MXPA98003749A - Hydrophobically modified polysaccharides in personal hygiene products - Google Patents

Abstract

The present invention relates to a personal care composition composed of: (a) from 0.1% to 99% by weight of a vehicle system comprising a water-soluble, non-ionic, hydrophobically modified polysaccharide polymer comprising a structure of water-soluble polysaccharide polymer and a hydrophobic fraction selected from the group consisting of a 3-alkoxy-2-hydroxypropyl group, wherein the alkyl fraction is a straight or branched chain having two to six carbon atoms, alkyl C3-C7, alkyl aryl, alkyl aryl groups and mixtures thereof, wherein the ratio of the hydrophilic portion to the hydrophobic portion of the polymer is from 2: 1 to 1000: 1 and (b) at least one ingredient for personal care. This composition can be used in a wide range of personal care products such as shampoos, conditioners, hair coloring and styling agents, soaps, body washing agents, underarm products, lubricating agents, oral care products , denture adhesives, sunscreen agents, make-up products and the like

Description

HYDROFILICALLY MODIFIED POLYACARIDES IN PRODUCTS FOR PERSONAL HYGIENE.

This invention relates to the use of hydrophobically modified polysaccharides in personal care products. More specifically, this invention relates to the use of said polysaccharides in personal care products where the alkyl fraction of the hydrophobe has from one to seven carbon atoms.

Prior to the present invention, nonionic water soluble polysaccharides were used in personal care applications of shaving products, such as shaving creams and gels for shaving, shampoos, hair conditioners, hair coloring systems, skin creams, lotions, facial cleansing products, underarm products, such as deodorants, antiperspirants and mixtures thereof, lubricating gels, products for the oral care, such as toothpastes and tooth washes, denture adhesives, conditioning agents for hair styling, such as hair gels and creams, soaps, rinse gels, body washes, make-up products, hair-blocking products sun, and the like. Widely used polysaccharides commercially available include nonionic water soluble polysaccharide ethers such as methyl cellulose (MC), hydroxypropylmethylcellulose (HPMC), hydroxyethylcellulose (HEC), hydroxypropylcellulose (HPC), and ethylhydroxyethylcellulose (EHEC) and hydroxypropyl guar (HP), hydroxyethyl guar, and HP starch and other nonionic starch and guar derivatives. In addition, hydrophobically modified polysaccharides are used in personal care products. The use of these prior art polysaccharides in personal care products sometimes have processing difficulties such as compatibility with other ingredients, solubility with some other ingredients, clarity (when necessary) and stability under alkaline conditions of care products. personal. In addition, the hydrophobically modified polysaccharide is used in personal care products.

U.S. Patent Nos. 5,106,609, 5,104,646 and 5,100,658 are examples of patents disclosing the use of nonionic cellulose ethers hydrophobically modified in personal care products. These patents disclose the use of high molecular weights (ie, 300,000 to 700,000) and substitution of long chain alkyl carbons in the hydrophobe (ie, 8 to 24 carbon atoms) for use in cosmetics for skin care and The hair. In addition, U.S. Patents Nos. 4,228,277 and 4,352,916 describe hydrophobically modified cellulose ether derivatives modified with long chain alkyl group substitution in the hydrophobe. U.S. Patent No. 4,845,207 discloses a non-ionic water-soluble, hydrifugically modified cellulose ether and U.S. Patent 4,939,192 discloses the use of said ether in building compositions.

Some of the nonionic cellulose ethers of the prior art have poor salt compatibility or solubility in some solvents used in personal care applications such as polyhydric alcohols while others are not tolerant to alkaline conditions. Accordingly, there is still a need in the personal care industry to have nonionic cellulose ethers that have good salt compatibility, good solubility in some solvents, and are tolerant to alkaline conditions while producing products that do not have color problems. , when it is desired.

It has been surprisingly found that the hydrophobically modified polysaccharide having a short chain alkyl group in the hydrophobic fraction has several advantageous properties over the water soluble polysaccharide of the prior art and its derivatives in personal care products. Any other water soluble polysaccharide or derivative can be used as the structure or backbone to form the hydrophobically modified polysaccharide of this invention. Consequently, for example, hydroxyethylcellulose (HEC), hydroxypropyl cellulose (HPC), methylcellulose (MC), hydroxypropylmethylcellulose (HPMC), ethylhydroxyethylcellulose (EHEC), and methylhydroxyethylcellulose (MHEC) and, agar, dextran, bean gum, starch, guar and other nonionic derivatives can all be modified. The amount of nonionic substituent such as methyl, hydroxyethyl, or hydroxypropyl does not appear critical insofar as there is a sufficient amount to ensure that the ether is soluble in water. The polysaccharides of this invention are nonionic having a sufficient degree of nonionic substitution to cause them to be soluble in water and to be further substituted with a hydrocarbon radical having about one to seven carbon atoms in an amount up to the amount which said polysaccharide is less than 1% by weight soluble in water.

The preferred polysaccharide structure is hydroxyethyl cellulose (HEC). The HEC that is modified to function in this invention is a commercially available material. Suitable commercially available materials are marketed by the Aqualon Division of Hercules Incorporated, of Wilmington, Delaware, United States of America, under the Natrosol brand.

The short chain alkyl modifier can be attached to the polysaccharide structure via an ether, ester, or urethane linkage. The ether bond is preferred since the reagents most commonly used to effect etherification are easily obtained, the reaction is similar to that commonly used for the initial etherification, and the reagents are usually handled more easily than the reagents used for modification via the other links The resulting bond is also usually more resistant to further reactions.

An example of the polysaccharides of the present invention is 3-alkoxy-2-hydroxypropylhydroxyethylcellulose which is completely soluble in water at room temperature. Typically, the 3-alkoxy-2-hydroxypropyl hydroxyethylcellulose used in this invention has a hydroxyethyl molar substitution (M.S.). (The number of moles of hydroxyethyl substituent per cellulose anhydroglucose unit in the cellulose molecule) of about 1.5 to 3.5. The alkylglycidyl radical is generally contained in an amount of about 0.05 to about 50% by weight, preferably about 0.1 to about 25% by weight, based on the dry weight of the substituted polymer. Preferably the alkyl group of the 3-alkoxy-2-hydroxypropyl group is a straight chain alkyl group having two to six carbon atoms. Exemplary radical modifiers are methyl-, ethyl-, propyl- butyl-, pentyl- and 2-ethylhexylglycidyl ether.

Generally, the preferred method for preparing the ethers of this invention comprises the precipitation of the nonionic polysaccharide in an inert organic diluent such as a lower aliphatic alcohol, ketone, or hydrocarbon and adding a solution of the alkali metal hydroxide to the resulting precipitate at a low temperature. When the ether is completely moistened, the reaction continues, with agitation, until it is complete. The residual alkaline is then neutralized and the product is recovered, washed with inert diluents, and dried. The etherification can also be carried out with C, C7 or halohydral halide but these are sometimes less reactive, less efficient, and more corrosive in such a way that it is preferred to use the epoxide.

Substantially the same procedure is used to join the hydrocarbon modifier via the ester or urethane linkage. Conventional methods of reaction precipitate of this type of modifier with polysaccharide, that is, without the alkaline, are ineffective. The alkaline step is required in order to ensure that the polysaccharide is india to the extent that the modifier can react substantially uniformly on all the polysaccharide molecules therethrough. If the reaction is not substantially uniform across the polysaccharide mass, the properties of improved solubility and cloud point are not met.

The hydrophobically modified polysaccharide of this invention shows significant improved salt tolerance in high salt systems compared to the hydrophobically modified polysaccharide which are commercially marketed for personal care applications.

Additionally, these polysaccharides have improved solubility in solvent systems used in personal care applications compared to the hydrophobically modified polysaccharide commercially marketed in the personal care industry. This salt tolerance of the polymer is determined by measuring the cloud point in a 15% sodium chloride solution. The cloud point is a temperature at which a clear solution begins to turn cloudy and the polymer begins to precipitate.

The hydroxyalkyl hydrophobically modified cellulose of the present invention is an essential ingredient of the vehicle system of personal care products. In some products, it may be substantially the only necessary ingredient for this vehicle system. Another ingredient that can be in the vehicle system is a surfactant that can be either soluble or insoluble in the composition. A compatible solvent can also be used in the vehicle system which can either be a single solvent or a mixture of solvents.

Examples of the surfactants are anionic, nonionic, cationic, switterionic, or amphoteric surfactants. The surfactant can be insoluble (or soluble) in the present invention and (when used) is present in the composition from 0.01 to about 25% by weight of the composition.

