MXPA03006718A - New polymers based on n-carbamyl-n -dimethylsilyl methyl-piperazine traceless linkers for the solid phase synthesis of phenyl based libraries. - Google Patents

New polymers based on n-carbamyl-n -dimethylsilyl methyl-piperazine traceless linkers for the solid phase synthesis of phenyl based libraries.

Info

Publication number
MXPA03006718A
MXPA03006718A MXPA03006718A MXPA03006718A MXPA03006718A MX PA03006718 A MXPA03006718 A MX PA03006718A MX PA03006718 A MXPA03006718 A MX PA03006718A MX PA03006718 A MXPA03006718 A MX PA03006718A MX PA03006718 A MXPA03006718 A MX PA03006718A
Authority
MX
Mexico
Prior art keywords
solid phase
carbamyl
phase synthesis
piperazine
new polymers
Prior art date
Application number
MXPA03006718A
Other languages
Spanish (es)
Inventor
Cereda Enzo
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MXPA03006718A publication Critical patent/MXPA03006718A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B80/00—Linkers or spacers specially adapted for combinatorial chemistry or libraries, e.g. traceless linkers or safety-catch linkers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/42—Introducing metal atoms or metal-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33303—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group
    • C08G65/3331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group cyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/336—Polymers modified by chemical after-treatment with organic compounds containing silicon
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/18—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

The present invention relates to polymers characterised by novel silicon linkers based on the carbamyl piperazine moiety, methods of preparing these polymers and their use in the solid phase synthesis of compounds or libraries of compounds embracing a phenyl ring in their structure.
MXPA03006718A 2001-01-29 2002-01-15 New polymers based on n-carbamyl-n -dimethylsilyl methyl-piperazine traceless linkers for the solid phase synthesis of phenyl based libraries. MXPA03006718A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01101946 2001-01-29
PCT/EP2002/000312 WO2002060960A2 (en) 2001-01-29 2002-01-15 New polymers based on n-carbamyl-n'-dimethylsilyl methyl-piperazine traceless linkers for the solid phase synthesis of phenyl based libraries

Publications (1)

Publication Number Publication Date
MXPA03006718A true MXPA03006718A (en) 2004-05-31

Family

ID=8176316

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03006718A MXPA03006718A (en) 2001-01-29 2002-01-15 New polymers based on n-carbamyl-n -dimethylsilyl methyl-piperazine traceless linkers for the solid phase synthesis of phenyl based libraries.

Country Status (5)

Country Link
EP (1) EP1360211A2 (en)
JP (1) JP2004518015A (en)
CA (1) CA2431927A1 (en)
MX (1) MXPA03006718A (en)
WO (1) WO2002060960A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102122470B1 (en) 2016-12-08 2020-06-12 주식회사 엘지화학 Modified agent and modified conjugated diene polymer comprising functional group derived from the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127489A (en) * 1996-05-20 2000-10-03 Smithkline Beecham Corporation Silyl linker for solid phase organic synthesis of aryl-containing molecules
WO1999017869A2 (en) * 1997-10-03 1999-04-15 Argonaut Technologies Compositions for organic synthesis on solid phase and methods of using the same

Also Published As

Publication number Publication date
WO2002060960A3 (en) 2002-10-17
JP2004518015A (en) 2004-06-17
WO2002060960A2 (en) 2002-08-08
CA2431927A1 (en) 2002-08-08
EP1360211A2 (en) 2003-11-12

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