MXPA98001689A

MXPA98001689A - Detergent formulation containing enz

Info

Publication number: MXPA98001689A
Application number: MXPA/A/1998/001689A
Authority: MX
Inventors: Muller Manfred; Engelhardt Fritz; Antwerpen Werner; Lerch Alexander
Original assignee: Clariant Gmbh 65929 Frankfurt De
Priority date: 1996-07-03
Filing date: 1998-03-02
Publication date: 1998-11-12

Abstract

The invention relates to a detergent formulation containing an enzyme, which is characterized in that it contains a compound of the general formula, HaC (CH2) mA- (CH2) nCOB, in which A represents a group of formula (I), or -CH = CH-, B represents NR1R2, C1-C8 alkoxy, OH or OM1, and R1 is C1-C8 alkyl, C2-C8 alkenyl, phenyl, alkylphenyl or phenylalkyl, each with 1 to 4 carbon atoms in the chain of alkyl, or cyclohexyl, R 2 is hydrogen or has one of the meanings of R 1, or R 1 and R 2, together with the nitrogen atom to which they are attached, form a heterocyclic radical, M and M 1, independently of each other, are a cation of alkali metal or ammonium cation or an equivalent of an alkaline earth metal cation or aluminum cation; and ym are, independently of each other, a number from 0 to

Description

DETERGENT FORMULATION CONTAINING ENZYME The present invention relates to an enzyme-containing detergent formulation, which comprises a compound of formula I. Enzyme-containing detergent formulations are formulations which, in addition to the usual basic substances such as, for example, anionic surfactants, do not ionic and cationic, detergency builders, bleaching systems, etc., comprise enzymes such as, for example, proteases, ilases, lipases, etc. The purpose of these enzymes is to remove the protein, starch or grease from the fabric to be washed. Detergents of this type containing enzyme are already known and are described, for example, in WO 92/06160. A disadvantage of these detergent formulations containing enzyme is that their ability to remove blood stains is only deficient. EP-A-496 315 discloses stable and homogeneous aqueous formulations of surfactants having an EHL of less than or equal to 13, further comprising compounds obtainable by reaction of unsaturated fatty acids with amines and subsequent sulfonation. It is the object of the present invention to provide a detergent formulation that is also satisfactorily capable of removing blood stains. Surprisingly this goal is achieved by adding a compound of the formula I to a detergent formulation containing enzyme. As a consequence, the present invention relates to an enzyme-containing detergent formulation, which comprises a compound of the formula I: H3C (CH2) m-A- (CH2) nC0B (I) in which: A is a group of the formula: -CH2-CH-; CH-CH2- or CH = CH-; I I 0S03M OS03M B is NRiR2, alkoxy of 1 to 8 carbon atoms, OH or OMi; Ri is alkyl of 1 to 8 carbon atoms, alkenyl of 2 to 8 carbon atoms, phenyl, alkylphenyl or phenylalkyl; each of which has 1 carbon atoms in the alkyl chain, or cyclohexyl; R2 is hydrogen or has one of the meanings of R1, or wherein R2, together with the nitrogen atom to which they are attached, form a heterocyclic radical; M and M1, independently of each other, are an alkali metal cation, a triethanolammonium cation or an ammonium cation, or an equivalent of an alkaline earth metal cation or aluminum cation; and and n, independently of each other, are each a number from 0 to 22. Of p reference, A is a group of the formula: -CH2-CH-; -CH-CH2- or CH = CH; i OSO3M OSO3M B, preferably, is NRiR2. The alkyl of 1 to 8 carbon atoms of R or R2 can be straight or branched chain and, for example, is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, secondary butyl, tertiary butyl, n -pentyl, n-hexyl, n-heptyl or n-octyl. The same applies to the alkenyl of 2 to 8 carbon atoms. The alkylphenyl having from 1 to 4 carbon atoms in the alkyl chain, for example, is methyl, ethyl, propyl or butylphenyl. Phenylalkyl having 1 to carbon atoms in the side chain, for example, is benzyl or phenethyl. A heterocyclic radical formed by Ri, R2 and the nitrogen atom to which they are attached, in particular, is 5 or 6 members and can be saturated, unsaturated or partially saturated. Additionally, it may also contain other hetero members of the series consisting of N, 0 and S. Examples of heterocyclic radicals of this type are the radicals pyperidine, morpholine, thiophene, tetrahydrofuran and tetrahydrothiophene. In the preferred compounds of formula I, R and R2 are: methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl, secondary butyl, tertiary butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, isooctyl, vinyl, allyl, methallyl or crotyl; or R1 and R, together with the nitrogen atom to which they are attached, form a piperidine ring or a morpholine ring. In the particularly preferred compounds of the formula I, R1 and R2 are n-butyl; R1 is methyl and R2 is phenyl; or Ri and R2, together with the nitrogen atom to which they are attached, form a morpholine ring. An alkali metal cation I or Mi, for example, may be the lithium, sodium or potassium cation. An equivalent of an alkaline earth metal cation M or Mi can be, for example, a magnesium, calcium or barium derivative. M and M, independently of one another, are preferably the ammonium cation, the sodium cation or the potassium cation. Particular preference is given to the sodium cation. Each of m and n, independently of each other, is preferably a number from 2 to 12, in particular, preferably, a number from 6 to 8. The detergent formulations according to the invention preferably comprise the compounds of the formula I in amounts from 0.1 to 6% by weight, in particular, preferably, in amounts of 1 to 5% by weight, based on the total amount of the detergent. The enzymes present in the detergent formulations according to the invention, for example, are proteases, amylases, lipases, cellulases or peroxidases, obtainable commercially. It is also possible to use mixtures of the specified enzymes.

