MXPA00006735A - Container for an inhalation anesthetic - Google Patents

Abstract

A pharmaceutical product. The pharmaceutical product includes a container constructed from a material containing one or more of polypropylene, polyethylene, and ionomeric resins. The container defines an interior space. A volume of a fluorether-containing inhalation anesthetic is contained in the interior space defined by the container.

Description

RECI PIENTE FOR AN ES ESTÉSICO OF IN HALACIÓN BACKGROUND OF THE INVENTION The present invention relates to a container for an inhalation anesthetic and a method for storing an inhalation anesthetic. In particular, the present invention is directed to a container constructed of a material that provides a barrier to the transmission of vapor through a wall of the container and that is not reactive with an inhalation anesthetic contained therein. Fluoroether inhalation anesthetics, such as sevoflurane (fluoromethyl-2, 2,2-trifluoro-1- (tri fluoromethyl) ethyl ether), enflurane (2-chloro-1,1,2-trifluoroethyl difluoromethyl ether), isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether), methoxyflurane (2,2-dichloro-1,1-difluoroethyl methyl ether) and desflurane (2-difluoromethyl-1,2,2,2-tetrafluoroethyl ether) They are normally distributed in glass containers. Although these fluoroether agents have been shown to be excellent anesthetic agents, it has been found that under certain conditions, the fluoroether agent and the glass container can interact, thereby facilitating the degradation of the fluoroether agent. It is believed that this interaction results from the presence of Lewis acids in the glass container material. The Lewis acids have an empty orbital, which can accept an unshared pair of electrons, and thus provide a potential site for reaction with the alpha fluoroether portion (-C-O-C-F) of the fluoroether agent. The degradation of these fluoroether agents in the presence of a Lewis acid can result in the production of degradation products, such as hydrofluoric acid. The glassware currently used to contain these fluoroether agents is referred to as Type ll glass. This material contains silicon dioxide, calcium hydroxide, sodium hydroxide and aluminum oxide. The Type l l l glass provides a barrier to the transmission of vapor through the wall of the container, thereby preventing the transmission of the fluoroether agent through the same and preventing the transmission of other vapors to the container. However, alumium oxide containing in glass materials, such as type ll glass, tends to act as Lewis acid when exposed directly to the fluoroether agent, thereby facilitating the degradation of the fluoroether agent. The degradation products produced by this degradation, for example, hydrofluoric acid, can etch the interior surface of the glass container, thereby exposing additional amounts of aluminum oxide to the fluoroether compound, and thereby facilitating further degradation of the fluoroether compound. In some cases, the resulting degradation products may compromise the structural integrity of the glass container. Efforts have been made to inhibit the reactivity of glass to various chemicals. For example, it has been found that treating glass with sulfur will protect the glass material in some cases. However, it will be appreciated that the presence of sulfur on the surface of a glass container is not acceptable in many applications.

Additionally, glass containers have a breaking concern. For example, glass containers may break when they fall or are otherwise subjected to sufficient force, either in use or during boarding and handling. Such a rupture may cause medical and incidental personnel to be exposed to the contents of the glass container. In this regard, anesthetic inhalation agents evaporate rapidly. In this way, if the glass container contains an inhalation anesthetic, such as sevoflurane, the breaking of the container may necessitate evacuation of the area immediately surrounding the broken container, for example, an operating room and medical department. Efforts to resolve breakage concerns have usually involved coating the exteriornon-contact surfaces of the glass product with polyvinyl chloride (PVC) or synthetic thermoplastic resin, such as, Surlyn® (a registered trademark of E. I. Du Pont De Nemours and Company). These efforts increase the cost of the containers, are not aesthetically pleasing, and do not overcome the problems discussed above related to degradation, which can occur when glass is used to contain inhalation anesthetics containing fluoroether. For these reasons, it is desirable to provide a container constructed of a material other than glass, for the purpose of storing, transporting and dispensing inhalation anesthetics, thereby avoiding the aforementioned disadvantages of glass. The preferred material does not contain Lewis acids, which can promote the degradation of the anesthetic inhalation agent, provide a sufficient barrier for the transmission of vapor into and out of the container and increase the resistance of the container to breaking in relation to the glass container. .

