MXPA97008108A - Yield complex of poliglucosi rent - Google Patents

Abstract

The present invention relates to a complex iodine concentrate containing (a) from about 0.5 to about 30% by weight of iodine, (b) from about 0.2 to about 14% by weight of an iodine component that it is selected from the group consisting of iodide salt, iodide acid and mixtures thereof, and (c) from about 2% to about 85% by weight of a nonionic sugar surfactant which is selected from the group consisting of alkyl esters glucose, aldobionamides, gluconamides, glyceramides, glycerol glycolipids, polyhydroxylated fatty acid amides, alkyl polyglucosides having the general formula I: R 1 O (R 2 O) b (Z) a I. Where R 2 is a monovalent organic radical having from about 6 to about 30 carbon atoms, R 2 is a divalent alkylene radical having from 2 to 4 carbon atoms, Z is a saccharide residue having 5 or 6 carbon atoms, b is a number having a value from 0 to about 12; is a number that has value from 1 to about 6, and mixes These, all weights are based on the weight of the concentrate

Description

YELLOW COMPLEX OF POLYGLUCOSID RENT FIELD OF THE INVENTION The present invention generally relates to a novel concentrate containing complex iodine. More particularly, the present invention relates to a complex iodine concentrate for use in compositions for antimicrobial use.

BACKGROUND OF THE INVENTION Iodine compositions have long been known to impart desirable antimicrobial and non-coloring characteristics. Complemented iodine compositions are known to be useful as sanitizers for elements in the range from contact surfaces and glassware to installations for plant formulations. An especially important application for the compositions of ycdo esc in systems cleaning in place (LEL). LEL systems are usually found in the industry that produce fluidized ingestible products for humans or animals such as the dairy industry, the pharmaceutical industry and the food industry. On-site cleaning systems are generally known as large systems in production plants that have tanks, tubes, pumps and mixing vessels that can not be separated to be cleaned. Additionally, on-site cleaning preparation systems often require high sanitization when used in the production of ingestible substances. To be reliable and useful for an end user, iodine compositions must be stable (ie, remain homogeneous) over a wide range of temperature and long periods of time. If stability is lost and the products are separated, the usefulness of the composition is significantly degraded and may present a potential risk to the user. Generally speaking, stability in this context means that a given product must remain completely homogeneous after prolonged storage at temperatures in the range from room temperature to as high as 40 ° C, which can occur during transport in closed vehicles. Furthermore, although a given product can be separated when frozen, especially after undergoing several freeze-thaw cycles, it must be easily reconstituted as a homogeneous mixture with simple agitation or mixing. Iodine-based antimicrobial products designed for topical application to the skin are usually formulated with a certain amount of emollient. The most common emollients that are used are glycerin, lanolin and its derivatives, sorbitol, fatty acid esters of polyhydroxy compounds and propylene glycol. These emollients are used in concentrations in the range from below 1% to 10% in the compositions of use. Glycerin is the most widely used emollient in udder bobbin baths and is also widely used at low concentrations in iodine-detergent and iodine-povidone formulations common for humans. Emollients are necessary due to the roughness of the skin associated with those surfactants contained in the detergent part of the composition. Another desirable functional feature for iodine-based antimicrobial use compositions designed for topical application is the ability to spread evenly over the skin and not be consumed so quickly to avoid insufficient germicidal contact time. Many of the common ingredients in antimicrobial products contribute to viscosity. However, it is common for topical products to be formulated with a specific thickener to provide additional viscosity. There are many viscosity modifiers compatible with iodine-based antimicrobial use systems, such as carboxymethyl cellulose derivatives, polyacrylate derivatives, alkylates, xanthates and polysaccharides. These are usually used in concentrations below 1% by weight in an end-use composition. These types of ingredients, suitably selected, have an insignificant effect on the homogeneity of a particular composition of use. On the other hand, when diluting concentrates are desired, viscosity modifying additives can be a problem and special care must be taken in the selection of the specific agents and their concentrations of use in the concentrates. The prior art contains examples of formulations of antimicrobial use with relatively high average detergent / iodine proportions available in more than 5: 1. However, there are a number of potential advantages associated with the use of very low average disposable detergent / iodine proportions in germicidal iodine concentrates and the use compositions designed for skin or tissue application. For example, in a low proportion product of this type, there would be less organic matter reacting with the iodine, making these compositions more stable in relation to the normal high proportion of the detergent content to the average available iodine content. Another advantage is that the reduced amounts of detergent would be expected to be less irritating to the skin and would therefore require a lower amount of emollient. Compositions with lower average available detergent / iodine ratios could be formulated to have higher and more stable free or uncomplexed iodine concentrations. The use of minimum quantities of detergent would also allow the possibility of reducing the amount of water in the concentrates, whereby correspondingly the packaging, shipping and storage costs would be reduced. However, an obvious disadvantage associated with these types of formulations is that lower amounts of the detergent component reduce the detergent or detergent effectiveness of the germicidal composition. Moreover, the use of lower proportions of average available detergent / iodine also gives rise to the composition becoming less stable during storage which makes them significantly less tradable. Accordingly, an object of the present invention is to provide complex iodine concentrates designed for topical applications in human and animal skin that employ a component that acts as a complexing agent for iodine and a mild surfactant and still effectively detergent that is less severe on the skin and tissue, which requires the addition of little if any of the emollients is used for the composition of antimicrobial use.

