MXPA02002695A - Thienoisoxazolyl and thienylpyrrazolyl phenoxy substituted propyl derivatives useful as d4. - Google Patents

Thienoisoxazolyl and thienylpyrrazolyl phenoxy substituted propyl derivatives useful as d4.

Info

Publication number
MXPA02002695A
MXPA02002695A MXPA02002695A MXPA02002695A MXPA02002695A MX PA02002695 A MXPA02002695 A MX PA02002695A MX PA02002695 A MXPA02002695 A MX PA02002695A MX PA02002695 A MXPA02002695 A MX PA02002695A MX PA02002695 A MXPA02002695 A MX PA02002695A
Authority
MX
Mexico
Prior art keywords
thienylpyrrazolyl
thienoisoxazolyl
compounds
disorder
phenoxy substituted
Prior art date
Application number
MXPA02002695A
Other languages
Spanish (es)
Inventor
M Fink David
Original Assignee
Aventis Pharm Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharm Prod Inc filed Critical Aventis Pharm Prod Inc
Publication of MXPA02002695A publication Critical patent/MXPA02002695A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

The compounds are of the class thienoisoxazolyl and thienylpyrrazolyl phenoxy substituted propyl derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson s Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.
MXPA02002695A 1999-09-14 2000-09-13 Thienoisoxazolyl and thienylpyrrazolyl phenoxy substituted propyl derivatives useful as d4. MXPA02002695A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39608199A 1999-09-14 1999-09-14
PCT/US2000/024962 WO2001019833A1 (en) 1999-09-14 2000-09-13 Thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists

Publications (1)

Publication Number Publication Date
MXPA02002695A true MXPA02002695A (en) 2002-07-30

Family

ID=23565772

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02002695A MXPA02002695A (en) 1999-09-14 2000-09-13 Thienoisoxazolyl and thienylpyrrazolyl phenoxy substituted propyl derivatives useful as d4.

Country Status (26)

Country Link
EP (1) EP1216250B1 (en)
JP (1) JP4847662B2 (en)
KR (1) KR20020027647A (en)
AR (1) AR032134A1 (en)
AT (1) ATE254621T1 (en)
AU (1) AU7577400A (en)
BR (1) BR0014515A (en)
CA (1) CA2383340C (en)
CY (1) CY1101692T1 (en)
CZ (1) CZ2002897A3 (en)
DE (1) DE60006699T2 (en)
DK (1) DK1216250T3 (en)
EA (1) EA200200355A1 (en)
EE (1) EE200200135A (en)
ES (1) ES2209995T3 (en)
HR (1) HRP20020220A2 (en)
HU (1) HUP0203526A3 (en)
IL (1) IL148623A0 (en)
MX (1) MXPA02002695A (en)
NO (1) NO20021251L (en)
PL (1) PL354515A1 (en)
PT (1) PT1216250E (en)
SK (1) SK3512002A3 (en)
TW (1) TW530060B (en)
WO (1) WO2001019833A1 (en)
ZA (1) ZA200201762B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
EP1688412A3 (en) * 2001-02-16 2006-08-16 Aventis Pharmaceuticals, Inc. Novel heterocyclic amide derivatives and their use as dopamine D3 receptor ligands
ATE449763T1 (en) * 2001-04-16 2009-12-15 Eisai R&D Man Co Ltd 1H-INDAZOLE COMPOUNDS THAT INHIBIT JNK
KR20040020457A (en) * 2002-08-30 2004-03-09 주식회사 대웅 A preparation process for 3-{2-[4-(6-fluorobenzo[d]isoxazol-3-yl) piperidino]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
JP2006515891A (en) * 2003-01-17 2006-06-08 シーブイ・セラピューティクス・インコーポレイテッド Substituted heterocyclic compounds effective for the treatment of cardiovascular diseases
JP2007297330A (en) * 2006-04-28 2007-11-15 Daiso Co Ltd Method of manufacturing 2-methylglycidyl derivative
JP2007297321A (en) * 2006-04-28 2007-11-15 Daiso Co Ltd Method for producing aryl 2-methylglycidyl ether
WO2014100716A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
US8906900B2 (en) 2012-12-21 2014-12-09 Epizyme, Inc. PRMT5 inhibitors and uses thereof
JP6678455B2 (en) 2012-12-21 2020-04-08 エピザイム，インコーポレイティド PRMT5 inhibitors and uses thereof
US8940726B2 (en) 2012-12-21 2015-01-27 Epizyme, Inc. PRMT5 inhibitors and uses thereof
US9221794B2 (en) 2012-12-21 2015-12-29 Epizyme, Inc. PRMT5 inhibitors and uses thereof
EP3160477A4 (en) * 2014-06-25 2018-07-04 Epizyme, Inc. Prmt5 inhibitors and uses thereof
WO2016022605A1 (en) 2014-08-04 2016-02-11 Epizyme, Inc. Prmt5 inhibitors and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728651A (en) * 1985-10-24 1988-03-01 Hoechst-Roussel Pharmaceuticals Inc. Antihypertensive thieno-isoxazoles and -pyrazoles
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
JP4627882B2 (en) * 1998-02-09 2011-02-09 デユフアー・インターナシヨナル・リサーチ・ベー・ブイ Benzisoxazole derivatives having D4-antagonist activity

Also Published As

Publication number Publication date
HRP20020220A2 (en) 2004-02-29
NO20021251L (en) 2002-05-10
TW530060B (en) 2003-05-01
PL354515A1 (en) 2004-01-26
BR0014515A (en) 2002-06-25
EP1216250B1 (en) 2003-11-19
IL148623A0 (en) 2002-09-12
CZ2002897A3 (en) 2002-07-17
WO2001019833A1 (en) 2001-03-22
DE60006699D1 (en) 2003-12-24
EA200200355A1 (en) 2002-10-31
DE60006699T2 (en) 2004-09-30
ES2209995T3 (en) 2004-07-01
ZA200201762B (en) 2003-08-27
CA2383340C (en) 2010-06-15
DK1216250T3 (en) 2004-02-23
NO20021251D0 (en) 2002-03-13
SK3512002A3 (en) 2003-03-04
AU7577400A (en) 2001-04-17
KR20020027647A (en) 2002-04-13
PT1216250E (en) 2004-04-30
EE200200135A (en) 2003-04-15
ATE254621T1 (en) 2003-12-15
CA2383340A1 (en) 2001-03-22
HUP0203526A3 (en) 2004-12-28
AR032134A1 (en) 2003-10-29
EP1216250A1 (en) 2002-06-26
HUP0203526A2 (en) 2003-01-28
JP4847662B2 (en) 2011-12-28
CY1101692T1 (en) 2010-07-28
JP2003509432A (en) 2003-03-11

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