MXPA97008330A - Polioxylycylene compounds in heteric blocks, liquid, which have better fluidity characteristics - Google Patents

Abstract

The present invention relates to liquid polyoxyalkylene compounds that have improved flow characteristics useful in a variety of industrial and personal care applications.

Description

POLIOXYLYCYLENE COMPOUNDS IN HETERIC BLOCKS, LIQUIDS, WHICH HAVE IMPROVED FLUIDITY CHARACTERISTICS FIELD OF THE INVENTION The present invention relates to liquid, heterogeneous block polyoxyalkylene compounds, which are homogeneous and have improved flow characteristics.

BACKGROUND Polyoxyalkylene block copolymers are well known to those skilled in the art of nonionic surfactants. Specifically, U.S. Patent 3,740,421 (Schmolka) assigned to BASF discloses aqueous gels that are prepared using a polyoxyethylene / polyoxypropylene block copolymer suitable for pharmaceutical and personal care compositions. U.S. Patent 3,639,574 (Schamolka) assigned to BASF discloses polyoxyethylene / polyoxypropylene block copolymers as gelling agents for hydrogen peroxide compositions. U.S. Patent 4,465,663, (Schmolka) assigned to BASF discloses polyoxybutylene / polyoxypropylene block copolymers as gelling agents for aqueous gels useful in pharmaceutical and personal care applications. Some of these compounds are sold by BASF Corporation under the trade name of PLURONIC®. Additionally, US Patents 4,272,394 and 4,411,810 disclose the use of polyoxyalkylene block polymers in applications for tackle washing machines. U.S. Patent 4,925,988 describes the use of a nonionic surfactant in a specific combination of alkanol, ethylene oxide and propylene oxide useful for automatic dishwashing application. U.S. Patent 5,374,368 describes the use of the copolymers in three EO / PO / EO liquid blocks (PLURONIC® L 31 and L 35 surfactants) in stable dental care compositions that release hydrogen peroxide in concentrations of 55-90% by weight of the composition for dental care. US Pat. No. 3,740,421 describes the three-block EO / PO / EO copolymers, solids, gel formers, useful in cosmetic formulations and for personal care in concentrations of approximately 20-25% by weight. Preferred solid, EO / PO / EO three-block copolymers have a molecular weight of 4,600-16,000. These copolymers in three EO / PO / EO blocks, solid, form a gel when they are added to an aqueous solution. U.S. Patent 3,867,533 discloses aqueous gel compositions containing copolymers in three EO / PO / EO blocks, solids, with a molecular weight of 6.450-20,000, useful in concentrations of about 20% by weight. These compositions are useful for preparing cosmetic formulations. U.S. Patent 4,465,663 discloses aqueous cosmetic gels containing copolymers in three blocks of EO / BO (butylene oxide) / EO, solids in concentrations of about 20%. U.S. Patent 5,035,880 discloses dentifrice compositions, stable containing a cetylpyridinium bactericide and the three block copolymers, EO / PO / EO solids, (PLURONIC® F 127 surfactant) and polyethylene glycol in concentrations of 15-80% by weight, US Patent 4,476,107 discloses a mouthwash containing copolymers in three blocks EO / BO (butylene oxide) / EO in concentrations of 0.5-5.0% by weight. U.S. Patent 5,057,307 describes oral hygiene gels containing nonionic surfactants, coating substances and viscosity modifiers. These nonionic surfactants are PLURONIC® F 108 and F 127 surfactants available from BASF Corporation, Mt. Olive, New Jersey. U.S. Patent 5,256,396 describes a topical composition containing an EO / PO / EO three-block copolymer, solid (PLURONIC® F 127 surfactant) used at a concentration of more than 10% to about 17% by weight. Patent EPO-546-627A describes compositions for mouthwash containing copolymers in three blocks, solids, of EO / PO / EO as surfactants PLURONIC® L 108, F 88, in concentrations of 0.5-3% by weight. U.S. Patent 5,073,368 describes mouthwashes containing copolymers in three blocks of EO / PO / EO, solids, as surfactant PLURONIC® F 87 in concentrations of 0.1-3% by weight. WO 93/13750 discloses an eye cleaning composition containing copolymers in three blocks, PLURONIC® F87 solid and in PLURONIC® P 85 paste. The PLURONIC® P 85 surfactant is 4-9% by weight of the cleaning composition, the PLURONIC® F 87 surfactant is 0.5-2% by weight of the cleaning composition. Finally, US Pat. No. 5,096,698 discloses a toothpaste composition containing a three-block EO / PO / EO, liquid, non-ionic copolymer, or an EO / PO / EO, three-block copolymer, solid, in concentrations of 0.1-5. % by weight. These copolymers help to avoid phase separation. The surfactant PLURONIC® F 108 (solid) is more preferred, followed by the surfactants PLURONIC® F 87, PLURONIC® F 127 and PLURONIC® L 72. US Pat. No. 4,272,394 describes the nonionic surfactant, with low foaming power, novel, for compositions for machine washing machines. U.S. Patent 4,411,810 discloses a nonionic surfactant, with low foaming power, low cloud point, in compositions for washing machines. U.S. Patents 5,496,452, 5,374,368 and 5,424,060 describe the use of a polyoxyalkylene compound to prepare a stable percarbonate formulation, as well as a dentifrice composition. U.S. Patent 5,187,191 discloses polyoxyalkylene ester block surfactants in formulations for agricultural use. Finally, Japanese Patent JP47-48366 B4 describes a process for producing liquid, tasteless, heteroteryl polyoxyalkylene compounds of molecular weight 1000 or higher. However, a major problem with these polymeric materials is that they have high pour points (closer to ambient temperatures) which limits their use in processes of cosmetic compositions and toiletries. In addition, the polymers of Japanese Patent Application 47-48366 B4 develop a higher degree of crystallinity which manifests as turbidity and solids precipitated during storage. Applicants have surprisingly discovered a method for producing polyoxyalkylene compounds in heteric, liquid blocks, with pour point significantly lower (i.e., closer to solidification temperatures) which substantially increases their utility in personal care compositions. In addition, the inventive polymers of the applicants were neutralized with common inorganic acids resulting essentially in compositions transparent and almost free of solids precipitated during storage. The applicants have achieved this by selectively controlling the distribution or placement of propylene oxide and ethylene oxide in the inventive polymers of the applicants. If limited to the theory, the applicants wish to emphasize that it is of particular importance to control the distribution or placement of the alkylene oxides of C3 or higher in the polymer chain, to effectively reduce or eliminate the formation of crystalline segments in the polymer. . When crystalline segments are allowed to form in the polymers, the crystalline segments are separated from the solution causing a two-phase, unwanted product. The applicants' approach to overcoming this problem in the art differs from the method described in Japanese Patent Application 47-48366 B4 wherein the alkylene oxides are randomly distributed throughout the polymer chain. These polymers, as described in Japanese Patent 47-48366 B4 which consist solely of a random distribution of the alkylene oxides throughout the polymer chain are outside the scope of the applicants' invention.Definitions and terms HOMOGENEITY is a term used to characterize the single phase, the physical form of the polyoxyalkylene compound in the heteric block of this invention. FLUIDITY refers to the ease of spillage of the liquid polyoxyalkylene compounds of this invention. The ease of spillage is manifested in the values of the spill points shown by the compounds in heteric, liquid blocks. HETERIC BLOCK The liquid polyoxyalkylene polymer of the present invention is a block copolymer of which at least one block is composed of a mixture of ethylene oxide and C3-e alkylene oxides randomized. This random arrangement of ethylene oxide and the alkylene oxides of C3-e is known as a heteric block.