Another objective of the present invention is to provide a complex iodine concentrate for use in compositions for antimicrobial use to disinfect and sanitize various contact surfaces including those present in LEL systems, as well as glassware, the concentrate is capable of being used relatively high average detergent / iodine proportions, thus making the antimicrobial formulations more stable during storage over prolonged periods of time and temperature ranges while imparting maximum detergent properties.

SUMMARY OF THE INVENTION The present invention overcomes the problems described in the foregoing by providing a complex stable iodine concentrate for use in various aqueous compositions for antimicrobial use. Accordingly, the present invention provides a complex of ycdo complex containing: (a) from about 0.5 to about 30% by weight of iodine; (b) from about 0.2 to about 14% by weight of a component that is selected from the group consisting of iodide salt, acid iodide and mixtures thereof; and (c) from about 2.0 to 85% by weight of a nonionic sugar surfactant that is selected from the group consisting of alkyl glucose esters, aldobionamides, gluconamides, glyceramides, glycerol glycolipids, polyhydroxy fatty acid amides, alkyl polyglycosides having the general formula I: RO (R20) b (Z) to I wherein Ri is a monovalent organic radical having from about 6 to about 30 carbon atoms; R2 is a divalent alkylene radical having from 2 to 4 carbon atoms; Z is a saccharide residue having 5 or 6 carbon atoms; b is a number that has a value from 0 to about 12; a is a number that has a value from 1 to about 6, and mixtures of these, all weights are based on the weight of the concentrate. The present invention also provides an aqueous composition for antimicrobial use that contains the complex iodine concentrate described above and a diluent.

The present invention also provides a process for cleaning, disinfecting and sanitizing a proposed surface that includes contacting the proposed surface with the above-described aqueous antimicrobial use composition.