Brief description of the invention The present invention is directed to a pharmaceutical product. The product includes a container constructed of a material containing one or more of polypropylene, polyethylene and ionomer resins. The container defines an interior space, in which a volume of an inhalation anesthetic containing fluoroether is contained. In an alternative embodiment, the present invention is directed to a pharmaceutical product, in which a container defining an interior space has an interior surface adjacent to the interior space. The interior surface of the container is constructed of a material containing one or more of polypropylene, polyethylene and ionomer resins. A volume of inhalation anesthetic containing fluoroether is contained in the interior space of the container. The present invention is further directed to a method for storing an inhalation anesthetic. The method includes the step of providing a predetermined volume of an inhalation anesthetic containing fluoroether. A container is also provided, the container being constructed of a material containing one or more of polypropylene, polyethylene and ionomer resins. The container defines an interior space. The predetermined volume of inhalation anesthetic containing fluoroether is placed in the interior space of the container.

In an alternative embodiment of the method of the present invention, a predetermined volume of an inhalation anesthetic containing fluoroether is provided. In addition, a container is provided having an interior surface defining an interior space. The interior surface of the container is constructed of a material containing one or more of polypropylene, polyethylene and ionomer resins. The predetermined volume of an inhalation anesthetic containing fluoroether is placed in the interior space of the container.

BRIEF DESCRIPTION OF THE DRAWINGS For a more complete understanding of the present invention, reference may be made to the following Detailed Description, read in connection with the accompanying drawing, in which: FIG. 1 is a cross-sectional view of a pharmaceutical product constructed in accordance with the present invention.

DETAILED DESCRIPTION A pharmaceutical product constructed in accordance with the present invention is generally indicated in FIG. 1 . The pharmaceutical product 1 0 includes a container 1 2 having an inner surface 14. The inner surface 14 defines an interior space 16 within the container 12. In a preferred embodiment of the present invention, the inhalation anesthetic 1 8 contains a compound of fluoroether. The fluoroether containing inhalation anesthetics useful in connection with the present invention include, but are not necessarily limited to, sevoflurane, enflurane, isoflurane, methoxyflurane and desflurane. The inhalation anesthetic 1 8 is a fluid, and may include a liquid phase, vapor phases, or both liquid and vapor phases. FIG. 1 shows the inhalation anesthetic 1 8 in a liquid phase. The purpose of the container 12 is to contain the inhalation anesthetic 1 8. In the embodiment of the present invention shown in FIG. 1, the container 12 is in the shape of a bottle. However, it will be appreciated that the container 12 may have a variety of configurations and volumes without departing from the spirit and scope of the present invention. For example, the container 1 2 can be configured as a shipping container for large volumes (eg, tens or hundreds of liters) of inhalation anesthetic 1 8. Such shipping containers can be of rectangular, spherical or oblong cross section, without departing from the intended scope of the invention. The container 1 2 is preferably constructed of a material that minimizes the amount of steam transmission in and out of the container 1 2., thereby minimizing the amount of inhalation anesthetic 1 8 that is released from the interior space 16 of the container 12, and thereby minimizing the amount of vapor transmission, eg, water vapor transmission, from an external environment of the container 1 2 towards the interior space 16, and thus towards the inhalation anesthetic 1 8. The container 12 is also preferably constructed of a material that does not facilitate the degradation of inhalation anesthetic 18. In addition, the container 12 is constructed , preferably, of a material that minimizes the potential for breaking of the container 12 during storage, shipping and use.

