MXPA03001528A - Improved specificity in treatment of diseases. - Google Patents
Improved specificity in treatment of diseases.Info
- Publication number
- MXPA03001528A MXPA03001528A MXPA03001528A MXPA03001528A MXPA03001528A MX PA03001528 A MXPA03001528 A MX PA03001528A MX PA03001528 A MXPA03001528 A MX PA03001528A MX PA03001528 A MXPA03001528 A MX PA03001528A MX PA03001528 A MXPA03001528 A MX PA03001528A
- Authority
- MX
- Mexico
- Prior art keywords
- drug
- blocking group
- reduction
- diseases
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A drug is modified by covalently coupling a blocking group to the drug via a nitrogen atom in the blocking group. The blocking group in the modified drug prevents metabolic conversion and sequestration of the drug in non-target cells, and the blocking group is enzymatically removed in the target cell. Particularly contemplated advantages of presented compounds and methods include reduction of cytotoxicity by inhibition of metabolic conversion to potentially cytotoxic metabolites, reduction of dosages of drugs by reduction of sequestration into non-target cells, and increase of selectivity of a drug.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22687100P | 2000-08-22 | 2000-08-22 | |
US22687000P | 2000-08-22 | 2000-08-22 | |
US22694800P | 2000-08-22 | 2000-08-22 | |
PCT/US2000/033454 WO2002016382A1 (en) | 2000-08-22 | 2000-12-07 | Improved specificity in treatment of diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA03001528A true MXPA03001528A (en) | 2004-04-02 |
Family
ID=27397667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03001528A MXPA03001528A (en) | 2000-08-22 | 2000-12-07 | Improved specificity in treatment of diseases. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP1351966A1 (en) |
JP (1) | JP2004518618A (en) |
KR (1) | KR20030040415A (en) |
CN (1) | CN1460109A (en) |
AU (1) | AU2001220806A1 (en) |
BR (1) | BR0017318A (en) |
CA (1) | CA2416748A1 (en) |
CZ (1) | CZ2003460A3 (en) |
HU (1) | HUP0302882A3 (en) |
IL (1) | IL154168A0 (en) |
MX (1) | MXPA03001528A (en) |
NO (1) | NO20030762L (en) |
PL (1) | PL365879A1 (en) |
TW (1) | TW200414903A (en) |
WO (1) | WO2002016382A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006516548A (en) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | Drug delivery from rapidly gelled polymer compositions |
US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
CN100448879C (en) * | 2004-07-22 | 2009-01-07 | 北京化工大学 | Method for preparing unformed cefuroxime axetil |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE29835E (en) * | 1971-06-01 | 1978-11-14 | Icn Pharmaceuticals | 1,2,4-Triazole nucleosides |
US3798209A (en) * | 1971-06-01 | 1974-03-19 | Icn Pharmaceuticals | 1,2,4-triazole nucleosides |
US3984396A (en) * | 1971-06-01 | 1976-10-05 | Icn Pharmaceuticals, Inc. | 1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters |
US3991078A (en) * | 1971-06-01 | 1976-11-09 | Icn Pharmaceuticals, Inc. | N-substituted 1,2,4-triazoles |
US4093624A (en) * | 1977-01-31 | 1978-06-06 | Icn Pharmaceuticals, Inc. | 1,2,4-Thiadiazolidine-3,5-dione |
JPS6426593A (en) * | 1987-07-21 | 1989-01-27 | Asahi Glass Co Ltd | Nucleoside derivative |
US4925930A (en) * | 1988-11-02 | 1990-05-15 | Nucleic Acid Research Institute | Synthesis and anti-leukemic activity of alkyl-1-(β-D-ribofuranosyl)[1,2,4]triazole-3-carboximidates |
-
2000
- 2000-12-07 AU AU2001220806A patent/AU2001220806A1/en not_active Abandoned
- 2000-12-07 HU HU0302882A patent/HUP0302882A3/en unknown
- 2000-12-07 BR BR0017318-5A patent/BR0017318A/en not_active IP Right Cessation
- 2000-12-07 CZ CZ2003460A patent/CZ2003460A3/en unknown
- 2000-12-07 IL IL15416800A patent/IL154168A0/en unknown
- 2000-12-07 PL PL00365879A patent/PL365879A1/en not_active Application Discontinuation
- 2000-12-07 MX MXPA03001528A patent/MXPA03001528A/en unknown
- 2000-12-07 EP EP00984134A patent/EP1351966A1/en not_active Withdrawn
- 2000-12-07 JP JP2002521479A patent/JP2004518618A/en active Pending
- 2000-12-07 CN CN00819838A patent/CN1460109A/en active Pending
- 2000-12-07 WO PCT/US2000/033454 patent/WO2002016382A1/en not_active Application Discontinuation
- 2000-12-07 KR KR10-2003-7002538A patent/KR20030040415A/en not_active Application Discontinuation
- 2000-12-07 CA CA002416748A patent/CA2416748A1/en not_active Abandoned
-
2003
- 2003-02-07 TW TW092102500A patent/TW200414903A/en unknown
- 2003-02-18 NO NO20030762A patent/NO20030762L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP0302882A2 (en) | 2003-12-29 |
WO2002016382A1 (en) | 2002-02-28 |
HUP0302882A3 (en) | 2005-06-28 |
KR20030040415A (en) | 2003-05-22 |
BR0017318A (en) | 2004-06-15 |
NO20030762L (en) | 2003-04-22 |
CA2416748A1 (en) | 2002-02-28 |
JP2004518618A (en) | 2004-06-24 |
CN1460109A (en) | 2003-12-03 |
IL154168A0 (en) | 2003-07-31 |
NO20030762D0 (en) | 2003-02-18 |
AU2001220806A1 (en) | 2002-03-04 |
EP1351966A1 (en) | 2003-10-15 |
TW200414903A (en) | 2004-08-16 |
PL365879A1 (en) | 2005-01-10 |
CZ2003460A3 (en) | 2003-10-15 |
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