several successive layers in the following order: a first layer, called the support layer, generally occlusive, that is to say, constituted by a waterproof material, mainly water, air, or active compound , so that it prevents deterioration and / or evaporation of the latter and facilitates the transfer; a second layer, called the REF layer. 29294 polymer, fixed on the support layer and containing the active compound, this layer being able to directly enter into contact with the skin; optionally, to facilitate the fixation of the patch on the skin, a layer of an adhesive material applied to the surface of the polymer layer and permeable to the active compound; finally, a protective release layer, which covers the polymer layer in an airtight manner, in order to protect it from any external contamination during the conservation time prior to the use of the patch. For example, it is known, in particular according to US-A-5 232 707, a patch structure consisting of an occlusive support layer and comprising, fixed on the latter, a polymer layer in a matrix of a polymer of silicone that includes, in a dispersed state, oil particles. On the other hand, an occlusive patch adapted for the treatment of wrinkles, of the aforementioned genus, comprising in an anhydrous matrix an active water-soluble compound in the form of a powder, can be described in document 096/14 822. This matrix can contain this matrix , in addition, an oil, used as a penetration agent.

By way of example also, we will say that FR-A-2 738 744 describes a patch for the regulated release of at least one cosmetically or dermopharmaceutically active compound, comprising a layer, fixed on a support layer, being constituted said layer by a hydrophobic polymeric matrix, in which particles of the possibly unstable active compound are dispersed in an oxidizing medium and particles of at least one hydroabsorbing agent, the deposit layer being anhydrous. Certain active agents such as keratolytics, such as salicylic acid, or also a-hydroxy acids are used by a "pickling" action, effective to rid the skin of all its impurities, in particular the dead skin cells. Other active ingredients are used for their absorption action of sebum, certain fatty residues or transpiration. All these active substances, which come into contact with the skin, in particular by regulated release on or within the epidermis, are often relatively aggressive to the skin. It is, therefore, desirable not to use them more than necessary. It is already known to incorporate such assets in patches of the type described above. A drawback linked to all these devices is that it is difficult to evaluate the frequency of application necessary and sufficient to achieve a desired result, without unnecessarily attacking the skin. In addition, the treatment used is not always the treatment that best suits the treated skin. Accordingly, one of the objects of the invention is to make a cleansing action patch, and apt to inform the person who uses it regarding the frequency of necessary and sufficient application, and / or about the type of treatment that the skin needs. Another object of the invention is to provide a patch that incorporates active ingredients, which in addition to its action to rid the skin of its impurities, in whatever form, offer another action, in particular moisturizing, softening or healing. The present invention proposes a patch suitable for ridding the skin of the impurities it presents, comprising, on a support, a polymer matrix containing at least one active, the surface of the patch intended to be placed in contact with the skin being adhesive, characterized in that it comprises a colored layer to be able to visu, quantify and / or qualify the impurities extracted from the skin and present on said adhesive surface.