Synthetic anionic surfactants include alkyl ether and alkyl sulfates. Specific examples of alkyl ether sulfates which can be used in the present invention are trimethylene glycol ether sulfate alkyl coconut sulfate; trimethylene ether sulfate, sodium tallow alkyl glycol; hexoxyethylene sulfate sodium tallow alkyl; diethylene glycol ether sulfate sodium tallow alkyl; and sodium tallow alkyl sulfate.

Nonionic surfactants can be broadly defined as compounds that contain a hydrophobic fraction and a nonionic hydrophilic fraction. Examples of the hydrophobic fraction may be alkyl, aromatic alkyl, dialkyl siloxane, polyoxyalkylene, and fluoro-substituted alkyls. Examples of hydrophilic moieties are polyoxyalkylenes, phosphine oxides, sulfoxides, amine oxides and amides.

Cationic surfactants useful in vehicle systems of the compositions of the present invention contain amino or hydrophilic quaternary ammonium moieties which are positively charged when dissolved in the aqueous composition of the present invention.

Zwitterionic surfactants are exemplified by those which can be broadly described as derivatives of aliphatic, phosphonium and sulfonium quaternary ammonium compounds, where the aliphatic radicals can be straight or branched chain, and where one of the aliphatic substituents contains from about 8 to about of 18 carbon atoms and contains as an anionic water solubilizing group, for example, carboxy, sulfonate, sulfate, phosphate or phosphonate.

Examples of amphoteric surfactants that can be used in vehicle systems of the compositions of the present invention are those which are broadly described as derivatives of aliphatic secondary and tertiary amines where the aliphatic radical can be straight or branched chain and where one of the aliphaticsubstitutants it contains from about 8 to about 18 carbon atoms and contains an anionic water solubilizing group, for example, carboxy, sulfonate, sulfate, phosphate, or phosphonate.

The water-soluble (or insoluble) surfactant is used with the polysaccharide of the present invention from about 0.01% to about 25% of the composition.

In accordance with the present invention, the solvent used in the vehicle system must be compatible with the other components in the present composition. Examples of the solvents used in the present invention are water, mixtures of lower-water alkanols, polyhydric alcohols having from 3 to 6 carbon atoms and from 2 to 6 hydroxyl groups. Preferred solvents are water, propylene glycol, water-glycerin, sorbitol-water, and water-ethanol. The solvent (when used) in the present invention is present in the composition at a level of from 0.1% to 99% by weight of the composition.

The active component for personal care is optional since the vehicle system can be the active ingredient component. An example of this is the use of the vehicle system in a denture adhesive such as a cream or powder. However, when an active ingredient is needed for personal care, it must provide some benefit to the user's body. Examples of substances that can be suitably included in the personal care products according to the present invention are as follows: 1) perfumes, which give rise to an olfactory response in the form of fragrance and deodorant perfumes which in addition to providing a fragrance response can also reduce body odor; 2) skin coolers, such as menthol, menthyl acetate, menthyl pyrrolidone carboxylate N-ethyl-p-menthane-3-carboxamide and other menthol derivatives, which lead to a tactile response in the form of a cold sensation on the skin; 3) emollients, such as isosiopropyl myristate, silicone oils, mineral oils and vegetable oils which give rise to a tactile response in the form of an increase in the lubricity of the skin; 4) deodorants other than perfumes, whose function is to reduce the level of or eliminate the micro flora on the surface of the skin, especially those that respond to the development of bad body odor. Precursors of deodorants other than perfumes can also be used; 5) antiperspirant assets, whose function is to reduce or eliminate the appearance of perspiration on the surface of the skin; 6) moisture agents, which keep the skin moist by either adding moisture or preventing the evaporation of the skin; 7) cleaning agents, which remove dirt and oil from the skin; 8) sunscreen active ingredients, which protect the skin and hair from ultraviolet rays and other unforeseen light rays coming from the sun. In accordance with this invention a therapeutically effective amount will usually be from 0.01 to 10% by weight, preferably 0.1 to 5% by weight of the composition; 9) Hair treatment agents, which condition hair, clean hair, disentangle hair, act as hair stylist, anti-scalping agent, and hair growth promoters, hair inks and pigments, hair perfumes, hair relaxers , hair whitening agents, hair moisturizer, hair oil treatment agent, antifreeze agent; 10) agents for oral care, such as dentrificos and mouthwashes, that clean, whiten, deodorize and protect the teeth and gums; 1 l) dental adhesives that provide adhesion properties to the teeth; 12) products for shaving, such as creams, gels and lotions and lubricating bands of razor blades; 13) Tissue paper products, such as cleaning tissue, and 14) beauty aids, such as make-up powders, lipsticks, and eyeliners.

The list above are only some examples and is not a complete list of active ingredients that can be used in personal care compositions. Other ingredients that are used in these types of products are well known in the industry. In addition to the ingredients of above conventionally used in personal care, the composition according to the present invention can optionally also include ingredients such as colorants, preservatives, antioxidants, vitamins, activity enhancers, spermicides, emulsifiers, viscorating agents (such as salts, that is, NaCl, NH4C1 and KCl), and fats and oils.

The vehicle systems and personal care compositions of the present invention can be manufactured using conventional formulation and mixing techniques. The methods of manufacturing the various types of personal care compositions are described more specifically in the following examples. The following examples are set forth for illustrative purposes only, but it should be understood that other modifications of the present invention within the skill of personal care artisans can be made without departing from the spirit and scope of the invention.

EXAMPLE 1 Opaque Liquid Soap Formula Ingredients Weight% Water 75.73 Sodium C, 4-CI6 olefin sulfonate, 40% active 7.50 Sarcosinate lauroyl sodium, 30% active 6.66 Betaine cocoamidopropyl, 35% active 6, 66 Glycol stearate 1.00 HMHEC1 * 0.80 Propylene glycol 0.50 Glycerin 0.50 Tetrasodium EDTA 0.30 Stearalkonium chloride 0.10 Methylparaben 0.25 100.00 Procedure: 1. HMHEC1 * was dispersed in water . The PH was raised to about 8.0 to 8.5 to dissolve the polymer and mixed for 45 minutes. Methylparaben was added to the finished solution. 2. While the water-soluble polymer solution was slowly stirred, stearalkonium chloride, olefin sulfonate and glycol stearate were added. The mixture was heated to 80 ° C until all the glycol stearate melted and the solution became opaque. 3. The remaining ingredients were added while cooling the solution slowly to room temperature. 4. Added color and fragrance.

* This compound is 3-butoxy-2-hydroxyprohydroxyethylcellulose, having an aqueous viscosity of 25 ° C from a minimum of 2500 mPa s at%. measured on a Brookfield LVTD viscometer, and a turbidity point of around 72 ° C to 78 ° C that was treated with glyoxal COMPARATIVE EXAMPLE A Opaque Liquid Soap Formula The same experiment as in Example 1 was run with the following changes. Supercol U product was used instead of HMHEC 1. The Supercol material was dispersed in water and mixed for 45 minutes. Then, methylparaben was added. The remaining procedure was the same.

EXAMPLE 2 Bath Soap Formula Ingredients Weight% Water 65.70 Sodium olefin sulfonate CH-C, 6.00 Sodium lauroyl sarcosinate 10.00 Cocoamide MEA 3.00 HMHEC3 * 0.75 Natrosol 250HR 0.25 Disodium EDTA 0.20 Methylparaben 0.10 100.00 Procedure: 1. HMHEC3 * and Natrosol 250HR product were dispersed in water. The PH was raised to about 8.0 to 8.5 to dissolve the polymer and mixed for 45 minutes. Methylparaben was added to the finished solution. 2. In a separate vessel, the surfactants were combined, heated to 80 ° C, and mixed until homogeneous.

* This compound is 3-butox-2-hydroxy? Ropilhydroxyethyl cellulose, having an aqueous viscosity at 25 ° C of a minimum of 2000 mPa.s at 1% measured in a Brookfield LVTD viscosimeter, and a turbidity point of around 62 ° to 68 ° C with glyoxal treatment. 3 The surfactant solution was added to the water soluble polymer solution and mixed until well bonded. 4. The EDTA disodium was added and cooled to room temperature.

COMPARATIVE EXAMPLE B Bath Soap Formula The same experiment as in Example 2 was run with the exception that Natrosol 250HR material was used instead of HMHEC3.

Source and Description of Products Used in Examples 1 and 2 Generic or adopted name CTFA Brand Supplier Stearalkonium Chloride Ammonyx 4002 Stepan Chemical Co. Northfield, Illinois Sodium olefin sulfonate Bio-Terge AS-40 Stepan Chemical Co.

