MXPA96005298A - Compositions containing dialquil peroxide (c1-c6) -cetone for the conservation of organic tissues, and application of such compositions in the conservation and anatomical preparation of organic tissues of animal or human origin - Google Patents

Abstract

The present invention relates to compositions for the preservation of organic tissues consisting of a mixture of 12 to 70% of at least one diacyl (C 1 -C 6) ketone peroxide, 10 to 15% of a glycerin, 10 to 75% of at least one alcohol and, optionally, from 0 to 10% of a complementary marker, dye and / or aromatic agent. These compositions can be mixed with other suitable diluents or agents, and are especially applied in the preservation of all kinds of tissues of human or animal origin, preferably by embalming or immersion.

Description

TITLE OF THE INVENTION COMPOSITIONS CONTAINING DIALKYL PEROXIDE (C, - C6) - CETONE FOR THE CONSERVATION OF ORGANIC TISSUES, AND APPLICATION OF SUCH COMPOSITIONS IN THE CONSERVATION AND , ANATOMICAL PREPARATION OF ORGANIC TISSUES OF ANIMAL ORIGIN OR HUMAN TECHNICAL FIELD OF THE INVENTION The present invention falls within the technical field of the conservation of organic animal or human tissues. More specifically, the invention provides compositions useful for the temporary or indefinite preservation of such dead tissues and of human and animal carcasses, against natural decomposition processes and contamination with fungi. ^ ^ ^ STATE OF THE TECHNIQUE PRIOR TO INV, ENCI_ON.

The conservation of animal and human corpses as well as organs and tissues isolated from such corpses has a long tradition in history initially for cultural reasons and, approximately since the Renaissance also for the purposes of anatomy studies. Nowadays, the conservation of human corpses continues to be carried out for cultural reasons but also for studies of pathology and anatomy, the transfer of bodies from one place to another. Likewise, the conservation of animal corpses continues to be used, apart from for the aforementioned purposes *, in public and private education. Current conservation technologies are essentially based on embalming and immersion techniques in which different agents are used. Such agents are alcohol as a means of fixation and preservation, tannic acid as a means to prevent the growth of fungi, mercury bichloride to inhibit putrefaction and facilitate mummification, arsenic, glycerin, paraffin, acetone combinations and silicone as well as the for aldehyde or formalin discovered by the chemist August Wilhelm V. Hofmann in 1868. For its low cost and excellent preservative properties, formaldehyde remains the preservative agent of corpses and tissues of animal and human origin more widespread and its low cost. However, due to its relative toxicity and its possible harmful and even carcinogenic effects, the use of formaldehyde is currently being questioned in scientific and health administration circles, and there are studies and projects that contemplate the prohibition of the use of formaldehyde as a preservative agent. Apart from this, formaldehyde has the well-known disadvantages as an irritant of the mucous membranes and respiratory tract as well as a typical odor that is often perceived as very unpleasant. On the other hand, through the techniques of * "" Conventional preservation and the use of current preservatives, protection of the totality of the tissues against the natural processes of decomposition caused by microbiological agents, fungi or conservation or the recovery of said tissues in a flexible state is not achieved. and as close as possible to the state of living tissues. Conventional techniques of temporary preservation, necessary or convenient in some cases, for example in the case of the transfer of corpses, preservation in funeral homes before burial or in forensic institutions before autopsy, are essentially limited to the disposition of the bodies in refrigerated chambers, or the application by arterial insufflation or of the corporal cavities with formalin, which, does not produce a satisfactory conservation, apart from that, in the case of the chambers, it results in high expenses for the construction, operation and maintenance of refrigeration chambers, and in the case of arterial insufflation, the intervention of a highly specialized technician is required.

