MXPA05001563A - Topic application compound for the treatment of onychomycosis - Google Patents
Topic application compound for the treatment of onychomycosisInfo
- Publication number
- MXPA05001563A MXPA05001563A MXPA/A/2005/001563A MXPA05001563A MXPA05001563A MX PA05001563 A MXPA05001563 A MX PA05001563A MX PA05001563 A MXPA05001563 A MX PA05001563A MX PA05001563 A MXPA05001563 A MX PA05001563A
- Authority
- MX
- Mexico
- Prior art keywords
- oil
- compound
- total weight
- fats
- toenails
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 27
- 208000010195 Onychomycosis Diseases 0.000 title claims abstract description 10
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N Oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims abstract description 17
- IPCSVZSSVZVIGE-UHFFFAOYSA-N Palmitic acid Natural products CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000203 mixture Substances 0.000 claims abstract description 14
- QIQXTHQIDYTFRH-UHFFFAOYSA-N Stearic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 12
- OYHQOLUKZRVURQ-IXWMQOLASA-N Linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims abstract description 11
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 10
- 239000000194 fatty acid Substances 0.000 claims abstract description 10
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 10
- 239000003429 antifungal agent Substances 0.000 claims abstract description 8
- 235000021314 Palmitic acid Nutrition 0.000 claims abstract description 6
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 6
- 235000020778 linoleic acid Nutrition 0.000 claims abstract description 6
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 4
- 235000013311 vegetables Nutrition 0.000 claims abstract description 4
- 235000019871 vegetable fat Nutrition 0.000 claims abstract 3
- 238000002360 preparation method Methods 0.000 claims description 10
- 230000000699 topical Effects 0.000 claims description 10
- 239000003921 oil Substances 0.000 claims description 7
- 235000019198 oils Nutrition 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000005642 Oleic acid Substances 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 6
- 239000003995 emulsifying agent Substances 0.000 claims description 4
- 239000008117 stearic acid Substances 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 3
- 239000003925 fat Substances 0.000 claims 12
- 235000019197 fats Nutrition 0.000 claims 12
- 210000004906 Toe nails Anatomy 0.000 claims 8
- 239000002674 ointment Substances 0.000 claims 4
- -1 oleic Chemical class 0.000 claims 4
- 235000019489 Almond oil Nutrition 0.000 claims 2
- 240000005781 Arachis hypogaea Species 0.000 claims 2
- 210000004905 Finger nails Anatomy 0.000 claims 2
- 240000007049 Juglans regia Species 0.000 claims 2
- 235000009496 Juglans regia Nutrition 0.000 claims 2
- 235000019482 Palm oil Nutrition 0.000 claims 2
- 235000019486 Sunflower oil Nutrition 0.000 claims 2
- 239000008168 almond oil Substances 0.000 claims 2
- 239000008163 avocado oil Substances 0.000 claims 2
- 235000021302 avocado oil Nutrition 0.000 claims 2
- 239000000828 canola oil Substances 0.000 claims 2
- 235000019519 canola oil Nutrition 0.000 claims 2
- 235000019868 cocoa butter Nutrition 0.000 claims 2
- 229940110456 cocoa butter Drugs 0.000 claims 2
- 239000003240 coconut oil Substances 0.000 claims 2
- 235000019864 coconut oil Nutrition 0.000 claims 2
- 239000002285 corn oil Substances 0.000 claims 2
- 235000005687 corn oil Nutrition 0.000 claims 2
- 235000012343 cottonseed oil Nutrition 0.000 claims 2
- 239000002385 cottonseed oil Substances 0.000 claims 2
- 150000002191 fatty alcohols Chemical class 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 239000008169 grapeseed oil Substances 0.000 claims 2
- 239000000944 linseed oil Substances 0.000 claims 2
- 235000021388 linseed oil Nutrition 0.000 claims 2
- 239000006210 lotion Substances 0.000 claims 2
- 239000004006 olive oil Substances 0.000 claims 2
- 235000008390 olive oil Nutrition 0.000 claims 2
- 239000002540 palm oil Substances 0.000 claims 2
- 235000020232 peanut Nutrition 0.000 claims 2
- 239000008159 sesame oil Substances 0.000 claims 2
- 235000011803 sesame oil Nutrition 0.000 claims 2
- 239000003549 soybean oil Substances 0.000 claims 2
- 235000012424 soybean oil Nutrition 0.000 claims 2
- 239000002600 sunflower oil Substances 0.000 claims 2
- 235000020234 walnut Nutrition 0.000 claims 2
- 150000002460 imidazoles Chemical class 0.000 claims 1
- 150000002780 morpholines Chemical class 0.000 claims 1
- 150000004291 polyenes Polymers 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
- 230000035515 penetration Effects 0.000 abstract description 7
- 239000008158 vegetable oil Substances 0.000 abstract description 2