C, 4-C16 Northfield, Illinois Sarcosinate sodium lauroyl Hamposyl L-30 W.R. Grace & Co. Nashua, NH Betaine cocoamidopropyl Lexaine C Inolex Chemical Co. Philadelphia, PA Cocamide MEA Monamid CMA Mona Industries Inc. Paterson, New Jersey EDTA Tetrasodium Perma Kleer 100 Stepan Chemical Co. Northfield, Illinois HMHEC 3 Hercules Incorporated Wilmington, Delaware HMHEC I Hercules Incorporated Wilmington, Delaware Natrosol 250HR Hercules Incorporated Wilmington, Delaware EXAMPLE 3 Formula of Hair Conditioner for Baby Ingredients Pon centaie in Deso HMHEC3 1, 0 Water 74.1 Cetrimonium Chloride (25%) 12.2 Lauramine Oxide (30%) 10.2 Polyquaternium- 17 (62%) 1.5 Propylene Glycol 1, 0 Perfume, preservative amount up to 100, 0 Procedure: 1. The HMHEC3 was dispersed in water with good agitation; and the PH was raised to about 8.0 to 8.5 to dissolve the polymer and the dispersion was mixed for 45 minutes or until the dispersion completely dissolved. 2. The remaining ingredients were added in the order listed, they were mixed well between additions.

COMPARATIVE EXAMPLE C Baby Hair Conditioning Formula The same experiment was run as in example 3 with the following exceptions. CMC 7HF was used instead of HMHEC3. The CMC was dispersed in water and mixed for 45 minutes or until it completely dissolved. The remaining ingredients were added in the order listed, mixing well between additions.

EXAMPLE 4 Pearl Cream Rinse Formulation Ingredients Percent in Weight Phase A. HMHEC 1 1, 0 Natrosol 250HHR 0.3 Water 82.3 Phase B. Stearalkonium chloride (25%) 10.1 Propylene glycol 1.5 Glycol stearate 1.5 Oleth-20 1.5 Polyquaternium- 17 (62%) 1, 8 Perfume, preservative amount up to 100.0 Procedure: 1. HMHEC 1 and Natrosol 250HHR product were dispersed in water with good agitation; the pH was raised to 8.0 to 8.5 and the dispersion mixed until completely dissolved. 2. In a separate vessel, the steralconium chloride and propylene glycol were mixed together and heated to 80 ° C. 3. The other ingredients listed in phase B except for the perfume and preservative were added one at a time in the order listed to the mixture of stearalkonium chloride and propylene glycol and mixed well between each addition. 4. The surfactant mixture from step 3 was added to the HMHEC 1 solution, mixed well, and cooled to 35 ° C. 5. The perfume and preservative were then added to form the final formulation.

COMPARATIVE EXAMPLE D Permeate Cream Rinse Formulation The same experiment was run as in Example 4 except that CMHEC 420H was used instead of HMHEC 1. Raw materials and their sources for examples 3 and 4 Name Adopted CTFA Brand Provider Quaternium-48 Adogen 470 Sherex Chemical Co., Inc. Dublin, Ohio Oleth-20 Emulphor Rhone-Poulenc ON-870 Cranbury, New Jersey Animal protein Lexein X-250 Inolex Chemical Company hydrolyzed Philadelphia, Pennsylvania Polyquaternium- 17 Mirapol AD-1 Rhone-Poulenc Cranbury, New Jersey Cocamidopropylamine Oxide Ammonyx CDO Stepan Company Northfield, Illinois Rust Lauramina Ammonyx LO Stepan Company Northfield, Illinois Cloniro Cetrimonio Vapsoft E228 Sherex Chemical Co., Inc. Dublin, Ohio Chloride Stearalkonium Varisoft SDC Sherex Chemical Co., Ine Dublin, Ohio Hydroxyethylcellulose Natrosol 250HHR Hercules Incorporated hydroxyethylcellulose Wilmington, Delaware (as defined above) Carboxymethylhydroxy- CMHEC420H Hercules Incorporated ethylcellulose Wilmington, Delaware EXAMPLE 5 Smooth shampoo for every day Ingredients Percent in Weight Distilled water quantity up to 100.00 Sodium laureth sulfate, 28% 19.60 Betaine Cocoamidopropyl, 35% 1 1.00 Sarcosinate lauroyl sodium, 30% 9.60 Disterate PEG-150 2.90 HMHEC3 1, 10 Methylchloroisothiazolinone and methylisothiazolinone , 1, 5% 0.08 Procedure: 1. The HMHEC3 was dispersed by adding to the vortex of well-stirred water, heated to 60-70 ° C, in a vessel. 2. The surfactants, one at a time, were added to the container while mixing well between each addition. 3. The PEG-150 distearate was then added to the vessel, mixed until dissolved, and then heated and then removed from heating. 4. When the temperature was cooled to 40 ° C or less, the fragrance and condom were added to the formulation.

COMPARATIVE EXAMPLE E Smooth Shampoo for every day The same experiment was run as in Example 5 except that the product Natrosol Plus 430 was used in place of HMHEC3.

Gross Materials and their Sources Name adopted CTFA Brand Provider Betaine Cocoamidopropyl Lexaine C Inolex Chemical Co. Philadelphia, Pennsylvania Methylchloroisothiazolinone Kathon CG Rohm & Haas Co. and Methylisothiazolinone Philadelphia, Pennsylvania Methyl Paraben Methyl Parasept Kalama Chemicals, Inc. Garfield, New Jersey Distearato PEG-150 Keesco PEG Stepan Company 6000 DS Northfield, Illinois Sodium Laureth Sulfate, 28% Steol 4N Stepan Company Northfield, Illinois Sarcosinate sodium lauroyl Hamposyl L-30 W.R. Grace & Co. Lexington, Massachusetts Hydroxyethyl cellulose Natrosol Plus Hercules Incorporated hydrophobically modified 420 Wilmington, Delaware EXAMPLE 6 Lotion for hands and body Part Ingredients Percent by weight A HMHEC 1 0.50 Distilled water 78.25 glycerin, USP 2.00 B Glycol stearate (Emerest ® 2400) 2.75 Stearic acid (Industrene ® 5016K) 2.50 Mineral Oil (Dra eol ® 7) 2.00 Acetylated lanolin (Lipolan ® 98) 0.50 Cetyl alcohol (Crodacol ® C95) 0.25 C Distilled water 10.00 Triethanolamine 0.50 D Propylene glycol and diazolidinyl urea and methylparaben and propylparaben (Germaben ® II) 0.75 100.00 Procedure. 1. The HMHEC4 was dispersed by adding to the vortex of well-stirred water in a container of part A. The goucerin was then added with continued mixing and heated at 80 ° C for about 15 minutes. 2. In a separate vessel, the ingredients of part B were mixed together, heated to 80 ° C and mixed well. 3. The components of part A and part B were slowly mixed together while stirring vigorously to produce an emulsion.

This emulsion was maintained at a temperature of about 80 ° C with constant stirring. 4. Then, the ingredients of part C were added to the emulsion and the mixture was mixed continuously while cooling to 40 ° C. 5. The part D component (preservative) was added to this new emulsion and mixed well. 6. The formulation was then cooled and then emptied into containers. * HMHEC4 is 3-butoxy-2-hydroxy? Propylhydroxyethylcellulose having an aqueous viscosity of 25 ° C of at least 500 mPa.s at 1.0% measured in a Brookfield LVTD viscosimeter and a cloud point of about 62 to 68 ° C with treatment with glyoxal.

COMPARATIVE EXAMPLE F Lotion for hands and body The same experiment was run as in Example 6 except that Natrosol ® 250MR was used instead of HMHEC4.

