MXPA00009595A - Skin lightening composition containing magnesium ascorbyl phosphate and uninontan-u34tm - Google Patents
Skin lightening composition containing magnesium ascorbyl phosphate and uninontan-u34tmInfo
- Publication number
- MXPA00009595A MXPA00009595A MXPA/A/2000/009595A MXPA00009595A MXPA00009595A MX PA00009595 A MXPA00009595 A MX PA00009595A MX PA00009595 A MXPA00009595 A MX PA00009595A MX PA00009595 A MXPA00009595 A MX PA00009595A
- Authority
- MX
- Mexico
- Prior art keywords
- extract
- oil
- peg
- cosmetic composition
- ingredients
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 98
- 229940078752 MAGNESIUM ASCORBYL PHOSPHATE Drugs 0.000 title claims abstract description 13
- 206010040829 Skin discolouration Diseases 0.000 title description 5
- 239000000284 extract Substances 0.000 claims abstract description 144
- 239000004615 ingredient Substances 0.000 claims abstract description 49
- 239000002537 cosmetic Substances 0.000 claims abstract description 30
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims abstract description 29
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- 238000009472 formulation Methods 0.000 claims abstract description 24
- 208000000069 Hyperpigmentation Diseases 0.000 claims abstract description 15
- 230000003810 hyperpigmentation Effects 0.000 claims abstract description 15
- 231100001006 hyperpigmentation Toxicity 0.000 claims abstract description 15
- 240000008067 Cucumis sativus Species 0.000 claims description 31
- 150000003700 vitamin C derivatives Chemical class 0.000 claims description 19
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- 229910052783 alkali metal Inorganic materials 0.000 claims description 3
- 150000001340 alkali metals Chemical class 0.000 claims description 3
- 238000004061 bleaching Methods 0.000 claims description 3
- 229910052723 transition metal Inorganic materials 0.000 claims description 3
- 150000003624 transition metals Chemical class 0.000 claims description 3
- 229940071097 ascorbyl phosphate Drugs 0.000 claims description 2
- 230000003203 everyday Effects 0.000 claims description 2
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- 239000008170 walnut oil Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 200000000019 wound Diseases 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- 239000011686 zinc sulphate Substances 0.000 description 1
- 235000009529 zinc sulphate Nutrition 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N β-Sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
Abstract
The present invention is directed to lightening cosmetic compositions for the treatment of hyperpigmentation. These compositions comprise two ligthening ingredients:magnesium ascorbyl phosphate and UNINONTAN-U34TM (extract formulation of cucumber extract and lemon extract). These two ingredients do not interfere with each other, and instead provide increased lightening capabilities for these compositions.
Description
COMPOSITION FOR CLARIFYING SKIN CONTAINING PHOSPHATE
ASCORBILO DE MAGN ESIO AND UNINONTAN-U34M (FORMU ESSENTIAL LATION OF CUCUMBER EXTRACT AND EXTRACT OF LI MÓN)
TECHNICAL FIELD The invention relates to a cosmetic composition that can be used to lighten the skin, and contains magnesium ascorbyl phosphate and UN I NONTAN-U34MR (essential formulation of cucumber extract and lemon extract).
BACKGROUND The color in human skin is caused by the pigment melanin. Melanin is produced especially in dendritic cells, melanocytes, which are below or between the basal cells of the epidermis of the skin. See US patent no. 5, 41 1, 741 (Zaias). Melanin is synthesized by a cascade of reactions triggered by the enzyme tyrosinase. See US patent no. 5, 262, 153 (Mishima et al.). Normal pigmentation is characterized by a uniform, uniform color. Many individuals have excess melanin pigmentation or hyperpigmentation. This disorder can lead to unwanted dark skin freckles or spots, such as lentigo senile, liver spots, melasma, brown or age spots, vitiligo, pigmentation from sunburn, post-inflammatory hyperpigmentation due to abrasion, burns, wounds or dermatitis, phototoxic reaction and other similar small fixed pigmented lesions. It is often desirable to clarify these areas. Individuals may also wish to increase whiteness or reduce the overall level of skin pigmentation. In any case, hyperpigmentation is usually seen as cosmetically undesirable and individuals often want to lighten their skin. There are many chemicals that have a deep physiological effect on the skin. Several groups of dermatological active compounds produce a clarifying effect on the skin. Known rinse agents include magnesium ascorbyl phosphate ("MAP"). MAP is a phosphate ester of vitamin C, and is more stable than vitamin C by itself. MAP works as a lightening agent by inhibiting tyrosinase activity. U N I NONTAN U-34M R, an essential formulation, is distributed by Lipo Chemicals of Paterson, N .J. , US and is manufactured by I nduchem of Switzerland. This composition is marketed as a cosmetic ingredient for its skin lightening properties. Its ingredients are cucumber extract (5.0%), lemon extract (6.0%), sodium citrate (20.0%), propylene glycol (23.5%) and water (25.5%). The use of a skin lightening ingredient may not be effective for individuals with significant hyperpigmentation or "silly" freckles or age spots. However, the combination of skin lightening ingredients can produce negative results. Some ingredients, such as MAP, are unstable at lower pH ranges and under other conditions. In this way, the use of MAP is incompatible with rinse ingredients that significantly reduce the pH of the composition, or alter it in other incompatible ways.
BRIEF DESCRIPTION OF THE INVENTION The characteristics of the invention can be realized and obtained by means of conduits and combinations particularly indicated in the appended claims. Additional features of the invention will be set forth in part in the description that follows, and in part will be apparent from the description, or may be taught by practicing the invention. In accordance with the purpose of the invention, one of its aspects encompassed and widely described herein, discloses: a cosmetic composition comprising a vitamin C derivative and an extract formulation including cucumber extract and lemon extract. It is further described: a method for treating hyperpigmentation comprising applying the cosmetic composition, which contains a vitamin C derivative and cucumber extract and lemon extract, and repeating the application on a regular basis. Additional aspects of the invention will be set forth in part in the description that follows, and in part will be apparent from the description, or may be taught by practicing the invention. The purposes and characteristics of the invention will be realized and obtained by means of the elements and combinations particularly indicated in the appended claims.