On the other hand, in practice, techniques are used for the preparation of anatomical samples in which formaldehyde / formaldehyde are used. Such techniques are the bleaching of bones, the restoration of corpses, bodies of mummified animals and pieces thereof, the staining of nervous tissue, the flexibilization of hollow viscera, the obtaining of samples of blood vessels by means of corrosion-reflection techniques, as well as the diafanization of animal bodies or fetuses. With the conventional techniques of whitening of bones, made with aggressive detergents, the result is not usually totally satisfactory in view of the fact that it is difficult to achieve a uniform whitening, in addition to the aggressiveness of the detergents used, the texture of the treated bone is damaged. With the conventional techniques of restoration of bodies or pieces of animal or human origin, to date has not achieved a technique that allows flexibility of mummified tissues while a conservation that allows exposure to room temperature and easy maintenance of the effects of conservation. With the conventional techniques of staining parts of nervous tissue of the central nervous system and of flexibility / preservation of hollow viscera, the obtaining of samples of blood vessels by means of techniques of ~, "corrosion-reflection, as well as the diafanization of animal bodies or fetuses, it is practically impossible to obtain anatomical pieces that are preserved with a high degree of flexibility and that are exposed without protection, they are preserved without degrading. conventional corrosion / reflection techniques, it is very difficult not to say practically impossible, to achieve the maintenance of most of the finer capillary vessels, while a further great disadvantage of conventional diaphanization techniques is that of the long processing time (approximately 120 days) that are usually required The further investigations carried out on the basis of those described in Spanish patent P-9500471 have * resulted that the compositions with the basic components described therein can be used in other useful applications, such as the temporary preservation of corpses by spraying / fogging or smearing, blanqueamie of bones, the restoration of corpses, bodies of mummified animals and parts thereof, the staining of nervous tissue, the flexibilization of hollow viscera, the obtaining of samples of blood vessels by means of corrosion-reflection techniques, as well as the diafanization of animal or fetus bodies. The present invention is intended to overcome the drawbacks of the state of the art by means of a product of negligible toxicity of easy preparation and handling, practically odorless, and of fast action and low cost, which allows to preserve and recover, in a flexible state and very similar to the structure and texture alive, all kinds of tissues of animal origin, whether whole bodies or parts or tissues extracted from them. Additionally, due to its antithrombotic and thrombolytic characteristics, the product allows its injection into the tissues and cadavers through the blood vessels and without prior preparation, that is, without prior washing of the blood vessels, without the use of compressors, antithrombotic substances, etc. DETAILED DESCRIPTION OF THE INVENTION The present invention, as indicated by its enunciation and is defined in the claims, refers to compositions containing dialkyl (Ci-C6) ketone peroxide, preferably ethyl-methyl ketone peroxides and methyl isobutyl ketone peroxides. or mixtures thereof, for the conservation of organic tissues as well as the use of said compositions in the conservation and partial regeneration of organic tissues of animal or human origin. Also, the compositions are useful in the preparation of anatomical parts. The compositions are generally characterized in that they comprise a mixture of (in% vol.) 12 to 70% of at least one dialkyl (Ci-C6) ketone peroxide, 15% of a glycerin, to 75% of at least one alcohol and, 0 to 10% of a marker, dye and / or flavoring agent.

The presence of markers, dyes or flavorings, such as sarsaparilla, doral hirate, citronella etc. it's optional. The compositions serve both conventional preservation techniques by arterial insufflation or embalming, and by immersion and combinations of both techniques. Also, for the temporary preservation a "superficial application technique by daubing or nebulization / spraying, which will be described later, can be applied." For preservation techniques by arterial insufflation (embalming) of human and mammalian bodies and tissues for an indefinitely long time, the compositions preferably have the following formulation: 50-70% dialkyl (Ci-C¿) ketone peroxide 10-15% glycerin 15-30% alcohol 0-5% marker, dye and / or aromatic agent i For preservation techniques by arterial insufflation (embalming) of human and mammalian bodies and tissues and mammals for a relatively short time of for example 1 to 3 months, the compositions preferably have the following formulation: - 15-20% dialkyl (Ci-C6) ketone 65- 70% alcohol 10 - 15% glycerin 0 - 10% marker, coloring and / or aromatic agent In the immersion preservation of animal and human bodies and tissues, the compositions preferably have the following formulation: 15-40% dialkyl (Ci-C6) ketone peroxide 10-15% glycerin 50-70% alcohol 0-5% marker agent , coloring and / or aromatic For the temporary preservation by superficial application of animal and human bodies and tissues, the compositions preferably have the following formulation: 12-18% dialkyl peroxide (Ci-C &) ketone 10-30% glycerin 47-78% alcohol 0-10 % marker, dye and / or aromatic agent will undergo the conservation of reptile bodies and tissues and, in general, of animals intended for pathology and veterinary anatomy, the compositions preferably have the following formulation: 15-70% dialkyl peroxide (Ci - C0) ketone 10-15% glycerin 15-70% alcohol 0-10% marker, dye and / or aromatic agent For preservation of bodies and tissues of marine animals, the compositions preferably have the following formulation: 15-60% peroxide dialkyl (Ci-C) ketone 10-15% glycerin 15-65% alcohol 0-10% of a marker, dye and / or aromatic agent For the conservation of bodies and tissues in entomology, the compositions preferably have the following formulation: 15-50% dialkyl (Ci-C6) ketone peroxide 10-15% glycerin 30-70% alcohol 0-10% of a marker agent, coloring and / or flavoring.