Materials and their suppliers Name adopted CTFA Brand Provider Emerest 2400 glycol stearate Henkel Coforation Hoboken, New Jersey Stearic acid Industrene 5016K Witco Coforation Newark, NJ Mineral oil Drakeol Penreco Karns City, NJ Alcohol Cetyl Crodacol C-95 Croda Inc. Parsippany, NJ Propylene Glycol, Germaben II Sutton Laboratories Diazolidinyl Urea, Chatham, NJ Methylparaben and Propylparaben Acetylated Lanolin Lipolan 98 Lipo Chemical Patterson, NJ Natrosol 250MR Hydroxyethylcellulose Hercules Incoforated Wilmington, DE EXAMPLE 7 Aerosol Shaving Cream Ingredients Quantity, g Desinonized water 790.0 Sodium hydroxide (24.6% solution) 9.6 Potassium hydroxide (34.2% solution) 34.2 Stearic acid, doubly pressed 71, 6 Coconut acid 10.0 Propylene glycol 27 , 0 Lauramida DEA 10,0 Coconut oil 2,5 Sebum glycerides 30,0 Preservative (Germaben II) 5,0 Precipitate HMHEC3 10,0 Total 1000,0 Procedure: To prepare the shaving cream concentrate, sodium hydroxide. and the potassium hydroxide were added to the deionized water in a vessel at room temperature. The temperature of the vessel was then raised to 75 ° C and stirred for 5 minutes. The stearic acid and the coconut acid were pre-melted separately and then each was added to the caustic / water mixture and then stirred for 30 minutes followed by cooling to 55 ° C. The HMHEC3 was precipitated in the propylene glycol and added to the mixture. One at a time, lauramide DEA (melted), coconut oil, tallow glycerides (melted), and preservative were added to the vessel and stirred for 15 minutes and allowed to cool. This concentrate (225g) was weighed in a can of standard shaving cream. The can was then sealed with a valve assembly using a canning laboratory equipment and loaded with 9.0 g of propellant.

COMPARATIVE PLO SHAFT G Spray Shaving Cream The same experiment as in Example 7 was repeated except that Natrosol® 250HR was used instead of HMHEC3.

List of Ingredients and Their Suppliers Name Adopted CTFA Brand Supplier Stearic acid Industrene 5016 Witco Coforation Memphis, Tennessee Coconut acid Industrene 328 Witco Coforation Memphis, Tennessee Lauramida DEA Standamid LD Henkel Coforation Ambler, Pennsylvania Coconut oil Coconut oil Sigma Chemical Co. St. Louis, Missouri Glycerides of tallow Peacock Acidless Geo. Pfau's Sons Co. Tallow Jeffersonville, Indiana Sorbitol Sorbo (70% active) ICI Americas, Inc. Wilmington, Delaware Propylene glycol (and) Germaben II Sutton Laboratories Diaxolidinil urea (and) Chatham, New Jersey Metilparaben (and) Propilparaben 88/12 Isobutane / Propane A-46 Propellant Aeropres Corporation Shreveport, Louisiana Propylene glycol Propylene glycol Eastman Chemical Co. Rochester, New York Hydroxyethylcellulose Natrosol 250HR Hercules Incorporated Wilmingtsn, Delaware EXAMPLE 8 Standard Cream Toothpaste with HMHEC2 Ingredient Percentage in neso I. HMHEC2 * 0.75 'Glycerin 100% 13.00 Sorbitol (70% solids) 16.86 Distilled water 15-612 II. Dicalcic Phosphate 45.00 Anhydrous III. Tetra Sodium pyrophosphate 0.42 Sodium saccharine 0.20 Sodium monofluorophosphate 0.76 Sodium benzoate 0.50 Distilled water 6.25 IV. Flavor 0.55 S Suullffaattoo llaauuririll ddee ssooddiioo 0.10 100.00 Procedure: 1. The salts of part III were added to the water in a container while stirring and heated to about 60 ° C to dissolve them. The container was covered during heating to prevent moisture loss. 2. Part I. The glycerin was weighed into a bowl and the polymer dispersed in our glycerin was stirred for about 5 minutes or until properly dispersed. Sorbitol was added and the mixture was continuously stirred for another 10 minutes. Water was added and stirred for an additional 15 to 30 minutes making sure that the polymer was completely hydrated (no gel). A warm salt solution was added while stirring continuously for an additional 15 minutes or until it was homogeneous (no lumps or gels). This mixture was transferred to a toothpaste mixer (Ross double planetary mixer). I Correct weight of poly ro for moisture content. 2. For water: adjust the amount of water in the polymer- 3 H HC2 is 3-buto? J-2-hydro? Propylene hydroxycellulose having a viscosity of a minimum of 2 000 mPa.sa 1% measured in a Brookficld Viscosimctro LVTD and has a turbidity point around 62 ° C to 68 ° C without treatment with oxal. 3. Part II DCP and water were added to a mixer and mixed for 10 minutes at low speed to completely wet the DCP. The mixer was then opened and the DCP paste mixture was scraped from the beaters and sides of the bowl. He dined the mixer and applied a vacuuum ?. The mixture was run at high speed under vacuum for 20 minutes or until the DCP paste mixture had a smooth consistency. 4. Part IV. SLS was added to the mixer and mixed for 5 minutes at low speed without vacuum. Flavor was added to the mixer and mixed for 2 minutes at low speed. Then the mixer was added and the beaters and the sides of the bowl were scraped. The mixer was closed and vacuum was applied and mixed at medium speed for 15 minutes, observing foam production.

. The mixer was turned off and the vacuum removed and the formulation packaged in a container as a paste.

COMPARATIVE EXAMPLE H Standard toothpaste cream with HMHEC2 The same experiment as in Example 8 was repeated except that Natrosol 250 HR from Hercules Incoforated was used in place of HMHEC2.

EXAMPLE 9 Standard Toothpaste Cream with HMHEC2 Ingredient Percentage in Weight 1. HMHEC2 0.75 'CMC 7MF (Hercules Incoforated) 0.25' Glycerin 100% 13.00 Sorbitol (70% solids) 16.86 Distilled water 14.462 II. Dicalcium Phosphate, anhydrous 45.00 III. Pyrophosphate tetra sodium 0.42 Saccharin sodium 0.20 Sodium monofluorophosphate 0.76 Sodium benzoate 0.50 Distilled water 6.25 IV. Flavor 0.55 Sodium lauryl sulfate 1.00 100.00 1. Start with part III. The salts were added to the water while stirring and heated to about 60 ° C to dissolve. The mixture of salt and water was covered during the heating to prevent the loss of moisture. 2. Part I. The glycerin was weighed into a bowl and the polymer dispersed in the glycerin while stirring. This mixture was stirred for 5 minutes or until properly dispersed. Sorbitol was added in this dispersion and stirred continuously for 10 minutes. Water was added and stirred for 15 to 30 minutes making sure that the polymer was completely hydrated (no gels). Then hot salt solution was added while stirring and was continuously stirred for 15 minutes or until homogeneity (no lumps or gels). This mixture was passed to a toothpaste mixer (Ross double planetary mixer).

Correct the weight of the polymer by moisture content for water: Adjust the amount of water for moisture in the polymer 3. Part II. DCP was added to the mixer and mixed for 10 minutes at low speed to completely wet the DCP. The mixer was then opened and the whisks and sides of the bowl scraped off. The mixer was closed and a vacuum applied. Then I mix the mixer at high speed under vacuum for 20 minutes or until the mixture softens. 4. Part IV. SLS was added and mixed for 5 minutes at low speed without any vacuum. Flavor was added and mixed for 2 minutes at low speed and the mixer was opened and the whisks and sides of the bowl were scraped. The mixer was closed and the vacuum applied. The mixer was run at medium speed for 15 minutes, observing foam production. 5. The mixer was turned off and the vacuum was broken. The mixture was packaged as pasta.

EXAMPLE 10 Toothpaste Cream with HMHEC 1 Ingredient Weight Percentage ( I. HMHEC1 0.75 15.00 Glycerin 100% 13.00 260.00 Sorbitol (70%) 16.86 337.20 Distilled Water I 6-962 339.2 II. Dicalcium phosphate, 45.00 900.00 dihydrate III. Pyrophosphate tetra sodium 0.42 8.40 Sodium monofluorophosphate 0.76 15.20 Sodium saccharin 0.20 4.00 Sodium benzoate 0.50 10.00 IV. Flavor 0.55 1 1.00 V. Sodium lauryl sulphate 1.00 20.00 Distilled water 4.00 80.00 100.00 2000.00 1. Part I. The glycerin was weighed in a bowl. Was the polymer dispersed in the glycerin in a Jiffy mixer? while stirring. This mixture of glycerin and polymer was stirred for 5 minutes or until properly dispersed. Sodium saccharin and sodium benzoate were added to the dispersion and mixed for an additional 5 minutes. Sorbitol was then added and mixed for 5 minutes. Then water was added and stirred for 30 minutes. After stirring 30 minutes the total weight of the bowl was noted and agitated again. The solution was heated to 80 ° C and mixed for 15 minutes at 80 ° C. The bowl was weighed again and the weight was adjusted for some weight loss due to evaporation. The content of the bowl was then transferred to the Ross planetary vacuum mixer.