The present invention relates to a polyoxyalkylene compound in heteric block, liquid, with better characteristics of flow and homogeneity, which tends the formula: I- [(AO) a- [(EO) b (XO) c] - ( EO) dM] x; wherein: I is an initiator or a mixture of initiators having at least one substituent selected from the group including, but not limited to OH, NH2 or COOH; AO is an alkylene oxide of 2-6 carbons or a mixture of alkylene oxides of 2-6 carbons arranged randomly or in a block sequence; EO is ethylene oxide; XO is a portion of alkylene oxide having 3-6 carbon atoms; M is hydrogen or alkali metal or alkaline earth metal; a is an integer from about 1-20; b is an integer from about 5-1500; c is an integer from about 2-700; d is an integer from about 1-15; x is an integer from about 1-8; The present invention furthermore relates to a method of making a liquid, heteric block polyoxyalkylene compound having improved flow characteristics, which has the formula: I- [(AO) a- [(EO) b (XO)] c] - (EO) dM] x; wherein I is an initiator or a mixture of initiators having at least one substituent selected from the group including, but not limited to OH, NH2 or COOH; AO is an alkylene oxide of 2-6 carbons or a mixture of alkylene oxides of 2-6 carbons arranged randomly or in a block sequence: EO is ethylene oxide and XO is a portion of ethylene oxide having 3-6 carbon atoms; M is a hydrogen or an alkali metal or alkaline earth metal; a is an integer from about 1-20; b is an integer from about 5-1500; c is an integer from about 2-700; d is an integer from about 1-15; x is an integer from about 1-8; which comprises the steps of: adding AO to an initiator and catalyst followed by b adding a mixture of EO and XO followed by, c adding EO. The molecular weight range is around 1,000-100,000.