Preferred dialkyl (Ci-CA) ketone peroxides for the composition are conventional. As an example of a product on the market, the BUTA OX M50 product marketed by AKZO can be mentioned. The most important function of the alcohol in the compositions is that of serving as a vehicle that facilitates the mixing of the peroxide and the penetration and diffusion of the composition in the tissues. Suitable alcohols are, for example, conventional alcohols of 60 °, 70 °, 80 ° and 96 ° and absolute ethanol. Glycerin has the function of a wetting agent in the composition. Conventional glycerines are suitable, for example 10 ° and 30 °. Coloring or flavoring agents such as sarsaparilla are optional components that are used mainly as a dye for muscle tissues, the deodorization of tissues that, prior to their preparation, have already gone into decomposition etc. The labeling agents can be incorporated to allow analysis of the manufacturing origin of the composition. They must be inert, that is, they must not enter »•" "in reactions with the other components. The full preservative and regenerative effects of the aforementioned compounds in the different tissues and preservation techniques are usually achieved by exposing the piece to the compositions according to the invention for 24 to 48 hours when trying to achieve long-lasting preservation effects. or indefinite although, for certain applications, the duration of exposure is usually less when it comes to achieving conservation for shorter periods such as conservation for the transfer of corpses, the storage of corpses in chambers awaiting burial or identification etc. . Apart from the application of the preservative compositions according to the invention for preservative-only purposes, their use in combination with suitable resins, in corrosion techniques with for example sodium hydroxide or potassium hydroxide the diafanization of bodies or anatomical parts, in the dyeing of the central nervous system, in cartilage conservation techniques and in microscopic capillary vascularization techniques. Advantageously, the compositions of the present invention do not generate toxic gases or residues in the incineration of corpses or pieces prepared by the application of said compositions, nor do they produce hazardous contaminant effluents in such corpses or pieces. MODES OF EMBODIMENT OF THE INVENTION The following examples, by way of illustration and representative but not limiting, describe practical embodiments of the invention.

EXAMPLE 1; A mixture comprising per liter 600 ml / 1 dialkyl (Ci-C6) ketone peroxide * »'150 ml / 1 glycerin 30 ° 200 ml / 1 96% ethanol was prepared by simple addition of the different components. v / v 50 ml / 1 of sarsaparilla.

EXAMPLE 2: A mixture comprising per liter 500 ml / 1 of dialkyl (Ci-C6) ketone peroxide 100 ml / 1 of glycerin 30 ° 350 ml / 1 of 96% ethanol was prepared by simple addition of the different components. v / v 50 ml / 1 of sarsaparilla.

EXAMPLE 3: A mixture of 400 ml / 1 of dialkyl (Ci-C6) ketone peroxide 150 ml / 1 of glycerin 30 ° 400 ml / 1 of alcohol 80% v / v was prepared by simple addition of the different components. 50 ml / 1 of sarsaparilla.

EXAMPLE 4: A mixture of 350 ml of dialkyl (C-) -C6 peroxide peroxide was prepared by simple addition of the different components 200 ml of glycerin 30 ml 400 ml of 70% ethanol v / v 50 ml of sarsaparilla .