DESCRIPTION OF THE INVENTION In contrast to the exemplary embodiments, or where otherwise indicated, all numbers expressing amounts of ingredients or reaction conditions used herein are to be understood as modified in all instances by the term "near". The above and other related objectives are achieved, and the disadvantages of the prior art are overcome by the surprising discovery that a nonionic sugar surfactant effectively functions as a complexing agent for iodine in complex iodine concentrates and a mild surfactant and still detergent when the complex iodine concentrates are diluted to form an aqueous composition of antimicrobial use. The term "nonionic sugar surfactant" as used herein refers to surfactants that are based on portions of saccharides. The nonionic sugar surfactants that can be employed in the present invention are selected from the group consisting of alkyl polyglycosides, alkyl glucose esters, aldobione idas, gluconamides, glyceramides, glyceroglucolipids, polyhydroxy fatty acid amides and mixtures thereof. Preferred alkyl polyglycosides that can be used as complexing agents in the concentrate of the invention have the formula I: R? O (R20) = (Z) to I wherein Z is a glucose residue and b is zero. These alkyl polyglucosides are commercially available, for example, as GLUCOPON®, or PLANTAREN® surfactants from Henkel Corporation Ambler, PA., 19002. Examples of these surfactants include but are not limited to: 1. GLUCOPON® surfactant 225-a alkyl polyglucoside in which the The alkyl group contains 8 to 10 carbon atoms and has an average degree of polymerization of 1.7. 2. GLUCOPON® 425 surfactant-an alkyl polyglucoside in which the alkyl group contains 8 to 16 carbon atoms and has an average degree of polymerization of 1.6. 3. GLUCOPON® 625 surfactant-an alkyl polyglucoside in which the alkyl group contains from 12 to 16 carbon atoms and which has an average degree of polymerization of 1.6. 4. APG® 325 surfactant-an alkyl polyglucoside in which the alkyl group contains 9 to 11 carbon atoms and which has an average degree of polymerization of 1.6. 5. GLUCOPON® 225 surfactant-an alkyl polyglucoside in which the alkyl group contains from 12 to 16 carbon atoms and which has an average degree of polymerization of 1.4. 6. PLANTAREN® 2000-a Ciß-is alkyl polyglycoside surfactant in which the alkyl group contains from 8 to 16 carbon atoms and which has an average degree of polymerization of 1.4. 7. PLANTAREN® Surfactant 1300- a ds-ie an alkyl polyglucoside in which the alkyl group contains from 12 to 16 carbon atoms and which has an average degree of polymerization of 1.6. Other examples include alkyl polyglycoside surfactant compositions comprising mixtures of compounds of the formula I wherein Z represents a portion derived from a reducing saccharide containing 5 or 6 carbon atoms; a is a number that has a value from 1 to about 6; b is zero; and Ri is an alkyl radical having from 8 to 20 carbon atoms. The compositions are characterized in that they have increased surfactant properties and an HLB in the range of from about 10 to about 16 and a non-fluoride distribution of glycosides, the compositions comprising a mixture of an alkyl monoglycoside and a mixture of alkyl polyglycosides having it. various degrees of polymerization of 2 and higher in progressively decreasing amounts, in which the amount by weight of the polyglucoside having a degree of polymerization of 2, or mixtures thereof with the polyglucoside having a degree of polymerization of 3, predominates. In relation to the amount of monoglycoside, this composition has an average degree of polymerization of about 1.3 to about 3.

These compositions, also known as maximally adjusted alkyl polyglucosides can be prepared by separating the monoglycoside from the original reaction mixture of alkyl monoglycoside and alkyl polyglucoside after removing the alcohol. This separation can be carried out by molecular distillation and usually results in the elimination of about 70-95% by weight of the alkylmonoglycosides. After removing the alkyl monoglycosides, the relative distribution of the various components, mono- and poly-glucosides, in the resulting product changes and the concentration in the product of the polyglucosides relative to the monoglycosides increases as well as the concentration of individual polyglucosides for the total, that is, fractions DP2 and DP3 in relation to the sum of all DP fractions. These compositions are described in U.S. Patent 5,266,690, all of which content is incorporated herein by reference. Other alkyl polyglucosides which can be used in the compositions according to the invention are those in which the alkyl portion contains from 6 to 18 carbon atoms and in which the average length of the carbon chain of the composition is from about 9. to about 14 comprises a mixture of 2 or more of the at least binary alkyl glucoside components, wherein each binary component is present in the mixture in relation to its average carbon chain length in an amount effective to provide the Tensoactive composition the average length of the carbon chain from about 9 to about 14 and where at least 1 or both binary components contain a Flory distribution of polyglucosides derived from an acid-catalyzed reaction of an alcohol containing 6 to 20 carbon atoms and a suitable saccharide from which the excess alcohol has been removed The alkyl polyglucoside of the present invention tua as the complexing agent for the iodine complex concentrate. The sugar surfactants of the alkylglucose ester are generally described in U.S. Patent Nos. 5,109,127 and 5,190,747, the total content of both is incorporated herein by reference. These sugar surfactants have the general formula II: < enter the formula of page 9 > wherein R represents a fatty acid residue of 6 to 20 carbon atoms, preferably of 6 to 12 carbon atoms and R 1 represents an alkyl group having 2 to 6 carbon atoms. Representative examples of these alkylglucose esters are 1-ethyl-caprylglucoside, 1-ethyl-6-lauryl glucoside, 1-butyl-6-capryl glucoside, 1-ethyl-6-palmityl glucoside and 1-ethyl-6-oleylglucoside.