DETAILED DESCRIPTION Some embodiments of the invention and one or more ways of practicing the invention will now be described in more detail. Some illustrative, non-limiting examples of the preferred embodiments will also be described. The present invention comprises a cosmetic lightening or bleaching preparation, which provides a safe and effective amount of magnesium ascorbyl phosphate and a safe and effective amount of UNI NONTAN U-34M R. The lightening composition of the skin of the present invention equals the skin tone and reduces hyperpigmentation, contains safe and effective ingredients to prevent the formation of melanin, and comprises a stable, aesthetically pleasing cosmetic composition. The present invention prevents the synthesis of melanin and reduces hyperpigmentation when used on a regular basis. The composition may have the additional benefit of acting as a skin moisturizer. Vitamin C derivatives, such as magnesium ascorbyl phosphate ("MAP"), are effective bleaching agents, but have certain stability problems. In this way, although it is advantageous to combine the vitamin C derivatives with other lightening ingredients, they can degrade and lose their effectiveness under certain conditions, including low pH. Other stable derivatives of vitamin C could also be used, such as other ascorbyl phosphates of alkali metals, alkaline metals or transition metals. These include sodium, potassium, calcium or zinc. Other stable vitamin C derivatives include, but are not limited to, ascorbyl palmitate and ascorbyl acetate. We believe that MAP also functions in the present invention as an environmental protector, an antioxidant and a collagen / ant i-aging reinforcing ingredient. UNI NONTAN-U34M R (essential formulation of cucumber extract and lemon extract), an essential formulation, is an effective lightening agent, and can be combined with relatively unstable vitamin C derivatives, such as MAP, without affect its stability. In this way, it creates an additive effect, increasing the total lightening function available to a user. This allows users to achieve the degree of clarification they desire in a shorter period. It also allows users to treat foolish hyperpigmentation that does not respond to traditional treatments. Of course, the present invention can be practiced by combining the raw materials comprising the product UN I NONTAN-U34M R (essential formulation of cucumber extract and lemon extract) in the specified amounts, or by creating reasonable variations in the ingredients. Its ingredients are cucumber extract (5.0%), lemon extract (6.0%), sodium citrate (20.0%), propylene glycol (23.5%) and water (25.5%). Although we do not want to link to any theory, we believe that the active lightening ingredients are cucumber extract and lemon extract, with the rest of the ingredients acting as preservatives and solvents. Another essential formulation of the present invention could preferably include from about 1 to about 50% cucumber extract, more preferably from about 1 to about 25% cucumber extract, and most preferably about 15% extract from cucumber. cucumber, together with from about 1 to about 50% lemon extract, more preferably from about 1 to about 25% lemon extract, and most preferably about 16% lemon extract, the rest being water, others solvents and / or preservatives. Alternatively to the lemon extract, another source of ascorbic acid or a vitamin C derivative can be added. However, we will refer to this combination of ingredients in the present invention by its trade name, UNI NONTAN-U34M R, solely by convenience. One skilled in the art could undoubtedly substitute raw material for the product without departing from the teachings and scope of the present invention. The present invention includes a vitamin C derivative from about 0.05 to about 10%, preferably from about 0.1 to about 5%. For an emulsion product, the most preferable level of the vitamin C derivative is from about 1 to about 5%, still more preferably about 3%, while a toning product the most preferable level of the vitamin C derivative is from about 0 1 to about 5%, even more preferably about 0.1%. One skilled in the art would understand that the active ingredients penetrate the skin better and faster in a toning product. Although it is not desired to join any theory, it is believed that in a hydro-alcoholic toner, the penetration of the active ingredients is intensified due to the presence of alcohol and the absence of oil. The vitamin C derivative may be selected from any stable derivative, more preferably selected from ascorbyl phosphates of alkali metals, torric alkaline metals or transition metals, such as sodium, postasium, calcium or zinc, and most preferably the derivative of vitamin C MAP. The present invention also includes UNI NONTAN-U34M R (essential formulation of cucumber extract and lemon extract), or a substitute derived from the raw material by itself, as discussed above, at a percentage from about 0.5 to about 10. %, preferably from about 1 to about 7%. For an emulsion product, the most preferable level for the U N I NONTAN-U34M R is approximately 5%, whereas it would be approximately 3% for the tonifier. Again, a skilled technician would understand that the active ingredients penetrate the skin better and faster into a toning product. As the vitamin C derivative, such as MAP, may be pH sensitive, the pH of the final composition should be above 4.5, preferably at or above 5.0, more preferably at or above 6.0, and even more preferably ao over 7.0. The pH of the composition should preferably be below 8.5 and still more preferably below 8.0, and most preferably below 7.5. One of ordinary skill in the art can add pH adjusting ingredients to the compositions of the present invention to adjust the pH to an acceptable range.
The composition should be applied to the affected area with hyperpigmentation or where the user wishes to achieve clarification on a regular basis. The appropriate treatment preferably is twice a week, more preferably every third day, even more preferably every day and more preferably twice a day. The frequency of treatment depends on the degree of hyperpigmentation, the degree of clarification desired, the responsiveness of the user's skin, the strength of the cosmetic product and the convenience to the user's lifestyle. The effectiveness of bleaching agents can be evaluated by using a skin analog, such as, for example, MELANODERM ™. Melanocytes, one of the cells in the skin analogue, stain positively when exposed to L-dihydrophenyl alanine (L-DOPA), a precursor of melanin. The skin analog, MELANODE RMMR, can be treated with a variety of bases containing the bleaching agents according to prevention or with the base alone as a control. Alternatively, a treated sample of the skin analog can be used as a control. The bleaching agents of the present invention can be combined with standard cosmetic bases. Bases that can be used in the present invention include: emulsions, creams, lotions, toning solutions (both aqueous and hydro-alcoholic), anhydrous bases (such as bars and powders) and ointments. One of ordinary skill in the art would generally recognize these and other standard cosmetic bases that can be used in the present invention. In this manner, the present invention can be formulated with a variety of cosmetic bases or vehicles, in addition to those described in the Examples below. Variations and other appropriate bases will be apparent to the skilled artisan and are suitable for use in the present invention. An acceptable bleaching base comprises water, TiO2, xanthan gum, magnesium aluminum silicate, methyl paraben, propyl paraben, hydroxyethylcellulose, EDTA, sodium citrate, isostearyl palmitate, butylene glycol, FI NSOLVEM R humectant, glycerin, dimethicone, stearic acid, stearate of PEG-100, stearyl alcohol, sorbitan stearate, TEA, water, Na lactate, vitamin E acetate and natural fragrances. Base A, an anhydrous base, preferably comprises one or more film-forming agents, to provide a novel cosmetic composition, which can be applied topically to deliver the hydrophilic agents to the skin. Base A can thus comprise a more or less volatile hydrophobic cosmetic solvent, in which a gelling agent is optionally dispersed to provide a desired consistency. For example, Base A may contain dimethicone, sorbitan isostearate, sononyl isononanoate, lauryl laurildone, cetyl dimethicone, propyl paraben, methyl paraben, cyclomethicone, zinc laurate, mica-aluminum myristate, kaolin, MBX8C (PMMA) polymethyl -methacrylate and thioxogel CYM. For Base A, the phase Y ingredients listed in Table 1 below are dispersed during mixing for at least three minutes at high speed. The phase X ingredients are mixed and heated to 65 ° C until they are clear. When phase X is transparent, the amalgamated phase Y mixture is added, in a propeller-type mixer until it is uniform and free of lumps. Once this mixture is uniform, the ingredients of the Z phase are added and the mixture is again amalgamated until uniform.
TABLE 1: Base A
To form an additional anhydrous base, Base A ', the waxy ingredients in Table 2 below (Phase X) are heated to 90 ° C to 95 ° C to melt the waxes. The phase X mixture is verified by unmelted particles. Next, the ingredients of phase Y are added and the mixture is removed from the heat. The homomixer, or similar apparatus, is then used and the Z-phase ingredients are added one at a time, and the mixture is homogenized well between each addition. The homomixer is then set in the sweep mode, and the mixture is allowed to cool to 40 ° C to 45 ° C. When the temperature reaches 40 ° C to 45 ° C, the ingredients of the W phase are added one at a time, mixing well between each addition. The batch is then cooled to 30 ° C.