EXAMPLE 5; A mixture of 300 ml of dialkyl peroxide (Ci-C (,) ketone 150 ml of glycerin 10 ° 600 ml of ethanol 60% v / v 50 ml of sarsaparilla was prepared by simple addition of the different components. EXAMPLE 6 A mixture of 150 ml of dialkyl (Ci-C6) ketone peroxide 150 ml of glycerin 10 ° 690 ml of ethanol 60% v / v 50 ml of chloral hirate was prepared by simple addition of the different components. 50 ml of a conventional marker. , _ -EJ-E-M-P-L - O ^ --- 7--; A human carcass was prepared by external washing with a conventional detergent substance, incision of the skin in the carotid and femoral regions to identify the arteries conventionally used for arterial insufflation of preservatives. Conventional polyethylene catheters were introduced into these blood vessels and slowly injected to facilitate their diffusion and impregnation in the tissues, the composition described in example 1 in a proportion of approximately 80-100 ce per kg body weight. The corpse thus prepared was placed in a stainless steel tray with water. After having been subjected to variable temperatures between 0 and 30oC at two years, the corpse showed no external signs of decomposition or contamination with fungi despite the fact that the surrounding water and the tray had very colonies of green fungi, blue dark and, mainly, white. All the joints of the body kept their elasticity so that it could be placed in different positions bending the different joints in a perfectly reversible way without suffering any type of damage. The dissection of the body could be performed with extraordinary ease and showed that the anatomical structures of the body preserved their original structure, elasticity and structure. A mild non-progressive lipolysis possibly attributable to the action of the preservative composition could be observed.

EXAMPLE 8 Two anatomical pieces were prepared from a human cadaver, namely a hemipelvis and a knee, by arterial insufflation of 80 to 100 ce per kg of weight of the composition prepared according to example 1. The pieces were covered with bags of polyethylene and seedlings in semi-humid soil at a depth of 30 cm. At three years, the pieces were exhumed and visually inspected with respect to their external appearance, tactilely with respect to their mobility, and by means of a dissection with respect to their anatomical characteristics. The pieces were covered with fatty tissues although after cleaning with water and a conventional detergent it could be observed that they maintained their natural coloration; - showed no contamination with any fungi or signs of putrefaction, nor destruction of their anatomical structures; they retained a total elasticity and passive mobility. The dissection of the pieces revealed that the joints of the knee and femoral cox were completely preserved and maintained the consistency and natural characteristics of their cartilages, capsule and ligamentous structures; the blood vessels maintained enough elasticity and structural consistency to allow their insufflation.

EXAMPLE 9 Several lungs from human cadavers were extracted in a variety of autopsies and immersed for 24 to 48 hours in the composition described in example 2. Subsequently, through the trachea, a conventional catheter and hypodermic syringe was introduced through the trachea. composition described in example 2. Very pressurized air was injected into said lungs by a conventional compressor and through the trachea, to achieve a uniform distribution of the preservative composition inside the lung. After 6 to 12 hours it was found that when insufflating and extracting air at higher pressure through the trachea, the movements of inspiration and pulmonary expiration could be observed and that, therefore, the lung tissue conserved its structure and elasticity intact.

EXAMPLE 10: Various pieces were prepared from human corpses, namely a heart, a mesentery and a thin target and the upper part of an arm, for insufflation of their blood vessels with coloring substances. Said pieces were kept immersed in the composition described in Example 2 for 24 to 48 hours. Subsequently, the composition prepared according to Example 1 was injected in a quantity proportional to each piece by means of a hypodermic syringe of adequate caliber for the dimensions of the blood vessel. Next, the pieces were kept immersed in the composition prepared according to example 2 for 24 hours after which the pieces were removed, and air was introduced into their blood vessels in order to clean them. Then a substance S, a gelatin-based dye, was injected into the vessels. It was observed in all the pieces that the coloring substance was introduced even in the fine capillary vessels, a total absence of blood clots as well as a great elasticity of all the vessels, when injecting air allowed to simulate vascular dilatation.

EXAMPLE 11: A dog head was immersed in a composition prepared according to Example 3 for 24 hours.

L / ^ _ hours. Then, it was injected into the main arteries by techniques and in an amount equivalent to the application of conventional embalming with formaldehyde, a composition prepared according to Example 3. After 36 hours a total regeneration of the passive mobility of the jaw could be observed, the tongue, the eyelids, an exceptional whitening of the teeth as well as a total flexibility of all the tissues of the head. After two years, the head, exposed to room temperature, showed no symptoms of loss of the above-mentioned qualities, neither of decomposition nor of microbiological contamination or fungi.