It has been found that containers constructed of a material containing polyethylene naphthalate provide the vapor barrier, the chemical interaction and desired strength characteristics, when used with inhalation anesthetics. 1 8. Someone of ordinary skill will appreciate that there are many types different from polyethylene naphthalate polymers, which vary in their molecular weight, additives and naphthalate content. These polymers can be categorized into three distinct groups, namely homopolymers, copolymers and mixtures. It has been found that polyethylene naphthalate homopolymers provide greater barriers to vapor transmission when compared to copolymers and blends. For this reason, it is preferable that the material from which container 1 2 of the present invention is constructed, contains a homopolymer of polyethylene naphthalate. However, it will be appreciated that certain copolymers and blends of polyethylene naphthalate can be used in connection with the present invention, provided that they provide an adequate barrier to the transmission of vapors, eg, vapors of inhalation anesthetic and water, through it. , and provided that they provide the desired strength and non-reactivity to the inhalation anesthetic 1 8. In addition to the desirable vapor barrier characteristics of polyethylene naphthalate-containing materials, polyethylene naphthalate does not contain Lewis acids, and therefore does not presents any threat to facilitate the degradation of an inhalation anesthetic containing fluoroether contained in a container constructed therefrom.

An example of a polyethylene naphthalate material useful in connection with the present invention is the HiPERTUFM® 90000 polyester resin (trademark of Shell Chemical Company), a polyethylene naphthalate based on 2,6-dimethyl naphthalate. One of ordinary skill will appreciate that other polyethylene naphthalates can be used without departing from the scope of the invention set forth in the appended claims. In a first embodiment of the present invention, the container 12 is constructed of a single layer of material. That is, the container 1 2 is substantially homogeneous through its thickness. In this embodiment, as discussed above, the container 12 is constructed of a material containing polyethylene naphthalate. In an alternative embodiment of the present invention, the container 12 is multi-laminar. As used herein, the term "multi-laminar" is intended to include (i) materials constructed of more than one sheet, wherein at least two of the sheets are constructed of different materials, ie, materials that are chemically or structurally different, or materials having different performance characteristics, wherein the sheets are joined to one another, or are aligned with each other in another manner, in order to form a single sheet; (ii) materials that have a coating of a different material; (iii) materials having a coating associated therewith, the coating of a different material being constructed; and (v) known variations of any of the foregoing. In this alternative embodiment of the present invention, the inner surface 14 of the container 12 is constructed, preferably of a material containing polyethylene naphthalate. It will be appreciated that the container surface 14 in contact with an inhalation anesthetic containing fluoroether contained therein will preferably contain polyethylene naphthalate in order to provide the desired vapor barrier characteristics and simultaneously minimize the likelihood of anesthetic degradation. of inhalation containing fluoroether. In an alternative embodiment of the present invention, the container 12 is constructed of a material containing polymethylpentene. In a preferred embodiment, polycylmethylpentene is used. An example of a polymethylpentene material useful in connection with the present invention is "Daikyo Resin CZ", which is manufactured and distributed by Daikyo (Pharma-Gummí / West Group) This is a polyclomethylpentene material Alternatively, the inner surface 14 of the container 1 2 is constructed of a polymethylpentene-containing material In this alternative embodiment, the inner surface 14 may be in the form of (i) a coating placed within a body defined by a different material, for example, glass; or (i) a coating applied to a body defined by a different material; or (iii) a layer of a multi-laminar material, as discussed above with respect to polyethylene naphthalate. In a second alternative embodiment of the present invention, the container 1 2 is constructed of a material containing one or more of polypropylene, polyethylene and ionomer. Alternatively, the inner surface 14 of the container 1 2 is constructed of a material containing one or more of