MXPA98001565A - Lice treatments, and insec repellent mixes, lotions and dressing - Google Patents

Abstract

Mixtures, lotions and dew sprays are supplied. The insect repellent mixture includes crystalline 3,8-P-mentanediol (Chinese crystals) and at least two of: citronella, geraniol, terpineol and rodinol. For the repellence of mosquitoes and mites, the mixture is dissolved or dispersed in a transport medium, so that the resulting product preferably has the following percentages by weight: approximately 0.05% of citronella, approximately 0.06% of geraniol, approximately 0.8 to 0.5% of crystalline 3,8-P-methanediol, approximately 0.06% of terpineol and / or approximately 0.08% of rodinol. For the treatment of lice, the mixture is preferably dissolved or dispersed in a water-based transport medium, so that the resulting product has percentages by weight of about 0.36% citronella, about 0.43% geraniol, about 2% crystalline 3,8-P-mentano-diol, approximately 0.43% of terpineol and / or approximately 0.57% of rodin

Description

LICE TREATMENTS. AND MIXES. LOTION AND REPELLENT INSECT ROCKS BACKGROUND OF THE INVENTION l. Field of the Invention The present invention relates, generally, to insect repellents, which include lice treatments. More particularly, the present invention relates to synergistic mixtures of natural insect repellents, which can be used in a carrier, such as a lotion or sprayed insect repellent or in the treatment of lice. Repellent mixtures, carried by a carrier, are useful in humans and animals as lotions, rubbish and non-toxic treatments, and these repellents are particularly effective for (but not limited to) the repulsion of mosquitoes and in repelling and / or kill lice and stop the development of the eggs of these lice (nits). 2. State of the Art In an attempt to repel insects, people have re-used lotions and rubbers, sold widely, which contain N, N-diethyl-m-toluamide (DEET) as their active ingredient. While DEET is an effective repellent, it is not particularly pleasant in its odor, it can be itchy when applied and it has a number of harmful side effects to humans. DEET is harmful to the eyes, mucous membranes and sensitive skin, and, because it is absorbed through the skin, can also produce toxic systemic reactions. Thus, there have been reports of attacks that are believed to be associated with the topical application of DEET. Other symptoms and harms associated with repeated exposure to DEET have included irritability, confusion, insomnia, encephalopathy and lethargy. As a result, preventive statements regarding the use of DEET have been issued by government agencies.

The potential dangers of using a product containing DEET as an active ingredient suggest that there is a great need for a comparable repellent product which is not dangerous to users.

It is known that several herbaceous and floral extracts are useful in repelling insects. For example, citronella oil (hereinafter referred to as "citronella") is widely known as an insect repellent, although it is not as effective as DEET.

US Patents Nos. 5,227,406 and 5,346,922 of the same owner, which are incorporated herein by reference, disclose a non-toxic, generally natural, insect repellent which includes terpineol ("T"), citronella ("C") and one or both rodinol ("R") extra and geraniol ("G") as active ingredients, provided in a transport medium. The active ingredients are preferably used in small percentages, for example as little as 0.01%, preferably between 0.05 and 0.08%, and more preferably less than 1%, which are still effective synergistically, in particular against mosquitoes and possibly against others insects, such as mites that carry Lyme disease. The means of transport can be, among other things, a moisturizing cosmetic lotion, with or without a sunscreen. For a spray, the means of transport may be based on water or alcohol. An attractive fragrance that does not interfere with the activity is preferably provided in about 0.4% of the insect repellent product and which is capable of masking (to humans) the aromas of the active ingredients, because they are present in concentrations low. The lotion or spray is applied, safely, in free amounts to humans and animals, without unpleasant side effects, such as itching. It has been discovered in controlled studies that the combination of the ingredients T, C, G and R, is effective due to the synergistic interaction between the ingredients and that the sub-combinations of the T, C, and R, or the T , C and G, are also synergistic. Better results are obtained with a repellent that has the following concentrations of ingredients: 0.06 of T, 0.05 of C, 0.08 of R and 0.06 of G.