EXAMPLE 12: 0 Three common lizards were kept immersed in a composition prepared according to Example 3 for 48 hours. It was found that, after immersion, the animals retained a total elasticity in the skin and 5 joints as well as a totally natural appearance. These qualities were still present 6 months after the dive. In addition, the animals did not present any symptoms of decomposition, contamination with fungi or microbiological or mummification. > EXAMPLE 13: Ten goldfish species were submerged in a composition prepared according to Example 4 for 24 hours. It was found that, after immersion, the animals retained a total elasticity in the fins, skin and joints as well as a totally natural appearance. These qualities were still present 6 months after the dive. In addition, the animals showed no symptoms of decomposition, contamination with fungi or microbiological or mummification.

EXAMPLE 14: Fifty common bees were kept submerged in a composition prepared according to example 5 for 24 hours. It was found that, after immersion, the animals retained a total elasticity in the wings, skin and joints as well as a totally natural appearance. These qualities were still present 6 months after the dive. In addition, the animals did not have any symptoms of decomposition, contamination with fungi or microbiological or mummification.

EXAMPLE 15: A human corpse is disposed, about 6 hours after death, on a smooth and impermeable surface. Preferably (although it is not essential) the natural orifices are gently plugged with cotton impregnated with a composition prepared according to any of the examples 1, 2 or 6. With a brush of about 6 to 10 cm in width, or by means of a conventional spray of mechanical-manual pressure, the composition prepared according to example 6 is applied over the entire body surface until it is uniformly impregnated. When dealing with a thick corpse, whether it is stirred or with signs of putrefaction or fermentation, especially at the abdominal level, it is advisable to inject 100 cc of the composition prepared according to Example 6, into its thoracic and abdominal cavities. When dealing with mutilated corpses, they can be injected additionally they can be injected additionally 20 to 25 ce in the mutilated areas to improve the conservation of these. Due to the discreetly oily nature of the preservative composition, it is advisable to leave the corpse resting without clothing for 60 to 90 minutes. The corpses thus prepared can be kept at room temperature for 3 to 20 days, which is especially advantageous, for example, for those corpses that require short or medium distance transport, or those that remain in funeral homes. If malodors or signs of putrefaction are observed, the application on the body surface described above can be repeated, for example on the third and / or seventh day after the first treatment.

EXAMPLE 16: For its bleaching, the bone pieces, once the soft matter has been removed from which it could be partially or totally coated, is introduced into a composition prepared according to example 2 during a period of one to three weeks, in «Dependence on its size. Subsequently, the piece is drained and placed in a 96 ° alcohol bath for 3 to 7 days. Afterwards, the piece is removed from the alcohol bath and kept at room temperature until it is completely dried (approximately 1 to 2 days). It can be observed that even when it comes to pieces from burials, the treatment described above produces a total whitening.

EXAMPLE 17: A mummified corpse is subjected to restoration for which it is first cleaned superficially, detached from inorganic remains and then immersed in a bath of a composition prepared according to example 2 for a minimum period of time of 3 to 5 days. During this period, the mummified corpse becomes progressively clearer while its tissues and even its joints acquire flexibility.

Once the desired coloration and elasticity have been observed, the corpse is removed from the bath and, once drained, it can be exposed to room temperature for a practically indefinite time. In case any drying occurs later, it can be overcome by introducing the body in the bath described above for 2 to 3 days.

EXAMPLE 18: A portion of nerve tissue is fixed and sectioned, and immersed for approximately 15 minutes in a solution of 5 g of copper sulfate in 500 ml of distilled water. The tissue is removed and washed in abundant distilled water for 1 to 2 minutes. After washing, the fabric is immersed in a solution of 5 g of potassium ferrocinate in 500 ml of distilled water. The tissue is removed and washed in abundant distilled water for 5 to 15 seconds. After the second wash, the piece is immersed in ferric chloride for approximately 15 seconds, after which it is again washed in abundant distilled water for 5 to 10 minutes. When it is desired to obtain a very clear tonality in the preserved tissue, the tissue is further immersed in a solution of copper sulfate - for a few minutes. The washed fabric is immersed in 96 ° alcohol for 5 to 6 minutes and then immersed for 15 to 30 minutes in a solution prepared according to example 2, until the fabric has acquired a light brown hue. The nervous tissue thus treated remains flexible and does not degrade when exposed to room temperature.