The adhesive surface is preferably self-adhesive when dry. As an alternative, the surface will be made adhesive by addition of water, forming a gel. In the latter case of figure, the patch can be applied dry on a previously wet skin, or applied wet on a dry skin. The active ingredient can be, in particular, a compound having an action that allows the impurities to be detached from the skin (for example, the keratolytic agents, which detach the cells from dead skin), and the separation can then be made on the patch by mechanical action. of the adhesive. It can also be one or several compounds contained in the matrix ', and capable of directly absorbing the fatty (tallow) or aqueous substances (perspiration). It can also be a mixture of such active ingredients. Thus, once detached from the skin, the patch will carry on its colored adhesive surface, all the impurities extracted in the course of the treatment. Such impurities are presented in different forms, mainly pieces of dead skin, black spots, fatty residues or transpiration. These impurities may have a solid form (usually light in color, particularly whitish) or in the case of fats or transpiration, form (relatively clear) aureoles visible on the colored surface of the patch, and as a result of "pumping" by the absorbent compounds present in the matrix- In the case of solid particles, these are detached by the adhesive layer, formed either by the matrix, or by an auxiliary layer. In other words, the adhesive itself can fulfill a mission of "peeling" the skin. In the case of particularly fatty liquids, the transfer to the patch can be done by absorption, thanks to the presence of absorbent assets in the matrix. The presence of the colored layer according to the invention makes it detectable visu, and 'allows to quantify (in number and size) and / or qualify the impurities on the colored surface of the patch. The amount of impurities taken is representative of the desirable frequency of application of said patch. Thus, the presence of a significant amount of such residues indicates to the user that the patch must be applied-on a relatively high frequency basis (eg, every day). A smaller amount of such impurities indicates that the frequency of use must be less (for example, once a week). Said in other terms, the patch according to the invention makes it possible to quantify the effectiveness of the treatment that it provides. In addition, the type of impurities released allows the user to choose in the best way the type of treatment necessary for their skin. Cleaning actives which can be used according to the invention include, in particular, keratolytic agents such as alpha- and beta-hydroxycarboxylic acids or beta-ketocarboxyliands, their salts, amides or esters and more particularly alpha-hydroxy acids such as the acid glycolic acid, lactic acid, tartaric acid, malic acid, citric acid, mandelic acid and, in general, fruit acids and beta-hydroxy acids such as salicylic acid and its derivatives, in particular alkoxylates such as n-octanoyl acid -5-salicylic. It is also possible to use active substances suitable for absorbing sebum, such as kaolin powder, polyamide particles (in particular those sold under the name "ORGASOL" by the Society ATOCHEM), the latter also having a softening action in contact with the skin. Tannins or Sienna can also be used for their absorbent properties. Also antibacterials, such as clindamycin phosphates, erythromycin or the antibiotics of the tet raciel inas class, can be used. Such active ingredients can be used in combination in particular with emollient agents, softening agents, in particular honey or waxes and / or healing agents, in particular certain mineral salts. Advantageously, the colored layer is of pronounced color, to make a sufficient contrast to highlight the impurities extracted from the skin, which are generally light in color. Typically, dark blue, dark green, dark red, black, brown, orange, etc. can be used. The polymer matrix can be constituted by a matrix with a polyacrylic, polyvinyl adhesive base or a hydrophobic matrix based on a silicone or polyurethane polymer of the polyester polyurethane or polyether polyurethane type. If appropriate, a crosslinking catalyst or polyaddition agent is preferably used in an amount such that crosslinking or polyaddition is not complete, so that the polymer layer itself has a satisfactory self-adhesive character, so as to advantageously avoid that the layer is supported is then coated with an adhesive layer. It is also possible