MXPA02001297A - Fluorene derivatives. - Google Patents

Fluorene derivatives.

Info

Publication number
MXPA02001297A
MXPA02001297A MXPA02001297A MXPA02001297A MXPA02001297A MX PA02001297 A MXPA02001297 A MX PA02001297A MX PA02001297 A MXPA02001297 A MX PA02001297A MX PA02001297 A MXPA02001297 A MX PA02001297A MX PA02001297 A MXPA02001297 A MX PA02001297A
Authority
MX
Mexico
Prior art keywords
fluorene derivatives
disorders
arteriosclerosis
thrombosis
osteoporosis
Prior art date
Application number
MXPA02001297A
Other languages
Spanish (es)
Inventor
St Hle Wolfgang
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MXPA02001297A publication Critical patent/MXPA02001297A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, m and n have the meaning given in Claim 1, and to their physiologically acceptable salts and solvates, which can be used as integrin inhibitors, especially for the prophylaxis and treatment of blood circulation disorders, thrombosis, myocardial infarction, coronary disorders, arteriosclerosis, osteoporosis, pathological processes which are maintained or propagated through angiogenesis, as well as in tumour therapy.
MXPA02001297A 1999-08-07 2000-07-26 Fluorene derivatives. MXPA02001297A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19937394A DE19937394A1 (en) 1999-08-07 1999-08-07 Fluorene derivatives
PCT/EP2000/007153 WO2001010841A2 (en) 1999-08-07 2000-07-26 Fluorene derivatives as integrin inhibitors

Publications (1)

Publication Number Publication Date
MXPA02001297A true MXPA02001297A (en) 2004-07-16

Family

ID=7917613

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02001297A MXPA02001297A (en) 1999-08-07 2000-07-26 Fluorene derivatives.

Country Status (18)

Country Link
EP (1) EP1208088A2 (en)
JP (1) JP2003506439A (en)
KR (1) KR20020012631A (en)
CN (1) CN1368962A (en)
AR (1) AR025042A1 (en)
AU (1) AU6828600A (en)
BR (1) BR0013083A (en)
CA (1) CA2380981A1 (en)
CZ (1) CZ2002298A3 (en)
DE (1) DE19937394A1 (en)
HK (1) HK1049006A1 (en)
HU (1) HUP0202464A3 (en)
MX (1) MXPA02001297A (en)
NO (1) NO20020592L (en)
PL (1) PL353054A1 (en)
SK (1) SK1402002A3 (en)
WO (1) WO2001010841A2 (en)
ZA (1) ZA200201873B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101102808B1 (en) * 2010-04-13 2012-01-05 윤태삼 Riser tensioner
US8574899B2 (en) 2010-12-22 2013-11-05 Vladimir B Serikov Methods for augmentation collection of placental hematopoietic stem cells and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04506350A (en) * 1989-06-22 1992-11-05 ノバ　ファーマスーティカル　コーポレイション Pharmaceutical compositions for treating inflammation and methods for treating inflammation
IL113196A0 (en) * 1994-03-31 1995-06-29 Bristol Myers Squibb Co Imidazole derivatives and pharmaceutical compositions containing the same
CA2250464A1 (en) * 1996-03-29 1997-10-09 G.D. Searle & Co. Meta-substituted phenylene derivatives and their use as alphavbeta3 integrin antagonists or inhibitors
DE19654483A1 (en) * 1996-06-28 1998-01-02 Merck Patent Gmbh Phenylalanine derivatives
CA2214931A1 (en) * 1996-09-26 1998-03-26 Henry Uhlman Bryant Tetrahydrobenzo-a-fluorene compounds and method of use

Also Published As

Publication number Publication date
JP2003506439A (en) 2003-02-18
KR20020012631A (en) 2002-02-16
AR025042A1 (en) 2002-11-06
DE19937394A1 (en) 2001-02-08
PL353054A1 (en) 2003-10-06
HUP0202464A2 (en) 2002-12-28
HUP0202464A3 (en) 2003-02-28
WO2001010841A2 (en) 2001-02-15
CZ2002298A3 (en) 2002-04-17
CN1368962A (en) 2002-09-11
ZA200201873B (en) 2003-08-27
SK1402002A3 (en) 2002-06-04
HK1049006A1 (en) 2003-04-25
CA2380981A1 (en) 2001-02-15
NO20020592L (en) 2002-04-04
AU6828600A (en) 2001-03-05
NO20020592D0 (en) 2002-02-06
WO2001010841A3 (en) 2001-09-07
EP1208088A2 (en) 2002-05-29
BR0013083A (en) 2002-04-23

Similar Documents

Publication Publication Date Title
TW372232B (en) Phenylalanine derivatives
NO20010203L (en) Diacylhydrazine derivatives as integrin inhibitors
NO986090L (en) Phenylalanine derivatives as integrin inhibitors
NZ511927A (en) Phenylglycine derivatives
MY134783A (en) Rho-kinase inhibitors
MY142915A (en) Rho-kinase inhibitors
DE60324183D1 (en) Aryl-, aryloxy- und alkyloxysubstituierte 1h-indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1)
HK1051539A1 (en) Benzamides and related inhibitors of factor xa
FI913478A0 (en) DIAZINDERIVAT.
ATE303359T1 (en) BIPHENYL COMPOUNDS AND BIPHENYL ANALOGUES AS INTERGRIN ANTAGONISTS
TR199901962T2 (en) Bicyclic amino acids.
BG106586A (en) Pyrazolopyramidines as therapeutic agents
ATE240328T1 (en) SUBSTITUTED AZAOXINDOLE DERIVATIVES
DK0939627T3 (en) Pentaflourobenzene sulfonamides and analogues
MY133897A (en) N-(4-carb-amimidophenyl) glycineamide derivatives
CA2348391A1 (en) Chromenone and chromanone derivatives as integrin inhibitors
CY1107149T1 (en) New amidinobenzylamine derivatives and their use as thrombin inhibitors
AR027398A1 (en) DERIVATIVES OF INDOL-3-ILO
WO2000071516A3 (en) INHIBITORS OF FACTOR Xa
HUP0105479A2 (en) Betha-alanine derivatives, process for producing them and pharmaceutical compositions containing them
NO20032754D0 (en) Urea and / or urethane derivatives as integrin inhibitors
NO20020131L (en) Diacylhydrazinderivater
MXPA02001297A (en) Fluorene derivatives.
MXPA03010205A (en) Oxalic acid derivatives.
NO20000016L (en) Cyclic azapeptides with angiogenic activity

Legal Events

Date Code Title Description
FA Abandonment or withdrawal