EXAMPLE 19: For the flexibilization of hollow viscera, such as lungs, intestine, etc. the pieces (previously emptied) are introduced into a solution prepared according to example 2 for 24 to 72 hours. During this time and being in complete immersion, the pieces are also insufflated at very low pressure with said solution, in the case of the lung block through the trachea and in the case of the intestinal mass at one end, the other being ligated extreme. In this way, not only a cleanliness of the contents is achieved but also a total elasticity and preservation of the viscera. The elasticity of the pieces thus treated is practically the same as that of living tissues. Once the pieces of the solution are removed, they can be blown with low pressure air, or filled with synthetic resins, colored elastic latex or semi-solid dyes. Preferably, the pieces are stored in polyethylene bags wrapped in cloths or cotton slightly impregnated with the composition according to example 1 or 2.

EXAMPLE 20: To obtain samples of blood vessels a corrosion-reflection technique is used which is described based on the example of a kidney. It is injected through a catheter, a solution according to example 2, into the renal artery until all the arterial vessels are filled with said solution. The piece thus treated is placed on a non-porous surface at room temperature for 24 to 48 hours. After resting, conventional acrylic resin is introduced into the arterial vessels, through the renal artery, until the piece has acquired the desired consistency. Then the piece is immersed in an aqueous solution containing 15 to 20 g of sodium hydroxide per liter of water, until all the kidney tissue has been corroded and the resin mold of the arterial vessels, including that of the thinnest ones capillary vessels, be discovered. The piece is cleaned with water and can be exposed to room temperature without any protection.

EXAMPLE 21: For diaphanization techniques (for example of fetuses), the procedure is as follows. The piece is placed in complete immersion in a solution according to example 2 for a minimum of 48 hours and a maximum of 7 days, depending on the type of piece in question. The piece is then drained and kept in a solution of 2 g of alizarin per liter of alcohol of 50 ° for 3 to 5 hours, and immersed in a solution according to example 2 for about 5 to 7 days, until its complete diafanization. The diaphanized part can be exposed to room temperature without any protection or coating, which advantageously highlights on the diaphanized pieces according to conventional methods that require glycerin maintenance. Another advantage of the use of the compositions of the present invention is that * -. the diaphanization requires substantially less time than the diafanization performed with the use of formaldehyde / formaldehyde which usually requires about 120 days. In those cases in which the pieces are exposed for prolonged periods in hot environments, diaphanization may decrease. To recover the complete diaphanization in these cases it is sufficient to submerge the pieces in a solution according to example 2.

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Claims (3)