APPENDIX TO PAGES 12 AND 13 OF THE TRANSLATION General Formula II Formula III Aldobionamide sugar surfactants are generally described in U.S. Patent No. 5,310,542 and in published European Patent Application No. 550,281, both of which are incorporated herein by reference. in the present as a reference. An aldobionamide is generally defined as the amide of an aldobionic acid or aldobionolactam and aldobionic acid in turn is defined as a sugar substance (e.g., any cyclic sugar) in which the aldehyde group has been replaced by a carboxylic acid the which with dehydration is able to cyclize to form an aldonolactam. The aldobionamides can be based on compounds containing two saccharide units, for example, lactobionamides, maltobionamides, celobionamides, melibionamides, or gentiobionamides, or they can be based on compounds containing more than two saccharide units as long as the polysaccharides have a terminal sugar unit with an available aldehyde group. Preferred aldobionamides of the present invention are lactobionamides of formula III: < enter the formula of page 11 > Where R1 and R2 are the same or different and are selected from hydrogen and an aliphatic hydrocarbon radical containing up to about 36 carbon atoms (e.g., alkyl groups and alkenyl groups whose groups may also include a heteroatom such as N, 0, S, present, for example, as an amide, carboxy, ether and / or saccharide moiety) except that R1 and R2 can not simultaneously be hydrogen. The aliphatic hydrocarbon radical preferably contains up to 24 carbon atoms, more preferably from 8 to 18 carbon atoms. Representative examples of these lactobionamides are N-propyl lactobionamide, N-pentyl lactobion ida, N-decyl lactobionamide, N-hexadecyl lactobionamide, N-oleyl lactobionamide, N-dodecyl-N-methyl-Lactobionamide and N-dodecyloxypropyl lactobionamide. Sugar gluconamide surfactants are generally described in US Patent No. 5,352,386, all of which is incorporated herein by reference. These surfactants have the general formula IV: H0CH2- (CHOH) m-C (0) -NHR wherein m is an integer from 2 to 5; and R is a linear or branched, saturated or unsaturated aliphatic hydrocarbon having from 4 to about 24 carbon atoms, preferably from 8 to 24 carbon atoms, whose R group can also contain an heteroatom selected from the group consisting of oxygen, nitrogen and sulfur. Representative examples of these co-surfactants are N-octyl erythronamide, N-decyl erythronamide, N-dodecyl erythronamide, N-tetradecyl erythronamide, N-decyl xylonamide and N-dodecyl xylonamide. The sugar glyceramide surfactants are generally described in US Pat. No. 5,352,387 the total content of which is incorporated herein by reference. These co-surfactants have the general formula V: HOCH2CH (OH) C (0) NHR wherein R is a linear or branched, saturated or unsaturated aliphatic hydrocarbon of Ca to C24 in which the R group can also be substituted by a selected heteroatom of oxygen, nitrogen and sulfur. Representative examples of these co-surfactants are N-octyl glyceramide, N-decyl glyceramide and N-hexadecyl glyceramide. The sugar glyceroglycolipid surfactants are generally described in U.S. Patent 5,358,656 and the published European patent application No. 550,279, the description of each is incorporated herein by reference. The glyceroglucolipids may be of the formula VI: A1-0-CH2-CH (B) -CH2NRRX wherein A1 is a saccharide, preferably having one or more units removed, more preferably a mono or disaccharide and more preferably a monosaccharide such as glucose or galactose; R and Ra are the same as different and are hydrogen, a branched or unbranched hydrocarbon radical having from 1 to about 24, preferably from about 6 to about 18 carbon atoms; B is OH or a group NR2R3, wherein R2 and R3 may be the same or different and are hydrogen, a branched or unbranched hydrocarbon radical having from 1 to 24, preferably from 6 to 18 carbon atoms, and NRRi and B They are interchangeable in their position. Representative examples of these co-surfactants are 3- (butylamino) -2-hydroxypropyl-β-D-galactopyranoside, 3- (octylamine) -2-hydroxypropyl-β-D-galactopyranoside, 3- (eicosylamine) -2-hydroxypropyl-β -D-galactopyranoside 3- (butylamino) -2-hydroxypropyl-β-D-glucopyranoside and 