TABLE 2: Base A '
Base B, an oil and water emulsion, may comprise the following ingredients: cetyl alcohol, arlacel 165, dimethicone, vitamin E acetate, methyl paraben, octyl palmitoate, propyl paraben, xanthan gum, citric acid and water. An example of a preferred Base B is as follows. The ingredients of phase X in the following table are heated to 75 ° C to obtain a clear solution. The Y-phase ingredients are combined by dispersing the xanthan gum slowly in water by stirring at high speed at 75 ° C. The Z phase ingredients are added and mixed well at 75 ° C. Next, the ingredients of phase X, already combined as before, are slowly added to the combined ingredients of phase Y and Z, using vigorous mixing to obtain a uniform emulsion. The ingredients are cooled slowly to room temperature while stirring to avoid lumping.
TABLE 3: Base B
Base C comprises the following ingredients: dimethicone, sorbitan isostearate, isononyl isononanoate, lauryl-pea lauridone, cetyl dimethicone, glyceryl tribehenate, ceresin, microcrystalline wax, propyl paraben, methyl paraben, cetomethicone pentamer, zinc laurate, mica, kaolin, titanium dioxide, nylon 1 2, lactic acid, nylon, glycerin, methyl methacrylate crosspolymer, quaternary cycromethicone of 1 8 carbons, tocopheryl linoleate, tocopheryl acetate, retinyl palmitate, hydrophobic sphingolipid. Base E, an emulsion stick base, comprises the following ingredients: deionized water, stearyl alcohol, decyl oleate, sorbitan isostearate, caprylic / capric triglyceride, cyclomethicone, dimethicone, MCZ parzo, kobo silica and MP 1 005 timiron. Base F, a gel base, comprises the following ingredients: water, ultrez-1 0, glyceret-26, glycerin, fucogel, lubrigel, TEA, DM DM hydantoin, pro-phosphorus, fosfovital, marine fennel, marine caterpillar, panthenol, water , niacinamide and water. Base G, a hydroalcoholic toning solution, comprises water and optionally may also include alcohol. The toner may be alcohol-free. In the preferred embodiment, the alcohol is included in a range from about 1% to about 35%. The tonifier may include, more preferably, humectants, antioxidants, free radical scavengers, anti-irritants and skin coolers. For formulation requirements, a preferred toner could also include pH adjusting agents, preservatives, chelating and cosolubilizing agents.
In addition to the base materials, other ingredients that may be present in the composition include, but are not limited to, the following ingredients. For additional clarifying efficacy, extra brightening agents can be added to the composition. These include, among others, licorice, bearberry extract, mulberry extract and chestnut extract.
Indians Additional lightening agents would be known to the skilled artisan. The humectants can be added to the present invention, including black band powder, diglycerin, erythritol, fructose, glucose, glycerin, glycol, 1, 2,6-hexanetriol, honey, hydrogenated honey, hydrogenated starch hydrolyzate, inositol, lactitol, maltitol, maltose, mannitol, methoxy
PEG-1 0, methoxy PEG-16, methoxy PEG-40, methoxy PEG-1 00, PEG-4, PEG-6,
PEG-8, PEG-9, PEG-10, PEG-1 2, PEG-14, PEG-16, PEG-1 8, PEG-20, PEG-32, PEG-40, PEG-55, PEG-60, PEG-75, PEG-90, PEG-1 00, PEG-1 35,
PEG-1 50, PEG-180, PEG-200, PEG-240, PEG-1 5 butanediol, PEG-5 pentaerythrityl ether, polyglyceryl sorbitol, PCA potassium, PPG-6-sorbet-245,
PPG-6-sorbet-500, propylene glycol, sodium glucuronate, sodium PCA, sorbet-6, sorbet-20, sorbet-30, seobet-40, sorbitol, sucrose, trehalose, urea and xylitol. Antioxidants that can be included in the composition include: acetyl cysteine, ascorbic acid, ascorbic acid polypeptide, ascorbyl dipalmitate, ascorbyl methylsilanol pectinate, ascorbyl palmitate, ascorbyl stearate, BHA, BHT, t-butyl hydroquinone, caffeic acid, chlorogenic acids, cysteine, cysteine HCl, decyl mercaptomethylimidazole, diamylhydroquinone, di-t-butylhydroquinone, dicetyl thiodipropionate, digaloyl trioleate, dilauryl thiodipropionate, dimyristyl thiodipropionate, dioleyl tocopheryl methylsilanol, disodium ascorbyl sulfate, disodium rutinyl disulfate, distearyl thiodipropionate, ditridecyl thiodipropionate, dodecyl gallate, erythorbic acid , ethyl ferulate, ferulic acid, gingko extract, green tea extract, hydroquinone, p-hydroxyanisole, hydroxylamine HCl, hydroxylamine sulfate, isooctyl thioglycolate, kojic acid, madecasicoside, magnesium ascorbate, ascorbyl phosphate of magnesium, methoxy-PEG-7 rutinyl succinate, methylsilanol ascorbate, nordihydro acid guaiarético, octyl gallate, phenylthioglycolic acid, phloroglucinol, potassium ascorbyl tocopheryl phosphate, potassium sulfite, propyl gallate, rosmarinic acid, sodium ascorbate, sodium bisulfite, sorbityl furfural, thiodiglycol, thiodiglycollamide, thiodiglycolic acid, thioglycolic acid, thiolactic acid, thiosalicylic acid, tocoferet-5, tocoferet-1 0, tocoferet- 12, tocoferet-1 8, tocoferet-50, tocopherol, tocofersolan, tocopheryl acetate, tocopheryl linoleate, tocopheryl nicotinate, tocopheryl succinate, or- tolyl biguanide and tris (nonylphenyl) phosphite. The ingredients for wetting preparations include: acetylated lanolin, acetylated lanolin alcohol, acrylates / C 10-30 alkyl acrylate crosspolymer, acrylate copolymers, alanine, alcohol, denat alcohol. , algae extract, allantoin, allantoin acetyl methionine, aloe barbadensis, aloe barbadensis extract, aloe barbadensis gel, althea officinalis extract, starch aluminum octenylsuccinate, aluminum stearate, ammonium glycyrrhizate, apricot kernel oil (armeniaca prunus) ), arachidonic acid, arginine, arginine aspartate, arnica montana extract, ascorbic acid, ascorbyl palmitate, aspartic acid, avocado oil (persea gratissima), barium sulfate, batyl alcohol, beeswax, behenyl alcohol, chloride of benzalkonium, benzoic acid, benzophenone-3, benzophenone-4, benzophenone-9, benzyl alcohol, beta-carotene, beta-sitosterol, BHA, BHT, biotin, birch bark extract (betula alba), bisbolol, currant extract black (ribes nigrum), borage extract (borago officinalis), boric acid, 2-bromo-2-nitropropane-1,3-diol, rusco extract (ruscus aculeatus), butylene glycol, butyl paraben, stearate of b utilo, calcium carbonate, calendula officinalis extract, calendula officinalis oil, C1 2-15 alkyl benzoate, camellia oleifera extract, camellia oleifera seed extract, camellia sinensis extract, camphor, candelilla wax ( euphorbia cerifera), canola oil, carpillic / capric triglyceride, caramel, carbomer, cardamom oil (elettaria cardamomum), carnauba wax (cerifera copernicia), carrageenan (chondrus crispus), carrot extract (daucus carota), carrot oil (daucus carota sativa), castor oil (ricinus communis), cellulose gum, ceresin, cetearet-5, cetearet-1 2, cetearet-20, cetearyl alcohol, cetearyl octanoate, cetet-20, cetet-24, bromide Cetrimonium, Cetrimonium Chloride, Cetyl Acetate, Cetyl Alcohol, Cetyl Octanoate, Cetyl Palm Itato, Cetyl Phosphate, Cetyl Ricinoleate, Chamomile Extract (Anthemis Nobilis), Chamomile Oil (Anthemis Nobilis), Dig chlorhexidine luconato, p-chloro-m-cresol, cholecalciferol, cholesterol, cholesteryl hydroxystearate, colet-24, Cl 40800, Cl 751 30, citric acid, amaro oil (salvia sclarea), cocoa butter (theobroma cacao), coco-caprylate / caprate, coconut oil (nucifera coconuts), collagen, collagen amino acids, comfrey extract (symphytum offininale), cone flower extract (echinacea paluda), cone flower extract (echinacea purpurea), corn flower extract (centaurea) cyanus), corn oil (zea mays), corn starch (zea mays), cucumber extract (cucumis sativus), cyclomethicone, D & amp; amp;; C green no. 5, D &C orange no. 4, C &C red no. 1 7, D &C no. 33, D &C yellow no. 1 0, D &C yellow no. 1 1, DEA-cetyl phosphate, DEA-methoxycinnamate, DEA-olet-1 0 phosphate, decyl oleate, dehydroacetic acid, dextrin, diazolidinyl urea, dichlorobenzyl alcohol, dihydrocolet-30, diisopropyl adipate, diisopropyl dimer dilinoleate , dilauryl thiodipropionate, dimethicone, dimethicone copolyol, dimethiconol, dioctyl adipate, dioctyl succinate, hexapeprylate / dipentaerythrityl hexacaprate, dipotassium glycyrrhizate, dipropylene glycol, disodium adenosine triphosphate, cocam ida MI PA-disodium sulfosuccinate, disodium EDTA, ricinoleamide M EA disodium sulfosuccinate, DMDM hydrantoin, DNA, EDTA, elastin, ergocalciferol, erythritol, ethoxydiglycol, ethylene brasilate, ethyl linoleate, ethyl paraben, eucalyptus globulus oil, donkey grass oil (oenothera biennis), ext. D &C violet no. 2, FD &C blue no. 1, FD &C red no. 4, FD &C red no. 40, FD &C yellow no. 5, FD &C yellow no. 6, fructose, gelatin, geranium maculatum oil, gingko biloba extract, ginseng extract (panax ginseng), glucosamine, glucose, glucose glutamate, glutamic acid, glyceret-26, glycerin, glyceryl distearate, glyceryl hydroxystearate, glyceryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl oleate, glyceryl polymethacrylate, glyceryl stearate, glyceryl stearate SE, glycine, glycol stearate, glycol stearate SE, glycosam inoglicans, glycyrrhetinic acid, grapefruit extract ( citrus grandis), grapefruit seed extract (citrus grandis), grape seed oil (vitis vinifera), guar gum (cyanopsis tetragonoloba), hazelnut oil (corylus americana), hazelnut acetyl (corylus avellana), diisethionate hexamidine, hexylene glycol, homosalate, honey, chestnut extract of I ndias (aesculus hippocastanum), horsetail extract (equisetum arvense), horsetail extract (equisetum hiemale ), hyaluronic acid, hybrid safflower oil (carthamus tinctorius), hydrogenated castor oil, hydrogenated coco-glycerides, hydrogenated coconut oil, hydrogenated lanolin, hydrogenated lecithin, hydrogenated palm glyceride, hydrogenated palm kernel oil, hydrogenated polyisobutene , hydrogenated soybean oil, hydrogenated soybean glyceride, hydrogenated bait glyceride, hydrogenated vegetable oil, hydrolyzed collagen, hydrolyzed elastin, hydrolyzed glycosaminoglycans, hydrolyzed keratin, hydrolyzed soybean protein, hydroxyethylcellulose, hydroxylated lanolin, hydroxyproline, hydroxypropylcellulose, hydroxypropyl methylcellulose , extract of hypericum perforatum, imidazolidinyl urea, iodopropynyl butylcarbamate, iron oxides, isobutyl paraben, isocetyl alcohol, isocetyl stearate, isocetyl stearoyl stearate, isodecyl oleate, isohexadecane, isopropyl alcohol, isopropyl isostearate, isopropyl lanolate, miri isopropyl ester, isopropyl palmitate, isopropyl stearate, isostearam ida DEA, isostearic acid, isostearyl lactate, isostearyl neopentanoate, ivy extract (hederá helix), jasmínin oil (jasminum officinale), jojoba oil (buxus chinensis ), kaolin, kelp, cola extract (cola acum inata), cola extract (nitida tail), kukui nut oil (aleurites moluccana), lactamide MEA, lanet-16, lanet-10 acetate, lanolin, lanolinic acid , lanolin alcohol, lanolin oil, lanolin wax, lanosterol, lauret-4, lauret-23, lavender oil (lavandula angustifolia), lecithin, lemon oil (citrus medica limonum), extract of lime (tilia cordata), extract of linden (tilia vulgaris), linoleic acid, linolenic acid, macadamia nutty ternifolia oil, magnesium aluminum silicate, magnesium ascorbyl phosphate, magnesium stearate, magnesium sulfate, mallow extract (malva sylvestris), maltitol, feverfew extract (chamomilla recutita), feverfew oil (chamomilla recutita), menthol, menthol crystals, methicone, methylchloroisothiazolinone, methyldihydrojasmonate, methyl glucet-1 0, methyl glucet-20, methyl glucose sesquistearate, methylisothiazolinone, methyl paraben, methylsilanol PCA, mica, microcrystalline wax, mineral oil, mink oil, mortierella oil, myristyl alcohol, myristyl lactate, myristyl myristate, myristyl propionate, neopentyl glycol dicaprylate / dicaprate, dehydrated skimmed milk, nylon- 1 12, oak root extract, oatmeal (avena sativa) octoxinol-1 1, octyl dimethyl PABA, octyldodecanol, octyldodecyl myristate, octyldodecyl stearoyl stearate, octyl hydroxystearate, octyl methoxycinnamate, octyl palm itoate, salicylate octyl, octyl stearate, oleic acid, olet-5, olet-1 0, olet-20, oleyl alcohol, olive oil (olea europaea), orange oil (citrus aura) ntium dulcis), oryzanol, ozocerite, PABA, palm oil (elaeis guineensis), palmic acid, pantethine, panthenol, pantenyl ethyl ether, papaya extract (carica papaya), paraffin, PCA, peach seed oil (prunus pérsica ), peanut oil (arachis hypogaea), PEG-6, PEG-8, PEG-1 2, PEG-20, PEG-32, PEG-75, PEG-40 castor oil, C 12- 1 8 ester of PEG-8, PEG-1 5 cocaine, distearate of PEG-1 50, glyceryl isostearate of PEG-60, glyceryl stearate of PEG-5, glyceryl stearate of PEG-30, hydrogenated castor oil of PEGA, hydrogenated castor oil of PEG-40, hydrogenated castor oil of PEG-60, methyl glucose sesquistearate of PEG-20, sorbitan peroleate of PEG-40, soy sterol of PEG-5, soy sterol of PEG-1 0, stearate of PEG-2, PEG-8 stearate, PEG-20 stearate, PEG-32 stearate, PEG-40 stearate, PEG-50 stearate, PEG-1 00 stearate, PEG-1 50 stearate, pentadecalactone, pentahydrosqualene, peppermint oil ( mentha piperita), perfluoropolyethylisopropyl ether, petrolatum, phenethyl alcohol, phenoxyethanol, phenyl d imethicone, phenyl trimethicone, phospholipids, phosphoric