1. CLAIMS 1. Compositions for the conservation of organic tissues of animal and human origin, characterized in that they contain the following a basic formulation comprising, in vol. %? - 12 to 70% of at least one dialkyl (Ci-C¿) ketone peroxide, 10 to 15% of a glycerin, 15 to 75% of at least one alcohol and, 0 to 10% of a marker, dye and / or 10 arom.
2. 2. Composition according to claim 1, characterized in that the basic formulation comprises 50-70% dialkyl (Ci-C6) ketone lipid, 10-15% glycerin 15-30% alcohol 0-5% marker, dye and / or aromatic agent.
3. 3. Composition according to claim 1, characterized in that the basic formulation comprises 15-20% dialkyl (Ci-C6) ketone 10-15% glycerin 65-70% alcohol 0-10% marker, dye and / or aromatic agent. 5, 4. Composition according to claim 1, characterized in that the basic formulation comprises 15-40% dialkyl (Ci-C6) ketone 10-15% glycerin 0 50-70% alcohol 0-10% marker, dye and / or aromatic. 5. Composition according to claim 1, characterized in that the basic formulation comprises 5 15-70% dialkyl (Ci-C6) ketone 10-15% glycerin 15-70% alcohol 0-5% marker, dye and / or aromatic agent, 6. Composition according to claim 1, characterized in that the basic formulation comprises 15-60% dialkyl (Ci-C6) ketone 10-15% glycerin 15-65% alcohol 0-10% of a marker, dye and / or aromatic agent. 8. Composition according to claim 1, characterized in that the basic formulation comprises 15-50% dialkyl (C- | - C6) ketone 10-15% glycerin 30-70% alcohol 0-10% of a labeling agent, dye and / or aromatic 9. Composition according to claim 1, characterized in that the basic formulation comprises 12-18% dialkyl (Ci-C6) ketone 10-30% glycerin 47-78% alcohol 0-10% marker, dye and / or aromatic agent r. 10. Composition according to claim 1, characterized in that the basic formulation comprises per liter 600 ml / 1 of dialkyl (Ci-C6) ketone peroxide 150 ml / 1 of glycerin 200 ml / 1 of alcohol 50 ml / 1 of an agent marker, colorant and / or aromatic. 11. Composition according to claim 1, characterized in that the basic formulation comprises per liter 500 ml / 1 dialkyl (Ci-C6) ketone peroxide 100 ml / 1 glycerin 350 ml / 1 alcohol 50 ml / 1 a marker, dye and / or aromatic. 12. Composition according to claim 1, characterized in that the basic formulation comprises per liter 400 ml of dialkyl (C- \ - C6) ketone 150 ml of glycerin 400 ml of alcohol 50 ml of a marker, dye and / or aromatic agent. 13. Composition according to claim 1, characterized in that the basic formulation comprises per liter 350 ml of dialkyl (Ci-C6) ketone peroxide 200 ml of glycerin 400 ml of alcohol 50 ml of a marker, dye and / or aromatic agent. 14. Composition according to claim 1, characterized in that the basic formulation comprises per liter 300 ml of dialkyl (Ci-C0) ketone peroxide 150 ml of glycerin 600 ml of alcohol 50 ml of a marker, dye and / or flavoring agent. ' ..5. Composition according to claim 1, characterized in that the basic formulation comprises per liter 150 ml of dialkyl (Ci-C6) ketone peroxide 150 ml of glycerin 10 ° 690 ml of ethanol 60% v / v 50 ml of chiral hirate 50 ml of a conventional marker. 16. Application of compositions containing a basic formulation comprising, in vol. % "- 12 to 70% of at least one dialkyl (Ci-C6) ketone peroxide, 10 to 15% of a glycerin, 15 to 75% of at least one alcohol and, - - 0 to 10J of a marker, coloring and / or aromatic agent for the conservation, anatomical preparation and / or regeneration of organic tissues of human and animal origin. 17. Application according to claim 14, characterized in that a basic formulation comprises 50-70% dialkyl peroxide (Ci-CO) ketone 10-15% glycerin 15-30% alcohol, 0.05% marker, dye and / or or aromatic in the embalming of human bodies and tissues and of mammalian animals for conservation for an indefinitely long time. 18. Application according to claim 14, characterized in that a basic formulation comprises 15-20% dialkyl (Ci-C6) ketone 10-15% glycerin 65-70% alcohol O-10% marker, dye or aromatic agent in embalming of bodies and tissues and of mammalian animals for conservation for a period of less than six months. 19. Application according to claim 14, characterized in that a basic formulation comprises 15-40% dialkyl (Ci-C0) ketone 10-15% glycerin 50-70% alcohol 0-10% marker, dye and / or aromatic agent in the conservation by immersion of animal and human bodies and tissues. r *. 20. Application according to claim 14, characterized in that a basic formulation comprises 15-70% dialkyl (Ci-C¿) ketone 10-15% glycerin 15-70% alcohol 0-5% marker agent, dye and / or aromatic in the conservation and anatomical preparation of animal, human and reptile bodies. 21. Application according to claim 14, characterized in that a basic formulation comprises 15-60% dialkyl (Ci-C [beta]) ketone 10-15% glycerin 15-65% alcohol 0-10% of a labeling agent, dye and / or aromatic for the conservation and anatomical preparation of marine animals. 