DETAILED DESCRIPTION The present invention relates to a polyoxyalkylene compound in heteric block, liquid, with better characteristics of fluidity and homogeneity, tending the formula: I- [(AO) a- [(EO) b (XO) c] - (EO) dM] x; wherein: I is an initiator or a mixture of initiators having at least one substituent selected from the group including, but not limited to OH, NH2 or COOH; AO is an alkylene oxide of 2-6 carbons or a mixture of alkylene oxides of 2-6 carbons arranged randomly or in a sequence of blocks; EO is ethylene oxide; XO is a portion of alkylene oxide having 3-6 carbon atoms; M is hydrogen or alkali metal or alkaline earth metal; a is an integer from about 1-20; b is an integer from about 5-1500; c is an integer from about 2-700; d is an integer from about 1-15; x is an integer from about 1-8; The present invention furthermore relates to a method of making a liquid, heteric block polyoxyalkylene compound having improved flow characteristics, which has the formula: I- [(AO) a- [(EO) b (XO)] c] - (EO) dM] x; wherein I is an initiator or a mixture of initiators having at least one substituent selected from the group including, but not limited to OH, NH2 or COOH; AO is an alkylene oxide of 2-6 carbons or a mixture of alkylene oxides of 2-6 carbons arranged randomly or in a block sequence: EO is ethylene oxide and XO is a portion of ethylene oxide having 3-6 carbon atoms; M is a hydrogen or an alkali metal or alkaline earth metal; a is an integer from about 1-20; b is an integer from about 5-1500; c is an integer from about 2-700; d is an integer from about 1-15; x is an integer from about 1-8; which comprises the steps of: adding AO to an initiator and catalyst followed by b adding a mixture of EO and XO followed by, c adding EO. The molecular weight range is around 1,000-100,000. Preferably, the initiator is selected from propylene glycol (PG), dipropylene glycol, ethylene glycol, triethylene glycol and glycerol, most preferably, the initiator is propylene glycol (PG). This initiator has at least one substituent selected from the group that includes, but is not limited to OH, NH 2 or COOH. AO is a portion of an alkylene oxide having 2-6 carbons, preferably the alkylene oxide portion is ethylene oxide, propylene oxide or butylene oxide, more preferably ethylene oxide, propylene oxide or ethylene oxide and propylene oxide, more preferably ethylene oxide or ethylene oxide and propylene oxide. In addition, AO can be a mixture of alkylene oxides with 2-6 carbons arranged randomly or in block sequences.

XO is a portion of alkylene oxide having from 3-6 carbons, preferably, this portion of alkylene oxide and is propylene oxide or butylene oxide, more preferably, propylene oxide. M is H or a catalyst selected from the group including, but not limited to alkali metal or alkaline earth metal bases, lithium hydroxide, potassium hydroxide, cesium hydroxide and most preferably potassium hydroxide. a preferably is about 1-20, more preferably about 1-10, most preferably 2-8. b is preferably about 5-1500, more preferably about 5-500, most preferably about 7-16. c is preferably about 1-700, more preferably about 1-250, most preferably about 1-10. d is preferably about 1-15, more preferably about 1-10, most preferably about 1-5 x is preferably about 1-8, most preferably about 2-3, most preferably about 2 The molecular weight range is almost 1,000-100,000. The most preferred values for molecular weight are from about 1,000-25,000.

The most preferred molecular weight is from about 1,000-3,000.