acid, plankton extract, poloxamer 333, sugar condensate of polyamino, polyethylene, polyglyceryl-3-diisoarate, polyquaternium -24, polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 80, polysorbate 85, polystyrene, potassium ascorbyl tocopheryl phosphate, potassium cetyl phosphate, potassium hydroxide, potassium laurate, potassium myristate, potassium palmitate, sorbate of potassium, potassium stearate, distearate of PPG-20 methyl glucose ether, propionate of PPG-2 myristyl ether, PPG-1 5 stearyl ether, proline, propolis extract, propylene carbonate, propylene glycol, propylene glycol dicaprylate / dicaprate, dioctanoate of propylene glycol, propylene glycol dipelargonate, propylene glycol laurate, propylene glycol stearate, propylene glycol stearate SE, propyl gallate, ropil paraben, PVP, PVP / eicosene copolymer, pyridoxine dipalmitate, quaternium-1 5, quaternium-1 8 hectorite, quaternium-22, retinol, retinyl palmitate, rice bran oil (oryza sativa), RNA, extract of rosemary (rosmarinus officinalis), rosemary oil (rosmariun officinalis), rose oil, royal jelly, saccharide isomerate, saccharin, safflower oil (carthamus tinctorius), artemisia extract (salvia officinalis), salicylic acid, sandalwood oil ( santalum album), serine, whey protein, sesame oil (sesaum indicum), shea butter (butyrospermum parkii), silica, silk powder, simethicone, sodium borate, sodium carbonate, sodium cetearyl sulfate, sodium, sodium chondroitin sulfate, sodium dihydroacetate, sodium DNA, sodium hexametaphosphate, sodium hyaluronate, sodium hydroxide, sodium lactate, sodium laurate, sodium lauryl sulfate, sodium methylbenzene, sodium myristate, sodium palmitoate , Sodium PCA, sodium polyglutamate, sodium stearate, sodium sulfate, soluble collagen, sorbic acid, sorbitan laurate, sorbitan oleate, sorbitan palmitate, sorbitan sesquioleate, sorbitan stearate, sorbitol, soybean oil, sphingol, squalene, squalene, stearamium chloride, stearalkonium chloride, stearalkonium hectorite, stearamide MEA-stearate, steareth-2, steareth-10, steareth-20, steareth-21, steareth-100, stearic acid, stearoxi dimethicone, stearoxitrimethylsilane, stearyl alcohol, stearyl glycyrrheate, stearyl heptanoate, stearyl stearate, sucrose, sunflower seed oil (helianthus annuus), sweet almond oil (prunus amygdalus dulcis), synthetic beeswax, talc, tartaric acid, TEA-stearate, tetrasodium EDTA , titanium dioxide, tocopherol, tocopheryl acetate, tocopheryl linoleate, tribehenin, triclosan, tridecyl neopentanoate, tridecyl stearate, triethanolamine, trimethylsi loxysilicate, trioctanoin, tristearin, tromethamine, ultramarine, urea, vanillin, vegetable oil, water, wheat germ glycerides, wheat germ oil (triticum vulgare), witch hazel extract (hamamelis virgin iana), xanthan gum, yarrow extract (achillea millefolium), yeast extract, ilang-ilang oil (cananga odorata), zinc oxide, zinc pyrithione and zinc stearate. The ingredients for night cream preparations include: acetylated lanolin, acetylated lanolin alcohol, alcohol, denat alcohol. , allantoin, aloe barbadensis, aloe barbadensis extract, aloe barbadensis gel, amniotic fluid, apricot kernel oil (armeniaca prunus), arachidonic acid, arnica montana extract, ascorbyl palmitate, avocado oil (persea gratissima), wax of bee, benzyl alcohol, beta-carotene, BHA, BHT, biotin, bisabolol, 2-bromo-2-nitropropane-1,3-diol, burdock extract (arctium majus), burdock extract (arctium minus), butylene glycol, butyl paraben, calendula officinalis extract, camellia sinensis oil, caprylic / capric triglyceride, carbomer, carnauba wax (cerifera copernicia), carrot oil (daucus carota), celandin extract (chelidonium majus), ceresin, cetearet-12, ceteareth-20, cetearyl alcohol, cetearyl octanoate, cetet-20, cetet-24, cetyl alcohol, cetyl palmitate, cetyl phosphate, chamomile extract (anthemis nobilis), chamomile oil (anthemis nobilis), chloroacetamide, cole calciferol, cholesterol, colet-24, Cl 40800, Cl 751 30, isoparaffin C 1 3-14, citric acid, cocoa butter (theobroma cacao), collagen, corn oil (zea mays), cucumber extract (cucumis sativus) ), cyclomethicone, D & amp;; C red no. 1 7, D &C red no. 33, D &C yellow no. 1 0, DEA-cetyl phosphate, decyl oleate, dehydroacetic acid, diazolidinyl urea, dimethicone, dimethicone copolyol, dimethiconol, dipotassium EDTA, dipropylene glycol, disodium EDTA, DMDM hydantoin, DNA, EDTA, ethyl linoleate, ethyl paraben, FD & amp;; C blue no. 1, FD &C red no. 4, FD &C yellow no. 5, FD &C yellow no. 6, ginseng extract (panax ginseng), glutamic acid, glycerin, glyceryl polymethacrylate, glyceryl stearate, glyceryl stearate SE, glycol stearate, glycosaminoglycans, glycyrrhetinic acid, hazelnut oil (corylus americana, hazelnut oil (corylus hazelnut), hexylene glycol, hops extract (humulus lupulus), chestnut extract of I ndias (aesculus hippocastanum), horsetail extract (equisetum arvense), horsetail extract (equisetum hiemale), hyaluronic acid, hydrocotyl extract (gotu kola), hydrogenated coconut oil, hydrogenated lanolin, hydrogenated palm oil, hydrogenated peanut oil, hydrolyzed collagen, hydrolyzed elastin, hydroxyethylcellulose, hydroxylated lanolin, hydroxyoctacosanil hydroxystearate, hypericum perforatum extract, imidazolidinyl urea, isocetyl stearate, isopropyl lanolate, isopropyl myristate, isopropyl palmitate, jojoba oil (buxus chinensis), lactoyl methylsilanol elastinate, lanet-1 0 acetate, lanolin, lanolin ínico alcohol, lanolin oil, laureth-7, lavender oil (lavandula angustifolia), lecithin, lime extract (tilia cordata), lime extract (tilia vulgaris), linoleic acid, macadamia nut oil, magnesium aluminum silicate, magnesium sulfate, mallow extract (malva sylvestris), feverfew extract (chamomilla recutita), methylchloroisothiazolinone, methyl glucet-20, methylisothiazolinone, methyl paraben, methylsilanol elastinate, microcrystalline wax, mineral oil, mink oil, myristyl myristate, octyldodecanol, octyl methoxycinnamate, octyl palmitate, ozocerite, palm oil (elaeis guineensis), panthenol, paraffin, PEG-8 , C 1 2-1 8 ester of PEG-8, PEG-22 / dodecyl glycol copolymer, PEG-45 / dodecyl glycol copolymer, PEG-7 hydrogenated castor oil, PEG-2 stearate, PEG stearate -6, PEG-40 stearate, stearate of PEG-1 00, petrolatum, phenoxyethanol, phenyl dimethicone, phospholipids, polyacrylamide, polyethylene, polisorbate 20, polysorbate 60, polysorbate 80, polystyrene, potassium cetyl phosphate, potassium sorbate, propolis extract, propylene glycol, dicaprylate / dicaprate of propylene glycol, propylene glycol stearate, propylene