22. Application according to claim 14, characterized in that a basic formulation comprises 15-50% dialkyl (Ci-C6) ketone 10-15% glycerin JO-70% alcohol 0-10% of a labeling agent, dye and / or aromatic for conservation and preparation in entomology. 23. Application according to claim 14, characterized in that a basic formulation is used per liter 600 ml / 1 of dialkyl (Ci-C6) ketone peroxide 150 ml / 1 of glycerin 200 ml / 1 of alcohol 50 ml / 1 of a marker agent , colorant and / or aromatic in the embalming and anatomical preparation of animal and human bodies and tissues for conservation for indefinitely long periods of time. 24. Application according to claim 14, characterized in that a basic formulation is used per liter 500 ml / 1 dialkyl peroxide (Ci-CA) ketone 100 ml / 1 glycerin 350 ml / 1 alcohol 50 ml / 1 a marker, dye and / or aromatic agent in the embalming and anatomical preparation of animal and human bodies and tissues for conservation for indefinitely long periods of time. 25. Application according to claim 14, characterized in that a basic formulation is used per liter 400 ml of dialkyl (Ci-C [beta]) ketone 150 ml of glycerin 400 ml of alcohol 50 ml of a marker, dye and / or aromatic agent. 26. Application according to claim 14, characterized in that a basic formulation is used per liter of 350 ml of dialkyl (Ci-C) ketone peroxide 2.00 ml of glycerin r 00 ml of alcohol 50 ml of a labeling agent, dye and / or aromatic. 27. Application according to claim 14, characterized in that a basic formulation is used per liter 300 ml of dialkyl (Ci-C¿) ketone peroxide 150 ml of glycerin 600 ml of alcohol 50 ml of a marker, dye and / or aromatic agent, in preparation and / or conservation in entomology. 27. Application according to claim 14, characterized in that a basic formulation is used per liter 150 ml of dialkyl peroxide (C | - C0) ketone 150 ml of glycerin 10 ° 690 ml of ethanol 60% v / v 50 ml of chloral hirate 50 ml of a conventional marker in temporary preservation by application by nebulization or dripping , on the surface of human or animal bodies. 28. Application according to claim 14, characterized in that the compositions are used to make the organic tissues more flexible. 29. Composition according to any of claims 1 to 13, characterized in that the alcohol is ethanol, absolute ethanol or mixtures thereof. 30. Composition according to any of claims 1 to 13, characterized in that the alcohol is ethanol, absolute ethanol or mixtures thereof. 3.1 Composition according to any of claims 1 to '.ti, characterized in that the alcohol is 80 °. 32. Composition according to any of claims 1 to 13, characterized in that the alcohol is 80 °. 33. Composition according to any of claims 1 to 13, characterized in that the alcohol is 70 °. 34. Composition according to any of claims 1 to 13, characterized in that the alcohol is 60 °. 35. Composition according to any of claims 1 to 13, characterized in that the glycerin is 30 °. 36. Composition according to any of claims 1 to 13, characterized in that the glycerin is 10 °. 37. Composition according to any of claims 1 to 13, characterized in that the coloring agent is selected from chloral hirate and sarsaparilla. 38. Composition according to any of claims 1 to 13, characterized in that the aromatic agent is citronella. 39. Composition according to any of claims 1 to 13, characterized in that the dialkyl (Ci-Cé) ketone peroxide is ethylmethyl ketone peroxide, ethyl isobutyl ketone peroxide or mixtures thereof. 40. Application according to any of claims 14 to 26, characterized in that the alcohol is ethanol, absolute ethanol or mixtures thereof. 41. Application according to any of claims 14 to 26, characterized in that the alcohol is ethanol, absolute ethanol or mixtures thereof. 42. Application according to any of claims 14 to 26, characterized in that the alcohol is 80 °. 43. Application according to any of claims 14 to 26, characterized in that the alcohol is 80 °. 44. Application according to any of claims 14 to 26, characterized in that the alcohol is 70 °. 45. Application according to any of claims 14 to 26, characterized in that the alcohol is 60 °. 46. Application according to any of claims 14 to 26, characterized in that the glycerin is 30 °. 47. Application according to any of claims 14 to 26, characterized in that the glycerin is 10 °. 48. Application according to any of claims 14 to 26, characterized in that the coloring agent is selected from chloral hirate and sarsaparilla. 49. Application according to any of claims 14 to 26, characterized in that the aromatic agent is citronella. 50. Application according to any of claims 14 to 26, characterized in that the dialkyl (Ci-C6) ketone peroxide is ethylmethyl ketone peroxide, methyl isobutyl ketone peroxide or mixtures thereof. r -