MXPA97008329A - Dentirical formulations containing miscibles liquid polioxylycylene compounds in a polialquilenglicol liquid carrier - Google Patents

Abstract

The present invention relates to a dentifrice composition containing a liquid polyalkylene glycol carrier and a liquid miscible polyoxyalkylene compound in this liquid polyalkylene glycol carrier.

Description

DENTÍFRICAS FORMULATIONS CONTAINING MISCIBLES LIQUID POLIOXY COMPOUNDS LIQUID IN A CARRIER OF LIQUID POLYALYQUENGLICOL Field of the invention The present invention relates to an oral care formulation containing a liquid polyoxyalkylene glycol carrier and a liquid polyoxyalkylene compound miscible in the liquid polyalkylene glycol carrier.

BACKGROUND Polyoxyalkylene block copolymers are well known to those skilled in the art of nonionic surfactants. Specifically, US Pat. No. 3,740,421 (Schmolka) assigned to BASF discloses aqueous gels prepared using a polyoxyethylene / polyoxypropylene block copolymer suitable for pharmaceutical and personal care compositions. U.S. Patent 3,639,574 (Schmolka) assigned to BASF discloses polyoxyethylene / polyoxypropylene block copolymers as gelling agents for compositions with hydrogen peroxide. U.S. Patent 4,465,663 (Schomolka) assigned to BASF discloses the polyoxybutylene / polyoxyethylene block copolymers as gelling agents for aqueous gels useful in personal care and pharmaceutical applications. These compounds are sold by BASF Corporation under the trade name PLURONIC®. Additionally, US Patent 4,272,394 and 4,411,810 describe the use of polyoxyalkylene block copolymers in applications for washing machines. U.S. Patent 4,925,988 discloses a nonionic surfactant which employs a specific combination of alkanol, ethylene oxide and propylene oxide useful in an automatic dishwashing application. U.S. Patent 5,374,368 describes the use of copolymers in three EO / PO / EO blocks, liquids (PLURONIC® L 31 and L 35 surfactants) in stable dental care compositions that release hydrogen peroxide in concentrations of 55-90% by weight. weight of the composition for dental care. US Pat. No. 3,740,421 discloses copolymers in three blocks EO / PO / EO, solids, gel formers, useful in cosmetic formulations and for personal care in concentrations of approximately 20-25% by weight. Preferred solid, EO / PO / three block copolymers have a molecular weight of 4,600-16,000. These copolymers in three EO / PO / EO blocks, solid, form a gel when they are added to an aqueous solution. US Pat. No. 3,867,533 discloses aqueous gel compositions containing copolymers in three EO / PO / EO blocks, solids, with a molecular weight of 6.450-20.000, useful in concentrations of approximately 20% by weight. These compositions are useful for preparing cosmetic formulations. U.S. Patent 4,465,663 describes transparent aqueous cosmetic gels containing copolymers in three blocks EO / BO (butylene oxide) / EO, solids in concentrations of approximately 20%. U.S. Patent 5,035,880 discloses a stable dentifrice composition containing a cetylpyridinium bactericide and three-block copolymers EO / PO / EO (PLURONIC® F 127 surfactant) and polyethylene glycol in concentrations of 15-80% by weight. U.S. Patent 4,476,107 discloses a mouthwash containing copolymers in three blocks EO / BO (butylene oxide) / EO in concentrations of 0.5-5.0% by weight. U.S. Patent 5,057,307 describes oral hygiene gels containing nonionic surfactants, coating substances and viscosity modifiers. These nonionic surfactants are PLURONIC® F 108 and F 127 surfactants available from BASF Corporation Mt. Olive, New Jersey. U.S. Patent 5,256,396 describes a common composition containing a three-block EO / PO / EO copolymer, solid (surfactant) PLURONIC® F 127) used at a concentration of more than 10% to about 17% by weight. Patent EPO-546-627A describes compositions for mouthwash containing copolymers in three EO / PO / EO blocks, solids such as surfactants PLURONIC® L 108, F 88, in concentrations of 0. 5-3% by weight. U.S. Patent 5,073,368 discloses mouthwashes containing copolymers in three EO / PO / EO blocks, solids, as surfactant PLURONIC® F 87 in concentrations of 0.1-3% by weight. Patent WO 93/13750 describes a composition for ocular cleaning containing copolymers in three EO / PO / EO blocks, solids, PLURONIC® F 87 and in PLURONIC® P 85 paste. The PLURONIC® P85 surfactant constitutes 4-9% by weight of the cleaning composition, the PLURONIC® F 87 surfactant is 0.5-2% by weight of the cleaning composition. Finally, U.S. Patent 5, 096, 698 discloses a toothpaste composition containing a three-block EO / PO / EO, liquid, non-ionic copolymer or an EO / PO / EO, three-block copolymer, solid, in concentrations of 0.1-5% by weight. These copolymers help to avoid the separation of the phases. The surfactant PLURONIC® F 108 (solid) is the most preferred, followed by the surfactants PLURONIC® F 87, PLURONIC® F 127 and PLURONIC® L 72. The US Patent 4,272,394 describes the novel nonionic surfactant, with low foaming power for compositions for washing