glycol stearate SE, propyl gallate, propyl paraben, quaternium-1 5, quaternium-1 8 hectorite, retinol, retinyl palmitate, RNA, rosemary extract (rosmarinus officinalis), royal jelly, oil of safflower (carthamus tinctorius), artemisa extract (salvia officinalis), sesame oil (sesamum indicum), shea butter (butyrospermum parkii), silica, simethicone, sodium borate, sodium cetearyl sulfate, sodium chloride, dhydroacetate sodium, sodium hyaluronate, sodium hydroxide, sodium PCA, soluble collagen, sorbic acid, sorbitan oleate, sorbitan sesquioleate, sorbitan stearate, sorbitol, soybean oil (glycine) e soya), squalane, stearic acid, stearyl alcohol, stearyl heptanoate, sunflower seed oil (helianthus annuus), sweet almond oil (prunus amygdalus dulcis), tetrasodium EDTA, titanium dioxide, tocopherol, tocopheryl acetate, linoleate of tocopheryl, triclosan, triethanolamine, urea, vegetable oil, water, wheat germ glycerides, wheat germ extract (triticum vulgare), wheat germ oil (triticum vulgare), wild tomillo extract (thymus serpillum), Xanthan gum and yeast extract. The ultraviolet light absorbers (UV light) could be incorporated in the present invention, and include the following ingredients: acetaminosalol, allantoin PABA, benzalphthalide, benzophenone, benzophenone-1, benzophenone-2, benzophenone-3, benzophenone-4, benzophenone-5, benzophenone-6, benzophenone-7, benzophenone-8, benzophenone -9, benzophenone-1 0, benzophenone-1 1, benzophenone-1 2, 3-benzylidene camphor, benzylidene camphor hydrolyzed collagen sulphonamide, benzylidene camphor sulfonic acid, benzyl salicylate, borneolone, bumetrizol, butyl methoxydibenzoylmethane, butyl PABA, cinoxate, DEA-methoxycinnamate, di-t-butyl hydroxybenzylidene camphor, digaloyl trioleate, diisoproyl methyl cinnamate, dimethyl PABA ethyl cetearyldimonium tosylate, disodium bisethylphenyl triaminotriazine stilbenedisulfonate, disodium disodiarybryl disulfonate, drometrizole, ethyl dihydroxypropyl PABA, ethyl diisopropylcinnamate , ethyl methoxycinnamate, ethyl PABA, ethyl urocanate, ethacrylene, ferulic acid, glyceryl octanoate dimethoxycinnamate, glyceryl PABA, salt glycol icilate, homosalate, isoamyl p-methoxycinnamate and isopropylbenzyl salicylate. The UV light absorbers can be added to the composition to prevent additional hyper-pigmentation induced by sun or skin damage. In this way, they present a very effective combination with the lightening agents, since they will reduce future hyperpigmentation induced by sun damage, while the lightening agents combat the existing hyperpigmentation. Additional skin care preparation ingredients include: acetylated lanolin, acetylated lanolin alcohol, acrylate cross-linked polymer / C 1 0-30 alkyl acrylate, alcloxa, alcohol, denat alcohol. , algae extract, algin, allantoin, aloe barbadensis, aloe barbadensis extract, aloe barbadensis gel, alpha hydroxy acids, althea officinalis extract, ammonium hydroxide, amniotic fluid, baricoque seed oil (armeniaca prunus), acid arachidonic, arachidyl propionate, arginine, arnica montana extract, ascorbic acid, ascorbyl palmitate, avocado oil (persea gratissima), azulene, balsam mint extract (melissa officinalis), basil oil (ocimum basilicum), wax of bees, behenyl alcohol, bentonite, benzethonium chloride, benzoic acid, benzophenone-2, benzophenone-3, benzophenone-4, benzophenone-5, benzyl alcohol, bergamot oil (citrus aurantium bergamie), beta-carotene, beta hydroxy acids , BHA, BHT, biotin, birch bark extract (betula alba), bisabolol, common black seaweed extract (fucus vesiculosus), 2-bromo-2-nitropropane-1,3-diol, burdock extract (arctium minus) , extract of ruscus (ruscus aculeatus), butylene glycol, butyl methoxydibenzoylmethane, butyl paraben, rose water of cabbage (rose centifolia), caffeine, calcium carbonate, calcium chloride, calendula officinalis extract, calendula officinalis oil, C 12 alkyl benzoate -1.5, oleifera camellia extract, camellia oleifera seed extract, camellia sinensis extract, camphor, candelilla wax (euphorbia cerifera), caprylic / capric triglyceride, caramel, carbomer, carnauba wax (cerifera copernicia), carrageenan ( chondrus crispus), carrot extract (daucus carota), carrot oil (daucus carota sativa), castor oil (ricinus communis), cedar wood oil, cellulose, cellulose gum, ceresin, cetearet-12, cetearet-20 , cetearyl alcohol, cetearyl octanoate, cetet-20, cetrimonium chloride, cetyl acetate, cetyl alcohol, cetyl octanoate, cetyl palm itato, cetyl phosphate, chamomile extract (anthemis nobi) lis), chamomile oil (anthemis nobilis), chloroacetamide, chloroxylenyl, chloropensin, cholesterol, cholesteryl hydroxystearate, cl 40800, cl 751 25, cl 751 30, cl 7581 0, cinnamon oil (cinnamomum cassia), citral, citric acid , clove oil (eugenia caryofhyllus), cocamida dea, cocamidopropyl betaine, cocoa butter (theobroma cacao), coconut oil (nucifera coconuts), collagen, comfrey extract (symphytum officinale), coneflower extract (echinacea angustifolia), coneflower extract (echinacea paluda), coneflower extract (echinacea purpurea), gluconate copper, corn flower extract (centaurea cyanus), corn oil (zea mays), corn starch (zea mays), paret-1 2 C 1 2-1 5, cucumber extract (cucumis sativus), cyclomethicone , cypress extract (cupressus sempervirens), cypress oil (cupressus sempervirens), D & amp; amp;; C blue no. 4, D &C green no. 5, orange D &C no. 4, D &C red no. 1 7, D &C red no. 33, D &C violet no. 2, D &C yellow no. 1 0, D &C yellow no. 1 1, DEA-cetyl phosphate, decyl oleate, dehydroacetic acid, diatomaceous earth, diazolidinyl urea, diisopropyl dimer dilinoleate, dimethicone, dimethicone copolyol, dimethiconol, dimethylsilanol hyaluronate, dioctyl adipate, dioleyl tocopheryl methylsilanol, dipropylene glycol , disodium cocoa-phenacetate, disodium EDTA, disodium phosphate, DM DM hydantoin, DNA, EDTA, elastin, ergocalciferol, escin, ethoxydiglycol, ethyl linoleate, ethyl paraben, eucalyptus globulus oil, farnesyl acetate, FD &C blue no. 1, FD &C green no. 3, FD &C red no. 4, FD &C red no. 40, FD &C yellow no. 5, FD &C yellow no. 5 aluminum lacquer, FD &C yellow no. 6, fennel extract (foeniculum vulgare), natural and artificial fragrances, geranium maculatum oil, gincgo biloba extract, ginseng (panax ginseng), ginseng extract (panax ginseng), glucose, glyceret-26, glycerin, glyceryl hydroxystearate , glyceryl oleate, glyceryl polymethacrylate, glyceryl stearate, glyceryl stearate SE, glycine, glycolic acid, glycol stearate, glycosaminoglycans, glycyrrhetinic acid, grape seed oil (vitis