- OYHQOLUKZRVURQ-UHFFFAOYSA-N Linoleic acid Chemical compound CCCCCC=CCC=CCCCCCCCC(O)=O OYHQOLUKZRVURQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000010297 mechanical methods and process Methods 0.000 abstract 1
- 235000021313 oleic acid Nutrition 0.000 abstract 1
- 150000002943 palmitic acids Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 9
- 229940079593 drugs Drugs 0.000 description 9
- 210000000282 Nails Anatomy 0.000 description 8
- 230000000843 anti-fungal Effects 0.000 description 6
- 210000003491 Skin Anatomy 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 229940121375 antifungals Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 201000003928 fungal infectious disease Diseases 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N Salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000008135 aqueous vehicle Substances 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 235000010446 mineral oil Nutrition 0.000 description 2
- 230000000149 penetrating Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- VHVPQPYKVGDNFY-TUJWMRSMSA-N 2-[(2S)-butan-2-yl]-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-TUJWMRSMSA-N 0.000 description 1
- 241001480043 Arthrodermataceae Species 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N Cetyl alcohol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N Fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
- 206010019851 Hepatotoxicity Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 206010028694 Nail disease Diseases 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Tris Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000001413 cellular Effects 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 231100000223 dermal penetration Toxicity 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 201000009910 diseases by infectious agent Diseases 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 235000004626 essential fatty acids Nutrition 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 210000004904 fingernail beds Anatomy 0.000 description 1
- 229960004884 fluconazole Drugs 0.000 description 1
- 230000000855 fungicidal Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000002496 gastric Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 231100000304 hepatotoxicity Toxicity 0.000 description 1
- 229960004130 itraconazole Drugs 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 231100000486 side effect Toxicity 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
- 230000036572 transepidermal water loss Effects 0.000 description 1
Abstract
Described herein is a method for the treatment of onychomycosis, which consists in the administration of a compound containing a mixture of vegetable fatty acids such as oleic, linoleic, stearic and palmitic acids, the mixture optionally but not necessarily including an antifungal agent. The compound may be manufactured using common vegetable oils and fats. The inventive compound is directly applied onto the affected area without performing mechanical processes for favouring the penetration or adhesion thereof.
Description
"COMPOSED OF TOPICAL APPLICATION FOR THE TREATMENT OF ONICOMYCOSES".
BACKGROUND OF THE INVENTION.
Onychomycosis is the most frequent pathology and is responsible for approximately 50% of nail diseases. Traditionally the treatment of this pathology has been difficult, obtaining low rates of cure and high rates of recurrence. The appearance of new antifungals for topical and systemic administration has represented an important advance in the treatment of omcomicosis. The most commonly used systemic treatment for onychomycosis includes oral administration of terbaphine, itraconazole and fluconazole. Even though the antifungals administered by this route are quite powerful to achieve healing, they often have secondary effects, among which are hepatotoxicity, gastrointestinal, skin and taste alterations. Topical treatment would constitute the ideal therapy since it does not produce adverse systemic effects, however, the low penetration of the antifungals administered by this route has limited its use. The current trend in the treatment of onychomycosis points towards the development of new compounds for topical application that offer a high cure rate and a low rate of side effects. The search for such treatment has led to propose methods that include the use of lacquers, acid or alkaline compounds and creams with high content of urea or salicylic acid, some of these treatments have been designed to be used alone or in combination with an antifungal agent. American patents (6,495,124, 6,676,953, 6,846,837, 6,743,417, 6,821,508), the objective is to facilitate the penetration of the drug and eliminate the fungus causing the infection.