to use a polymer, for example a polyacrylic compound, in solution in a solvent, in particular ethyl acetate or alcohol. The adhesion of the patching according to the invention is typically between 50 and 800 g / cm 2 (force exerted perpendicular to the plane of the adhesive surface, necessary for its peeling) and preferably between 100 and 700 g / cm 2, and even better between 300 and 600 g / cm2. The surface of the matrix intended to contact the skin can be smooth or have roughness or relief. Advantageously, the matrix formed by the polymer layer may contain particles of at least one hydro-absorbing agent dispersed homogeneously in said matrix. Indeed, upon contact with skin moisture, the particles of the hydroabsorbing agent take up water, thus favoring the solubilization of the solid, water-soluble active compound. In some way, by this "in situ" solubilization of the water-soluble active, its bioavailability is almost instantaneous and any eventual interaction with the other compounds present in the polymeric layer is minimized. The moisture of the skin can play the role of solubilizing the water-soluble active, the more so as the layer supporting the patch can create occlusive conditions. Among the hydroabsorbent agents that may be present in the hydrophobic polymer matrix in the dispersed state, there may be mentioned, preferably, the superabsorbent crosslinked polyacrylates of high expansion index in water, such as those marketed by NORSOLOR under the name Aqua eep, polyvinyl alcohol; carboxyvinyl polymers such as those marketed by the GOODRICH Company under the names of "Carbopol"; Semisynthetic derivatives of cellulose, such as carboxymethylcellulose / natural substances such as starches, natural gums (guar gum, gum arabic, gum trapping), casein, phytocolloids (carrageenans, alginates, agar-agar), cotton fibers and gelatin. It is very particularly preferred to use the superabsorbent crosslinked polyacrylates whose presence in a dispersed state in a hydrophobic polymer matrix makes it possible to pump the perspiration for example, and favors, after hydration, a better contact with the particles of the other active substances present in the matrix, if appropriate. . The hydroabsorbent agent as defined is preferably present in a proportion between about 0.2 and about 20% by weight, and more particularly 0.5 to 10% relative to the total weight of the polymer layer. The support layer according to the present invention may be constituted by any suitable material impermeable to the active compounds contained in the adjacent polymer layer. The function of the support layer is not only to support the polymer layer, but also to serve as a protective coating thereof. It can have the same dimension as the polymer layer or a larger dimension, so that it extends beyond the periphery of the polymer layer. The support can be an occlusive support. By way of example, the support consists of a thermoplastic material, selected from high and low density polyethylenes, polypropylenes, polyvinyl chloride, ethylene and vinyl acetate copolymers, polyesters and polyurethanes, or a complex of such materials. These materials may also be present in layered form with at least one sheet of metal, such as an aluminum foil. The support layer can be of any suitable thickness, which provides the desired support and protection functions. Preferably, the thickness of the support layer is between about 20 and about 1.5 mm. Advantageously, the support layer is sufficiently flexible to be able to match perfectly with the profile of the skin, and not to cause the user an uncomfortable feeling. Preferably, however, the support is non-occlusive. In this latter hypothesis, a support consisting of a paper, a porous or perforated thermoplastic material, a fabric, a nonwoven fabric, a perforated nonwoven fabric is advantageously used. Preferably, the colored layer is formed with said matrix. The polymeric matrix can be colored by incorporation of colored pigments that do not operate any transfer on the skin. Such pigments are incorporated in a concentration that can vary from 0.1 to 10% relative to the total weight of the matrix, and preferably, from 0.1 to 2%. The support can be identical in color or different from that of the colored matrix. Advantageously, the support is of a light color or close to the color of the skin, in order to make the patch as discreet as possible on the skin. According to an alternative, the colored layer is formed by the support itself, the polymer matrix being transparent.