Correct the weight of the polymer by moisture content Adjust the water level by polymer moisture correction 2. During the hydration period of the polymer, part V began. It was added to the SLS water while stirring and dissolved to 50 ° C in a water bath. If it was piled up, the process would start again. 3. Part II DCP was added to a mixer and mixed for 10 minutes at a low speed to completely wet the DCP. The mixer and the beaters stopped and the sides of the rate were scraped. The mixer was sawn and a vacuum was applied. The mixer was run at high speed under vacuum for 20 minutes or until the paste softens. 4. TSPP was added to the mixer and mixed 5. Part IV. The SLS was added and mixed for 5 minutes at low speed without vacuum. The flavor was added and mixed for 2 minutes at low speed. The mixer opened and the whisks and sides of the bowl were scraped. The mixer was dunned and vacuum applied and mixed at medium speed for 15 minutes, foaming was observed. 6. The speed of the mixer was refuted and cut subsequently and the vacuum broke. The contents of the mixer were removed and packed as a paste.

EXAMPLE 11 Cream toothpaste with HMHEC 1 Ingredient Percentage Weight (g) HMHEC 1 0.75 15.00 Genuvsco TPHl 0.25 5.00 (Hercules Incoforated) 100% glycerin 13.00 260.00 Sorbitol (70%) 16.86 337.20 Distilled Water 16,712 334.2 II. Dicalcium phosphate, 45.00 900.00 dihydrate III. Pyrophosphate tetra sodium 0.42 8.40 Sodium monofluorophosphate 0.76 15.20 Sodium saccharin 0.20 4.00 Sodium benzoate 0.50 10.00 IV. Taste 0.55 1 1.00 V. Sodium lauryl sulphate 1, 00 20.00 Distilled water 4.00 80.00 100.00 2 000 Correct the weight of the polymer by moisture content Adjust the water level by polymer moisture correction 1. Part I. The glycerin was weighed in a bowl. The polymer was dispersed in the glycerin in a Ji-Yy mixer while stirring. This mixture of glycerin and polymer was stirred for 5 minutes or until properly dispersed. Sodium saccharin and sodium benzoate were added to the dispersion and mixed for an additional 5 minutes. Sorbitol was then added and mixed for 5 minutes. Then water was added and stirred for 30 minutes. After stirring 30 minutes the total weight of the bowl was noted and agitated again. The solution was heated to 80 ° C and mixed for 15 minutes at 80 ° C. The bowl was weighed again and the weight was adjusted for some weight loss due to evaporation. The content of the bowl was then transferred to the Ross planetary vacuum mixer. 2. During the hydration period of the polymer, part V was started. It was added to the SLS water while stirring and dissolved heated to 50 ° C in a water bath. If it was piled up, the process would start again. 3. Part II. DCP was added to a mixer and mixed for 10 minutes at a low speed to completely wet the DCP. The mixer and the beaters stopped and the sides of the rate were scraped. The mixer was sawn and a vacuum was applied. The mixer was run at high speed under vacuum for 20 minutes or until the paste softens. 4. TSPP was added to the mixer and mixed for 5 minutes.

Then S FP was added and mixed for 5 minutes. Then the saccharin was added and mixed for 5 minutes. Then the sodium benxate was added and mixed for 5 minutes, at low speed followed by the minute at medium speed or until softening. 5. Part IV. The SLS was added and mixed for 5 minutes at low speed without vacuum. The flavor was added and mixed for 2 minutes at low speed. The mixer opened and the whisks and sides of the bowl were scraped. The mixer was closed and vacuum was applied and mixed at medium speed for 15 minutes, foaming was observed. 6. The speed of the mixer was gradually reduced and finally cut and the vacuum broke. The contents of the mixer were removed and packed as a paste.

EXAMPLE 12 Lubricant Gelatine (or liquid) FORMULATION 1 2.2% Nonoxynol 9 3.0% HMHEC2 94.9% Propylene Glycol 0.1% Methyl parasept FORMULATION 2 2.2% Nonoxynol 9 1.5% HMHEC2 1.5% Natrosol 250 HHX (Hercules Incoforated) 24.9% Water 70.9% Propylene Glycol 0.1% Methyl parasept FORMULATION 3 4.0% HMHEC2 95.9% Propylene Glycol 0.1% Methyl parasept FORMULATION 4 2.0% HMHEC2 1.5% Klucel HF (Hercules Incoforated) 94.9% Propylene Glycol 0.1% Methyl parasept FORMULATION 5 0.5% HMHEC2 0.5% Klucel HF 10.0% mineral oil 34.9% Propylene glycol 54.0% Water 0, 1% Methyl parasept The polymer was dispersed in vigorously stirred propylene glycol vortex and / or mineral oil and mixed for ten minutes. Water was added.

After the temperature was raised to 90 ° C and a hota was mixed and then gradually cooled to around 25 ° C while mixing slowly, the nonoxynol and the condom (as required) were added while mixing, then the formulation it was deaerated and it was packed.

EXAMPLE 13 Dental Adhesive FORMULATION 1 25.0% CMC 7HSXF (Hercules Incoforated) 25,% HMHEC2 45.0% Petrolatum (Snow White from Penerico) 5.0% Mineral Oil (Drakeol 9 from Penerico) FORMULATION 2 50.0% HMHEC2 45.0% Petrolatum (Snow White from Penerico) 5.0% Mineral Oil (Drakeol 9 from Penerico) The petrolatum was preheated to 60 ° C in a vessel and mineral oil was added and mixed for 5 minutes. The polymer was then added to the vessel and mixing was continued for 30 minutes. The formulation was then transferred to a packing container and allowed to cool to about 25 ° C.

EXAMPLE 14 Transparent Antiperspirant in Bar A two-phase method was used to prepare the antiperspirant on a clear ba background as follows: Phase I About 65% of the total propylene glycol used (excluding that which is part of the antiperspirant salt solution) was charged to a reaction vessel. HMHEC 1 was added to the vessel and stirred well until dissolved. The vessel was heated to dissolve the polymer. Once the polymer dissolved, the solution was heated to 10 ° C until 1 15 ° C, and the sorbitol dibenzylidine was added and mixed until completely dissolved. This solution of phase I was then cooled to about 100 ° C.

Phase II. About 35% of the propylene glycol used (excluding that which is part of the antiperspirant salt solution) was added in another vessel, stirred and heated to about 60 ° C to 70 ° C. Na 4 EDTA was added and mixed well to form a precipitate. The antiperspirant salt solution was immediately added to the container and the solution mixed well until it became clear and homogeneous. The emollients, dimethicone copolymer, were added in the phase II solution and mixed until they became clear.

Combined phase: Phase II was added to phase I while mixed and cooled to 80 ° C. Optionally you can add a fragrance at this point and let it mix well. The product was emptied in one ounce glass jars and allowed to cool overnight. After cooling overnight, the samples were tested for their physical and chemical properties.

Equipment used: 2 400 ml glass bakers, oil bath, clamps, mechanical stirrer, Jiffy agitator and thermometer, and a cover to avoid contamination, such as a plastic cover.

Total formulation for this example 1. Propylene glycol 49.70 g 2. Al / Zr tetrachloridazide-gly 30.60 g 3. Dibenzilide sorbitol 0.50 g 4. HMHEC 1 0.50 g 5. Sodium EDTA 0.20 g 6. Dimethicone copolymer (ABIL B 8851) 0.25 g 7. Fragrance (optional) 1.25 g Phase I: Propylene glycol 32,30 | Dibenzilide sorbitol 0.50 f HMHEC 1 0.30 i Phase II: Polypropylene glycol I 7.40 g Al / Zr tetrachlorohydrate-gly 36.60 g Sodium EDTA 0.20 g Dimethicone copolymer 0.25 g Fragrance (optional) 1 , 25 g Chemicals, Suppliers: 1. Propylene glycol (EM Science UPS grade) 2. Al / Zr tetrachlorohydrate-gly (Westwood Chemical Co.) Westchlor A2Z 8160 30% PG solution. 3. Dibenzilide sorbitol (Milliken Chemical) Mittithix 925. 4. HMHEC 1 (Hercules Incoforated) 5. Sodium EDTA (Aldrich No. 5403EJ) 7. Dimethicone copolymer (Goldschmitdt Chemical) ABIL B 8851 8. Fragrance * 30% active solution EXAMPLE 15 Lubricating gel Ingredient Percentage by weight Weight (g) HMHEC2 1, 00 4.00 * Klucel ® HF 1.00 4.00 Propylene glycol 97.9 391, 60 Methylparaben 0.10 0.40 100.00 400.00 Procedure: 1. A dry mixture of HMHEC2 and Klucel HF was dispersed in vigorously stirred propylene glycol and mixed for 10 minutes. 2. Next, the temperature was raised to 90 ° C and mixed for one hour. 3. It cooled to room temperature while mixing. 4. The methylparaben condom was added and mixed for 10 minutes. 5. It was dispensed into containers.