3- (pentylamine) -2-hydroxypropyl-β-D-mannopyranoside. Other glyceroglycolipid surfactants are described in the published European patent application No. 550,280 which is incorporated herein by reference. These co-surfactants are of formula VII: A1-0-CH2-CH (O i) -CH2OR wherein A1 is from 1 to 4 saccharide units and most preferably represents a mono or disaccharide, and most preferably a mono saccharide, example, glucose or galactose; R and Ri are the same or different and are hydrogen or a branched or unbranched, saturated or unsaturated hydrocarbon radical having from 1 to 24 carbon atoms, preferably from 6 to 18 carbon atoms. Representative examples of these co-surfactants are 3- (butyloxy) -2-hydroxypropyl-β-D galactopyranoside, 3- (eicosyloxy) -2-hydroxypropyl-β-D-galactopyranoside, 3- (decyloxy) -2-hydroxypropyl-β- D-galactopyranoside 3- (butyloxy) -2- hydroxypropyl-β-D-diglucopyranoside and 3- (oxyloxy) -2- hydrosylgipropyl-β-D-mannopyranoside, 3- (tetradexloxy) -2-hydroxypropyl-β-D- lactoside, 3- (octadecyloxy) -2- hydroxypropyl-β-D-maltoside, 3- (oxyloxy) -2- hydroxypropyl-β-D-galactotrioside, and 3- (dodesiloxy) -2- hydroxypropyl-β-D-celotrusside . The sugar surfactants of the polyhydroxy fatty acid amide are generally described in US Patent Nos. 5,174,927, 5,222,179 and 5,332,528, the entire disclosure of which is incorporated herein by reference. The surfactant component of the polyhydroxy fatty acid amide of the present invention comprises the compounds of structural formula VIII: R2C (0) N (R1) Z wherein R1 is H, C? -C, 2-hydroxyethyl hydrocarbyl, 2-hydroxypropyl or a mixture thereof, preferably Ci-C4 alkyl, more preferably Ci or C2 alkyl, more preferably Ci alkyl (i.e., methyl); and R2 is a C5-C3 hydrocarbyl, preferably straight chain C7-C19 alkyl or alkenyl, more preferably Cg-C.7 / straight chain alkyl or alkenyl, more preferably Cn alkyl or alkenyl -Civ, of • linear chain or mixtures thereof; and Z is a polyhydroxy hydrocarbyl having a linear hydrocarbyl chain with at least 3 hydroxyls directly connected to the chain, or an alkoxylated derivative (preferably ethoxylated or propoxylated) thereof. Z preferably will be derived from a reducing sugar in a reductive amination reaction; more preferably Z is a glycityl. Suitable reducing sugars include glucose, fluctuous maltose, lactose, galactose, mannose, and xylose. As raw materials, high-dextrose corn syrup, high-fructose corn syrup and high-maltose corn syrup can be used as well as the individual sugars listed above. These corn syrups can produce a mixture of sugar components for Z. It should be understood that by no means is it intended to exclude other suitable raw materials. Z will preferably be selected from the group consisting of -CH2- (CHOH) n-CH2OH, -CH (CH2OH) - (CHOH) n -.?- CH2OH, -CH2- (CHOH) 2 (CHOR ') (CHOH) -CH 2 OH, wherein n is an integer from 3 to 5, inclusive, and -R 1 is H or a cyclic or aliphatic monosaccharide and alkoxylated derivatives thereof. Most preferred are glycityls wherein n is 4, particularly -CH2- (CHOH) 4-CH2OH. In the above formula R1 can be, for example, N-methyl, N-ethyl, N-propyl, N-isopropyl, N-butyl, N-2-hydroxyethyl or N-2-hydroxypropyl, R2C (0) N < it may be, for example, cocamide, stearamide, oleamide, lauramide, myristamide, capricamide, palmitamine, and ceboamide, etc. Z can be 1-dexosiglucityl, 2-dexodifructityl, 1-dexomaldityl, 1-dexosilactityl, 1-dexosigalactityl, 1-dexomanityl, 1-dexomalothototyl, etc. Representative examples of these surfactants are N-methyl-N-1-dexoglucityl cocoamide and N-methyl-N-dexosiglucityl ceboamide. Other suitable polyhydric fatty acid amide surfactants (see U.S. Patent Nos. 5,223,179 and 5,338,491, all of the contents of which are incorporated herein by reference) are those of formula IX: RC (O) N (R1) CH2CH) OH) CH20H wherein R is a C-C21 hydrocarbyl species, that is, coconut alkyl, bait, palm and oleyl, and R1 is a C? -C6 hydrocarbyl or substituted hydrocarbyl species, i.e., N-alkyl- N- (1,2-propanediol) and fatty acid amides of N-hydroxyalkyl-N-1,2-propane diol. Representative examples of these co-surfactants are 3- [2- (hydroxyethyl) amino] -l, 2-propanediol baitamide (HEAPD), 3-methylamino-1,2-propanediol palmitate amide (MAPD) and lauramide. of MAPD.