These enzymes are preferably present in amounts of 0.5 to 2.0% by weight, in particular, preferably in amounts of 0.8 to 1.2% by weight, based on the total amount of detergent. The detergent formulations according to the invention are based on commercially available ingredients, which are known to the person skilled in the art. Suitable ingredients are, for example, anionic surfactants such as, for example: alkyl sulfates, alkyl ether sulphates, linear alkylbenzene sulphonates, secondary alkan sulfonates, olefinsulfonates of 8 to 24 carbon atoms, phosphates, such as those commonly used in detergents, and other anionic surfactants, such as those described, for example, in WO 92/06160, the nonionic surfactants, such as, for example, the polyglycol fatty alcohol ethers, the polyglycol ethers of fatty acid amide, the alkylphenol polyglycol ethers and the cationic surfactants, the positive and negative charge or amphoteric surfactants, such as, for example, the alkylbetaines, the alkylaminobetaines, the sulfobetaines and the inoglycinates. Preferably the ingredients are present in powder detergent formulations in amounts of 92 to 99.4% by weight, in particular, preferably, in amounts of 93 to 97% by weight, based on the total amount of detergent.

In liquid detergent formulations, the ingredients are preferably present in amounts of 35 to 60% by weight, particularly preferably in amounts of 40 to 50% by weight, based on the total amount of detergent. Additionally, the detergent formulations according to the invention may also comprise other customary auxiliaries and additives. Their examples include: perfumes, dyes, disinfectants, corrosion inhibitors, bleaches / activators, dye transfer inhibitors, etc. The base used for the detergent formulations according to the invention, preferably, is any of the usual detergent formulations, known to those skilled in the art. They may be powdery or liquid and may differ from the product according to the invention only by virtue of the fact that they do not contain the compound of the formula I. The compounds of the formula I can be prepared, for example, by reaction of the fatty acids unsaturated of the formula II: H3C (CH2) -CH = CH- (CH2) nC00H (II) wherein Ri and R2 are as defined above, and sulfuric acid. Suitable examples of fatty acids of the formula II are, in particular: oleic acid, ricinogenic fatty acids and elaidic acids.

The specified synthesis of the compounds of the formula I usually produces mixtures of compounds of the formula I which, in addition, may also comprise unreacted fatty acid of the formula II. The individual compounds of the formula I can be obtained in pure form from these mixtures by methods known to the person skilled in the art. However, this, as a rule, is unnecessary, since said mixtures can be used directly in the detergent formulations according to the invention. The detergent formulations according to the invention can be prepared, for example, by simply mixing the individual constituents, which can then be spray-dried, agglomerated or extruded. Those skilled in the art are familiar with these techniques. The detergent formulations according to the invention obtain the desired objective in an excellent manner. Surprisingly, it has been discovered that the compounds of the formula I also have a softening effect and greatly improve the handling of the test fabrics, for example, of a terry towel.

EXAMPLE 1 95% by weight of a commercially available powder detergent, consisting of sodium alkylbenzenesulfonate, of 12 carbon atoms, is mixed; sodium alkylsulfate of 15 to 18 carbon atoms and ethoxylated fatty alcohols; 2% by weight of a mixture of enzymes comprising protease, lipase and cellulase, and 3% by weight of a product of the reaction of elaidic acid with dimethylamine and sulfuric acid; to give a powdery detergent formulation that is capable of removing blood stains in a satisfactory manner.

EXAMPLE 2 The use of a product of the reaction of dicylenic fatty acid with dipropylamine and sulfuric acid, instead of the product of the reaction of elaidic acid with dimethylamine and sulfuric acid, as in example 1, produces an equally good detergent formulation.