machines. U.S. Patent 4,411,810 describes a nonionic surfactant with low foaming power and low cloud point for compositions for machine washing. Finally, Japanese Patent 47-48366 B4 discloses a process for producing heteric, liquid and tasteless polyoxyalkylene compounds of molecular weight 1000 or higher. U.S. Patent 5,187,191 describes polyoxyalkylene block copolymers in formulations for agricultural use. U.S. Patent Nos. 5,496,542, 5,374,368 and 5,424,060 describe the use of a polyoxyalkylene compound to prepare a stable percarbonate formulation as well as a dentifrice composition. The present invention relates to compositions for oral care, such as tooth formulations. Toothpaste formulations usually contain substantial amounts of humectants. The humectants help the formulation to maintain its moisture, thus preventing the formation of hardening when the lid of the container is left open for prolonged periods. The common moisturizers that are used in these formulations are glycerol, sorbitol, which are usually the preferred humectants because of their sweet taste. Other humectants that are also used are polyethylene glycols of low molecular weight usually between 200-600. Liquid polyethylene glycols are an excellent choice as a carrier to formulate a non-accusative dentifrice formulation, since they provide various advantages such as good hygroscopicity, low viscosity, good compatibility with various tooth ingredients, low volatility, low cost, low toxicity, little 'odor and low pour point. At present toothpaste compositions are being formulated without significant water incorporation. Examples of these toothpaste compositions are those that do not tolerate the presence of significant levels of water due to the aspects related to the decomposition of the key ingredients that give rise to the loss of activity or the reactivity of the ingredients, for example, sodium bicarbonate and a peroxygen compound such as hydrogen peroxide or sodium percarbonate. The formulation and increased stability of these toothpaste compositions is achieved by employing a non-aqueous carrier that is usually selected from liquid polyethylene glycols of low molecular weight. The dentifrice formulations also contain an anionic surfactant which is usually selected from esters of alcohol sulfates of C? -18- An example of an anionic surfactant is sodium lauryl sulfate. The primary function of the anionic surfactant is to provide efficient foaming action during brushing. However, in many cases, the foaming action provided by the anionic surfactant is only inadequate and often additional ingredients have to be added in combination with the anionic surfactant to achieve the desired foam profile during brushing. A common ingredient that is normally selected for additional foam reinforcement are block copolymers, solids, high molecular weight of ethylene oxide and propylene oxide. Examples of these solid block copolymers are those which have an average molecular weight above 8,000 and also contain at least 50% ethylene oxide. Particularly preferred are those which contain between 70% -80% ethylene oxide and have an average molecular weight greater than 9,000. In addition, there is also a limitation with the use of the high molecular weight, solid block, block copolymers of ethylene oxide and propylene oxide in a non-aqueous dentifrice formulation because they are insoluble in the liquid polyalkylene glycol carrier. The solution of the block copolymer in the polyalkylene glycol line carrier is obtained by heating the two components until there is a single transparent phase. Unfortunately, with the cooling at ambient temperatures, the solid block copolymer has a tendency to separate the phase giving rise to the formation of a heterogeneous mixture. The formation of a heterogeneous phase is particularly problematic since it can cause a preferential separation of certain dentifrice components in any of the phases and a modification of the homogeneity of the formulation. This modification of the homogeneity of the formulation is particularly noticeable when the dentifrice formulation undergoes multiple cycles of heating and cooling during transportation and storage. The applicants have solved the aforementioned problems in the art. Surprisingly, applicants have discovered that if the block copolymers, solids become liquid during their preparation by adding small amounts of alkylene oxide of C3 or greater to the crystalline, hydrophilic portion of the block copolymer, solid, to produce a compound of polyoxyalkylene liquid of similar hydrophilicity and molecular weight, then a single homogeneous, transparent phase is obtained with the addition to the carrier polyoxyalkylene glycol liquid. A further advantage with the use of the high molecular weight liquid polyoxyalkylene compounds of this invention is that, with the addition to the polyalkylene glycol carrier, they are easily miscible and form a single phase, homogeneous and transparent composition and do not have to be heated to achieve dissolution.