The treatment subject of the present invention comprises the administration of a compound for topical use with fungicide potential, penetrating power, low toxicity and which optionally but not necessarily may include a known antifungal agent.
DESCRIPTION OF THE INVENTION
The objective of this invention is directed to the use of vegetable fatty acids: oleic, linoleic, stearic and palmitic for the preparation of a topical administration compound, useful in the treatment of onychomycosis and which can optionally be incorporated as one of its ingredients, a known antifungal agent. Many dermatological preparations incorporate fatty acids in their formulation due to their proven properties as emollients, restorers and skin protectors. Some of them have proven to be useful as facilitators of drug penetration. Oleic acid, due to its action on the stratum corneum (considered one of the forming elements of the dermal barrier), has been used successfully in the formulation of preparations in which a high dermal penetration power is necessary. Applied topically it has been shown to produce structural changes in this tissue which facilitates the penetration of drugs with pharmacological action. Jim Jiang S, Jun Zhou X. Biol Pharm Bull 2003; 26 (1): 66-68. The deficiency of essential fatty acids results in skin disturbances such as increased trans-epidermal water loss and cellular hyperproliferation. There is evidence that not only the dietary supplementation of these acids is effective for the treatment of such alterations. Also the topical application of oils rich in polyunsaturated fatty acids and in particular linoleic acid, has been shown to be able to reverse these effects Nugteren DH, Christ-Hazelhof E, Van der Beek A, Houtsmuller UM. Biochim Biophis Acta 1985; 834: 429-436. Prottey C, Hartop PJ, Press M. J Invest Dermatol 1975; 64: 228-234. Skolnik P, Eaglstein WH, Ziboh VA. Arch Dermatol 1977; 113 (7): 939-41. The stearic and pálñitic acids also favor the balance of fatty acids in the compound, a factor of great importance in the recovery of the functionality of the dermal barrier. Man MQ M, Feingold KR, Thornfeldt CR, Elias PM. J Invest Dermatol 1996; 106 (5): 1096-1101. They contribute in the elaboration and the characteristics of the same for their usefulness in the preparation of oil-in-water emulsions, which have great penetrating power solubility and as thickeners and film formers, an important quality for the topical administration of drugs.
The antifungal potential against dermatophytes of fatty acids has been reported in studies in which the original source (vegetable oils) has been used Abraham A, Mohapatra LN, Kandhari KC, Pandhi RK, Bhutani LK. Dermatological 1975; 151 (3): 144-8. Garg AP, Muller. J Mycoses 1992; 35 (ll-12): 363-9 and J Mycoses 1993; 36 (l-2): 51-63. Or as isolated elements el-Naghy MA, Maghazy SN, Fadl-AUah EM, eí-Gendy ZK. Zentralbl Mkrobiol 1992; 147 (3-4); 214-20. They have also been shown to possess antifungal activity against some fungi that infest plants Walters D, Ra nor L, Mitchell A, Walker R, Walker K. Mycopathologia 2004; l57 (1): 87-90. Topically applied antifungal agents have been shown to be useful in the management of skin mycoses; however, its effectiveness for the treatment of onychomycosis is limited due to the low penetration of the drug in the affected area. The absorption of water and the subsequent softening of the nail plate is a well-known event. When an aqueous formulation is used, the nail softens as the water is incorporated by the nail plate and consequently, the keratin web expands to form pores through which the molecules can penetrate more easily. In practice, the use of aqueous vehicles is less useful than the use of lipid vehicles because the aqueous vehicles are easily removed and do not adhere properly to the nail plate. Mertin and Lippold J Pharm Pharmacol 1997; 49: 241-245, proposed that as long as the vehicle does not produce changes in the nail barrier, the flow of the drug from a suspension is independent of the vehicle because the higher concentration of the drug , is located on the donor side of the plate and therefore, the concentration gradient is achieved with the maximum flow of the drug. In the case of the proposed preparation, due to its characteristics (oil-in-water emulsion), they favor both the permanence of the drug in the nail plate (mainly due to the use of stearic and palmitic acid), as well as its flow to the nail bed for the presence of oleic acid. In this way, the combination of fatty acids used for the preparation, the source thereof, and its formulation give the compound both pharmacological and dermatological characteristics, which are very useful for the treatment of onychomycosis.