polypropylene, polyethylene and ionomeric resins, such as an S U RLYN® ionomer resin, manufactured by DuPont. As used herein, the term "ionomeric resin" refers to a thermoplastic polymer that is ionically crosslinked. In this alternative embodiment, the inner surface 1 4 may be in the form of (i) a coating placed within a body defined by a different material, e.g., glass; or (ii) a coating applied to a body defined by a different material; or (iii) a layer of a multi-laminar material, as discussed above, with respect to polyethylene naphthalate. One of ordinary skill in the art will appreciate that a coating can be applied to an interior surface of the container 12, using a variety of known techniques. The preferred technique will vary depending on (i) the material from which the container 12 is made; and (ii) the coating material being applied to the container 12. For example, if the container 1 2 is constructed of a known glass material, a coating can be applied to the interior surface of the container 12 upon heating the container 1 2. to at least the melting point of the coating material being applied thereto. The coating material is then applied to the heated container 1 2, using a variety of known techniques, for example, by atomizing the coating material on the interior surface. The vessel 12 is then allowed to cool to a temperature below the melting point of the coating material, thereby causing the coating material to form a simple, non-rotating film or layer, i.e., the inner surface. As shown in FIG. 1, the container 12 defines an opening 20. The opening 20 facilitates the filling of the container 12 and provides access to the contents of the container 12, thereby allowing the contents to be removed from the container 1 2 when needed. In the embodiment of the present invention shown in FIG. 1, opening 20 is the mouth of a bottle. However, it will be appreciated that the opening 20 may have a variety of known configurations without departing from the scope of the present invention. The lid 22 is constructed to fluidly seal the opening 20, thereby fluidly sealing the inhalation anesthetic 1 6 within the container 12. The lid 22 can be constructed from a variety of known materials. However, it is preferable that the lid 22 be constructed of a material that minimizes the transmission of vapor therethrough and that minimizes the likelihood of degradation of the inhalation anesthetic 1 6. In a preferred embodiment of the present invention, the Top 22 is constructed of a material containing polyethylene naphthalate. In an alternative embodiment of the present invention, the lid 22 has an interior surface 24 that is constructed of a material containing polyethylene naphthalate. In another alternative embodiment of the present invention, the lid 22, and / or inner surface 24 thereof, is constructed of a material containing polypropylene, polyethylene and / or ionomer, the material having sufficient vapor barrier characteristics to minimize the transm ission of water vapor and anesthetic vapor through the same. Still in another alternative embodiment of the present invention, the lid 22 and / or inner surface 24 thereof, is constructed of polypropylene, polyethylene, polyethylene naphthalate, polymethylpentene, ionomer resins and combinations thereof. As discussed above with respect to the container 1 2, the lid 22 may be homogeneous, or it may be multi-laminar in nature. The lid 22 and the container 1 2 can be constructed so that the lid 22 can be secured by means of a thread to the same. Containers and lids of this type are well known. Alternative embodiments of the lid 22 and the container 12 are also possible and will immediately be recognized by those of ordinary skill in the relevant art. Such alternative embodiments include, but are not necessarily limited to, caps that can be "snapped" into containers, caps that can be secured with adhesive to containers, and caps that can be secured to containers using known mechanical devices, for example, a ferrule. In the preferred embodiment of the present invention, the lid 22 and the container 1 2 are configured so that the lid 22 can be removed from the container 12 without causing permanent damage to either the lid 22 or the container 12, thereby allowing a user resets the opening 20 with the lid 22, after the desired volume of inhalation anesthetic 1 8 has been removed from the container 12. The container 12 may include additional features that are not part of the present invention. For example, the container 12 can be configured to include a system for dispensing inhalation anesthetic 18 from the container 12 into an anesthetic vaporizer. U.S. Patent No. 5, 505,236 for Grabenkort describes such a system.