DESCRIPTION OF THE METHOD OF MANUFACTURE OF POLYMEXALKYLENE IN HETERIC BLOCK, LIQUID OF THE PRESENT INVENTION Note: The charges of ethylene oxide and oxides mixed in these experiments were added with nitrogen at 34 psig with addition rates to maintain the EO concentration in the vapor phase. below the explosive safety limit which can be calculated according to Siwek in Siwek R., Rozenberg, E., "Ethylene Oxide Vapor Decomposition-Process and Protective Measures" Zeitschrift fur die fett-, 01-, Tensid-, Kosmetik- undPharmaindutrie, Vol. 115, Augsburg, September 1, 1989, NR14-1. A two gallon stainless steel autoclave was charged with 1089 g of propylene glycol, 46.6 g of 45% potassium hydroxide and purged with nitrogen. The contents were heated to 80 ° C and distilled to remove the volatiles for 2.5 hours. The contents were heated to 130 ° C and the pressure in the vessel was adjusted to 34 psig with nitrogen. The ethylene oxide (4412.9 g) was added over a period of 6 hours. After the addition was completed the mixture was maintained at 130 ° C for 1 hour and then the volatiles were removed for half an hour. A five-gallon stainless steel autoclave will charged with 3075.6 g of the aforementioned material and purged with nitrogen. The material was heated to 116 ° C and 11.168 g of a mixture of ethylene oxide at 76.8% by weight and propylene oxide at 23.2% by weight were added over a period of 9.5 hours. After the addition was completed, the mixture was maintained at 116 ° C for an additional 2 hours. A final charge of 1762 g of ethylene oxide was added for 2 hours and then maintained at 116 ° C for 2 hours. The mixture was distilled for half an hour, it was cooled to 80 ° C and 30.1 g of 50% hypophosphoric acid or 17.5 g of 85% phosphoric acid were added. The mixture was stirred for half an hour in the autoclave and then discharged. alternatively, the material can be treated with magnesium silicate and filtered instead of neutralized with acid. Table 1 Comparison of the present invention with polyethylene glycol 400 and heteric materials. Material PEG PEG ABCBEFGH 400 2000 20% 20% 20% 23% 23% 25% 25% 25% PO PO PO PO PO PO weight 400 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 molecular point of 5.0 52.0 13 9 4.4 3.3 -0.5 6.1 -3.9 -5.0 fluency ° C amount nin solid +++ +++ +++ ++ ++ ++ <; + + of gun sediment * or @ 21 ° C flavor very flavor flavor flavor flavor flavor flavor flavor flavor flavor smooth r r r r r r r io mellow mellow mellow mellow mellow mellow mellow mellow mellow * ++++ sediment most + minimum sediment, little solid present PEG 400 is a polyethylene glycol of molecular weight 400. PEG 2000 is a polyethylene glycol of molecular weight 2000. The percentage of propylene oxide (PO) is calculated as the percentage of the total weight that contributes to the initiator of propylene glycol (PG) and propylene oxide. Sample A is a comparative sample of an all-heteric material similar to that of JP 478366 B4 Sample B of the present invention has the structure: PG [(E03.5 (E012.2 \ P02.8) (EO) 2.5H] 2 The sample C of the present invention has the structure: PG [(EO PO EOe.?POi.β) (EO) 4H] 2 The sample D of the present invention has the structure: PG [(EO) 3.5 (EO) ??.? PO 3.3 (EO) 2.5H] 2 Sample E of the present invention has the structure: PG [(E06 (PO)? 7 (E07.5 \ PO 1.7) (EO) 4 H] 2 Sample F is a comparative sample of an all-heteric material similar to that of JP 478366 B4 PG - [(E017 \ P03.7) H] 2 Sample G of the present invention has the structure: Sample H of the present invention has the structure: PG [(EO) 6 (PO)? 9E07 \ PO ig) (EO) 4H] 2 The material of all heteric with 20% PO compared to materials in heteric blocks with 20% PO prepared in accordance with this invention (B and C) show that A has a considerably high pour point. Materials with PO at 25%, F, G and H show the same behavior. Examples D and E are given as further evidence of the tendency of lower pour points when materials are made according to this invention. The amount of sedimented material in these samples is also considerably lower for those that are made incorporating heteric blocks according to this invention. The pour point comparison of Polyethylene glycol 400 with examples C, D, E, G and H of the present invention show a pour point reduction despite the fact that the molecular weights of these materials are higher. The pour point for the PEG 2000 is 52 ° C. Utility of Polyoxyalkylene Compounds Having Improved Flowability Because the polyoxyalkylene compounds made according to the method of the present invention have improved flow characteristics, they are useful in a variety of pharmaceutical and personal care applications, particularly as carriers for personal care compositions.