The function of iodine in the present invention is to provide antimicrobial, sanitizing and disinfecting efficacy. Iodine is usually chosen over other disinfectants and elemental sanitizers due to its high antimicrobial efficacy for short periods of time.

Iodine is a non-metallic element that belongs to the family of halogens in the VIIA group of the periodic table. It is the heaviest common element in this family and the only solid at room temperature. Iodine, like other halogens, is chemically very active, but more desirable than other halogens because it is less violent in its action. Iodine is slightly soluble in water, the solubility increases with temperature. Iodine also dissolves in many organic solvents.

The iodine component of the present invention is derived from two sources, ie from the iodine itself and from a constituent iodide such as sodium iodide, potassium iodide or hydroiodic acid and, optionally, water. In general, the amount of available iodine present in the complex iodine concentrate of the invention is in the range from about 200 to about 20,000 ppm of iodine. Also, the weight ratio of the nonionic sugar surfactant acting as complexing agent for the available iodine in the concentrate is in the range from about 6: 2 to about 1: 1, respectively, and about 4: 1 is preferred. .

In a preferred embodiment of the present invention the iodine complex concentrate of the present invention contains from about 5 to about 20% by weight of iodine, from about 0.2 to about 14% by weight of iodine salt and from about from 2.0 to about 85% by weight of an alkyl polyglucoside having the general formula I: R-_O (R20) b (Z) to I wherein Ri is a monovalent organic radical having from about 6 to about 30 carbon atoms; R2 is a divalent alkylene radical having from 2 to 4 carbon atoms; Z is a saccharide residue having 5 or 6 carbon atoms; b is a number that has a value from 0 to about 12; a is a number that has a value from 1 to about 6, and mixtures of these, all weights are based on the weight of the concentrate. It should also be noted that the complex iodine complex formed of the present invention can be liquid or solid, i.e., powder. The complex iodine concentrate of the present invention can be diluted with a diluent such as water to form an aqueous composition of antimicrobial use. Aqueous compositions of antimicrobial use are well known in the art and are used for a variety of uses such as on-site cleaning systems (LEL) which are used in industries that manufacture fluidized ingestible products for humans or animals such as industry. dairy, the pharmaceutical industry and the food industry, to clean the contact surfaces of glass materials. Aqueous antimicrobial compositions are also conicidated by their use in topical applications for the skin to clean disinfect and sanitize the skin of humans and animals. Aqueous compositions for topical antimicrobial use are mainly used as pre-operative antiseptic preparations, hand cleansers and in udder coil baths for the prevention of mastitis. In this manner, the present invention provides an antimicrobial use composition resulting from the dilution of the iodine complex concentrate of the present invention at a concentration of the available iodine content from about 0.5 to about 200 ppm of iodine. The diluent that is commonly used is water, although any other type of desirable diluent can also be used. In the same way, the specific amount of the diluent to be employed will depend on the particular use of the antimicrobial use composition. In general, however, the amount of diluent that is used should be sufficient to form an antimicrobial use composition with a concentration of available iodine content from about 0.5 to about 200 ppm of iodine, as set forth above. It should also be noted that while the non-ionic sugar surfactant acts primarily as a complexing agent for iodine, it also acts as a detergent surfactant. In this way, if it is desired to improve the cleaning efficiency of an aqueous composition for antimicrobial use, the additional surfactants can also be used in the formulation of the iodine complex concentrate or the aqueous composition for antimicrobial use. Examples of suitable surfactants include the anionic, nonionic, cationic, amphoteric