The colored pigments may in particular consist of pigments of the type used in the food or cosmetic field, in particular for lip polishes or nail polishes. By way of example, synthetic pigments or mineral pigments, in particular pigments of zirconium or cerium oxide, as well as iron or chromium oxides and ferric blue, can be mentioned, alone or in combination. Organic pigments can be used, particularly carbon black, barium, strontium, calcium lacquers (DC Red No. 7), aluminum. By way of a more specific example, a pigment bearing the reference DC violet 2 k7014, ® marketed by KOHNSTA M is used. Particles of one or more solid, water-soluble active compounds can be incorporated into the polymer matrix. Such active ingredients, used alone or in combination, are chosen from hydrophilic active ingredients classically used as antioxidants, anti-free radicals, moisturizers, depigmenting agents, lipo-regulators, anti-acne, anti-seborrheic, anti-aging, softeners, anti-wrinkles, keratol. T icos, anti-inflammatory, refreshing, healing, vascular protectors, antibacterials, antifungals, antiperspirants, deodorants, skin conditioners, immuno oduladores and nutrients. In particular, one or more active ingredients chosen, in particular, between ascorbic acid and its biologically compatible salts, enzymes, antibiotics such as clindamycin phosphate, tensor effect components such as soybean or wheat protein powders, can be used in particular. a-hydroxy acids and their salts, hydroxylated polyacids, sucrose and their derivatives, urea, amino acids, oligopéctides, water-soluble plant extracts, and yeasts, protein hydrolysates such as collagen and elastin, hyaluronic acid, mucopolysaccharides, vitamins B2, Bs, H, PP, panthenol, folic acid, acetylsalicylic acid, allantoin, glycolic acid, cdjic acid, hydroquinone, etc ... The matrix may also contain at least one fat-soluble compound selected from the following compounds: Da-tocopherol, DL-α-tocopherol, Da-tocopherol acetate, DL-α-tocopherol acetate / p ascorbyl starch, vitamin F and vitamin F glycerides, vitamins D, vitamin D2, vitamin B3, retinol, retinol esters, retinol palmitate, retinol propionate, ß-carotene, D-panthenol, farnesol, farnesyl acetate; jojoba and cassis oils rich in essential fatty acids; keratolytics such as salicylic acid, its salts and esters, n-octanoyl-5-salicylic acid and its esters, alkylesters of α-hydroxy acids such as citric acid, lactic acid, glycolic acid; Asian acid, madecassic acid, asiaticoside, centella asiatica extract, ß-glycyrrhetinic acid, α-bisabolol, ceramides such as 2-oleocilamino-1,3-octadecane; phytanetriol, milk sphingomycline, phospholipids of marine origin rich in polyunsaturated essential fatty acids, ethoxyquin; rosemary extract, lemon balm extract, quercetin, dried microalgae extract, steroidal anti-inflammatory. Such active ingredients can be incorporated in a solubilized state in oils, used alone or in combination, oils among which may be mentioned: oils of animal, vegetable or mineral origin, and in particular animal or vegetable oils formed by esters of fatty acid and of polyols, in particular liquid triglycerides, for example sunflower, corn, soya, pumpkin, grape pips, sesame, hazelnut, pistachio, apricot, almond or avocado oils; fish oils, glycerol tricaprocaprylate, or vegetable or animal oils of the R? COOR2 form where Ri represents the remainder of a higher fatty acid comprising from 7 to 19 carbon atoms and R2 represents a branched hydrocarbon chain containing from 3 to 20 carbon atoms, for example Purcellin oil; the oil of wheat germs, of calophyllum, of sesame, of cilantro, of safflower, the passionflower oil or passionflower, the oil of rosehip, of macadamia, of fruit nuggets (grape, blackcurrant, orange, kiwi), rape, copra, peanut, evening primrose, palm, castor, flax, jojoba, chila, olive or cereal germs, such as wheat germ oil, rice bran oil, shea oil; acetylglycerides; octanoates, decanates or ricinoleates of alcohols or polyalcohols; triglycerides of fatty acids; glycerides; paraffin oil, petroleum jelly, perhydroscale; fatty alcohols (stearyl alcohol, cetyl alcohol) and fatty acids (stearic acid) and their esters; polyalkyl (C? -C20) siloxanes and in particular those having trimethylsilyl end groups, preferably those whose viscosity is less than 0.06 m2 / s, among which linear polydimethylsiloxanes and alkylmethylpolysiloxanes such as cetyldimethicone (name CTFA). Mention may also be made of partially fluorinated hydrocarbon oils or perfluorinated oils, and in particular perfluoropolyethers and perfluoroalkanes. The oily phase, ie, the oil droplets dispersed by the polymer layer is present in a proportion of 0.1 to 30% by weight relative to the total weight of the composition. Preferably, this percentage is between 5 and 25%. Alternatively, the lipid-soluble active compound is incorporated in a