Methods for making containers of the type used in the present invention are known in the art. For example, it is known that polyethylene naphthalate should be dried at a moisture level of about 0.005% before processing, in order to produce the optimum physical properties in container 12 and lid 22. A preferred method of making containers 12 and lids 22 useful in connection with the present invention, bring about the injection-blow-elongation molding of a material containing polyethylene naphthalate. Machines manufactured by AOKI Technical Laboratory, Inc. of Tokyo, Japan, are particularly useful for performing this molding operation. The material containing polyethylene naphthalate is injection molded into a preform, which is then transferred to a blowing station, where it is elongated and blown to form the container. The container is then heated by batch and tempered in a convection oven. It has been found that tempering a material containing polyethylene naphthalate increases the degree of crystallization in the material to a level not achievable using a blow molding process alone. The increased crystallization results in a greater barrier to vapor transmission, thereby intensifying the performance characteristics of the vapor barrier of a container 12 constructed of a tempered material containing polyethylene naphthalate. The increased crystallization also reduces the overall weight of the container 1 2 (based on the weight required to achieve a selected container force) and the amount of material required to achieve a given container force for the container 1 2. The container force Increased allows a container to support higher loads during shipping, storage and use, thereby minimizing container breakage. For example, greater strength of the container is desirable when placing the containers 1 2 on top of each other, as may occur when the containers 1 2 or cartons or pallets of containers 12, are stacked for shipping or storage. It should be noted that a container constructed of a material containing a tempered polyethylene naphthalate weighs less than a glass container having comparable strength characteristics, is less susceptible to breakage than a glass container of comparable weight, and its manufacture costs less than a glass container with comparable performance characteristics. A smaller container weight also reduces the costs associated with shipping, such as, containers. In addition, such a container does not exhibit the potential for degradation of an inhalation anesthetic containing fluoroether that is present with a glass container. The method of the present invention includes the step of providing a predetermined volume of an inhalation anesthetic containing fluoroether 16. The inhalation anesthetic containing fluoroether 16 can be one or more of sevoflurane, enflurane, isoflurane, methoxyflurane and desflurane. A container 12 constructed in accordance with the pharmaceutical product described above is also provided. In particular, the container 12 defines an interior space and is constructed of a material containing polyethylene naphthalate, wherein the polyethylene naphthalate is present on the inner surface 14 of the container 1 2, either as a result of the characteristics of homogeneous material of the container 12, or as a result of the inner surface 14 of a multi-laminar material being constructed of polyethylene naphthalate, as discussed above. The method of the present invention further includes the step of placing the predetermined volume of inhalation anesthetic containing fluoroether 16 in the interior space defined by the container. In an alternative embodiment of the method of the present invention, a predetermined volume of an anesthetic and inhalation containing fluoroether 1 is provided. The inhalation anesthetic containing fluoroether 16 may be one or more of sevoflurane, enflurane, isoflurane, methoxyflurane and desflurane. Also provided is a container 1 2 constructed in accordance with the product described above. In particular, the container 12 defines an interior space and is constructed of a polymethylpentene-containing material, wherein the polymethylpentene is present on the inner surface 14 of the container 1 2, either as a result of the homogeneous material characteristic of the container 1 2, or as a result of inner surface 14 of a multi-lam material being constructed of polymethylpentene, as discussed above. The method further includes the step of placing the predetermined volume of inhalation anesthetic containing fluoroether in the interior space defined by the container. In another alternative embodiment of the method of the present invention, a predetermined volume of an inhalation anesthetic containing fluoroether 16 is provided. The inhalation anesthetic containing fluoroether 16 may be one or more of sevoflurane, enflurane, soflurane, methoxyflurane and desflurane. Also provided is a container 12 constructed in accordance with the product described above. In particular, the container 1 2 defines an interior space 16 and is constructed of a material containing one or more of polypropylene, polyethylene and ionomer resins, wherein the declared material or materials are present on the inner surface 14 of the container 1 2, either as a result of the homogeneous material characteristic of the container 12, or as a result of the inner surface 14 of a multi-lam material being constructed of one of the materials referred to, as discussed above. The method further includes the step of placing the predetermined volume of an inhalation anesthetic containing fluoroether 1 6 in the interior space defined by the container. It will be appreciated that the container 12, and the inner surface 14 thereof, can be constructed of more than one of the aforementioned materials. In each of the embodiments of the method of the present invention, the container 1 2 can define an opening 20 therein, provided the fluid communication opening 20 between the interior space 16 of the container 12 and an external environment of the container 1 2. Each of the embodiments of the present invention may further include the step of providing a lid 22 constructed of a material containing one or more of: polypropylene, polyethylene, an ionomeric resin, polyethylene naphthalate and polymethylpentene. In the alternative, the lid 22 can be constructed so that an inner surface thereof is constructed of a material containing one or more of: polypropylene, polyethylene, an ionomer resin, polyethylene naphthalate and polymethylpentene. The method of the present invention further includes the step of sealing the opening defined by the container 12 with the lid 22. Although the pharmaceutical and the method of the present invention have been described herein with respect to certain preferred embodiments, it will be evident for one of ordinary skill in the art that various modifications to the invention may be made without departing from the spirit and scope of the invention described herein, as claimed in the appended claims.