It is reported in the literature that a plant derivative, known as "Chinese crystals", is also an effective herbaceous insect repellent. Chinese crystals, are components that occur naturally from an essential oil obtained from China, and are available from Shaw Mudge & Company, of Stamford, CT, E. U. A., with the name "Chínese Botanical I". It is a crystalline compound, commonly referred to as 3,8-methanediol (also known as 2-hydroxy-a, 4-trimethyl-cyclohexane-methanol) and has a molecular structure as shown below in Diagram 1.

Diagram 1 BRIEF DESCRIPTION OF THE INVENTION Therefore, it is an object of the invention to provide effective and safe insect repellent mixtures, and repellents comprising the mixtures and means of transport. Other objects of the invention include: providing effective insect repellent mixtures, which are dispersed or dissolved in or used in conjunction with different means of transport, such as lotions, dew, or the like; provide these mixtures, sprays and insect repellent lotions that effectively repel mosquitoes and other insects and that effectively repel lice and stop the development of lice nits; providing a safe and effective insect repellent mixture in a transport medium which can be applied in free form to one or more of a person's face, skin, hair and clothing; provide insect repellents, safe and effective for animals; provide an insect repellent or lice treatment, which uses herbal and floral extracts ingredients, generally safe, or the natural oils that contain them, and achieve an efficiency comparable to DEET; and supplying an insect repellent which can be impregnated in a cloth or plastic, incorporated in a spray mist and can be used in other applications, such as in surface treatments.

According to the objects of the invention, an insect repellent mixture is supplied, which includes the Chinese crystals (CC), and at least two: citronella (C), geraniol (G), terpineol (T) and rodinol (extra) (R). For insect repellency, such as mosquitoes or mites, this repellent mixture preferably comprises from 5 to 25% by weight of C, from 5 to 25% by weight of G, from 30 to 75% by weight of CC, approximately, and T and / or R are 5 to 30% by weight, so that the components of the total mixture are 100% by weight. The mixture is typically dispersed or dissolved in a transport medium, such as a lotion, spray, or the like. When dispersed or dissolved, the concentration of the components in the general formulation typically ranges from 0.01 to 1 weight percent each of C, G and T and / or R, and 0.01 to 5 weight percent of CC , approximately, and the rest includes the means of transport. This means of transport may include one or more of humectants, sunscreens, fragrances and other ingredients, if desired. According to another aspect of the invention, the insect repellent mixture, which includes the CC, and at least two of C, G, T and R, is used in higher concentrations (for example more than 1% and preferably 2%). to 5% of the general formulation) as a treatment for lice. In a particularly preferred embodiment, an insect repellent mixture for the treatment of lice includes about 7% citronella, about 9% geraniol, about 9% terpineol and about 75% Chinese crystals. The mixture is then provided in a carrier, with this mixture constituting approximately 4% by weight of the formulation. The preferred carrier is a "leave-in-rinse" conditioner spray on hair and skin, which includes water, and one or more conditioners, humectants, lubricants, preservatives and emulsifiers.

Additional objects and advantages of the invention will become apparent to those skilled in the art with reference to the following detailed description, taken in conjunction with the figures provided. BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a bar graph showing the average repellency, as a percentage of the insect stings regimes observed in a control, for each of the embodiments of the invention tested for mosquito repellency and for each of the ingredients of the invention; Figure 2 is a graph of the 95% confidence intervals and the narrow sense additivity model for one embodiment of the invention; Figure 3 is a graph of the 95% confidence intervals and the narrow sense additivity model for another embodiment of the invention; Figure 4 is a graph of the 95% confidence intervals and the narrow sense additivity model for a further embodiment of the invention; Figure 5 is a graph of the 95% confidence intervals and the narrow sense additivity model for yet another embodiment of the invention; Y Figures 6a to 6f are graphs showing the amounts of live nits and lice, and dead nits and lice, in six subjects of a test for periods of several days. DETAILED DESCRIPTION OF THE PREFERRED MODALITIES The insect repellent mixture, according to the invention, includes a combination of Chinese crystals and at least two of the citronella, geraniol and terpineol or rodinol (extra). Preferably, the mixture includes CC, C, G and T and / or R. This mixture is typically dispersed or dissolved in a transport medium, such as a lotion, spray or the like. For the purposes of mosquito repellency, four embodiments of the invention were tested as the individual constituents of each modality and a control. Table 1 lists the various constituents (rows 1 to 6) of the embodiments of the invention and their concentration as a percentage by weight of a fragrance-free Lubriderm ™ skin lotion carrier. Table 1 also lists the four embodiments of the invention (rows 7 to 10) which indicate the concentration of the active ingredients of each embodiment as a percentage by weight in the carrier of the Lubriderm ™ skin lotion, free of fragrances. The first two modalities, the Combination IA (row 7 of Table 1) and the Combination IB (row 8 of Table 1), have the CC, C, G and T as active ingredients and differ only in the concentration of the CC of 0.5% versus 0.08%. The second two modalities, Combination 2A (row 9 in Table 1) and Combination 2B (row 10 of Table 1) have the CC, C, G and R as ingredients and differ only in the concentration of CCs of 0.5. % versus 0.08%. In row 11 in Table 1, 100% of the fragrance-free Lubriderm ™ was also tested as a control.