hydrophobic polymer layer, in the form of a powder or granules. The patches according to the present invention can furthermore be protected with the presence of a peelable or peelable protective layer adjacent to the polymer layer and / or by an appropriate packaging, in particular impermeable to water and water vapor. When the polymer layer is protected by a protective release layer, it is removed at the time of use. It can be constituted with any material impermeable to the active compound as well as to any other component present in the polymeric matrix. Among the materials that can be used, we can preferably mention a sheet of silicone paper or a sheet of thermoplastic material treated to make it anti-adherent, for example by means of a varnish. Preferably, this protective release layer is made of polyethylene. Advantageously, the protection sheet is constituted by two parts that overlap in a middle portion of the patch, to facilitate its placement without the fingers coming into contact with the matrix containing the asset or the assets. In an alternative, the protection sheet extends on a surface superior to the surface of the patch, and protrudes beyond the limits of the same, to favor the takeoff. As is known, the patches according to the present invention can be cut following an appropriate contour corresponding to the surface area of skin to be treated, for example in the form of a mask for application on the face, in particular for application on the nose , the lips, the cheeks, the area between the nose and the upper lip, or on the forehead. It is well understood that the patches according to the present invention can be cut out in any other form necessary for an application on a certain area of the body. In general, the size of a patch according to the invention is between 0.25 and 500 cm2 and preferably between 1 and 30 cm2. The patches thus constituted and cut can be used, after the removal of the protective release layer, on a surface of skin that is treated, applying them directly on a skin whose transpiration liquid allows to obtain the desired release, if any, of the active compounds. hydrophilic. Preferably, such a patch is used for a relatively short application time, in comparison with the usual transdermal patches. Its duration of application is preferably between 30 s and 15 mn, and better still between 30 s and 5 mn. This relatively short period of application allows the incorporation of loads or assets in higher concentrations, the adherence factor being less critical than in the long-term application patches. Advantageously also, the patch according to the invention comprises at least one area of small dimension, in the form of a tongue or tab suitable for promoting the detachment of the patch. According to a preferred embodiment of the invention, a mixture is made from a polymer, mainly an acrylic polymer, solubilized in a solvent such as an alcohol, for example ethyl or ethyl acetate. The active ingredient (s) as well as the pigment or the coloring pigments are added to the mixture. The mixture is deposited on a non-adherent surface, in particular a siliconed polyethylene. The evaporation of the solvents is caused at a temperature between 30 and 100 ° C. An adhesive layer is thus obtained, on which a support is deposited, particularly a non-woven fabric. According to another embodiment of the present invention, in the case of a silicone or polyurethane matrix, the polymer matrix constituting the polymer layer is prepared by intimately mixing with stirring a silicone or polyurethane prepolymer, pigment or of the colored pigments and the active compound (s). The mixture thus obtained is then added at low temperature, generally at room temperature, either a crosslinking catalyst if the prepolymer is a silicone polymer, or an isocyanate polyisocyanate if the prepolymer is a polyester polyol or a polyether-polyol. The mixture is then introduced into a hopper and poured onto a polyethylene sheet, for example, constituting the removable or peelable protection film of the patch. Beyond the hopper, a scraper has been arranged which makes it possible to equalize the thickness of the polymer layer of the polymeric matrix, this thickness generally being between 10 and 300 μm. A sheet of the occlusive support layer or not, which can also be a polyethylene sheet, is then applied prior to calendering. The polymerization or polyaddition is preferably carried out at room temperature, in order not to deteriorate the active compound or compounds. In general, the polymerization or polyaddition that completes after about 24 hours at room temperature. After the calendering and before the polymerization or polyaddition is completed, the composite structure obtained in the desired forms can be trimmed immediately, which allows obtaining adjusted edges that avoid any escape phenomenon.