surfactants and mixtures thereof. The additional additives may also be employed when formulating the complex iodine concentrate or the aqueous composition for antimicrobial use such as fragrances, colorants, fillers, viscosity modifiers, foam regulators or additional complexing agents. The present invention also provides a process for cleaning disinfect and sanitize the various proposed surfaces. Examples of the proposed surfaces include the skin of humans and animals as well as contact surfaces such as those present in the cleaning-in-place (LEL) systems used to manufacture fluidized ingestible products, as well as glass materials. In general, however, any surface that requires cleaning, disinfection and sanitation qualifies as a proposed surface. The process includes contacting the proposed surface with the aqueous composition for antimicrobial use described in the foregoing. The present invention will be better understood from the following examples, all of which are suggested as illustrative only and are not intended to unduly limit the scope of the invention. Unless stated otherwise, the percentages are weight by weight. Example 1 A concentrated iodine complex composition having the following formulation was prepared. Component% by weight (a) GLUCOPON® 325 79-0 (b) Nal 6.8 (c) iodine (crystals) 14.2 100.0 The Nal was added to the alkyl polyglucoside with stirring, and the mixture was stirred for an additional 25 minutes. The iodine crystals were then added to the mixture in increments with stirring, and then that mixture was stirred for an additional 4 hours at room temperature. The mixture was then heated to 35 to 40 ° C and maintained at this temperature for about 30 minutes with agitation to form the concentrated composition of the iodine complex. Example 2 A concentrated composition of the iodine complex was prepared as in Example 1 with the following formulation. Component% by weight (a) GLUCOPON® 425 83.8 (b) Nal 5.2 (c) iodine (crystals) 11.0 100.0 Example 3 A concentrated iodine complex composition having the following formulation was prepared. Component% by weight (a) GLUCOPON® 600 60-6 (b) Nal 5.2 (c) iodine (crystals) 11.0 (d) deionized water 23.2 100.0 Example 4 A concentrated iodine complex composition having the following formulation was prepared. Component% by weight (a) GLUCOPON® 225 47- ° (b) Nal 5.2 (c) iodine (crystals) 11.0 (d) deionized water 36.8 100.0 Table 1 summarizes the initial iodine content of the examples at a temperature of 25 ° C. Table 1 Examples ID to IT to value value% iodine% iodine 25 ° C 25 ° C theoretical theoretical produced YD YT YD 1 12.8 20.6 14.3 21 89.5 98.0 2 9.5 15.7 10.0 16.2 95.0 96.93 3 9.7 15.5 11.0 16.2 88.2 95.6 4 9.9 15.4 11.0 16.2 90.0 95.0 Cl * 21.2 27.2 22.0 31.0 96.3 88.1 * C1 = BIOPAL® NR 20, an iodine-complexing agent noniofenoxi poly (ethyleneoxy) ethanol available from Rhone Poulenc, Cranbury, NJ 085512. ID = available iodine IT = total iodine Table 2 summarizes the iodine content of the examples at a temperature of 25 ° C and 50 ° C after a storage period of 9 weeks. Table 2? J. YD to YT to value value% iodine% iodine 25 ° C / 50 25 ° C / 50 ° theoretical theoretical produced produced or ID IT or ID 1 13.0 / 50 ° 21.0 / 20.8 14.3 21 90.9 / 86.0 100 / 99.0 2 9.4 / 8.7 15.7 / 16.1 10.0 16.2 94.0 / 87.0 97.0 / 99.3 3 9.7 / 12.1 16.0 / 21.0 11.0 16.2 88.2 / - 98.7 / - 4 10.0 / 9.3 15.7 / 15.8 11.0 16.2 90.9 / 84.5 97.0 / 97.5 Cl * 21.1 / 20.9 26.9 / 16.6 22.0 31.0 96.3 / 95.0 87.0 / 86 * C1 = BIOPAL® NR 20, an iodine-complexing agent noniofenoxi poly (ethyleneoxy) ethanol available from Rhone Poulenc, Cranbury, NJ 085512. YD = available iodine YT = total iodine Example 5 An aqueous formulation for antimicrobial use was prepared for topical application to the skin using the concentrate of the iodine complex which was prepared in the Example 1 with the following formulation. Component% by weight (a) iodine complex of Example 1 18.4 (b) GLUCOPON® 325 25- (c) 70% H3P04 36.0 (d) propylene glycol 8.0 (e) deionized water 12.6 100.0 Table 3 summarizes the results of the stability of Example 5 obtained after one week of storage at a temperature of 25 ° C. Table 3 Theoretical Real AI 2.43 2.44 IT 3.72 3.63

Claims (1)