TABLE 1; List of Constituents, combinations and Control Each of the constituents, combinations and control in Table 1 was tested, treating a human hand with 1 ml of the treatment and submitting the hand, thus treated, to the attack by Aedes aegypti mosquitoes. The mosquitoes were kept in captivity in cubic cages of Plexiglas ™ (0.3 meters per side) with 200 mosquitoes per cage, kept in sugar water. The tests were conducted by placing the treated hand inside the cage and counting the number of bites for a period of 15 seconds. The test was conducted during 110 trials for each of the constituents, combinations and control ("treatments"). Seven subjects participated in the test. The hands were thoroughly washed with mild soap between the tests. The treatments were tested one after the other, with the random order between trials. The number of bites in one hand treated with the control, over a period of 15 seconds, ranged from 5 to 33 in 110 control trials, with an average of 17.33 and a standard deviation of 6.65. Data from the 1,210 trials were collected between subjects for analysis, The average and 95% confidence intervals for each treatment were calculated. The 95% confidence interval is the estimated range of the two, within which the next hypothetical point of data collected from the same experiment is expected to occur in 95% of cases. Table 2 shows the results calculated for each treatment as a percentage of the pits regimen of the control treatment. It will be understood that a lower percentage represents greater repellency.

TABLE 2; Average values of repellency and intervals of 95% confidence for each constituent and combination of Treatment, Expressed as a Percentage of the Regimen of Stings of Control Treatment.

As shown in Table 2, the average repellency regimen of C, G, R and T, when tested individually, ranged from 81 to 85% of the control pest regime. The CC (lines 6 and 7) exhibited a better repellency regime of approximately 52 to 67% of the control bite regime. Each of the combinations (lines 7 to 10) exhibited a repellency rate drastically better than any of the ingredients, ie from about 11 to 18% of the control pitting regime.

The average values shown in Table 2 are illustrated graphically in Figure 1. Referring to Table 2 and Figure 1, it can be seen that the most effective treatment was the Combination IA (line 7 of Table 2 and Figure 1) , which contains approximately 0.06 T, approximately 0.05% C, approximately 0.06% G, and approximately 0.5% CC, which exhibits a repellency rate of 11.3%. Combination 2A (line 9 of Table 2 and Figure 1), which contains approximately 0.08% R, approximately 0.05% C, approximately 0.06% G, and approximately 0.5% CC, was almost as effective, exhibited an average repellency rate of 13.1%. The IB combination (line 8 of Table 2 and Figure 1), which contains approximately 0.06% T, approximately 0.05% C, approximately 0.06% G, and approximately 0.08% CC, and Combination 2B (line 10 of Table 2 and Figure 1) that contains approximately 0.08% of R, approximately 0.05% of C, approximately 0.06% of G and approximately 0.08% of CC, have the same average value of repellency. 17.7%. These findings suggest that an increased concentration of Chinese crystals (CC) significantly increases repellency and that the contribution of rodinol was substantially identical to the contribution of terpineol.

