MXPA05012253A - Suministro intravenoso de polinucleotidos a celulas en extremidades de mamiferos. - Google Patents

Suministro intravenoso de polinucleotidos a celulas en extremidades de mamiferos.

Info

Publication number
MXPA05012253A
MXPA05012253A MXPA05012253A MXPA05012253A MXPA05012253A MX PA05012253 A MXPA05012253 A MX PA05012253A MX PA05012253 A MXPA05012253 A MX PA05012253A MX PA05012253 A MXPA05012253 A MX PA05012253A MX PA05012253 A MXPA05012253 A MX PA05012253A
Authority
MX
Mexico
Prior art keywords
polynucleotides
cells
limb
intravenous delivery
delivery
Prior art date
Application number
MXPA05012253A
Other languages
English (en)
Inventor
Julia Hegge
Original Assignee
Mirus Bio Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirus Bio Corp filed Critical Mirus Bio Corp
Publication of MXPA05012253A publication Critical patent/MXPA05012253A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invencion se refiere a un metodo para el suministro intravenoso, que es capaz de suministrar polinucleotidos a celulas extravasculares de una extremidad de mamifero. El metodo involucra la inyeccion de polinucleotidos en una vena distal de una extremidad que es ocluida temporalmente. El suministro del polinucleotido es facilitado por la inyeccion rapida en un volumen suficiente para permitir la extravasacion de la solucion en el tejido circundante.
MXPA05012253A 2003-05-28 2004-05-28 Suministro intravenoso de polinucleotidos a celulas en extremidades de mamiferos. MXPA05012253A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47365403P 2003-05-28 2003-05-28
US50021103P 2003-09-04 2003-09-04
US10/855,175 US7803782B2 (en) 2003-05-28 2004-05-27 Intravenous delivery of polynucleotides to cells in mammalian limb
PCT/US2004/017000 WO2004105836A2 (en) 2003-05-28 2004-05-28 Intravenous delivery of polynucleotides to cells in mammalian limb

Publications (1)

Publication Number Publication Date
MXPA05012253A true MXPA05012253A (es) 2006-02-10

Family

ID=33458804

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05012253A MXPA05012253A (es) 2003-05-28 2004-05-28 Suministro intravenoso de polinucleotidos a celulas en extremidades de mamiferos.

Country Status (7)

Country Link
US (1) US7803782B2 (es)
EP (1) EP1626755A4 (es)
JP (1) JP2007501282A (es)
AU (1) AU2004242978B2 (es)
CA (1) CA2527303A1 (es)
MX (1) MXPA05012253A (es)
WO (1) WO2004105836A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7642248B2 (en) * 1999-11-05 2010-01-05 Roche Madison Inc Devices and processes for distribution of genetic material to mammalian limb
US6784291B2 (en) 2000-05-04 2004-08-31 Avi Biopharma, Inc. Splice-region antisense composition and method
US20060115462A1 (en) * 2004-12-01 2006-06-01 Vladimir Subbotin Direct DNA delivery to bone cells
AU2006213686A1 (en) * 2005-02-09 2006-08-17 Avi Bio Pharma, Inc. Antisense composition and method for treating muscle atrophy
AU2015203791B2 (en) * 2005-02-09 2017-06-29 Sarepta Therapeutics, Inc. Antisense composition and method for treating
AU2013201250B2 (en) * 2005-02-09 2015-04-30 Sarepta Therapeutics, Inc. Antisense composition and method for treating muscle atrophy
JP2009519339A (ja) 2005-12-12 2009-05-14 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 筋細胞増殖及び分化を調節するマイクロｒｎａ
WO2008127654A2 (en) * 2007-04-11 2008-10-23 The University Of North Carolina At Chapel Hill Methods and compositions for intra-articular coagulation proteins
US20130085139A1 (en) 2011-10-04 2013-04-04 Royal Holloway And Bedford New College Oligomers
US20150328249A1 (en) * 2012-12-11 2015-11-19 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Modulation of myofiber repair by anti-myostatin strategies and/or ppar gamma ligands, alone or in combination with stem cells, for the therapy of critical limb ischemia and other ischemic processes affecting the skeletal muscle
US9752143B2 (en) 2013-03-15 2017-09-05 MiRagen Therapeutics, Inc. Locked nucleic acid inhibitor of miR-145 and uses thereof
MA41795A (fr) 2015-03-18 2018-01-23 Sarepta Therapeutics Inc Exclusion d'un exon induite par des composés antisens dans la myostatine
WO2017180279A2 (en) * 2016-04-15 2017-10-19 Thegents Of The University Of Michigan Assistive device for subcutaneous injections or implants
WO2019096325A1 (zh) * 2017-11-20 2019-05-23 江苏达骏生物科技有限公司 一种双酰胺复合物及其制备方法和用途
CN109886600B (zh) * 2019-03-06 2021-04-27 绍兴文理学院 监测预警煤层分叉合并区冲击地压危险性的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) * 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5698531A (en) * 1989-03-31 1997-12-16 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5521291A (en) * 1991-09-30 1996-05-28 Boehringer Ingelheim International, Gmbh Conjugates for introducing nucleic acid into higher eucaryotic cells
US5583020A (en) * 1992-11-24 1996-12-10 Ribozyme Pharmaceuticals, Inc. Permeability enhancers for negatively charged polynucleotides
US5922687A (en) * 1995-05-04 1999-07-13 Board Of Trustees Of The Leland Stanford Junior University Intracellular delivery of nucleic acids using pressure
US5744335A (en) * 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
US6627616B2 (en) 1995-12-13 2003-09-30 Mirus Corporation Intravascular delivery of non-viral nucleic acid
US6265387B1 (en) * 1995-10-11 2001-07-24 Mirus, Inc. Process of delivering naked DNA into a hepatocyte via bile duct
JP3813669B2 (ja) * 1995-10-27 2006-08-23 松下電器産業株式会社 端末装置及び端末装置の能力情報通知方法
US6177403B1 (en) * 1996-10-21 2001-01-23 The Trustees Of The University Of Pennsylvania Compositions, methods, and apparatus for delivery of a macromolecular assembly to an extravascular tissue of an animal
DE69738316T2 (de) * 1997-06-20 2008-09-25 Mirus Bio Corp., Madison Verfahren zur verabreichung eines polynukleotids über das gefä system
CA2290736A1 (en) * 1997-07-11 1999-01-21 Introgene B.V. Interleukin-3 gene therapy for cancer
US6699231B1 (en) * 1997-12-31 2004-03-02 Heartport, Inc. Methods and apparatus for perfusion of isolated tissue structure
EP1209971A4 (en) 1999-08-20 2004-04-14 Mirus Corp POLYION COMPLEX LOAD INVERSION
US7214369B2 (en) * 2003-05-05 2007-05-08 Mirus Bio Corporation Devices and processes for distribution of genetic material to mammalian limb
US20040136960A1 (en) * 2003-01-10 2004-07-15 Wolff Jon A. Devices and processes for distribution of genetic material to mammalian limb

Also Published As

Publication number Publication date
US20040242528A1 (en) 2004-12-02
AU2004242978A1 (en) 2004-12-09
WO2004105836A3 (en) 2006-02-02
AU2004242978B2 (en) 2007-05-31
JP2007501282A (ja) 2007-01-25
US7803782B2 (en) 2010-09-28
CA2527303A1 (en) 2004-12-09
WO2004105836A2 (en) 2004-12-09
EP1626755A4 (en) 2008-01-23
EP1626755A2 (en) 2006-02-22

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