1. CLAIMS A complex iodine concentrate containing: (a) from about 0.5 to about 30% by weight of iodine; (b) from about 0.2 to about 14% by weight of an iodine component that is selected from the group consisting of iodide salt, acid iodide and mixtures thereof; and (c) from about 2% to about 85% by weight of a nonionic sugar surfactant that is selected from the group consisting of alkyl glucose esters, aldobionamides, gluconamides, glyceramides, glycerol glycolipids, polyhydroxy fatty acid amides, alkyl polyclucosides having the general formula I: R! (R20) b (Z) to I wherein Ri is a monovalent organic radical having from about 6 to about 30 carbon atoms; R2 is a divalent alkylene radical having from 2 to 4 carbon atoms; Z is a saccharide residue having 5 or 6 carbon atoms; b is a number that has a value from 0 to about 12; a is a number that has a value from 1 to about 6, and mixtures of these, all weights are based on the weight of the concentrate. The concentrate of claim 1, wherein the nonionic sugar surfactant is alkyl polyglucoside. The concentrate of claim 1, wherein the iodide salt is selected from the group consisting of sodium iodide, potassium iodide and mixtures thereof. The concentrate of claim 2, wherein b of the general formula I is 0. The concentrate of claim 1, which has an iodine content available from about 200 to about 20,000 ppm. The concentrate of claim 1, wherein the component (a) is present in an amount from about 5 to about 20% by weight based on the weight of the concentrate. The concentrate of claim 1, having a weight ratio of component (c) for the available iodine in components (a) + (b) from about 6: 1 to about 1: 1, respectively. The concentrate of claim 7, wherein the weight ratio is 4: 1. The concentrate of claim 1, which contains an additive that is selected from the group consisting of [sic] nonionic, anionic, -. cationic, amphoteric, viscosity modifiers, fragrances, dyes, fillers, foam regulators and mixtures thereof. The concentrate of claim 1, having a pH from about 2 to about 7. an aqueous composition for antimicrobial use comprising a complex concentrate of iodine and a diluent, the concentrate consists of: (a) from about 0.5 to about 30% by weight of iodine; (b) from about 0.2 to about 14% by weight of a component that is selected from the group consisting of acid and mixtures thereof; and (c) from about 2.0 to about 85% by weight of a nonionic sugar surfactant that is selected from the group consisting of alkyl glucose esters, aldobionamides, gluconamides, glyceramides, glycerol glycolipids, polyhydroxy fatty acid amides, alkyl polyglycosides having the general formula I: R! (R20) b (Z) to I wherein Ri is a monovalent organic radical having from about 6 to about 30 carbon atoms; R2 is a divalent alkyne radical having from 2 to 4 carbon atoms; Z is a saccharide residue having 5 or 6 carbon atoms; b is a number that has a value from 0 to about 12; a is a number that has a value from 1 to about 6, and mixtures of these, all weights are based on the weight of the concentrate. The composition of claim 11, wherein the nonionic sugar surfactant is alkyl polyglucoside. The composition of claim 11, wherein the iodide salt is selected from the group consisting of sodium iodide, potassium iodide and mixtures thereof. The composition of claim 12, wherein b of the general formula I is 0. The composition of claim 11, which has an iodine content available from about 0.5 to about 200 ppm of iodine. The composition of claim 11 wherein the diluyenne is water. The composition of claim 11, wherein the concentrate has a weight ratio of component (c) for the available iodine in components (a) + (b) from about 6: 1 to about 1: 1, respectively. The process for cleaning, sanitizing and disinfecting a proposed surface, the process comprises contacting the proposed surface with an aqueous composition for antimicrobial use containing an iodine complex concentrate and a diluent, the concentrate in: (a) from about 0.5 to about 30% by weight of iodine; (b) from about 0.2 to about 14% by weight of a component that is selected from the group consisting of acid and mixtures thereof; and (c) from about 2.0 to about 85% by weight of a nonionic sugar surfactant that is selected from the group consisting of alkyl glucose esters, aldobionamides, glucone idas, glyceramides, glycerol glycolipids, polyhydroxy fatty acid amides, alkyl polyglucosides having the general formula I: R? O (R20) b (Z) to I wherein Ri is a monovalent organic radical having from about 6 to about 30 carbon atoms; R2 is a divalent alkylene radical having from 2 to 4 carbon atoms; Z is a saccharide residue having 5 or 6 carbon atoms; b is a number that has a value from 0 to about 12; a is a number that has a value from 1 to about 6, and mixtures of these, all weights are based on the weight of the concentrate. 19. The process of claim 18, wherein the nonionic sugar surfactant is alkyl polyglucoside. The process of claim 18, wherein the iodine salt is selected from the group consisting of sodium iodide potassium iodide and mixtures thereof. The process of claim 19, wherein b of the general formula I is 0. 22. The process of claim 18, wherein the 'aqueous composition for antimicrobial use has an available iodine content from about 0.5 to about of 200 ppm of iodine. 23. The process of claim 18, wherein the * diluent is water. The process of claim 18, wherein the proposed surface is selected from the group consisting of contact surfaces, human skin, animal skin and glass material. The process of claim 18, wherein the concentrate has a weight ratio of component (c) for the available iodine in components (a) + (b) from about 6: 1 to about 1: 1, respectively.