EXAMPLE 1 A composition comprising 79.5% by weight of acrylic polymer in solution in ethyl acetate is made; 0.5% red iron oxide pigments; ® 10% ORGASOL (polyamide particles); and 10% ascorbic acid.

After homogenization, the product is introduced into a hopper and extended by means of a scraper in a 0.8 mm thick layer on a polyethylene sheet with a thickness of 200 μm. This sheet can be previously treated on the surface to reduce its adhesion. The assembly is heated to 60 ° C to allow evaporation of the solvent. The adhesive matrix is dark red. A film of polyethylene (without anti-adhesive treatment) of 30 μm thickness constituting the support layer of the patch is then applied, and the assembly is calendered. An assembly is thus obtained comprising a support layer and a layer of self-adhesive polymer formed by a colored polyacrylic matrix, this assembly also comprising a protective release layer. From this set, different patch shapes can be cut out according to the desired uses. The patches, after being cut, are packed in polyethylene envelopes. For use, the patch, after removal of the protective cap-release, is applied directly on the forehead, for example, for a period of approximately 5 minutes.

Such a patch has a whitening action on the skin, linked to the presence of ascorbic acid. The ® presence of ORGASOL allows the released sebum ® to be pumped through the skin. The ORGASOL also has a softening action. After the detachment, the observation of the red face of the patch shows the presence mainly of visible aureoles, formed by the absorbed sebum, as well as of dead skin cells, of a light color, torn from the skin by mechanical action of the adhesive layer. The quantitative evaluation of the visible impurities on the colored surface allows to evaluate the necessary frequency of application of the patch.

EXAMPLE II A composition comprising by weight: 69.5% acrylic polymer in solution in ethyl acetate; 0.5% prussian blue pigments; 20% urea; and 10% salicylic acid. The operative modality corresponds substantially to that described in the preceding example. The adhesive matrix of the patch is dark blue.

Such a patch is particularly suited to the treatment of acne, with urea favoring the opening of the sebaceous glands. It also has a keratolytic action, due to the presence of salicylic acid, which favors the detachment of dead skin cells on the surface. The observation of the pronounced blue face of the patch shows the presence of dead skin cells, as well as other residues, generally of a light color, released under the combined action of salicylic acid and urea, and detached on the skin by mechanical action of the adhesive layer. The frequency of application of the patch depends on its number.

EXAMPLE III A solution is made which comprises by weight: 69.5% acrylic polymer in solution in ethyl acetate; 0.5% brown iron oxide pigments; 20% starch; and 10% ORGASOL®. The operative form corresponds substantially to that described in example I. The adhesive matrix of the patch is brown.

The combination of these active ingredients allows to absorb the fatty constituents (sebum) and hydrophilic constituents secreted by the skin, which gives the skin a matt, natural appearance and also provides a great sensation of softness. Again, the constituents absorbed by the patch are visible, in particular in the form of aureoles, on the colored side of the patch.

It is noted that in relation to this date, the best method known by the applicant to carry out the present invention, is the conventional one for the manufacture of the objects or products to which it refers. Having described the invention as above, the content of the following is claimed as property:

Claims (20)

1. Patch able to free the skin of the impurities it presents, which comprises, on a support, a polymeric matrix containing at least one active, the surface of the patch intended to be in contact with being adhesive. the skin, characterized in that it comprises a colored layer to be able to visu, quantify and / or qualify the impurities collected by said adhesive surface.

Patch according to claim 1, characterized in that the active ingredient is chosen from keratolytic agents such as alpha- and beta-hydroxycarboxylic acids or beta-ketocarboxylic acids, their salts, amides or esters and more particularly alpha-hydroxy acids such as glycolic acid, lactic acid, tartaric acid, malic acid, citric acid, mandelic acid and, in general, fruit acids and beta-hydroxy acids such as salicylic acid and its particularly alkylated derivatives such as n-octanoyl acid -5-salicylic; kaolin powder, ® polyamide particles (ORGASOL), waxes, honey, earth of Siena, tannins or mineral salts.

Patch according to claim 1 or 2, characterized in that the colored layer is of pronounced color, in order to make a sufficient contrast in order to show the impurities extracted from the skin.

4. Patch according to any of claims 1 to 3, characterized in that the polymer matrix is formed on the basis of an acrylic, vinyl, silicone or polyurethane polymer.

5. Patch according to any of claims 1 to 4, characterized in that the matrix contains at least one water-absorbing agent, selected from cross-linked superabsorbent polyacrylates, polyvinyl alcohol, carboxyvinyl polymers, isynthetic derivatives of cellulose, starches, guar, gum arabic or gum gums, casein, phytocolloids, cotton fibers and gelatin.

