MXPA00005424A - Minoxidil-containing liquid preparation composition - Google Patents
Minoxidil-containing liquid preparation compositionInfo
- Publication number
- MXPA00005424A MXPA00005424A MXPA/A/2000/005424A MXPA00005424A MXPA00005424A MX PA00005424 A MXPA00005424 A MX PA00005424A MX PA00005424 A MXPA00005424 A MX PA00005424A MX PA00005424 A MXPA00005424 A MX PA00005424A
- Authority
- MX
- Mexico
- Prior art keywords
- minoxidil
- amino acid
- liquid composition
- composition according
- liquid preparation
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Loniten Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 title claims abstract description 24
- 229960003632 Minoxidil Drugs 0.000 title claims abstract description 24
- 150000001413 amino acids Chemical class 0.000 claims abstract description 23
- XOAAWQZATWQOTB-UHFFFAOYSA-N Taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 229960003080 Taurine Drugs 0.000 claims description 7
- 125000004432 carbon atoms Chemical group C* 0.000 claims description 4
- 229940058015 1,3-butylene glycol Drugs 0.000 claims description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N butylene glycol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 239000011593 sulfur Substances 0.000 claims description 2
- 238000002845 discoloration Methods 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 description 15
- 230000000694 effects Effects 0.000 description 6
- 239000003960 organic solvent Substances 0.000 description 6
- 230000003698 anagen phase Effects 0.000 description 5
- 230000003779 hair growth Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 210000003491 Skin Anatomy 0.000 description 3
- 238000004043 dyeing Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- -1 taurine Chemical class 0.000 description 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229960002433 Cysteine Drugs 0.000 description 1
- 229960003067 Cystine Drugs 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine zwitterion Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 description 1
- 229960004452 Methionine Drugs 0.000 description 1
- 239000004698 Polyethylene (PE) Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 210000003625 Skull Anatomy 0.000 description 1
- 241000536399 Tina Species 0.000 description 1
- 239000003655 absorption accelerator Substances 0.000 description 1
- 230000003110 anti-inflammatory Effects 0.000 description 1
- 230000001139 anti-pruritic Effects 0.000 description 1
- 230000003078 antioxidant Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004526 pharmaceutical effect Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propanol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
Abstract
A liquid preparation composition comprising minoxidil and an amino acid, which is excellent in marketability because it can beprevented from undergoing discoloration with the lapse of time, unlike conventional minoxidil-containing liquid preparations.
Description
LIQUID COMPOSITION CONTAINING MINOXIDYL
TECHNICAL FIELD The present invention relates to a liquid composition containing minoxidil which is prevented from tining over time. BACKGROUND OF THE TECHNOLOGY Minoxidil is a component used as an external hair growth agent because it has an effect on hair growth. However, minoxidil, when stored in a liquid state, has a setback in a tendency to stain with time, and thus results in a decrease in the value of the merchandise. The coloring mechanism of the liquid preparation that contains noxidium does not necessarily become clear, but it is presumed that this is due to light. Therefore, it is necessary to use shaded containers for the commercialization of the liquid preparation containing minoxidil. However, these containers are inconvenient for their use, for example, in that the residual content in the containers is not clear.
Generally, the liquid preparation containing the component that tends to be dyed is improved in a combination with an antioxidant or an anti-smoldering agent, however, this combination is insufficient in an effect to prevent the liquid preparation containing minoxidil which is time. ~~ On the other hand, in order to avoid the outstanding color when a preparation is dyed, is that the preparation is allowed to be tina from the beginning. However, since the preparation of hair growth is used through the application on the skull, the preparation that is allowed to be washed from the beginning is unpleasant because it stains clothing or bedding. SUMMARY OF THE INVENTION "As a result of various investigators in order to prevent the liquid preparation containing minoxidil from being tinted, the present inventor has found that a liquid preparation containing minoxidil can surprisingly prevent it from being tinted through a combination with an amino acid, particularly taurine, being that the present invention has been achieved.This is that, the present invention is directed to a liquid composition containing minoxidil and an amino acid ~ According to the present invention, the amino acid refers to any amino acid that can be contained in external liquid preparations, and that includes a salt for this Among the amino acids in the present invention, in view of the prevention of the effect of dyeing, sulfur-containing amino acids are preferably found (for example taurine, cysteine , cystine, methionine or homocysteine) and especially taurine. liquid composition of the present invention, a combination preferably of minoxidil is in the order of 0.1 to 5% by weight based on the liquid preparation. In the case of less than 0.1% by weight, the hair growth effect of the minoxidil is weak, and in the case of more than 5% by weight, it is difficult to design the preparation In accordance with the present invention, as long as there is A higher amount of amino acid is expected to be greater than the color-preventing effect of a liquid preparation, but a preferred amount of the amino acid is 0.01 to 20 parts by weight per 1 part by weight of minoxidil. for the preferred preparation in the liquid composition of the present invention is an aqueous organic solvent, because the amino acid can not be dissolved only in an organic solvent, although minoxidil can not be dissolved in water only. order of 10 to 50 V / V% It is necessary for the organic solvent used here that has the ability to mix homogeneously with water and not cause an adverse effect on the the skin when used as an external preparation for the skin. With this view, preferred examples of organic solvent are an alcohol having 1 to 6 carbon atoms (eg, ethanol, propanol, isopropanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, glycerol, etc.), and particularly the solvents are preferably one or more of the members selected from the group consisting of ethanol, propylene glycol and 1,3-butylene glycol.