COMPARATIVE EXAMPLE I Lubricating gel The same experiment was repeated as in example 15 except that ** Benecel® MP 943W was used in place of HMHEC2.

• Klucel HF: Hydroxypropylcellulose from Hercules Incorporated, Wilmington, Delaware. ** Benecel MP943W: Hydroxypropylmethylchloride from Hercules Incorporated.

EXAMPLE 16 Lubricating gel Ingredient% by weight Weight (g) HMHEC2 1, 50 7.50 Glycerin, USP 20.00 100.00 Distilled water 78.00 390.00 Urea diaxolidinil, PG ethylparaben, Propylparaben 0.50 2.50 ( Germaben 11, ISP) 100.00 500.00 Procedure: 1 . The glycerin was heated while stirring at 60 ° C in a water bath and covered with a Saran cover while heating. 2. The HMHEC2 was dispersed in hot glycerin by shaking it in the vortex of the stirred glycerin. 3. The distilled water was heated to 60 ° C in a separate vessel and added slowly to the dispersion and mixed for an additional 30 minutes while maintaining the temperature at 60 ° C. 4. The condom was then added and cooled to room temperature and the lubricating gel was placed in containers.

COMPARATIVE EXAMPLE J Lubricating Gel The same experiment as in Example 16 was repeated except that * Natrosol® 250H NF was used instead of HMHEC2.

* Natrosol 250 NF is hydroxyethylchloride from Hercules Incorporated EXAMPLE 17 Dental Adhesive Lots of 100 grams of dental adhesive were prepared according to the following formulas: Petrolatum 50.0 HMHEC2 50.0 and 00.0 Procedure: The petrolatum was weighed in a 250ml hoe. The homogenizer was placed in a circulating oil bath heated to 67 ° C. The content was stirred at low speed on an electric mixer having 3.8 l mm in diameter spaced at l, 27 m on the shaft. When the content was at 65 ° C, the polymer was added slowly while adjusting the speed of the mixer to maintain a vortex in the mix. Mixing continued for one hour.

Preparation of artificial saliva solution for mechanical testing: Artificial saliva was prepared according to the following formula: Concentrate: Potassium thiocyanate 2.0 Potassium chloride 14.0 Sodium phosphate, dibasic, 7-hydrate 2.0 Sodium phosphate, monobasic, monohydrate 1.8 Deionized water, boiling 1000.0 1019.8 Dilution: Concentrate 1 part in weight Deionized water, boiling 9 parts by weight 10 parts by weight The pH of the solution was adjusted to 7.0 with sodium phosphate, dibasic, 7-hydrate.

Testing of dental adhesives: COMPRESSION TEST / CYCLIC TENSION MTS The apparatus consisted of a specially designed arrangement having a Plexiglas top plate of 3.8 tcm in diameter, and a bottom plate of Plexiglas 5.08 cm in diameter surrounded by a Plexiglas cylinder 4.5 x 2.54 cm in diameter. diameter to form a reservoir. Special adapters were manufactured for mounting on the MTS instrument. 2ml of the DA sample was delivered from a 5ml disposable syringe and continuously scattered in the lower stage of the test device. The reservoir of the device was filled with artificial saliva in order to adjust the immersed surface of the sample (± 180ml). The upper stage of the device was brought into contact with the sample, leaving an initial position expansion of 0.04 x 2.54 cm above the lower plate, and the instrument was clicked to travel to an expansion of 0.06 x 2 , 54cm and below an expansion of 0.03 x 2.54cm at a transverse speed of 0.20 in / min and a full scale load of 20 to 50 pounds. The test was operated for 200 cycles, and the tension and compression forces were recorded in table 4. The formulations were conjoined in triplicate and the averages were reported * 1, 2. COMPARATIVE EXAMPLE K Dental adhesive The same experiment as in Example 17 was repeated except * Natrosol® 250 HX was used in place of HMHEC2. 'AGAF Chemicals Co .. Method of Procedure No. MP-675-W, September 7. 1 69 2 Gilbert Banker and David P, DeMagistris, Evaluation of adhesion properties of polymer samples using the Instron universal stress / strain analyzer, Purdue University Report Not Published by GAF, July 10, 1979. * Natrosol 250HX is Hercules Incorporated hydroxycyclic acid.

EXAMPLE 18 Transparent antiperspirant in bath A two-phase method was used to prepare the transparent antiperspirant in ba as follows: Phase I About 65% of the total propylene glycol used (excluding that which is part of the antiperspirant salt solution) was charged to a reaction vessel. HMHEC 1 was added to the vessel and stirred until dissolved. The vessel was heated to dissolve the polymer. Once the polymer dissolved, the solution was heated to 10 ° C until 1 15 ° C, and dibenzylidin sorbitol was added and mixed until completely dissolved. This solution of phase I was then cooled to about 100 ° C.

Phase II About 35% of the total propylene glycol used (excluding that which is part of the antiperspirant salt solution) was added to another vessel, stirred and heated to about 60 to 70 ° C. Na4EDTA was added and mixed until a precipitate formed. The antiperspirant salt solution was then added to this container and the solution mixed well until it became clear and homogeneous. The emollient, dimethicone copolymer, was added and the phase II solution mixed until it became clear.

Combined phase: Phase II was added to phase I while mixing and cooling to 80 ° C. A fragrance was added at this point and it was left to mix well. The product was emptied into one-ounce glass jars and allowed to cool overnight. After cooling overnight, the samples were tested for their physical and chemical properties.

Equipment used: 2 400ml glass bakers, oil bath, jaws, mechanical agitator, Jiffy agitator and thermometer, and a cover to prevent contamination, such as plastic cover.

Total formulation for this example: 1. Propylene glycol 49.67g 2. Al / Zr tetrachlorohydrate-gl and 36.60g * 3. Dibenzilide sorbitol 0.50g 4. HMHEC 1 0.30g 5. Sodium EDTA 0.20g 6. Dimethicone copolymer 0.25g (ABIL B 8851) 87.45g * 30% active solution Phase I: Polypropylene glycol 32.07g Dibenzilidene sorbitol 0.50g HMHEC 1 Q.30g 32.87g Phase II: Polypropylene glycol 17.60g Al / Zr tetrachlorohydrate-gly 36.60g Sodium EDTA 0.20g dimethicone copolymer 0.25g 54 , 65g COMPARATIVE EXAMPLE L Transparent antiperspirant in bar The same experiment as in Example 1 was repeated except that CMHEC 420H was used instead of HMHEC 1.

Raw Materials and Their Sources for Antiperspirant Bar Raw materials Supplier Propylene glycol (USP grade) EM Science Gibbstown, NJ Al / Zr tetrachlorohydrate-gly Westwood Chemical Coforation A2Z 8160 30% solution PG Middletown, New York Dibenzilide sorbitol Milliken Chemicals Millithix 925 HMHEC 1 Hercules Incoforated Wilmington, DE Carboxymethylhydroxyethylcellulose Hercules Incoforated CMHEC420H Sodium EDTA Aldrich Chemical Company Aldrich No. 5403EJ Milwaukee, Wisconsin Dimethicone Copolymer Goldschmidt Chemical Coforation ABIL B 8851 Hopewell, VA EXAMPLE 19 Shampoo Ingredient Percentage by weight Distilled water 58.80 Ammonium lauryl sulphate, 30% (Ste-AM) 27.50 Disodium cocoamphodiacetate, 50% (Miranol C2M) 6.90 Sodium laureth sulfate, 60% (Steol CS460) 5.70 HMHEC2 0.60 Germaben II 0.50 Citric acid up to PH 5.5 100.00 Process: In a water bath, the water was heated to 70 ° C while stirring and kept covered to prevent moisture loss. The HMHEC2 was placed slowly in the vortex of the water. 3. The mixture was cooled to 40 ° C. 4. The remaining ingredients were added, one at a time, while mixing well between each addition. 5. The PH was adjusted to 5.5 with citric acid.

COMPARATIVE EXAMPLE M Shampoo The same experiment as in Example 19 was repeated except that Benecel MP 943W was used instead of HMHEC2.