vinifera), guaiazulene, guanine, guanosine, guar hydroxypropyltrimonium chloride, hazelnut oil (corylus americana), hazelnut oil (corylus avellana), hexylene glycol, honey, hops extract (humulus hops), horse chestnut extract (aesculus hippocastanum), horsetail extract ( equisetum arvense), horsetail extract (equisetum hiemale), hyaluronic acid, hydrocotyl extract (centella asiatica), hydrogenated castor oil, hydro coconut oil genada, hydrogenated lanolin, hydrogenated lecithin, hydrogenated palm kernel oil, hydrogenated peanut oil, hydrogenated polyisobutene, hydrogenated bait glyceride, hydrogenated vegetable oil, hydrolyzed casyne, hydrolyzed collagen, hydrolysed elastin, hydrolyzed glycosaminoglycans, hydrolysed milk protein, protein of hydrolyzed soy, hydrolysed yeast protein, hydroquinone, hydroxyethylcellulose, hydroxyproline, hydroxypropyl methylceulose, extract of hypericum perforatum, imidazolidinyl urea, iodopropynyl butylcarbamate, iron oxides, isobutyl paraben, isocetyl stearate, isopropyl alcohol, isopropyl isostearate, lanolate isopropyl, isopropyl myristate, isopropyl palmitate, isostearyl isostearate, isostearyl neopentanoate, ivy extract (hederá helix), jasmínin oil (jasminum officinale), jojoba oil (busus chinensis), juniperus communis extract, extract juniperus oxyc edrus, kaolin, lactoil metilsilanol elastinate, lady's mantle extract (alchemilla vulgaris), lanolin, lanolin alcohol, lanolin oil, lanolin wax, lauramide DEA, lauret-4, lauret-23, lauryl chloride Ipirid in io, lavender oil (lavandula angustifolia), lecithin, lemon extract (citrus medica limonum), lemon juice (citrus medica limonum), lemon oil (citrus medica limonum), lime oil (citrus aurantifolia), lime extract (tilia) cordata), extract of lime (tilia vulgaris), linoleic acid, linolenic acid, linseed oil (linum usitatissimum), locust bean gum (ceratonia siliqua), macadamia nut oil ternifolia, magnesium aluminum silicate alumium, magnesium chloride, magnesium gluconate, magensium sulfate, mallow extract (malva sylvestris), maltitol, manganese gluconate, feverfew extract (chamomilla recutita), menthol, menthyl lactate, methylcellulose, methylchloroisothiazolinone, methyldihydrojasmonate, methyl gl ucet-1 0, methyl glucet-20, methylisothiazolinone, methyl paraben, methyl salicylate, methylsilanol manuronate, mica, microcrystalline wax, mineral oil, mink oil, myristyl lactate, myristyl myristate, myrrh extract (commiphora myrrha), niacinam ida, nonoxynol-12, oak root extract, octoxinol-1 1, octoxinol-1 3, octyl dimethyl PABA, octyldodecanol, octyldodecyl myristate, octyl methoxycinnamate, octyl palmitate, octyl stearate, oleic acid, olet-5, olet-1 0, olet-20, oleyl alcohol, oleyl erucate, olive leaf extract (olea europaea), oil olive (olea europaea), orange oil (citrus aurantium dulcis), oryzanol, ozocerite, palmarosa oil (cymbopogon martini), palm oil (elaeis guineensis), extract of thought (viola tricolor), pantethine, panthenol, pantenil ethyl ether, panthenol triacetate, paraffin, PEG-4, PEG-6, PEG-8, PEG-32, PEG-75, PEG-33 castor oil, PEG-40 castor oil, C 1 2 ester -1.8 of PEG-8, distearate of PEG-1 50, glyceryl cocoate of PEGA, hydrogenated castor oil of PEG-40, hydrogenated castor oil of PEG- 60, PEG-4 octanoate, sorbitan laurate of PEG-44, soy sterol of PEG-5, stearate of PEG-2, stearate of PEG-2 SE, stearate of PEG-6, stearate of PEG-40, stearate of PEG-100, mint extract (mentha piperita), peppermint oil (mentha piperita), petrolatum, phenethyl alcohol, phenol, penoxethanol, phenoxyethanol, phenyl trimethicone, phosphoric acid, pork skin extract, plankton extract, extract plantain (plantago mayor), banana seed extract (plantago ovata), polyamino sugar condensate, polydextrose, polyethylene, polyglyceryl-2-diisostearate, polymethyl methacrylate, polyquaternium-1 0, polysorbate 20, polysorbate 40, polysorbate 60 , polysorbate 80, polystyrene, polyvinyl alcohol, potassium ascorbyl tocopheryl phosphate, potassium cetyl phosphate, potassium hydroxide, potassium sorbate, potassium stearate, AWS, proline, propyl alcohol, propylene glycol, propylene glycol dicaprylate / dicaprate, dipelargonat or of propylene glycol, propylene glycol laurate, propylene glycol myristate, propylene glycol stearate, propyl gallate, propyl paraben, PVP, quaternium-1 5, quaternium-1 8 hectorite, retinol, retinyl palmitate, rice bran oil (oryza sativa) ), rice starch (oryza sativa), RNA, rose extract, rosemary extract (rosmariuns officinalis), rosemary oil (rosmarinus officinalis), rose oil, rosewood oil (rosemary seed), royal jelly, oil of safflower (carthamus tinctorius), artemisa extract (salvia officinalis), sagebrush oil (salvia officinalis), salicylic acid, sandalwood oil (santalum album), serine, whey albumin, whey protein, sesame oil (sesamum indicum) ), shea butter (butyrospermum parkii), silica, simethicone, sodium benzoate, sodium bicarbonate, sodium bisulfite, sodium borate, sodium C 12-1 alkyl sulfate, sodium cetearyl sulfate, sodium chloride , chondroitin sulfate a sodium, sodium citrate, sodium dehydroacetate, sodium hexametaphosphate, sodium hyaluronate, sodium hydroxide, sodium lactate, sodium laureth sulfate, sodium lauryl sulfate, sodium mannilonate methylsilanol, sodium metabisulfite, PCA sodium, sodium sulfate, soluble collagen, sorbic acid, sorbitan laurate, sorbitan sesquioleate, sorbitan stearate, sorbitol, soybean oil (glycine soy), maximal spirulina extract, squalane, squalene, steareth-2, steareth-20 , stearic acid, dimethicone stearoxi, stearyl alcohol, stearyl glycyrrhetenate, stearyl heptanoate, sunflower seed oil (helianthus annuus), sweet almond oil (prunus amygdalus dulcis), talc, ASD, TEA-lactate, TEA- stearate, tetrasodium EDTA, thyme oil (thymus vulgaris), titanium dioxide, tocopherol, tocopheryl acetate, tocopheryl linoleate, triclosan, triethanolamine, trictanoin, tromethamine, groceries, urea, Vegetable tea, walnut oil (Juglans regia), vitamins, water, wheat germ glycerides, wheat germ extract (triticum vulgare), wheat germ oil (triticum vulgare), witch hazel (hamamelis virginiana), witch hazel extract (hamamelis virginiana), xanthan gum, extract yarrow (achillea millefolium), yeast extract, ilang-ilang oil (cananga odorata), zinc gluconate, ci nc oxide, zinc stearate and zinc sulphate. One skilled in the art will understand that the terms "blend" and "mixed" in this patent are used in the broad sense of the words, including the term "mixed", but not limiting, agitation, mixing, dispersion, grinding, homogenization and other similar methods.