EXAMPLE 3 A spray-dried detergent, comprising 7. 5% by weight of sodium alkylbenzenesulfonate of 12 carbon atoms in the alkyl; 3.0 wt% of sodium alkyl sulphate of 16 to 18 carbon atoms; 6.0% by weight of an ethoxylated fatty alcohol; 7.0% by weight of sodium bicarbonate; 11.0% by weight of silicate in SKS 6 sheet; 17.0% by weight of zeolite A, 5.0% by weight of sodium citrate, 5.0% by weight of borax, 20.0% by weight of perchlorinate, 5.0% by weight of TAED, 0.5% by weight of phosphonate, 6.0% by weight of polymers, 1.0% by weight of enzymes (protease, lipase, cellulase), 0.2% by weight of an optical brightener obtainable in commerce and 5.8% by weight of a product of the reaction of oleic acid, methylphenylamine and sulfuric acid. The product was able to eliminate blood stains in a satisfactory manner.

EXAMPLE 4 11.05 by weight of a secondary sodium alcansulfonate, 16.0% by weight of soap, 12.0% by weight of an ethoxylated fatty acid alcohol are mixed; 5.0% by weight of sodium citrate, 1.0% by weight of phosphonate, 0.5% by weight of polymers, 1.1% by weight of enzymes (protease, lipase, cellulase), 0.2% by weight of an optical brightener obtainable in commerce; 3.0% by weight of ethanol, 5.0% by weight of 1,2-propylene glycol and 2.0% by weight of a product of the reaction of elaidic acid with dipropylamine and sulfuric acid; and subsequently, up to 100% by weight is carried with water, to give a liquid detergent that is capable of removing blood stains in a satisfactory manner. Examples 5 to 7 below investigated the effectiveness of the compounds of formula I in the form of aqueous solutions with a concentration of approximately 40%, with respect to the elimination of blood in washing experiments, in various washing machines, in a single-load procedure, using a variety of detergents. The load, in each experiment, was 2.5 kg of ballast cloth, which consisted of bedding, barley grain and cotton crepe fabric with terry twist. A strip of combined fabric Empa 103 was attached to each of the two sheets. The lightness of the test rubbers was determined after washing, in each case, from reflectance measurements made using an Elrepho 2000.

EXAMPLE 5 Investigation of the blood eliminating effect using newly added enzymes, at 60 ° C. The base detergent used for the experiments in a Miele 918 washer was: 100 g of a commercially available powder detergent, which has usual ingredients, but no added enzymes. The following comparisons were made in triplicate: Determine Enzyme Reaction product of oleic acid added ba, di-n-butylamine Type se, (g). da (1) and sulfuric acid. a 100 no no b 100 no 5% of tq c 100 yes no d 100 yes 3% of tq e 100 yes 5% of tq (1) Enzyme added: 0.2% of Esperase < R > + 0.2% Lipolase (R > + 0.3% Te rmamyl C R > 300 + 0.5% Savinase < R > (All enzymes used were obtained from Dete rgent Enzime Division, Bioindustrial Group, Novo Nordisk A / S, Novo Alié, DK-2880 Bagsvae rd).

VALUES OF REFLECTION (R46) Dirt / 100 g a b c of detergent + blood 79.2 80.4 79.6 80.3 85 blood / milk / ink 48.8 59.1 55.3 56.3 59.8 EXAMPLE 6 Investigation of the blood eliminating effect in detergents obtainable commercially at 40 ° C and 60 ° C. The base detergents used for the experiments in a Miele W 723 washing machine were commercially available liquid laundry detergents or laundry powders having the usual ingredients. The following was compared: a) 95 g of liquid detergent; b) 95 g of liquid detergent + 5 g of a product of the reaction of oleic acid, di-n-butylamine and sulfuric acid, as an aqueous solution at a concentration of 40%; c) 95 g of washing powder d) 95 g of washing powder + 5 g of the reaction product of b), as an aqueous solution at a concentration of 40%.

Reflectance values (R46) after washing at 40 ° C DetergenDetergen Dust Powder for liquid tea liquilavar coto wash preserve Hugre do coto - do coto - in c) in d) in a) in b) Sang re (test test 103) 74.4 81.1 82.5 84.1 Blood / milk / ink (paper strip 103) 51.8 52.4 48.4 50.5 Sang re (individual ra t samples) 63.0 58.9 58.5 60 .4 Blood / milk / ink (individual rag samples) 37.9 39.8 38.0 38.8 Reflectance values (R46) after washing at 60 ° C DetergenDetergen Dust Powder for liquid tea liquilavar preserve COIO ttu re do COIO - do coto - en c) in d) in a) in b) Sang re (test test 103 70.3 80.1 82.4 87.5 Sang re / milk / ink (paper strip 103) 54.9 59.6 61.1 63.0 Sang re (individual t rapo samples) 61.4 67.7 66.2 76 .5 Sang re / milk / ink (individual ra t samples) 42.5 47.5 50.2 59.7 EXAMPLE 7 TACTO TEST: INVESTIGATION OF THE SMOOTHING EFFECT Example 6 was repeated using a hand towel made of terry cloth, as a test cloth, and about 2.3 kg of cotton cloth as a ballast. The following were compared: a) 100 g of liquid detergent, b) 95 g of liquid detergent + 5 g of a product of the reaction of oleic acid, di-n-butylamine and sulfuric acid, as an aqueous solution at a concentration of 40% The determination of terrycloth towels by experts, after the third and fifth washes revealed a clear improvement in the feel.