Compendium A dentifrice composition contains: (a) a liquid polyalkylene glycol carrier and; (b) a liquid polyoxyalkylene compound miscible in the liquid polyalkylene glycol carrier, wherein: the liquid polyalkylene glycol carrier (a) is selected from: (i) liquid polyethylene glycols having a molecular weight of not more than about 600; or (ii) liquid polyoxyalkylene glycols having a molecular weight greater than 600 and less than about 3,000 of Formula I or mixtures of (i) and (ii): I - [(E0) a (A0) b-M] x; Formula I wherein, in formula I, I is an initiator or a mixture of initiators having at least two carbon atoms and at least 2 or more hydroxyl substituents; AO is an alkylene oxide of C3-. or a mixture of C3-4 alkylene oxides; EO is ethylene oxide; wherein, in addition, EO and AO can be randomly distributed and / or arranged in a sequence of blocks. M is a hydrogen or an alkali metal or an alkaline earth metal; a is an integer from about 6-22; b is an integer from about 1-9; x is an integer from about 2-4; and on the condition that; this liquid polyoxyalkylene compound (b), which is miscible in (a), is represented by Formula II: I - [(EO) to (XO) -M] x; Formula II wherein, in formula I, I is an initiator or a mixture of initiators having at least two carbon atoms and two hydroxyl substituents; AO is an alkylene oxide of C3-4 or a mixture of alkylene oxides of C3-4 arranged in a block sequence; XO is (EO) b (AO) c where EO is ethylene oxide and EO and AO are randomly distributed; M is a hydrogen or an alkali metal or an alkaline earth metal; a is an integer from 15-35; b is an integer from 50-150; c is an integer from 7-90; x is 2. The molecular weight of the compound of Formula II is from 8,000-28,000.

DETAILED DESCRIPTION A dentifrice composition contains: (a) a liquid polyalkylene glycol carrier and; (b) a liquid polyoxyalkylene compound miscible in the liquid polyalkylene glycol carrier, wherein: the liquid polyalkylene glycol carrier (a) is selected from: (i) liquid polyethylene glycols having a molecular weight of not more than about 600; or (ii) liquid polyoxyalkylene glycols having a molecular weight greater than 600 and less than about 3,000 of Formula I or mixtures of (i) and (ii): I - [(E0) a (A0) b-M] x; Formula I wherein, in formula I, I is an initiator or a mixture of initiators having at least two carbon atoms and at least 2 or more hydroxyl substituents; AO is an alkylene oxide of C3-4 or a mixture of alkylene oxides of C3-4; EO is ethylene oxide; wherein, in addition, EO and AO can be randomly distributed and / or arranged in a sequence of blocks. M is a hydrogen or an alkali metal or an alkaline earth metal; a is an integer from about 6-22; b is an integer from about 1-9; x is an integer from about 2-4; and on the condition that; this liquid polyoxyalkylene compound (b), which is miscible in (a), is represented by Formula II: I - [(EO) to (XO) _M] x; Formula II wherein, in formula I, I is an initiator or a mixture of initiators having at least two carbon atoms and two hydroxyl substituents; AO is an alkylene oxide of C3-4 or a mixture of alkylene oxides of C3-4 arranged in a block sequence; XO is (EO) b (AO) c where EO is ethylene oxide and EO and AO are randomly distributed; M is a hydrogen or an alkali metal or an alkaline earth metal; a is an integer from 15-35; b is an integer from 50-150; c is an integer from 7-90; x is 2 The molecular weight range for Formula I is from about 600-3,000. The most preferred values for molecular weight are from about 1,000-2,500. The most preferred molecular weight is from 1,500,000 wax. The molecular weight of the liquid polyoxyalkylene compound of Formula II is from 8,000-28,000, more preferably from 9,000-24,000 and most preferably from 10,000-19,500. In Formula I, a is an integer from about 6-22, preferably from about 7-20 and most preferably from about 10-16; b is an integer from about 1-9, preferably from about 1-7 most preferably from about 2-5; x is an integer from about 2-4, preferably from about 2-3 and most preferably 2. In Formula II, a is an integer from about 15-35, preferably 20-32, more preferred 24-31; b is an integer from 50-150, preferably 65-135; more preferably 70-120; c is an integer from 7-90, preferably 10-70; more preferably 15-45; x is 2. The initiator (I) in Formula I is selected from the group consisting of propylene glycol, dipropylene glycol, ethylene glycol and diethylene glycol and glycerol, more preferably the initiator is propylene glycol. The initiator (I) in Formula II is selected from the group consisting of propylene glycol, dipropylene glycol, ethylene glycol and diethylene glycol. Preferably the initiator is propylene glycol. In Formula I and II, EO is ethylene oxide. In Formula I and II, AO is a portion of alkylene oxide having 3-4 carbons, preferably this portion of alkylene oxide is propylene oxide or butylene oxide, more preferably propylene oxide. In addition, EO and AO in Formula I may be randomly distributed and / or arranged in a sequence of blocks. In Formula II the distribution must be random. In Formula I and II, M is H or a cation that is selected from the group that includes, but is not limited to lithium, calcium, potassium and cesium, most preferably potassium or hydrogen.