Personal care The compounds prepared according to the method of the present invention are particularly useful in personal care, particulate compositions in oral care compositions, such as toothpastes. Toothpaste formulations usually contain substantial amounts of humectants. The humectants help the formulation maintain its moisture, thus preventing the formation of hardening when the lid of the container is left open for prolonged periods. The common moisturizers that are used in these formulations are glycerol, sorbitol which are usually the preferred humectants due to their sweet taste. Other humectants that are also used are polyethylene glycols of molecular weight usually between 200-600. For economic reasons, a combination of humectants is used in most formulations for personal care. At present toothpaste compositions are being formulated without significant water incorporation. The examples of these toothpaste compositions are those that do not tolerate presence of significant levels of water due to the aspects related to the decomposition of the key ingredients that give rise to the loss of activity or the reactivity of the ingredients, for example, sodium bicarbonate and a peroxygen composition such as hydrogen peroxide or percarbonate of sodium. The formulation and increased stability of these toothpaste compositions is achieved by employing a non-aqueous carrier that is usually selected from liquid polyethylene glycols of low molecular weight. Toothpaste compositions containing peroxygen source and sodium bicarbonate are usually formulated by premixing toothpaste ingredients in the presence of a liquid protractor, as liquid polyethylene glycol to achieve a composition with consistency similar to toothpaste. The choice of liquid polyethylene glycols as carriers for non-aqueous formulations has several advantages, such as good hygroscopicity, low viscosity, good compatibility with various dentifrice ingredients, low volatility, low cost, low toxicity, low odor and low pour point. However, a significant disadvantage that is associated with the use of low molecular weight polyethylene glycols is their bitter taste. The bitter taste of liquid polyethylene glycols gives the finished formulation an unpleasant taste that often has to be marketed by including expensive sweeteners or masking agents. A large number of pharmaceutical compositions which are orally administered, and furthermore limited to use the liquid polyethylene glycols as carriers at present have little flexibility to modify the bitter taste of the resulting composition. The polyalkylene glycols in heteric, liquid blocks of the present invention, which are essentially transparent and almost free of precipitates, and have no bitter taste, can serve as suitable carriers for various compositions for personal care, oral care and pharmaceuticals that fall within the scope of the invention. in contact with the human body.

Preparation of Personal Care Compositions Containing the Novel Polyoxyalkylene Compound of the Present Invention The liquid, heteric block polyoxyalkylene compounds of the present invention are presented in personal care compositions at preferred concentrations of 1-99%, more preference at a concentration of 20-79%; more preferably at a concentration of 30-50% by weight of the composition for personal care. In general, the level of incorporation depends on the final use of the liquid polyoxyalkylene compound of the invention. Yes they function as carriers, for example, in an essentially non-aqueous dentifrice formulation, then higher use levels in the formulation are necessary. The personal care formulations may also contain other ingredients such as surfactants that are selected from anionic surfactants including sodium lauryl sulfate; sodium alkyl glyceryl ether sulfonate; alkyl benzene sulfonates. Other anionic surfactants also include oxyalkylates of Ce-C? & It is also known to those skilled in the art to use block copolymers, solids, polyoxyethylene and polyoxypropylene to further provide a reinforcement in the foaming function of the dentifrice composition. In addition, small amounts of cationic surfactants having quaternary nitrogen can also be used, which shows compatibility with the nonionic carrier mixtures of this invention. It is also possible to use various other materials in the formulation of personal care products. For example, peroxygen compounds such as hydrogen peroxide, sodium percarbonate can be used in these dentifrice compositions. In a toothpaste, dental abrasives consisting of finely divided silica or calcium carbonate, sodium bicarbonate, calcium pyrophosphate and hydrated alumina are added to function as polishers. Additionally, thickeners such as xanthan gum, gum arabic, hydroxyethylcellulose, polyvinylpyrrolidone, gum tragacanth, carrageenan can also be used to provide sufficient thickening consistency to the formulation. Also, flavoring agents such as peppermint oils, spearmint oils, or preservatives, opacifying agents, buffer salts, sweeteners, antibacterial agents or antiplaque agents, anti-inflammatory agents, anticaries agents such as fluoride salts may also be included in small amounts. Polymeric agents that accelerate the transport of active materials can also be included. Also, emollients of cosmetic creams such as glycerin, mineral oil and petrolatum can be added. The personal care products are formulated according to methods known to those skilled in the art. Representative formulations of personal care products are described in Cosmetics, Science Technology, 2nd Edition, Vol.l, Edited by M-S. Balsam, et al., And A Formulary of Cosmetic Preparations, Michael and Iren Ash, Chemical Publishing, N-Y., N-Y., And both are incorporated herein by reference. The following non-limiting examples will furthermore serve to illustrate the utility of the present invention. Everybody the percentages are in percent by weight of the total composition unless otherwise indicated.