According to the present invention, in view of the prevention of dyeing, the liquid preparation is preferably adjusted to a pH of 4-9, when diluted to 20 folds with purified water. The present invention makes it possible for a storage container of a liquid composition containing minoxidil to be drawn from any of the containers used for an ordinary liquid preparation, but the preferred materials of the container are PET, glass, polyethylene, polypropylene , etc. The liquid preparation of the present invention can be produced by an ordinary method to produce a liquid preparation, however, when the amino acid is combined, preferably it is a method where a solution of the amino acid that was previously dissolved in water is mixed with a organic solvent, because it takes more time to dissolve the amino acid in an aqueous organic solvent subsequently, in view of the dissolution rate of the amino acid. ~~~ The liquid preparation of the present invention can contain any of the components that are generally used for external liquid preparations (eg solubilizers, thickeners, absorption accelerators, pH regulators, etc.). According to the present invention, the prevention effect on the dyeing of the preparation is recognized through a combination with the amino acid, and in addition it is expected to exert the pharmaceutical effect originally possessed by the amino acid (anti-inflammatory action, decrease action of irritation of the skin, antipruritic action, etc.) at the same time. BEST MODE FOR CARRYING OUT THE INVENTION The present invention is illustrated in greater detail through the following example and experiments. Example 1 One gram of minoxidil, 0.04 grams of taurine, 10 grams of propylene glycol, 60 grams of ethanol and purified water were dissolved with stirring to obtain 100 ml of the total volume of the volume, in this way a liquid preparation was obtained. Comparative Example 1 Following the same procedure as in Example 1 using the same formulation except for taurine, a comparative liquid preparation was obtained Experiment 1 The liquid preparations obtained in Example 1 and Comparative Example 1 were each set in 3 clear glass bottles, and irradiated at room temperature with a light of 300 lux for 34 days.The absorbance was measured at the wavelength of 420 nm, 1 cm per cell length, at the beginning and at the end of the experiment The results are shown in Table 1. TABLE 1
Example 2 One gram of minoxidil, 0.1 g of taurine, 10 g of propylene glycol, 60 g of ethanol and purified water were dissolved with stirring to obtain 100 ml of the total volume, thereby obtaining an "liquid preparation." Experiment 2 - The liquid preparations obtained in Example 2 and Comparative Example 1 were each placed in a colorless glass bottle, and allowed to rest at room temperature next to a window to recieve the sunlight for 6 months. 30 days and at 6 months, 3 investigators who did not know the content of the liquid preparations judged the dye macroscopically, in addition, the absorbance of the wavelength of 420 nm, 1 cm of cell length was measured at the beginning and after of the 6 months of the experiment.The results are shown in Table 2. Table 2
INDUSTRIAL APPLICABILITY The present invention makes it possible to prevent a liquid preparation containing minoxidil from being tinted, and thus can be used commercially as an excellent preparation for hair growth.
Claims (10)
1. A liquid composition containing minoxidil and an amino acid.
2. The liquid composition according to Claim 1 wherein the amino acid is a sulfur-containing amino acid.
3. The liquid composition according to claim 1 wherein the amino acid is taurine.
4. The liquid composition according to claim 1, wherein the amount of amino acid is of the order of 0.01 to 20 parts by weight- per 1 part by weight of minoxidil.
5. The liquid composition according to any of Claims 1 to 4, wherein a solvent to be used in a mixture with water- and an alcohol has from 1 to 6 carbon atoms.
6. The liquid composition according to Claim 5, wherein the water content in the water mixture and the alcohol having 1 to 6 carbon atoms is from 10 to 50 v / v%. The liquid composition according to Claim 5, wherein the alcohol having 1 to 6 carbon atoms is one or more of the members selected from the group consisting of ethanol, propylene glycol and 1,3-butylene glycol. . 8. The liquid composition according to any of Claims 1 to 7, wherein the amount of minoxidil is from 0.1 to 5% per weight based on the entire preparation. 9. An agent to prevent the liquid composition containing minoxidil from being tinted, which contains an amino acid as an effective component. 10. A method for preventing a liquid composition containing minoxidil from being tinted comprises the addition of an amino acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9/333060 | 1997-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA00005424A true MXPA00005424A (en) | 2001-07-03 |
Family
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