6. Patch according to any of claims 1 to 5, characterized in that the support is an occlusive support.

7. Patch according to claim 6, characterized in that the support is constituted by a thermoplastic material, chosen between polyethylenes of high and low density, polypropylenes, polychlorides of vinyl, copolymers of ethylene and of, vinyl acetate, polyesters and polyurethanes, or a complex of such materials.

8. Patch according to any of claims 1 to 5, characterized in that the support is non-occlusive.

9. Patch according to claim 8, characterized in that the support is constituted by a paper, a porous or perforated thermoplastic material, of a woven material, of a non-woven material, of a perforated nonwoven material.

10. Patch according to any of claims 1 to 9, characterized in that the colored layer is formed by said polymer matrix.

11. Patch according to claim 10, characterized in that the polymer matrix is colored by incorporation of colored pigments.

Patch according to Claim 11, characterized in that the pigments are chosen from synthetic, mineral pigments, in particular pigments of titanium oxide, zirconium or cerium, as well as zinc, iron or chromium oxides and blue ferric, or organic pigments, mainly carbon black, barium, strontium, calcium (DC Red No. 7), aluminum or a mixture of such pigments.

A patch according to any one of claims 1 to 12, characterized in that the matrix comprises at least one water-soluble active chosen from the following compounds: ascorbic acid and its biologically compatible salts, enzymes, antibiotics, components with a tensor effect, a- > hydroxy acids and their salts, hydroxylated polyacids, sucrose and their derivatives, urea, amino acids, oligopéctides, water-soluble and yeast plant extracts, protein hydrolysates, hyaluronic acid, mucopolysaccharides, vitamins B2, Bo H, PP, panthenol, folic acid, acetylsalicylic acid, allantoin, glyceric acid, kojic acid, hydroquinone.

14. Patch according to any of claims 1 to 13, characterized in that the matrix comprises at least one liposoluble compound selected from the following compounds: Da-tocopherol, DL-a-tocopherol, Da-tocopherol acetate, DL-a acetate - tocopherol, ascorbyl palmitate, vitamin F and vitamin F glycerides, vitamins D, vitamin D2, vitamin B3, retinol, retinol esters, retinol palmitate, retinol propionate, beta-carotene, D-panthenol, farnesol, acetate farnesyl; jojoba and cassis or blackcurrant oils rich in essential fatty acids; keratolytics such as salicylic acid, its salts and esters, n-octanoyl-5-salicylic acid and its esters, alkylesters of α-hydroxy acids such as citric acid, lactic acid, glycolic acid; Asian acid, acetic acid, asiaticoside, total extract of gotu kola, ß-glycyrrhetinic acid, α-bisabolol, ceramides such as 2-oleoylamino-1,3-octadecane; phytanetriol, milk sphingomycline, phospholipids of marine origin rich in polyunsaturated essential fatty acids, ethoxyquin; rosemary extract, lemon balm extract, quercetin, dried microalgae extract, steroidal anti-inflammatory.

15. Patch according to any of claims 1 to 14, characterized in that it comprises a peelable protection sheet before the application of the patch and impermeable to the component or components that enter the composition of the polymeric layer.

16. Patch according to claim 15, characterized in that the protection sheet is constituted by two parts that are superimposed on a middle portion of the patch.

17. Patch according to any of claims 1 to 16, characterized in that it comprises at least one area of small dimension, able to form a pressure zone to detach the patch.

18. Patch according to any of the preceding claims, characterized in that its duration of application is between 30 s and 15 nm, and preferably between 30 s and 5 nm.

19. Patch according to any of the preceding claims, characterized in that its adhesive power is between 50 and 800 g / cm2, preferably between 100 and 700 g / cm2, and better still, between 300 and 600 g / cm2.

20. Patch according to any of the preceding claims, characterized in that its shape adapts to the shape of the nose, the lips, the area between the nose and the upper lip, or the forehead.