The analyzed data of the 1,210 trials were examined using the factorial additivity model. According to this model, the average confidence interval and 95% for each ingredient of each combination are combined in multiplied form. The resulting average and "narrow sense additivity" predict an average and a confidence interval expected from the combination if the contribution of each ingredient was simply "additive". The average expected repellency of the IA combination, therefore, is calculated by multiplying the observed regimes of average repellency of each of the ingredients of the Combination IA. Referring to Table 2, it will be appreciated that the average expected repellency of the AI Combination is 29.52% = (81% x 81.5% x 85% x 52.6%). Similarly, the expected 95% confidence interval (narrow sense additivity) for the AI Combination is 17.12% to 46.73%. It will be appreciated, however, that the average observed repellency of the IAA combination was actually 11.3%, which is much lower than the expected rate of 29.52%. In addition, the confidence interval of the observed treatment of the AI Combination (9.2% to 13.4%) is well below the expected confidence interval of 17.2% to 46.73%. The comparison of the observed average and the confidence interval for the Combination IA and the expected average and the additivity of narrow sense, are shown graphically in Figure 2. The fact that there is no overlap between the confidence interval of the Combination IA and the The narrow sense additivity model indicates that there is a statistically significant difference (of at least P <0.05) between the model and the cumulative data for the AI Combination. In other words, it is at least 95% likely that the interaction between the ingredients of the AI Combination is synergistic rather than merely additive. The same analysis was applied to the data accumulated by the Combination IB and is represented graphically in Figure 3. Referring to Table 2, it will be appreciated that the expected average repellency of the IB Combination is 37.65% = (81% x 81.5% x 85% x 67.1%). The expected 95% confidence interval (narrow sense additivity) for Combination IB is from 22.62 to 58.06%. However, it will be appreciated that the average observed repellency of the IB Combination was actually 17.7%, which is much lower than the expected rate of 37.65%. In addition, the confidence interval of the observed treatment of the IB combination (24.8% to 20.7%) is well below the expected confidence interval of 22.62% to 58.06% without overlapping. Therefore, at least 95% is likely that the ingredients of the IB Combination act synergistically rather than additively.

Turning now to Figure 4 and with reference to table 2, the expected average repellency of combination 2A is 28.47%. The expected 95% confidence interval (narrow sense additivity) for the 2A Combination is from 18.69% to 44.27%. It will be appreciated, however, that the average observed repellency of Combination 2A was actually 13.1%, which is much lower than the expected 28.47% regimen. In addition, the confidence interval of the observed treatment of the 2A Combination (10.3% to 15.8%) is well below the expected confidence interval of 18.69% to 44.27%, without overlapping. Therefore, it is at least 95% likely that the ingredients of combination 2A act synergistically rather than additively.

The same analysis was applied to the data for Combination 2B and was demonstrated graphically in Figure 5. The average observed repellency of combination 2B was actually 17.7%, which is much lower than the expected 36.32% regimen. In addition, the confidence interval of the treatment observed for combination 2B (13.3% to 22.0%) is below the expected confidence interval of 22.32% to 55.01% without overlapping. Therefore, at least 95% is likely that the ingredients of combination 2B act synergistically rather than additively.

Based on the foregoing observations and analyzes, it is concluded that each embodiment of the invention represents a synergistic interaction of ingredients. Average repellency regimes of each of the embodiments of the invention averaged twice as much as predicted by the factorial additive model. In addition, the predicted 95% confidence intervals of the additivity models do not overlap those calculated for the observed performance of the embodiments of the invention. Thus, the actual performance of the embodiments of the invention is significantly superior to the predicted performance without synergy between the ingredients. It should also be noted that the performance of the embodiments of the invention was significantly less variable than the performance of the individual ingredients, as indicated by the significantly narrower confidence intervals, listed in Table 2. It is believed that the greater repellency of Combinations IA and 2A, as compared to combinations IB and 2B, are due to the higher concentration of Chinese crystals, which were the most repellent of the individual constituents. It is also believed that the similar results obtained with Combination IA and 2A versus IB and 2B are due to the similar repellency of terpineol and extra rodinol. It is also believed that similar results are obtained when the active components of the insect repellent mixture are used with or without a means of transport. In addition, it is believed that CC combinations with any of two of the four other active ingredients will also exhibit synergistic results.

It will also be noted that the tests presented here were done using a mosquito species (Aedes aegypti), which is widely maintained in the laboratory colonies. This species is known as the most aggressive (less repelled) than other species. While no claim has been made regarding efficacy in the field, it is possible that an even greater repellency with other species can be observed.