EXAMPLES Example 1: Preparation of a base of cosmetic composition In order to prepare the cosmetic composition, the steps presented below were followed. Phase B ingredients were dispersed in the water, butylene glycol and glycerin, and the ingredients were heated at 80 ° C for 5 minutes. Next, the remaining ingredients of phase A were added, together with the ingredients of phase C. The preparation was mixed vigorously for 5 minutes. Additionally, the preparation was homogenized until it was smooth.
Then the ingredients of phase D were added. The preparation was cooled to 40 ° C. Finally, the remaining ingredients, phase E, were added to the composition. This composition has a pH of about 7.0.
TABLE 4: A base of cosmetic composition
Table 4 (continued)
The total percentage only amounts to 74.42% since the formulation was prepared for the subsequent addition of 25.58% of active ingredients. In this way, the water in the upper part of the table represents 45.21% of the w / w after the addition of 25.58% of active ingredients in Example 2. This method of formulation for base compositions is common in the cosmetic industry and would be easily understood by someone of ordinary skill in the art.
Example 2: Cosmetic composition containing MAP and U NINONTAN-U34M R (essential formulation of cucumber extract and lemon extract)
A cosmetic base was prepared as in Example 1. He
UN I NONTAN-U3434 (essential formulation of cucumber extract and lemon extract) and the MAP were added to the base composition, MAP being predisposed in water before being added to the preparation. Water (17.58 grams), MAP (3.0 grams) and UN I NONTAN-U3434 (essential formulation of cucumber extract and lemon extract) (5.0 grams) were added to 74.42 grams of the base composition of Example 1.
Example 3: Toning Composition In order to prepare a toning composition, water and water-soluble ingredients were mixed and heated to 40 ° C, then cooled to 30 ° C. Alcohol and any other ingredient were mixed in the cosolubilizer phase in the water soluble phase. Additional ingredients that did not require cosolubilization, including MAP (0.1%) and UN I NONTAN-U34M R (3%), were added to the composition. A final mixing step was carried out.
Example 4: Effect of Lightening Agents The lightening composition was prepared as in Example 2. Samples of the composition were stored for 4 weeks at different temperatures to determine the temperature stability of the composition. The storage temperatures were 5 ° C, 25 ° C,
38 ° C and 45 ° C. The compositions were applied to MELANODERM ™, which was incubated for three days, changing the medium each day. At the end of the incubation, the cream was removed and the MELANODERMM R was rinsed. Then MELANODERMM R was stained with L-DOPA to measure the tyrosinase activity. The MELANODERM ™ was washed with PBS, fixed for 1 5 minutes with 1.0% formalin, incubated with 0.1% L-DOPA for 1 hour, incubated with 0.1% fresh L-DOPA for 4 hours, and post-treated. -fixed with 1.0% formalin. Qualitative conclusions were made regarding the effectiveness of the bleaching agent by visual inspection under a microscope. The quantitative evaluations were based on the extraction of melanin and "OD" optical density readings. Melanin was extracted from M ELANODERM ™ by soaking M ELANODERM ™ in 2.0 M NaOH (500 ml) at 80 ° C for 10 hours, and then at 60 ° C for 24 hours. The sample was then centrifuged and transferred to a ELI SA planer. The OD was measured in a microplate reader to determine the amount of melanin in the sample. The percent inhibition was calculated for each sample, by comparing the readings of the samples with those of their respective control with the same base composition. The percent inhibition is calculated using the following formula:
100 -. 100 - Sample IOD x1 00". Control lOD)
TABLE 5: Effect of clarification agents
These data show that the combination of MAP and U NI NONTAN- U3434 (essential formulation of cucumber extract and lemon extract) provides effective skin lightening effects and is also quite stable at room temperature. As it is known that MAP has significant stability problems, this combination remains remarkably stable after 4 weeks. Only at very high temperatures, 45 ° C, the composition of MAP and U N I NONTAN-U3434 (essential formulation of cucumber extract and lemon extract) begins to lose effectiveness. Additionally, these results show the increased efficacy available with the unique combination of MAP and U N I NONTAN-U3434 (essential formulation of cucumber extract and lemon extract). Although illustrative embodiments of the invention have been described and enclosed, it is understood, of course, that various modifications will be apparent to those of ordinary skill in the art.
Claims (9)
1 . A bleaching cosmetic composition comprising a derivative of vitamin C and an essential formulation including cucumber extract and lemon extract. The cosmetic composition of claim 1, wherein the vitamin C derivative is an ascorbyl phosphate of an alkali metal, an alkaline earth metal or a transition metal. 3. The composition of claim 1, wherein the vitamin C derivative is magnesium ascorbyl phosphate (MAP). 4. The cosmetic composition of claim 1, wherein the cucumber extract and the lemon extract are added as a mixture with the following percentages of each ingredient: cucumber extract (5.0%) and lemon extract (16.0%) ). 5. The cosmetic composition of claim 3, wherein the cucumber extract and the lemon extract are added to a product, an essential formulation. 6. The cosmetic composition of claim 5, wherein the MAP is at a concentration from 0.05 to 10%. The cosmetic composition of claim 5, wherein the essential formulation is at a concentration of 0.5 to 10%. 8. The cosmetic composition of claim 5, wherein the MAP is at a concentration of 3%. 9. The cosmetic composition of claim 5, wherein the MAP is at a concentration of 0. 1%. 1 0. The cosmetic composition of claim 5, wherein the essential formulation is at a concentration of 5%. eleven . The cosmetic composition of claim 5, wherein the essential formulation is at a concentration of 3%.
2. The cosmetic composition of claim 7, wherein the pH of the composition is between 6 and 7.5.
3. A method for treating hyperpigmentation comprising applying the cosmetic composition of claim 1 and repeating the application on a regular basis. 1
4. The method of claim 9, wherein the application is repeated every day. SUMMARY The present invention is directed to cleansing cosmetic compositions for the treatment of hyperpigmentation. These compositions comprise two lightening ingredients: magnesium ascorbyl phosphate and UN I NONTAN-U3434 (essential formulation of cucumber extract and lemon extract). These two ingredients do not interfere with one another, and instead provide increased clarification capabilities for these compositions.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US60/080,180 | 1998-03-31 |
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MXPA00009595A true MXPA00009595A (en) | 2002-03-26 |
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