Claims (9)

REVIVALATION IS

1 . An inhalation anesthetic product comprising: a container constructed of a material comprising a compound selected from the group consisting of polyethylene naphthalate, polymethylpentene, polypropylene, polyethylene, ionomer resins and combinations thereof, said container defining an interior constructed space to contain therein, external to a patient's body, an inhalation anesthetic; and a volume of sevolfuran contained in said interior space defined by said container.

2. An inhalation anesthetic product according to claim 1, wherein said container defines an opening therein, said opening providing fluid communication between said interior space defined by said container and an external environment of said container, further comprising said inhalation anesthetic product a lid, said lid is constructed to seal said defined opening in said container, said lid comprising a material comprising a compound selected from the group consisting of polypropylene, polyethylene, polyethylene naphthalate, polimethylpentene, ionomer resins and combinations thereof. 3. An inhalation anesthetic product according to claim 1, wherein said container defines an opening therein, said fluid communication opening provided between said interior space defined by said container and an external environment of said container, further comprising said inhalation anesthetic product a lid having an inner surface, said lid is constructed to seal said defined opening in said container, said inner surface of said lid constructed of a material comprising a compound selected from a group consisting of polypropylene, polyethylene, polyethylene naphthalate, polymethylpentene, ionomeric resins and combinations thereof. 4. An inhalation anesthetic product comprising: a container defining an interior space constructed to contain therein, external to a patient's body, an inhalation anesthetic, said container having an interior surface adjacent to said interior space, said inner surface is constructed of a material comprising a compound selected from a group consisting of polyethylene naphthalate, polymethylpentene, polypropylene, polyethylene, ionomer resins and combinations of the same; and a volume of sevoflurane contained in said container. 5. An inhalation anesthetic product according to claim 4, wherein said container defines an opening therein, said opening providing fluid communication between said interior space defined by said container and an external environment of said container, further comprising said inhalation anesthetic product a lid, said lid is constructed to seal said defined opening in said container, said lid comprising a material comprising a compound selected from the group consisting of polypropylene, polyethylene, polyethylene naphthalate, polymethylpentene, ionomer resins and combinations thereof. 6. An inhalation anesthetic product according to claim 4, wherein said container defines an opening therein, said fluid communication opening provided between said interior space defined by said container and an external environment of said container, further comprising said inhalation anesthetic product a lid having an inner surface, said lid is constructed to seal said defined opening in said container, said inner surface of said lid constructed of a material comprising a compound selected from a group consisting of polypropylene, polyethylene, polyethylene naphthalate, polymethylpentene, ionomer resins and combinations thereof. 7. A method for storing an external inhalation anesthetic to a patient's body, said method comprising the steps of: providing a predetermined volume of sevoflurane; providing a container defining an interior space, said container being constructed of a material comprising a compound selected from the group consisting of polyethylene naphthalate, polymethylpentene, polypropylene, polyethylene, ionomer resins, and combinations thereof; placing said predetermined volume of sevoflurane in said interior space defined by said container. A method for storing an anesthetic agent according to claim 7, wherein said container defines an opening therein, said opening providing fluid communication between said interior space defined by said container and an external environment of said container, said method further comprising the steps of: providing a lid constructed to seal said opening defined by said container, said lid is constructed of a material comprising a compound selected from a group consisting of polypropylene, polyethylene, polyethylene naphthalate, polymethylpentene, resins ionomeric and combinations thereof; and sealing said defined opening in said container with said lid. A method for storing an anesthetic agent according to claim 7, wherein said container defines an opening therein, said opening providing fluid communication between said interior space defined by said container and an external environment of said container, said method further comprising the steps of: providing a lid constructed to seal said opening defined by said container, said lid having an inner surface constructed of a material comprising a compound selected from a group consisting of polypropylene, polyethylene, polyethylene naphthalate, polymethylpentene, ionomeric resins and combinations thereof; and sealing said defined opening in said container with said lid. 1 0. A method for storing an inhalation anesthetic, said method comprising the steps of: providing a predetermined volume of sevoflurane; providing a container defining an interior space, said container having an interior wall adjacent to said interior space defined by said container, said interior wall of said container being constructed of a material comprising a compound selected from a group consisting of polyethylene naphthalate , polymethylpentene, polypropylene, polyethylene, ionomer resins and combinations thereof; and placing said predetermined volume of said inhalation anesthetic containing fluoroether in said interior space defined by said container. eleven . A method for storing an anesthetic agent according to claim 10, wherein said container defines an opening therein, said opening providing fluid communication between said interior space defined by said container and an external environment of said container, further comprising said method the steps of: providing a lid constructed to seal said opening defined by said container, said lid is constructed of a material comprising a compound selected from a group consisting of polypropylene, polyethylene, polyethylene naphthalate, polymethylpentene, ionomer resins and combinations thereof; and sealing said defined opening in said container with said lid. A method for storing an anesthetic agent according to claim 10, wherein said container defines an opening therein, said opening providing fluid communication between said interior space defined by said container and an external environment of said container, said method further comprising the steps of: providing a lid constructed to seal said opening defined by said container, said lid having an interior surface constructed of a material comprising a compound selected from a group consisting of polypropylene, polyethylene, polyethylene naphthalate , polymethylpentene, ionomeric resins and combinations thereof; and sealing said defined opening in said container with said lid.