Tooth composition: 1-55% abrasive which is selected from the group including, but not limited to, anhydrous dicalcium phosphate, calcium carbonate, calcium pyrophosphate and sodium bicarbonate. 0-0.6% of a fluorinating agent that includes, but is not limited to, stannous fluoride, sodium fluoride, sodium monofluorophosphate. 2-10% binders including, but not limited to, karaya gum, USP tragacanth, sodium alginate, Irish moss and methylcellulose. 0-10% of a peroxygen source that includes, but is not limited to, hydrogen peroxide, sodium percarbonate. 0-8% surfactants including, but not limited to sodium lauryl sulfate, sodium N-lauryl sarcosinate; sodium dioctyl sulfosuccinate. 0-5% block copolymers of EO and PO. 5-50% humectants including, but not limited to glycerin, propylene glycol; sorbitol; polyethylene glycol. 5-70% polyoxyalkylene compound that has the formula: I- [(AO) a- [(EO) b (XO) c] - (EO) d-M] x; wherein: I is an initiator or a mixture of initiators having at least one substituent selected from the group including, but not limited to OH, NH2 or COOH; AO is an alkylene oxide of 2-6 carbons or a mixture of alkylene oxides of 2-6 carbons arranged randomly or in a block sequence; EO is ethylene oxide; XO is a portion of alkylene oxide having 3-6 carbon atoms; M is hydrogen or alkali metal or alkaline earth metal; a is an integer from about 1-20; b is an integer from about 5-1500; c is an integer from about 2-700; d is an integer from about 1-15; x is an integer from about 1-8; Composition for body cleansing: 1-5% emollients that include, but are not limited to lanolin, sterols (cholesterol) and fatty acids. 0.1-3% barrier forming agents that include but are not limited to petrolatum, beeswax, casein. 0.01-0.1% healing agents that include, but are not limited to to allantoin and urea. 2-20% humectants including, but not limited to, glycerin; polyethylene glycol; sorbitol; polyethylene glycol. 0.01-1% thickeners that include, but are not limited to guar gum, cellulose derivatives and Irish moss. 0.5-3% emulsifiers including, but not limited to, cetylpyridinium chloride; polyoxyethylene lauryl alcohol. 5-70% polyoxyalkylene compound having the formula: I- [(AO) a- [(EO) b (XO) c] - (EO) d-M] x; wherein: I is an initiator or a mixture of initiators having at least one substituent selected from the group including, but not limited to OH, NH2 or COOH; AO is an alkylene oxide of 2-6 carbons or a mixture of alkylene oxides of 2-6 carbons arranged randomly or in a block sequence; EO is ethylene oxide; XO is a portion of alkylene oxide having 3-6 carbon atoms; M is hydrogen or alkali metal or alkaline earth metal; a is an integer from about 1-20; b is an integer from about 5-1500; c is an integer from about 2-700; d is an integer from about 1-15; x is an integer from about 1-8; Antiperspirant deodorant composition: 36-50% aluminum hydrochloride or 1-15% zinc oxide or 1-15% boronic acid 5-70% polyoxyalkylene compound: I- [(AO) a- [(EO) b (XO) c] - (EO) dM] x; wherein: I is an initiator or a mixture of initiators having at least one substituent selected from the group including, but not limited to OH, NH2 or COOH; AO is an alkylene oxide of 2-6 carbons or a mixture of alkylene oxides of 2-6 carbons arranged randomly or in a block sequence; EO is ethylene oxide; XO is a portion of alkylene oxide having 3-6 carbon atoms; M is hydrogen or alkali metal or alkaline earth metal; a is an integer from about 1-20; b is an integer from about 5-1500; c is an integer from about 2-700; d is an integer from about 1-15; x is an integer from about 1-8; 25-50% SD alcohol (40) The antiperspirant compositions may also contain emollients and perfume.