Description of the method of preparing the liquid polyalkylene glycol carrier and the miscible liquid polyoxyalkylene compound in this liquid polyalkylene glycol carrier of the present invention Preparation of the liquid polyoxyalkylene compound of the invention The liquid polyoxyalkylene compounds of the invention were prepared by conventional techniques in one or two gallon stainless steel autoclaves which were equipped with stirring, pressure gauge, thermocouple and addition tube. For example, an initiator, in all cases propylene glycol, and the catalyst were vacuumed out in an autoclave with stirring, of stainless steel, at 120 ° C to remove the water. Alkylene oxide block formation was obtained by the addition of propylene oxide at 105 ° C with set addition rates so that the total pressure did not interfere 90 psig. To the polyoxypropylene block was added a mixture of ethylene oxide and propylene oxide to form a hydrophilic block of mixed oxides. Additions of mixed oxides were carried out at 135 ° C with the same pressure restrictions as mentioned. The final products were neutralized by adding 85% phosphoric acid and were inhibited with the addition of 100 ppm of t-butylhydroxytoluene.

Preparation of the liquid polyalkylene glycol carrier of the invention A 2-gallon stainless steel autoclave was charged with 1089 g of propylene glycol, 46.6 g of 45% potassium hydroxide and purged with nitrogen. The contents were heated to 80 ° C and distilled for 2 hours to remove the volatiles. The contents were heated to 130 ° C and 4412.9 g of ethylene oxide were added over a period of 6 hours. After the addition was completed, the mixture was maintained at 130 ° C for 1 hour and then the volatiles were evaporated during * 1 hour.

A 5 gallon stainless steel autoclave was charged with 3075.6 g of the above material and purged with nitrogen. The material was heated to 116 ° C and 11168 g of a mixture of 76.8% ethylene oxide and 23.2% propylene oxide was added over a period of 9.5 hours. After the addition was complete, the mixture was maintained at 116 ° C for an additional 2 hours. A final charge of 1762 g of ethylene oxide was added for 2 hours and then maintained at 116 ° C for 2.5 hours. The mixture was distilled for 1/2, cooled to 80 ° C and 30.5 g of 50% hypophosphorous acid were added. The mixture was stirred for an hour in the autoclave and then discharged.