In addition, it will be noted that the concentrations of extra citronella, geraniol, terpineol and rodinol used in the disclosed embodiments are the optimum concentrations of these ingredients, described in the above-mentioned commonly owned US patents Nos. 5,227,406 and 5,346,922. . However, it is believed that the concentrations of these ingredients in the present invention can vary significantly up to and beyond the 1% described in these commonly owned U.S. Patent Nos. 5,227,406 and 5,346,522. In addition, it is believed that concentrations of Chinese crystals up to and above 5% in the general formulation, can be useful, since the larger quantities of Chinese crystals are easily masked by fragrances that do not interfere in the activity.

Still further, it should be appreciated that while a preferred means of transport for the insect repellent of the invention has been described, this means of transport can take many forms. For example, the insect repellent of the invention can be incorporated in media including, but not limited to, lotions, sprays, creams, soaps (liquid or in bars), powders, candles, perfumes, etc. In fact, other active ingredients for other purposes, such as sunscreens, sunscreens, sun blockers, skin moisturizers, etc., can be added to lotions, sprays, creams, soaps, powders, candles, perfumes, etc. Similarly, the insect repellent can be impregnated into a cloth or plastic, in a manner known in the art, where other repellents are impregnated into these fabrics or plastics, thus effectively causing the fabric or plastic to become the means of transport. . Likewise, the insect repellent of the invention can be used in other applications, such as in surface treatments, for example by incorporating the repellent into a wax or other surface coating.

It should also be noted that while the described modalities were described for use on human skin to effectively repel mosquitoes, the insect repellent is believed to repel other insects (as discussed with reference to Figures 6a-6f) and may be used in animals as well as in humans. According to another aspect of the invention, the insect repellent mixture which includes the CC and two or more of C, G, T and R, can be used in higher concentrations (for example more than 1% and preferably 2 to 5). % of a general formulation) as a lice treatment. In a particularly preferred embodiment, an insect repellent mixture for the treatment of lice includes about 7% citronella, about 9% geraniol, about 9% terpineol and about 75% Chinese crystals. The mixture is then provided in a carrier, with this mixture constituting approximately 3% by weight of the formulation. The preferred carrier is a "leave-in-rinse" conditioner spray on hair and skin, which includes water, one or more hair and skin conditioners, humectants, lubricants, preservatives and emulsifiers. The conditioners act to condition the hair (and skin) by binding to the proteins in this hair (and skin). The humectants act to retain the water (which includes the insect repellent mixture that is emulsified and / or dissolved in the water) on the hair. Lubricants act to lubricate the hair to allow easier styling. The condoms act to preserve the proteins that can be contained in the conditioners. The emulsifiers act to emulsify the insect repellent mixture as well as the lubricant and other carrier ingredients in the water.

According to the aspect of the invention of the treatment of lice, an insect repellent mixture for the treatment of lice is prepared with approximately 7% C, approximately 9% G, approximately 9% T and approximately 75%. % of CC, by weight. The mixture in conjunction with an aroma masker is then added to the water-based spraying medium (carrier) to create a formulation. The carrier used is "left un-rinsed" in the hair conditioner spray, which includes water, hair and skin conditioners, humectants, a lubricant, a condom and emulsifiers, which are all known in the art. The ingredients of the formulation, by weight, are approximately: Water: 91.41% conditioners: 2.53% humectants: 1.59% lubricants: 0.12% condoms: 0.11% emulsifiers 0.99% masking of 0.33% Repellent mixture: 3.22% aromas: Using the formulation prepared for the treatment of lice, a first study was conducted on six subjects, using the following basic protocol. On day 1, the back of the scalp of each subject was found in the presence of nits and lice, combing twenty times, and the hair removed with the comb were kept for microscopic examination and to determine the number of live and dead nits and lice. The lice treatment conditioner was applied as a spray to the hair until it was completely wetted. On day 3 and following, the hair was combed again, and the hair pulled with the comb was kept and examined, and the conditioner was reapplied as before. The six subjects were told to apply the conditioner and combed daily during the study, although only two subjects received additional applications.

Before going back to Figures 6a-6f, it will be noted that the numbers contained therein are samples, not absolute population measures. In addition, some of the subjects lived in their homes, where the environment and other members of the family were infected, so the lice could have been acquired after starting the treatment. Also, it will be noted that the eggs of the lice took 7 to 11 days to incubate, and the maturation occurred about eight days after that.