Claims (3)

2. A polyoxyalkylene compound in heteric block, liquid, with characteristics of improved fluidity and homogeneity, which tends the formula: I- [(AO) a- [(EO) b (XO) d- (EO) d-M] x; wherein: I is an initiator or a mixture of initiators having at least one substituent selected from the group including, but not limited to OH, NH2 or COOH; AO is an alkylene oxide of 2-6 carbons or a mixture of alkylene oxides of 2-6 carbons arranged randomly or in a block sequence; EO is ethylene oxide; XO is a portion of alkylene oxide that has
3. 3-6 carbon atoms; M is hydrogen or alkali metal or alkaline earth metal; a is an integer from about 1-20; b is an integer from about 5-1500; c is an integer from about 2-700; d is an integer from about 1-15; x is an integer from about 1-8; The polyoxyalkylene compound in heteric block, liquid, of claim 1, wherein the initiator I is propylene glycol, AO is ethylene oxide or ethylene oxide and propylene oxide, XO is propylene oxide, M is H, a is 1-10, b is 5- 500, c is 1-250, d is 1-10 and x is 2. The polyoxyalkylene compound in the liquid, heteric block of claim 1, wherein the initiator I is propylene glycol, AO is ethylene oxide or ethylene oxide and propylene oxide, XO is propylene oxide, M is H, a is 2-8, b is 7-16, c is 1-10, d is 1 -5 and x is 2. A method of making a polyoxyalkylene compound in heteric blocks, liquid, having improved characteristics of fluidity and homogeneity, having the formula: I- [(AO) a- [(EO) b (XO) c] - (EO) dM] x; wherein I is an initiator or a mixture of initiators having at least one substituent selected from the group including, but not limited to OH, NH2 or COOH; AO is an alkylene oxide of 2-6 carbons or a mixture of alkylene oxides of 2-6 carbons arranged randomly or in a block sequence; EO is ethylene oxide; XO is a portion of ethylene oxide that has 3-6 carbon atoms; M is a hydrogen or an alkali metal or alkaline earth metal; a is an integer from about 1-20; b is an integer from about 5-1500; c is an integer from about 2-700; d is an integer from about 1-15; x is an integer from about 1-8; which comprises the steps of: adding AO to an initiator and catalyst followed by b adding a mixture of EO and XO followed by c adding EO. . A dentifrice composition containing: -55% abrasive that is selected from the group including, but not limited to, anhydrous dicalcium phosphate, calcium carbonate, calcium pyrophosphate, and sodium bicarbonate. -0.6% of a fluorinating agent including, but not limited to, stannous fluoride, sodium fluoride, sodium monofluorophosphate. -10% binders including, but not limited to, karaya gum, USP tragacanth, sodium alginate, Irish moss and methylcellulose. -10% of a peroxygen source including, but not limited to, hydrogen peroxide, percarbonate of sodium. 0-8% surfactants including, but not limited to sodium lauryl sulfate, sodium N-lauryl sarcosinate; sodium dioctyl sulfosuccinate. 0-5% block copolymers of EO and PO. 5-50% humectants including, but not limited to glycerin, propylene glycol; sorbitol; polyethylene glycol. 5-70% polyoxyalkylene compound having the formula: I- [(AO) a- [(EO) b (XO) c] - (EO) d-M] x; wherein: I is an initiator or a mixture of initiators having at least one substituent selected from the group including, but not limited to OH, NH2 or COOH; AO is an alkylene oxide of 2-6 carbons or a mixture of alkylene oxides of 2-6 carbons arranged randomly or in a block sequence; EO is ethylene oxide; XO is a portion of alkylene oxide having 3-6 carbon atoms; M is hydrogen or alkali metal or alkaline earth metal; a is an integer from about 1-20; b is an integer from about 5-1500; c is an integer from about 2-700; d is an integer from about 1-15; x is an integer from about 1-8; The dentifrice composition of claim 5, wherein the initiator I is propylene glycol, AO 'is ethylene oxide or ethylene oxide and propylene oxide, XO is propylene oxide, M is H, a is 1-10, b is 5-500, c is 1-250, d is 1-10 and x is 2-3. The dentifrice composition of claim 5, wherein the initiator I is propylene glycol, AO is ethylene oxide or ethylene oxide and propylene oxide, XO is propylene oxide, M is H, a is 2-8, b is 7. -16, c is 1-10, d is 1-5 and x is 2.