Materials and Suppliers for the Shampoo Name adopted CTFA Brand Provider Ammonium lauryl sulphate Stepanol AM Stepan Chemical Co. Northfield, IL. Disodium Cocoanfodiacetate Miranol C2M Rhone-Polenc, Cranbury, NJ Sodium laureth sulfate Steol CS460 Stepan Chemical Co.

Condom Germaben II Sutton Labs Chatham, NJ Hydrixopropylmethylcellulose Benecel Hercules Incoforated MP943W Wilmington, DE EXAMPLE 20 Perpetuous Shampoo Ingredient% by weight Weight (g) Distilled water quantity up to 100.00 347.25 TEA-lauryl sulfate (40% active) (Stepanol WAT) 15.00 75.00 Sodium lauroanfoacetate (y) Sodium trideceth sulfate (Miranol MHT) 10.00 50.00 Coca ida DEA (Ninol 40CO) 2.50 12.50 Glycol stearate (Emerest 2400) 1, 20 6.00 Propylene glycol (and) diazolidinyl urea (and) Methylparaben (y) Propylparaben (Germaben II) 0.75 3.75 HMHEC 1 0.60 3.00 N-Hance® 3000 cationic guar 0.50 2.50 Citric acid (50% solution) adjustment of the PH - 100.00 500.00 Procedure: 1. The N-Hancc® product was dispersed by slowly adding to the vortex of well-stirred water in a vessel. The pH was reduced to 7.0 with citric acid solution to promote the dissolution of the surface treated N-Hance and the solution was heated to 50 ° C. 2. HMHEC 1 was added slowly in the heated N-Hance® solution and mixed until completely dissolved. 3. The temperature rose to 70 ° C. Next, TEALS and glycol stearate were added, one at a time. Between each addition, the mixture was stirred well. Heating was removed once it looked homogeneous. The mixing is continued. 4. When the temperature reached 55 ° C, the remaining ingredients were added one at a time. 5. The pH was adjusted to 5.0 with citric acid solution. 6. It was cooled to 40 ° C and fragrance was added.

COMPARATIVE EXAMPLE N Shampoo perlejcente The same experiment as in Example 20 was repeated except that Benecel MP943W from Hercules Incoforated was used instead of HMHEC 1.

List of Ingredients and Their Suppliers for Perpetuous Shampoo Name Adopted CTFA Brand Provider Sulfate TEA-lauryl Stepanol WAT Stepan Company Northfield, Illinois Sodium lauroanfoacetate (and) trideceth sodium sulfate Miranol MHT Rhone-Poulenc Cranbury, NJ Name Adopted CTFA Brand Supplier Cocamida DEA Ninol 40CO Stepan Company Northfield, IL Glycol stearate Emerest 2400 Henkel Coforation Hoboken, NJ P propylene glycol (and) diazolidinyl urea (and) methylparaben (y) propylparaben Germaben II Sutton Lab Chatham, NJ Guar Hydroxypropyltrimonium chloride N-Hance® 3000 Hercules I ncoforated Wilmington, DE EXAMPLE 21 Solar Blocker Lotion Ingredient% by weight Weight (g) Mineral oil (Learol, Witco) 13.00 65.00 Polyoxypropylene 15 stearyl ether (Arlamol E, ICI) 6.00 30.00 Octyl etoxicinimate (Neo Heliopan AV, H & R) 5.00 25.00 Benzophenone-3 ( Uvinul M40, BASF) 3.00 15.00 Hydrogenated Castor Oil (Castor Wax, Ross) 1.40 7.00 Sorbiton Monoisostearate (Arlacel 987, ICI) 1.20 6.00 Polyoxyethylene Polyol fatty acid ester ( Arlatone T, ICI) 1.00 5.00 Ozokerite wax (O Wax 77W, Ross) 1.00 5.00 Polyoxyethylene fatty acid ester (Arlacel 989, ICI) 0.50 2.50 B. HMHEC 1 0.50 2.50 Distilled water 63.60 318.00 Glycerin 3.00 15.00 Ingredient% by weight Weight (g) Magnesium sulfate EYE 3.50 Diazolidinyl urea, PG, Methylparaben, Propylparaben (Germaben II, ISP) 0, 10 0.50 100.00 500.00 Process: 1. All the ingredients of part A were mixed together in a container while stirring. 2. The temperature was raised to 70 ° C, and the mixture was stirred for 30 minutes. 3. For part B, HMHEC 1 was dispersed in the distilled water. The pH of the precipitate was raised to 8.5 with NaOH and mixed until dissolved. Glycerin, magnesium sulfate, and condoms were added one at a time while mixing. The mixture was stirred between each addition to make sure there were no lumps. 4. Part B was added to part A slowly while stirring and stirred for 30 minutes at 70 ° C. 5. This new mixture was cooled to room temperature while stirring and filled into the containers.

COMPARATIVE EXAMPLE OR Solar Blocker Lotion The same experiment as in Example 21 was repeated except that CMC 7HF NF was used instead of HMHEC 1.

Materials and Their Suppliers for the Solar Blocker Lotion Name Adopted CTFA Brand Provider Mineral Oil Klearol Witco Corporation Dublin, OH Ether Stearyl Polyoxypropylene 15 Arlamol E ICI Surfactants Wilmington, DE Octyl Metoxycinatin Neo Heliopan AV H & R Coforation Springfield, NJ Benzofenon-3 Uvinul M40 BASF Coforation Washington, NJ Castor Hydrogenated Beaver Oil Wax Ross Monoisostearate of Sorbiton Arlacel 987 ICI Surfactants Fatty Acid Ester Poliol Arlatone T ICI Surfactants Polyoxyethylene Wax Ozokerita O Wax 77W Ross Polyoxyethylene Fatty Acid Ester Arlacel 989 ICI Surfactants Diazol dinil urea, PG, Methylparaben, Propilparaben Germaben II Sutton Labs Chatham, NJ Carboxymethyl cellulose CMC 7HF NF Hercules Incorporated EXAMPLE 22 Hydroalcoholic Deodorant Part Ingredients% by weight Weight (g) A Solution REACH174® 501 40.00 160.00 (50% Chlorohydrate Al) B Procethyl AWS (PPG-5 ceteth-20) 2.00 8.00 C HMHEC4 0.20 0.80 D Deionized water 15.70 62, 80 E Alcohol SD 40 41, 10 164.40 F Fragrance (d) 1.00 4.00 100.00 400.00 Process: 1. HMHEC4 was dispersed within the deionized water (D) in a vessel and the pH of the dispersion was adjusted to 8.5 with NaOH solution. The dispersion was then mixed for 30 minutes. 2. Component A was gradually added to the dispersion and mixed rapidly using overhead stirring to dissolve. 3. Components B and E were combined in a separate vessel and then added slowly with constant agitation for the rest of the batch. 4. The fragrance was then added and mixed for 5 minutes. 5. The resulting mixture was emptied into wheeled containers.

COMPARATIVE EXAMPLE P Rolled deodorant Hydroalcoholic The same experiment was run as in Example 22 except that Natrosol 250MR CS from Hercules Incoforated was used instead of HMHEC4.