Utility of the present invention To illustrate the utility of the present invention, the applicants prepared binary mixtures with liquid polyalkylene glycol and a solid, high molecular weight block copolymer with a molecular weight greater than 8,000. These binary mixtures were then compared with the mixtures of the present invention by comparing compound A of Formula II (liquid) and compound B of Formula I (liquid). See Table 1. Binary mixtures (solid / liquid) were prepared by first mixing the block copolymer, solid, with the liquid polyalkylene glycol then heating the mixture above the melting point of the solid block copolymer to obtain a single-strength composition. phase, transparent. The resulting clear composition was then gradually allowed to cool to room temperature while continuously stirring at 100 rpm in a LIGHTNIN mixer. The final composition was stored at ambient temperatures and the physical stability of the composition was noted. The binary mixtures (liquid / liquid) of the present invention were prepared simply by mixing the components (a), liquid polyalkylene glycol carrier, and (b) liquid polyalkylene compound as defined above. As indicated in Table 1, all mixtures containing a liquid polyethylene glycol of molecular weight 4,000 and the solid block copolymer were unstable during storage and separated into two phases. This is particularly evident when samples are stored at 45 ° C. It is clear that, test 8 and 9 (the present invention) illustrates the utility of the present invention while maintaining the stability and uniformity of dentifrice formulations.

However, when the solid block copolymer was replaced with the liquid polyoxyalkylene compound of Formula II (compound A), then the solubility was instantaneous and the resulting composition was a homogeneous, single-phase, transparent and stable liquid. The table further shows that, when the liquid polyethylene glycol of molecular weight 400 is replaced with liquid polyalkylene glycol of Formula I (Compound B), a homogeneous, transparent, single-phase and stable composition is obtained by mixing with the liquid polyoxyalkylene compound of the Formula II (compound A). Table 1 Test Component Component B Remarks Stability # 1 PEG400 Pluronic F38 heat for two phases-unstable dissolve PEG400 Pluronic F68 heat for two phases-unstable dissolve PEG400 Pluronic F87 heat for two phases-unstable dissolve PEG400 Pluronic F8? heat for two phases-unstable dissolve PEG400 Pluronic F98 heat for two phases-unstable dissolve PEG400 Pluronic F108 heat for two phases-unstable dissolve PEG400 Pluronic F127 heat for two phases-unstable dissolve PEG400 Compound A easily transparent, one of Formula II soluble phase- stable Compound B Compound A easily transparent, one of Formula I of Formula II soluble phase-stable I In each mixture, the weight ratio of the liquid polyalkylene glycol of block copolymer, solid or component B was 90:10.

Explanation of the terms of Table 1 PEG400 - Polyethylene glycol liquid of molecular weight 400. Available from BASF Corporation as PLURACOL E-400 polyethylene glycol. PLURONIC® - is a registered trademark of BASF, the surfactant Pluronic is a three-block copolymer of ethylene oxide and propylene oxide available from BASF. The surfactant Pluronic F refers to the three-block, solid copolymers of ethylene oxide and propylene oxide. PLURONIC® F 38 surfactant - is a three-block, solid copolymer of ethylene oxide and propylene oxide with an average molecular weight of 4,700. PLURONIC® F 68 Surfactant - is a solid, three-block copolymer of ethylene oxide and propylene oxide with an average molecular weight of 8,400. PLURONIC® F 87 surfactant - is a three-block, solid copolymer of ethylene oxide and propylene oxide with an average molecular weight of 7,700. PLURONIC® F 88 Surfactant - is a three-block, solid copolymer of ethylene oxide and propylene oxide with an average molecular weight of 11,400. PLURONIC® F 98 Surfactant - is a three-block, solid copolymer of ethylene oxide and propylene oxide with an average molecular weight of 13,000. PLURONIC® F 108 Surfactant - is a three-block, solid copolymer of ethylene oxide and propylene oxide with an average molecular weight of 14,600. PLURONIC® F 127 surfactant - is a three-block, solid copolymer of ethylene oxide and propylene oxide with an average molecular weight of 12,600. Compound A of Formula II, wherein I is propylene glycol, AO is propylene oxide and a is 29, b is 78, c is 15 and x is 2, and M is hydrogen. Compound B of Formula I, wherein I is propylene glycol, AO is propylene oxide and a is 18, b is 3, M is hydrogen.

