MXPA02010405A - Derivados de aminocarboxialquilo novedosos de acido barbiturico. - Google Patents

Derivados de aminocarboxialquilo novedosos de acido barbiturico.

Info

Publication number
MXPA02010405A
MXPA02010405A MXPA02010405A MXPA02010405A MXPA02010405A MX PA02010405 A MXPA02010405 A MX PA02010405A MX PA02010405 A MXPA02010405 A MX PA02010405A MX PA02010405 A MXPA02010405 A MX PA02010405A MX PA02010405 A MXPA02010405 A MX PA02010405A
Authority
MX
Mexico
Prior art keywords
barbituric acid
alkyl derivatives
novel amino
carboxy alkyl
amino carboxy
Prior art date
Application number
MXPA02010405A
Other languages
English (en)
Inventor
Kenneth Curry
Original Assignee
Kenneth Curry
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kenneth Curry filed Critical Kenneth Curry
Publication of MXPA02010405A publication Critical patent/MXPA02010405A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/66—Thiobarbituric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion se refiere a derivados novedosos de amino carboxi alquilo terapeuticamente activos de acido barbiturico de formula (ver formula I) en donde por lo menos uno de R1, R2, R3 o R4 comprende una porcion. NH2 y por lo menos uno de R1, R2, R3 o R4 comprende una porcion COOH; se provee tambien un metodo para preparar compuestos de formula I y composiciones farmaceuticas que comprenden los compuestos; los compuestos novedosos actuan como moduladores de receptores de glutamato metabotropicos y, como tales, son utiles en el tratamiento de enfermedades del sistema nervioso central relacionadas con el sistema de receptores de glutamato metabotropicos.
MXPA02010405A 2000-04-18 2001-04-18 Derivados de aminocarboxialquilo novedosos de acido barbiturico. MXPA02010405A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002306170A CA2306170A1 (en) 2000-04-18 2000-04-18 Novel amino, carboxy derivatives of barbituric acid
PCT/CA2001/000503 WO2001079185A1 (en) 2000-04-18 2001-04-18 Novel amino carboxy alkyl derivatives of barbituric acid

Publications (1)

Publication Number Publication Date
MXPA02010405A true MXPA02010405A (es) 2004-09-06

Family

ID=4165956

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02010405A MXPA02010405A (es) 2000-04-18 2001-04-18 Derivados de aminocarboxialquilo novedosos de acido barbiturico.

Country Status (7)

Country Link
US (1) US20030199533A1 (es)
EP (1) EP1276727A1 (es)
AU (1) AU2001248197A1 (es)
CA (1) CA2306170A1 (es)
MX (1) MXPA02010405A (es)
NZ (1) NZ522195A (es)
WO (1) WO2001079185A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093820A (en) 1997-10-02 2000-07-25 Taro Pharmaceutical Industries Ltd. Method and reagents for N-alkylating ureides
US6939873B2 (en) 2000-07-26 2005-09-06 Taro Pharmaceuticals Industries Limited Non-sedating barbituric acid derivatives
US7683071B2 (en) 2000-07-26 2010-03-23 Taro Pharmaceuticals Industries Ltd. Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid
US6756379B2 (en) 2001-07-26 2004-06-29 Taro Pharmaceutical Industries Ltd. Non-sedating barbiturate compounds as neuroprotective agents
CN1896084A (zh) * 2002-01-30 2007-01-17 塔罗制药工业有限公司 非镇静性巴比土酸衍生物
BR0317289A (pt) 2002-12-11 2005-11-08 Taro Pharma Ind Método para tratar distúrbios do movimento usando derivados do ácido barbitúrico
JP2007513170A (ja) * 2003-12-04 2007-05-24 スリーエム イノベイティブ プロパティズ カンパニー スルホン置換イミダゾ環エーテル
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
KR101027480B1 (ko) * 2006-01-04 2011-04-06 삼성전자주식회사 통신 시스템에서 데이터 송수신 방법 및 시스템
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US20230416231A1 (en) * 2022-02-25 2023-12-28 Southern Research Institute Uracil Derivatives for Stimulating Read-Through of Premature Termination Codons

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS176667B1 (es) * 1975-02-17 1977-06-30
IL69722A (en) * 1983-09-14 1986-09-30 Taro Pharma Ind Oxopyrimidine derivatives and pharmaceutical compositions containing them
US4714838A (en) * 1986-10-31 1987-12-22 Minnesota Mining And Manufacturing Company Second harmonic generation with N,N'-substituted barbituric acids
GB9325368D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds
US5959109A (en) * 1996-05-15 1999-09-28 Neurocrine Biosciences, Inc. Compounds and methods for increasing endogenous levels of corticotropin-releasing factor

Also Published As

Publication number Publication date
US20030199533A1 (en) 2003-10-23
NZ522195A (en) 2004-12-24
EP1276727A1 (en) 2003-01-22
AU2001248197A1 (en) 2001-10-30
CA2306170A1 (en) 2001-10-18
WO2001079185A1 (en) 2001-10-25

Similar Documents

Publication Publication Date Title
MXPA02010405A (es) Derivados de aminocarboxialquilo novedosos de acido barbiturico.
ATE265419T1 (de) Spiro(2.4)heptanaminocarbonsäure und ihre derivate
MXPA02001340A (es) Compuestos novedosos 1,4-benzodiazepina y derivados de los mismos.
GEP19991870B (en) Alkyl Amine Derivatives of Substituted Quinoxaline 2,3-Diones as Glutamate Receptor Antagonists
UA44254C2 (uk) Похідні 4-(заміщеного феніламіно)хіназоліну, спосіб їх одержання, спосіб лікування і фармацевтична композиція
CA2401229A1 (en) Aryl fused azapolycyclic compounds
JO2371B1 (en) 4-phenyl-pyridine derivatives
IL177291A0 (en) Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
FR2743562B1 (fr) Derives de n-(arylsulfonyl) aminoacides, leur preparation, les compositions pharmaceutiques en contenant
NO963850D0 (no) Heterosykliske forbindelser, deres fremstilling og anvendelse
AU6999796A (en) Heterocyclic compounds as bradykinin antagonists
BR9910130A (pt) Derivados de cubana como antagonistas de receptor de glutamato metabotrópico e processo para a sua preparação
GR3036639T3 (en) 5-(4-subst.-piperidinyl-1)-3-aryl-pentanoic acid derivatives as tachykinin receptor antagonist
DE69611728D1 (de) N-(4-substituerte benzyl)-2-aminolactamderivate
IL125982A0 (en) 2-(arylphenyl) amino-imidazoline derivatives
MXPA02000242A (es) Analogos de 2-aminoindano.
AU1466295A (en) Amino acid derivatives and their use as phospholipase a2 inhibitors
GEP19991869B (en) Amino Acid Derivatives of Substituted Quinoxaline 2,3-Dione Derivatives as Glutamate Receptor Antagonists
AU5644296A (en) Novel heterocyclic chemistry
WO2001002340A3 (en) Novel aminoindanes
DK1003749T3 (da) 8-Substituerede-9H-1,3dioxolo/4,5-h/2,3-benzodiazepinderivater som ampa/kainat-receptor-hæmmere
HK1040237A1 (en) Fused polycyclic amino acids as pharmaceutical agents.
HUP0302255A2 (hu) Szulfonamidszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
AU5398300A (en) Excitatory amino acid receptor modulators
YU38498A (sh) Derivati 2-(arilfenil)amino-imidazolina