Materials and Suppliers for the Hydroalcoholic Rolled Deodorant Name adopted CTFA Brand Suppliers Aluminum chlorohydrate REACH 501 Rehies Incorporation Berkeley Height, NJ PPG-5 ceteth-20 Procetil AWS Croda Incoforation Parsippany, NJ Ethyl Alcohol SD Alcohol 40 Oriental Classical Fragrance / Species No.Q-7148 Quest International Fragrances Inc. Mount Olive, NJ Hydroxyethylcellulose Natrosol 250MR Hercules Incorporated CS Wilmington, DE EXAMPLE 23 Rinsing Gel Inj g redien e% in weight Weight A. Deionized water csp 100.00 282, 10 B. HMHEC 1 (Hercules Inc.) 0.95 4.75 C. Sodium laureth sulfate 1 1, 53.65.55 (Steol CS460, Stepan) Sulfosuconate laureth disodium ( Stepan Mi Id SL3, Stepan) 1 1, 80 59.00 Disodium cocoamphodiacetate (Miranol C2M Conc NP, Rhone-Poulenc) 6.00 30.00 Sarcosinate sodium lauroyl (Crodasinic LS 30, Croda) 7.25 36.25 Ingredient % by weight Weight (g) Propylene glycol 2.00 10.00 Quaternized wheat protein (Wheataflor, Croda) 1, 00 5.00 Hydroxylate wheat protein and Hydrolyzate and wheat germ oil and polysorbate 20 Glycol and laureth-4 distearate and CAPB (Euperian P 3000 , Henkel) 2,00 10,00 Disodium EDTA (EDETA, BD, BASF) 0, 10 0,50 Perfume (Drom 229033, Drom) 0,35 1, 75 Phenoxyethanol and methylparaben and ethylparaben and propylparaben and butylparaben (Phinonip, Ñipa ) 0.60 3.00 00.00 500.00 Process: 1. The HMHEC was dispersed in well-stirred water to form a precipitate. 2. The PH of the precipitate was adjusted to 8.5 with NaOH solution and the precipitate was mixed until a solution formed and there were no lumps. Next, the ingredients of phase C were added to the solution in the order listed above while mixing for one minute between each addition or until the mixture became homogeneous. 3. The PH of the final gel product was adjusted to 5.3 to 5.7 and filled into the containers. COMPARATIVE EXAMPLE Q Rinsing gel The same experiment as in Example 23 was carried out except that N-Hance 3196 was used instead of HMHEC 1; the polymer was dispersed in water and mixed for 5 minutes. The pH of the precipitate was lowered below 6.0 to 7.0 and mixed for one hour or until no lumps were observed, followed by the addition of phase C as above. Raw Materials and Their Sources For Rinsing Gel Name Adopted CTFA Brand Supplier Chloride Hydroxypropyltrimonium N-Hance® 196 Hercules I ncorporated Guar Wilmington, DE Sodium laureth sulfate Steol CS460 Stepan Company Northfield, NJ Sulfosucinate laureth disodium Stepan Mild Stepan Company SL3 Disodium Cocoamphodiacetate Miranol C2M Rhone-Poulenc Conc NP Cranbury, NJ Sarcosinate sodium lauroyl Crodasinic Croda I ncorporated LS 30 Parsipanny, NJ Wheat protein quaternized WheataFlor Croda Incorporated Wheat protein hydrolyzate and Euperlan PK Henkel Co-hydration and oil of 3000 Hoboken, NJ wheat germ and polysorbate 20 glycol distearate and laureth-4 and CAPB Disodium EDTA EDTA BD BASF Corporation Washington, NJ Perfume Drom 229033 Drom International Towaco, NJ Phenoxyethanol and methylparaben and Ñipa Hardwicke Inc. ethylparaben and propilparaben and Phinonip Wilmington, DE butylparaben Guar Hydroxypropyl Hercules Incorporated Trimoniochloride N-Hance 3196 Wilmington. FROM.

Table ND = Not determined All data after 24 hours of storage stability Viscosity. All viscosities are measured in Brookfield LVT Viscosity measured at 30 f, 25 ° C, after two minutes of spindle rotation except where noted (1) Viscosity measured at 6.0 fm, 25 ° C, after two minutes of spindle rotation ** The solution had excessive foam * The solution was not homogeneous. It had two phases.

Table 2 ND = Not determined All data after 24 hours of storage stability Viscosity: All viscosities are measured in Brookfield LVT Viscosity measured at 30 fm, 25 ° C, after two minutes of spindle rotation except where noted (2) Viscosity measured at 0.6 fm, 25 ° C, two minutes of spindle rotation * Transparent * Turbid Table 3 ND = Not determined All data after 24 hours of storage stability (3) Viscosity measured at 5.0 fm, three minutes of "T" spindle rotation using a Helipath Brookfield Viscometer Valor Cuban: Reflects the lifting characteristic of the dental pastina Value Cordoning: Reflects the characteristic of tape cutting of toothpaste Table 4

Claims (41)

1. I. A composition for personal care that comprises. (a) from about 0.1% to about 99% by weight of a vehicle system comprising a hydrophobically modified nonionic water soluble polysaccharide polymer comprising a structure of water-soluble polysaccharide polymer and a selected hydrophobic fraction from the group consisting of 3-alkoxy-2-hydroxypropyl group where the alkyl moiety is a straight or branched chain having 2 to 6 carbon atoms, C? -C7 alkyl, aryl alkyl, alkyl aryl groups and mixtures thereof , wherein the ratio of the hydrophilic portion to the hydrophobic portion of the polymer is from about 2: 1 to 1000: 1, and (b) At least one other personal care ingredient.
2. 2. The composition of claim 1 wherein the composition also comprises from about 0.01% to about 25% by weight of the personal care composition of a surfactant.
3. 3. The composition of claim 2 wherein the surfactant is selected from the group consisting of anionic, nonionic, cationic, zirutionic, and amphoteric and mixtures thereof.
4. 4. The composition of claim 1 wherein the composition also comprises from about 0.1% to about 99% by weight of the personal care composition of a compatible solvent or solvent mixtures.
5. 5. The composition of claim 4 wherein the solvent or mixture of solvents is selected from the group consisting of water, mixtures of water and lower alkanols, polyhydric alcohols having from 3 to 6 carbon atoms and from 2 to 6 hydroxyl groups, and mixtures of them.
6. 6. The composition of claim 5 wherein the solvent or mixture of solvents is selected from the group consisting of water, propylene glycol, water-glycerin, sorbitol-water, water-ethanol and mixtures thereof.
7. 7. The composition of claim 2 wherein the composition also comprises from about 0.1% to about 99% by weight of the personal care composition of a compatible solvent or mixture of solvents.
8. 8. The composition of claim 1 wherein the hydrophobically modified polysaccharide structure is selected from the group of hydroxyethylcellulose (HEC9, hydroxypropylcellulose (HPC), methylcellulose (MC), hydroxypropylmethylcellulose (HPMC), ethylhydroxyethylcellulose (EHEC), and methylhydroxyethylcellulose (MHEC), and agar, dextran, bean gum, starch, guar, and their nonionic derivatives, and mixtures thereof.
9. 9. The composition of claim 1 wherein the polyscaride structure is HEC and the hydrophobic moiety is 3-butoxy-2-hydroxypropyl.
10. 10. The composition of claim 4 wherein the composition also comprises an effective viscosifying amount of a salt.
11. 1 1. A hair or skin care composition comprising a solvent and an effective amount of the personal care composition of claim 7.
12. 12. A shampoo comprising an effective amount of the personal care composition of claim 4.
13. 13. A conditioner comprising an effective amount of the personal care composition of claim 4.
14. 14. A conditioning shampoo comprising an effective amount of the composition of claim 1.
15. 15. A sun care product comprising a solvent and an effective amount of the personal care composition of claim 1.
16. 16. A rinse gel comprising an effective amount of the cleansing composition of claim 1.
17. 17. A soap comprising an effective amount of the personal care composition of claim 1.
18. 18. A hair styling gel composition comprising an effective amount of the personal care composition of claim 1.
19. 19. A hair styling gel composition comprising an effective amount of the personal care composition of claim 4.
20. 20. An anti-dandruff composition of the hair comprising solvent and an effective amount of the personal care composition of claim 7.
21. 21. A hair growth promoting composition comprising an effective amount of the personal care composition of claim I.
22. 22. A hair coloring composition comprising an effective amount of the personal care composition of claim 1.
23. 23. A hair bleaching agent composition comprising an effective amount of the personal care composition. of claim 1.
24. 24. An antifreeze agent composition comprising an effective amount of the personal care composition of claim I.
25. 25. A relaxing hair composition comprising an effective amount of the personal care composition of claim I.
26. 26. A dentifrice composition comprising an effective amount of the personal care composition of the claim.
27. 27. A mouthwash composition comprising an effective amount of the personal care composition of claim 1.
28. 28. A dental adhesive composition comprising an effective amount of the personal care composition of claim 1.
29. 29. A shaving product composition comprising an effective amount of the personal care composition of claim 1.
30. 30. A lubricating gel composition comprising an effective amount of the personal care composition of claim 1.
31. 31. A spermicidal gel composition comprising an effective amount of the personal care composition of claim I.
32. 32. A beauty aid composition comprising an effective amount of the personal care composition of claim 1.
33. 33. A solid bar composition for the armpits comprising an effective amount of the personal care composition of claim 1.
34. 34. An underarm gel composition comprising an effective amount of the personal care composition of claim 1.
35. 35. A liquid underarm composition comprising an effective amount of the personal care composition of claim 1.
36. 36. A liquid underarm composition of claim 35 wherein the composition comprises an aerosol ingredient.
37. 37. The composition of claim 1 wherein the composition also comprises an oil in water or water in oil emulsion.
38. 38. A cleaning composition comprising an effective amount of the composition of claim 1.
39. 39. A hair detangler composition comprising an effective amount of the personal care composition of claim 1.
40. 40. A laminated razor blade lubrication composition comprising an effective amount of the personal care composition of claim 1.
41. 41. A fabric cleaning composition comprising an effective amount of the personal care composition of claim 1.