Preparation of dentifrice compositions containing the liquid polyalkylene glycol carrier and the miscible liquid polyoxyalkylene compound in this liquid polyalkylene glycol carrier of the present invention. The liquid polyalkylene glycol carrier and the liquid polyoxyalkylene compound miscible in this liquid polyalkylene glycol carrier of the present invention are present in dentifrice compositions in a preferred concentration of 1-99%, most preferably in a concentration of 20-79%; more preferably a concentration of 30-50% by weight of the dentifrice composition. In general, the level of incorporation depends on the final use of the liquid polyalkylene compound of the invention. If these function as carriers, for example, in an essentially non-aqueous dentifrice formulation, then higher use concentrations in the formulation are required. Toothpaste formulations also contain other ingredients such as surfactants that are selected from anionic surfactants that include sodium lauryl sulfate; sodium alkyl glyceryl ether sulfonate; alkyl benzenesulfonates. Other anionic surfactants also include oxyalkylatoses of C6-C? Β alcohols. It is also known to those skilled in the art to use block copolymers, polyoxyethylene and polyoxypropylene solids to further provide a reinforcement in the foaming function of the dentifrice composition. These solid, block copolymers of ethylene oxide and propylene oxide are excluded from the scope of this invention. In addition, small amounts of cationic surfactants with quaternary nitrogen, which show compatibility with the mixtures of the nonionic carrier of this invention, can also be used. It is also possible to use various other materials in the formulation in personal care products. For example, peroxygen compounds such as hydrogen peroxide, sodium percarbonate can be used in these dentifrice compositions. Dental abrasives consisting of finely divided silica or calcium carbonate, sodium bicarbonate, calcium pyrophosphate and hydrated alumina are added to function as polishers. Additionally, thickeners such as colloidal silica, xanthan gum, gum arabic, hydroxyethylcellulose, polyvinylpyrrolidone, gum tragacanth, carrageenan can also be used to provide sufficient thickening consistency to the formulation. Likewise, flavoring agents such as peppermint, spearmint oils or preservatives, opacifying agents, buffer salts, sweeteners, antibacterial agents, anticalculus agents or anti-plaque agents, anti-inflammatory agents, anti-caries agents such as fluoride salts, may also be included in small amounts. Polymeric agents that accelerate the transport of active materials may also be included. Additionally, dentifrice compositions may contain small amounts of water. Personal care products, such as toothpastes, are formulated according to methods known to those skilled in the art. Representative formulations of personal care products are described in Cosmetics, Science Technology, 2nd Edition, Vol.l, Edited by M-S. Balsam, et al., And A Formulary of Cosmetic Preparations, Michael and Iren Ash, Chemical Publishing, N-Y., N-Y., And both are incorporated herein by reference. The following examples do not serve to illustrate the utility of the present invention. All percentages are in percent by weight of the total composition unless otherwise indicated.

Tooth composition: 1-55% abrasive that is selected from the group that includes, but is not limited to, anhydrous dicylic phosphate, calcium carbonate, calcium pyrophosphate and sodium bicarbonate. 0-0.6% of a fluorinating agent, which includes, but is not limited to, stannous fluoride, sodium fluoride, sodium onofluorophosphate. 2-10% aglutinates, which includes, but is not limited to, karaya gum, USP gum tragacanth, sodium alginate, Irish moss and methylcellulose. 1-5% thickening agent that includes, but is not limited to, colloidal silica. 0-10% of a peroxygen source that includes, but is not limited to, sodium percarbonate hydrogen peroxide. 0-8% surfactants including, but not limited to sodium lauryl sulfate, N-lauryl sarcosinate sodium; sodium dioctyl sulfosuccinate. 0.1-10% of the liquid polyoxyalkylene compound (b) represented by Formula II: I - [(EO) to (XO) -M] x; Formula II wherein, in formula I, I is an initiator or a mixture of initiators having at least two carbon atoms and two hydroxyl substituents; AO is an alkylene oxide of C3-4 or a mixture of alkylene oxides of C3-4 arranged in a block sequence; XO is (E0) b (A0) c where EO is ethylene oxide and EO and AO are randomly distributed; M is a hydrogen or an alkali metal or an alkaline earth metal; a is an integer from 15-35; b is an integer from 50-150; c is an integer from 7-90; x is 2 I - [(EO) a (AO) b-M] x; Formula I wherein, in formula I, I is an initiator or a mixture of initiators having at least two carbon atoms and at least 2 or more hydroxyl substituents; AO is an alkylene oxide of C3-4 or a mixture of alkylene oxides of C3-4; EO is ethylene oxide; wherein, in addition, EO and AO can be randomly distributed and / or arranged in a sequence of blocks. M is a hydrogen or an alkali metal or an alkaline earth metal; a is an integer from about 6-22; b is an integer from close fde 1-9; x is an integer from about 2-4;