3. An inhalation anesthetic product comprising: a container constructed of a material comprising polyethylene naphthalate, said container defining an interior space constructed to contain therein, external to a patient's body, an inhalation anesthetic; and a volume of sevoflurane contained in said interior space defined by said container. 1

4. An inhalation anesthetic product comprising: a container constructed of a material comprising polymethylpentene, said container defining an interior space constructed to contain therein, external to a patient's body, an inhalation anesthetic; and a volume of sevoflurane contained in said interior space defined by said container. 1

5. A product of inhalation anesthetic comprising: a container constructed of a material comprising polypropylene, said container defining an interior space constructed to contain therein, external to a patient's body, an inhalation anesthetic; and a volume of sevoflurane contained in said interior space defined by said container. 1

6. An inhalation anesthetic product comprising: a container constructed of a material comprising polyethylene, said container defining an interior space constructed to contain therein, external to a patient's body, an inhalation anesthetic; and a volume of sevoflurane contained in said interior space defined by said container.

7. An inhalation anesthetic product comprising: a container constructed of a material comprising ionomeric resins, said container defining an interior space constructed to contain therein, external to a patient's body, an inhalation anesthetic; and a volume of sevoflurane contained in said interior space defined by said container. SUMMARY A pharmaceutical product The pharmaceutical product includes a container constructed of a material containing one or more of polypropylene, polyethylene and ionomer resins. The container defines an interior space. A volume of an inhalation anesthetic containing fluoroether is contained in the interior space defined by the container.