Turning now to Figures 6a-6f, it is seen that the information was collected in each subject on days 1, 3, 5 and in the case of subject # 1, (Figure 6a) on day 10. It will be noted that in almost all cases, on day 1 there were no nit deaths (except subject # 6) and there were live lice (except in subject # 4) and live nits (except in subject # 5). By day 3, live nits had been eradicated in subjects # 1, 2 and 6, although in subject # 1 the nits reappeared on day 5 and eradicated by day 10. Also, by day 5 , live nits and live lice were eradicated in all subjects, except in subject # 1, where they were eradicated by day 10.

The following additional observations regarding the first lice study were made. The hairstyle and the use of lice treatment reduced lice populations in the subjects to zero and all six subjects were free of lice at least two weeks after finishing the graphic study. The hairstyle itself was very probably not responsible for the elimination of the infestation, because not all the hair / scalp was combed, and because twenty hairstyles is a low number from the point of view of scrupulousness. Many lice responded to the treatment of them by moving away from the scalp and thus were easier to comb and separate. In addition, as reported by all subjects who had had prior experience with lice removal, the application of the lice treatment spray made it easier to remove nits by combing with their fingers. Using the prepared treatment of lice, a second study was carried out where a female pregnant louse was induced to put nine eggs on the hair of an investigator's arm. Five of these nits were treated with the conditioner, while the remaining four eggs were not treated. The eggs were kept separately in Petri dishes with filter paper flats. All untreated eggs showed normal development. All the treated eggs failed in their development. Studies of lice suggest that control is gained, at least partially, through the mortality of eggs (ovicidal action). The absence of subsequent infestations in the six subjects of the first study indicated that there were no live eggs present at the time of termination of the applications and that the use of lice treatment may discourage reinfestation, perhaps for substantial periods of time after cessation. application of lice treatment.

Synergistic mixtures that repel insects have been described here, which incorporate the Chinese crystals, citronella, geraniol and either terpineol or rodinol (extra), which can be dispersed or dissolved in a transport medium, such as a lotion or dew, so that the mixture comprises a smaller percentage of the transport medium. While particular embodiments have been described, the invention is not intended to be limited by them, since the invention can be practiced in the broad aspect allowed by the art. Thus, while the preferred percentages and ranges of the active ingredients are described, it will be appreciated that different relative percentages of the active ingredients, within and outside those preferred ranges, can be used, although it is not known whether the resulting combination will be as effective as the preferred modalities. In addition, while insect repellents were tested and approved as effective in mosquitoes and lice, it is believed that the repellent has efficacy in other insects, which include mites. Therefore, it will be appreciated by those skilled in the art that other modifications can still be made to the supplied invention, without deviating from its spirit and scope, as claimed.

Claims (22)