Claims (1)

1. CLAIMS . A composition for oral care comprising: A dentifrice composition contains: (a) a liquid polyalkylene glycol carrier; (b) a liquid polyoxyalkylene compound miscible in the liquid polyalkylene glycol carrier, wherein: the liquid polyalkylene glycol carrier (a) is selected from: (i) liquid polyethylene glycols having a molecular weight of not more than about 600; or (ii) liquid polyoxyalkylene glycols having a molecular weight greater than 600 and less than about 3,000 of Formula I or mixtures of (i) and (ii): I - [(EO) a (AO) b-M] x; Formula I wherein, in formula I, I is an initiator or a mixture of initiators having at least two carbon atoms and at least 2 or more hydroxyl substituents; AO is an alkylene oxide of C3_4 or a mixture of alkylene oxides of C3-4; EO is ethylene oxide; wherein, in addition, EO and AO can be randomly distributed and / or arranged in a sequence of blocks. M is a hydrogen or an alkali metal or an alkaline earth metal; a is an integer from about 6-22; b is an integer from about 1-9; x is an integer from about 2-4; and on the condition that; this liquid polyoxyalkylene compound (b), which is miscible in (a), is represented by Formula II: I - [(EO) to (XO) _M] x; Formula II wherein, in formula I, I is an initiator or a mixture of initiators having at least two carbon atoms and two hydroxyl substituents; AO is an alkylene oxide of C3-4 or a mixture of alkylene oxides of C3-.4 arranged in a block sequence; XO is (EO) b (AO) c where EO is ethylene oxide and EO and AO are randomly distributed; M is a hydrogen or an alkali metal or an alkaline earth metal; a is an integer from 15-35; b is an integer from 50-150; c is an integer from 7-90; x is 2 . The composition, according to claim 1, wherein in Formula I, a is 7-20; b is 1-7; x is 2; I is propylene glycol; AO is propylene oxide and M is hydrogen. . The composition, according to claim 1, wherein in Formula II, a is 20-32; b is 65-135; c is 10-70; x is 2; I is propylene glycol; AO is propylene oxide. . The composition, according to claim 1, wherein in Formula I, a is 10-16; b is 2-5; and in Formula II, a is 24-31; b is 70-120; c is 15-45. . A dentifrice composition containing: -55% abrasive which is selected from the group including, but not limited to, anhydrous dicylic phosphate, calcium carbonate, calcium pyrophosphate and sodium bicarbonate. -0.6% of a fluorinating agent, including, but not limited to, stannous fluoride, sodium fluoride, sodium onofluorophosphate. -10% aglutinates, which includes, but is not limited to, karaya gum, USP tragacanth gum, sodium alginate, Irish moss and methylcellulose. -5% thickening agent that includes, but is not limited to, colloidal silica. 0-10% of a peroxygen source that includes, but is not limited to, sodium percarbonate hydrogen peroxide. 0-8% surfactants including, but not limited to sodium lauryl sulfate, N-lauryl sarcosinate sodium; sodium dioctyl sulfosuccinate. 0.1-10% of the liquid polyoxyalkylene compound (b) represented by Formula II: I - [(EO) to (XO) _M] x; Formula II wherein, in formula I, I is an initiator or a mixture of initiators having at least two carbon atoms and two hydroxyl substituents; AO is an alkylene oxide of C3-4 or a mixture of alkylene oxides of C3-arranged in a block sequence; XO is (EO) b (AO) c where EO is ethylene oxide and EO and AO are randomly distributed; M is a hydrogen or an alkali metal or an alkaline earth metal; a is an integer from 15-35; b is an integer from 50-150; c is an integer from 7-90; x is 2 I - [(EO) a (AO) b-M] x; Formula I wherein, in formula I, I is an initiator or a mixture of initiators having at least two carbon atoms and at least 2 or more hydroxyl substituents; AO is an alkylene oxide of C3-.4 or a mixture of alkylene oxides of C3-4; EO is ethylene oxide; wherein, in addition, EO and AO can be randomly distributed and / or arranged in a sequence of blocks. M is a hydrogen or an alkali metal or an alkaline earth metal; a is an integer from about 6-22; b is an integer from about 1-9; x is an integer from about 2-4;