Claims

NOVELTY OF THE INVENTION CLAIMS 1. - An enzyme-containing detergent formulation, characterized in that it comprises a compound of the formula: H3C (CH2) m-A- (CH2) nC0B (I) in which: A is a group of the formula: -CH2-CH-; CH-CH2- or CH = CH-; I I 0S03M S03M B is NRiR2, alkoxy of 1 to 8 carbon atoms, OH or OMi; R 1 is alkyl of 1 to 8 carbon atoms, alkenyl of 2 to 8 carbon atoms, phenyl, alkylphenyl or phenylalkyl; each of which has from 1 to 4 carbon atoms in the alkyl chain, or cyclohexyl; R2 is hydrogen or has one of the meanings of Ri, or wherein R1 and R2, together with the nitrogen atom to which they are attached, form a heterocyclic radical; M and i, independently of each other, are an alkali metal cation, a triethanolamine cation or an ammonium cation, or an equivalent of an alkaline earth metal cation or aluminum cation; and m and n, independently of each other, are each a number from 0 to 22.
2. The formulation according to claim 1, further characterized in that A is a group of the formula: -CH2-CH-; -CH-CH2- 1 or 'SO3M 0S03M 3.- The formulation according to claim 1 and / or 2, further characterized in that B is NRiR2. 4. The formulation according to one or more of claims 1 to 3, further characterized in that R1 and R2 are methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl, secondary butyl, tertiary butyl, n-pentyl, n -hexyl, n-heptyl, n-octyl, isooctyl, vinyl, allyl, etalyl or crotyl; or Ri and R2, together with the nitrogen atom to which they are attached, form a piperidine ring or a morpholine ring. 5. The formulation according to any of claims 1 to 4, further characterized in that R and R2 are n-butyl; Ri is methyl and R2 is phenyl; or Rl and R, together with the nitrogen atom to which they are attached, form a morpholine ring. 6. The formulation according to one or more of claims 1 to 5, further characterized in that the compounds of the formula I are present in amounts of 0.1 to 6% by weight, particularly, preferably, in amounts of 1 to 5% by weight, based on the total amount of detergent. 7. The formulation according to one or more of claims 1 to 6, further characterized in that the enzymes present are: proteases, Ilases, lipases, cellulases, peroxidases or mixtures thereof. 8. - The formulation according to one or more of claims 1 to 7, further characterized in that the enzymes are present in amounts of 0.5 to 2.0% by weight, in particular, preferably, in amounts of 0.8 to 1.2% by weight, with based on the total amount of detergent. 9. The formulation according to any of claims 1 to 8, further characterized in that it is based on anionic surfactants, such as, for example: alkyl sulfates, alkyl ether sulfates, linear alkylbenzene sulphonates, secondary alkan sulfonates, olefinsulfonates of 8 to 24 carbon atoms, phosphates; nonionic surfactants, such as, for example, fatty alcohol polyglycol ethers, polyglycol fatty acid amide ethers, polyglycol ethers of alkylphenol; and cationic surfactants, of positive and negative or amphoteric ions, such as, for example: alkylbetaines, alkylaminobetaines, sulfobetaines and aminoglycinates. FIELD ANNEX FIELD (57) SUMMARY OF THE INVENTION The invention relates to a detergent formulation containing enzyme, which is characterized in that it contains a compound of the general formula, H 3 C (CH 2) m -A- (CH 2) nCOB, in which A represents a group of formula -CH2-CH- (a) OSO3M -CH-CH2- (b) OSO3M or -CH = CH-, B represents NRiR2, Ci-Ce alkoxy, OH or OM'i; and R 1 is C 1 -Ce alkyl, C 2 -Ce alkenyl, phenyl alkylphenyl or phenylalkyl, each having 1 to 4 carbon atoms in the alkyl chain, or cyclohexyl; R2 is hydrogen or has one of the meanings of R'1, or R1 and R2, together with the nitrogen atom to which they are attached, form a heterocyclic radical; M and M1, independently of one another, are an alkali metal cation or ammonium cation or an equivalent of an alkaline earth metal cation or aluminum cation; and y n are, independently of each other, a number from 0 to 22. P98 / 224F