1. NOVELTY OF THE INVENTION Having described the present invention, it is considered as a novelty and, therefore, the content of the following is claimed as property: CLAIMS 1. An insect repellent, which comprises: a mixture of 3,8 P - Crystalline magnesium and at least two of: citronella, geraniol, terpineol and rodinol.
2. 2. An insect repellent, according to claim 1, wherein: at least two of the citronella, geraniol, terpineol and rodinol, comprise citronella, geraniol and terpineol and / or rodinol.
3. 3. An insect repellent, according to claim 2, wherein: said geraniol comprises about 5 to 25% by weight of said mixture; said citronella comprises about 5 to 25% by weight of said mixture; said crystalline 3, 8-P-mentanediol comprises about 30 to 75% by weight of said mixture; and said terpineol and / or rodinol comprises about 5 to 50% by weight of said mixture.
4. 4. An insect repellent, according to claim 1, further comprising: a means of transport, wherein said mixture is dispersed, dissolved or otherwise carried in said means of transport.
5. 5. An insect repellent, according to claim 2, further comprising: a means of transport, wherein said mixture is dispersed, dissolved or otherwise carried in said transport means, wherein said geraniol constitutes at least .01 % of insect repellent; said citronella constitutes at least .01% of the insect repellent; said terpineol and / or rodinol constitute at least .01% of the insect repellent; and said crystalline 3, 8-P-mentanediol constitutes at least .01% of the insect repellent; where all the percentages (%) listed are percentages by weight.
6. 6. An insect repellent, according to claim 5, wherein: said geraniol constitutes no more than 1% of the insect repellent; said citronella constitutes no more than 1% of the insect repellent; said terpineol and / or rodinol constitute no more than 2% of the insect repellent; said 3, crystalline 8-P-mentanediol constitutes no more than 5% of the insect repellent; where all the percentages (%) listed are percentages by weight.
7. 7. An insect repellent, according to claim 5, wherein: said geraniol constitutes approximately 0.01% to 1% by weight of the insect repellent; said citronella constitutes approximately 0.01% to 1% by weight of the insect repellent; said 3, 8-P-menthanediol constitutes approximately 0.01% to 5% by weight of the insect repellent; said terpineol and / or rodinol constitute approximately 0.01 to 2% by weight of the insect repellent; said means of transport comprises the rest of the insect repellent.
8. 8. An insect repellent, according to claim 7, wherein: said 3,8-P-menthanediol constitutes approximately 0.08% by weight of said insect repellent.
9. 9. An insect repellent, according to claim 7, wherein: 3,8-P-menthanediol constitutes about 0.5% by weight of said insect repellent.
10. 10. An insect repellent, according to claim 7, wherein: 3,8-P-mennediol constitutes approximately 1% to 3% by weight of the insect repellent.
11. 11. An insect repellent, according to claim 8, wherein: said geraniol constitutes approximately 0.06% by weight of said insect repellent, said citronella constituting approximately 0.05% by weight of said insect repellent, and said terpineol and / or rodinol constitutes approximately 0.06% to 0.014% by weight of said insect repellent.
12. 12. An insect repellent, according to claim 9, wherein: said geraniol constitutes approximately 0.06% by weight of said insect repellent, said citronella constituting approximately 0.05% by weight of said insect repellent, and said terpineol and / or rodinol constitutes approximately 0.06% to 0.014% by weight of the insect repellent.
13. 13. An insect repellent, according to claim 10, wherein: said geraniol constitutes about .4% by weight of said insect repellent, said citronella constitutes approximately .4% by weight of said insect repellent, said terpineol and / or rodinol constitutes approximately .4 to 1% by weight of said insect repellent, and said 3, 8-P-menthanediol constitutes approximately 2% by weight of the insect repellent.
14. 14. A treatment for lice, which includes: a mixture of crystalline 3, 8-P-mentanediol, and at least two of: citronella, geraniol, terpineol and rodinol, all carried in a carrier.
15. 15. A treatment against lice according to claim 14, wherein: said at least two of the citronella, geraniol, terpineol and rodinol, comprise citronella, geraniol and terpineol and / or rodinol.
16. 16. A treatment against lice according to claim 15, wherein: said geraniol constitutes approximately 0.01% to 1% by weight of said treatment against lice, said citronella constitutes approximately 0.01% to 1% by weight of said treatment against Lice, said 3.8 P-methanediol constitutes approximately 0.01% to 5% by weight of said lice treatment, said terpineol and / or rodinol constitutes approximately 0.01% to 2% by weight of said lice treatment, said means of transport comprises substantially the rest of said treatment against lice.
17. 17. A lice treatment according to claim 15, wherein: said carrier is a water-based spraying means.
18. 18. A treatment against lice, according to claim 17, wherein: said carrier comprises water, a conditioner for the hair, a humectant and an emulsifier.
19. 19. A treatment against lice, according to claim 18, wherein: said means of transport further comprises a lubricant and a condom.
20. 20. A treatment against lice, according to claim 18, wherein: said carrier further comprises a cover of aroma that substantially covers the odor of said geraniol, said citronella, said 3,8 P-menthanediol, and said terpineol and / or rodmol, for the use of humans.
21. 21. A method for treating lice, comprising: treating an area infested with lice with a treatment comprising 3.8 crystalline P-methanediol and at least two of: citronella, geraniol, terpineol and rodinol, all carried in a carrier.
22. 22. A method according to claim 21, wherein: said carrier in a water-based carrier, and said treatment comprises wetting the infested area of lice with said treatment.