Example 1 for the preparation of the compound. Ingredient Percentage Water 60.0% Stearic acid 10.0% Oleic acid 4.0% Palmitic acid 2.0% Linoleic acid 6.0% Mineral oil 11.0% Cetyl alcohol 2.0% Emulsifier 3.0% Triethanolamine 1.7% Fragrance 0.3%
Example 2 for the preparation of the compound. Ingredient Percentage Water 60.0% Stearic acid 10.0% Oleic acid 4.0% Palmitic acid 2.0% Linoleic acid 6.0% Mineral oil 9.0% Cetilic alcohol 2.0% Antifungal 2.0% Emulsifier 3.0% Triethanoiamine 1.7% Fragrance 0.3%
The application of this compound is direct on the affected nails and the adjacent area in sufficient quantity to cover it. Twice a day and for at least 180 days. It is not necessary to perforate or scrape the surface of the nails to facilitate the fixation or penetration of it.
Claims (11)
1. A method for the treatment of onychomycosis involving topical administration on the infected fingernails of the patient's fingers or feet, of a compound containing a combination of vegetable origin fatty acids including: oleic, stearic, linoleic and palmitic
2. A method for the treatment of onychomycosis involving topical administration in the infected fingernails of the patient's fingers or feet, of a compound containing a combination of vegetable fatty acids including: oleic, stearic , linoleic and palmitic plus an antifungal agent.
3. The method of claim 1 wherein said compound is a semisolid formulation, ointment, ointment, cream, gel, lotion, oil, suspension or emulsion.
4. The method of claim 2 wherein said compound is a semisolid formulation, ointment, ointment, cream, gel, lotion, oil, suspension or emulsion.
The method of claim 1 wherein the compound applied topically on the infected toenails of the toenails or to the feet of the patient contains between 15 and 40% fats.
The method of claim 2 wherein the compound applied topically on the infected toenails of the toenails or feet of the patient contains between 15 and 40% of fats.
The method of claim 1 wherein the topically applied compound on the infected toenails of the toenails or feet of the patient contains: between 2 and 10% of the total weight of oleic acid fats; between 3 and 15% of the total weight of linoleic acid fats; between 5 and 25% of the total weight of stearic acid fats; between 1 and 5% of the total weight of palmitic acid fats; between 1 and 2% of the total fat weight of a fatty alcohol; between 1.5 and 3% of the total weight of the emulsifier compound; between 1 and 2.5% of the total weight of the triethanolamine compound; the water necessary for the preparation.
8. The method of claim 2 wherein the compound applied topically on the infected toenails of the toenails or feet of the patient contains: between 2 and 10% of the total weight of oleic acid fats; between 3 and 15% of the total weight of linoleic acid fats; between 5 and 25% of the total weight of stearic acid fats; between 1 and 5% of the total weight of palmitic acid fats; between 1 and 2% of the total fat weight of a fatty alcohol; between 1.5 and 3% of the total weight of the emulsifier compound; between 1 and 2% of the total weight of the compound of an antifungal agent; between 1 and 2.5% of the total weight of the triethanolamine compound; the water necessary for the preparation. The compound of claim 7 wherein the source of the fatty acids can be selected from the group of vegetable fats or oils comprising but not limited to: coconut oil, cottonseed oil, palm oil, oil peanuts, walnut kernel oil, sesame oil, cocoa butter, linseed oil, soybean oil, canola oil, grape seed oil, olive oil, sunflower oil, almond oil, avocado oil, corn oil or mixtures of them. The compound of claim 8 wherein the source of the fatty acids may be selected from the group of vegetable fats or oils comprising but not limited to: coconut oil, cottonseed oil, palm oil, oil peanuts, walnut kernel oil, sesame oil, cocoa butter, linseed oil, soybean oil, canola oil, grape seed oil, olive oil, sunflower oil, almond oil, avocado oil, corn oil or mixtures of them. The compound of claim 8 wherein the antifungal agent is selected from the group consisting of but not limited to: Polyenes, Imidazoles, Triazoles, Allylamines, and Morpholines
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05001563A true MXPA05001563A (en) | 2006-10-17 |
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