MXPA00005088A - Antiperspirant or deodorant compositions - Google Patents

Abstract

Deodorant and antiperspirant compositions can suffer from perceived irritancy when applied topically, which can be ameliorated or overcome by incorporating within the composition borage seed oil, and especially an amount selected in the range of from 0.5 to 10 wt.%. The compositions advantageously comprise an aluminium or aluminium-zirconium active.

Description

ANTITRANSPIRANT OR DEODORANT COMPOSITIONS DESCRIPTION OF THE INVENTION The invention relates to compositions ant i t ran spi ran t e s or deodorants. In particular, it relates to compositions of antimicrobials or deodorants comprising borage seed oil. The antiperspirant market is referred to by products based on aluminum or zirconium salts which are intended to prevent, or at least control, transiration on the surface of the skin, particularly in the underarms, since they frequently provide a perceived degree of deodorant. In contrast, deodorants are formulations which are designed to hide odor or prevent their formation by reducing the local population of microorganisms. The antiperspirant and deodorant compositions are used in many product applications, for example, pellets, creams, sticks, aerosols, pumping sprinklers. However all applications suffer from a number of disadvantages as well.

A major disadvantage of many deodorants and antiperspirants is their unfavorable perception on the skin. More particularly, the presence of volatile carriers such as ethanol and volatile silicones, and of course the deodorants and the titranspirant actives are perceived as well as a multitude of other ingredients commonly used in deodorant and antiperspirant formulations that have a adverse effect, in particular an irritant effect, on the user's skin followed by the application. Irritation can be alleviated by decreasing the amount of an active ingredient in the composition or by reducing the penetration of the active substance through the skin. A serious disadvantage of both approaches is that efficiency is affected. Adverse effects discourage many consumers from using deodorants and antiperspirants, thus depriving the consumer of the benefits derived from such cosmetics. An object of the invention is to provide a composition having excellent deodorant or anti-oxidant performance, excellent cosmetic and aesthetic properties with reduced irritation or without irritation. European Patent Application 0416855 (Efamol) describes the treatment of skin damage due to radiotherapy with gamma linolenic acid (GLA) also teaches a variety of suitable plant sources of GLA, including Borage species. PCT application WO 90/07331 (Went) teaches the treatment of inflammation arising from arthritis or headache by local application of GLA; Borage seed is taught as an adequate source. European Patent Application 0173478 (Efamol) describes the treatment of skin flammable disorders with compositions containing GLA and glucocorticoids; Borage species such as B or r a go or f f i c i n a l e s are mentioned as a rich source of GLA. French Patent 2,704,390 (Boiron) discloses an oral supplement containing borage seed oil to provide anti-aging benefits to the skin, French Patent 2,604,624 (Parfums Rochas) discloses skin care compositions containing polyunsaturated carboxylic acids , such as GLA; It is said that borage is rich in GLA. U.S. Patent 5,445,822 (Braceo) describes cosmetic compositions containing polyunsaturated acids such as 1 GLA. British Patent 2,271,928 (Laing) describes the use of plant extracts from the borage family for the relief of skin disorders and irritations. Tollesson et al., "Transepidermal Water Loss and Water Content in the Stratum Corneum in Infatué Sebhorreic Dermatitis", Derm Venereol Act (Sweden), Feb. 1993, 73 (1), p. 18-20 describes the use of locally applied borage oil for the treatment of seborrheic dermatitis. Bahemer et al. , "Treatment of Atopic Dermatitis with Borage Seed Oil (Glandol) - A Time Series Analytic Study", Kinderarztl Prax (Germany), Oct. 1992, 60 (7), p. 199-202, describes the use of borage oil for the treatment of local dermatitis. The technique does not teach the use of GLA or borage seed oil to reduce the irritation or itching associated with the use of deodorants or antiperspirants. It was found that among the plant sources containing GLA, borage seed oil was particularly effective in relieving irritation and that this effect can not be attributed merely to the presence of GLA in borage seed oil. It was also found that borage seed oil was more effective than any other plant that does not contain GLA. Surprisingly, it has been found that borage seed oil can be incorporated into a cosmetic composition of anti-oxidant deodorant to produce a composition having attractive and improved cosmetic characteristics, expected from such compositions as well as excellent efficiency, low potential irritation and without stinging by the application. According to the invention there is provided a cosmetic deodorant composition or a n t i t r ansp r an t suitable for local application to human skin, comprising: i. an active deodorant or antiperspirant; ii. a carrier for the antiperspirant or deodorant active; and iii. borage seed oil. Wherein the formulation is an antiperspirant which commonly comprises 1-35% by weight of the composition of an antiperspirant active. Borage seed oil is obtained from the seeds of the borage plant, also known as Borago of fie ina 1 is L. (Bo ragi na ce ae), which is an annual herbaceous plant, native to Europe, Asia Minor and North Africa, naturalized in the United States. The oil seed contains two: gamma linolenic acid (GLA), -24% sterols (for example, peastrol and sitosterol), tocopherols, linoleic acid (-38%), oleic acid (-14.5-23%), palmitic acid (-4.7) %), amabilina, etc. See Whipkey et al., "In Vivo and In Vitro Lipid Accumulation in Borago officinalis L", JAOCS, 65 (6), 979-984 (1988); and Leung al., "Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics," 2nd ed. , John Wiley & Sons, Inc., New York (1996). The borage seed oil is used in accordance with the present invention to reduce or eliminate skin irritation and / or stinging caused by co-composing of the antiperspirant or deodorant composition according to the invention. The amount of borage seed oil in the inventive compositions generally ranges from at least 0.05%, preferably from 0.1% to 20%, more preferably from 0.5% to 10%. In some compositions it is convenient to use a concentration of up to 5% by weight as well as 0.5 to 1% by weight. An antiperspirant composition according to the invention comprises an antiperspirant active. Examples of suitable active ingredients include aluminum salts, zirconium salts, aluminum and / or zirconium complexes, for example aluminum halides, aluminum oxides of aluminum, zirconium oxyalides, hydrogen peroxide and zirconium oxides. and mixtures thereof. Specific examples include activated aluminum chlorohydrate, aluminum chlorohydrate, p e n a c 1 or r h i dr a t of aluminum and zirconium aluminum chlorihydrate. Useful zirconium salts include zirconium or zirconium and zirconium oxychloride. Other assets generally used will be known to those skilled in the art. Preferred assets include AAZG (Glycine of C i r coni or -Al umi n i o Activated), ZAG (Glycine Al uminoC i r conio) and AACH (Activated Aluminum Hydrochloride). The antiperspirant antimicrobial active may be present in the form of a particle or in a solution such as, for example, in aqueous solution, advantageously 30 to 60% by weight of the solution. The amount of antiperspirant active present in the composition according to the invention can be 1-35- by weight of the composition, preferably 10-30% by weight and more preferably 20-30% by weight of the composition. compo si ci on. The deodorant compositions according to the invention typically comprise from 0.01 to 90% of a deodorant active. The deodorant active used in the cosmetics of the invention can be any deodorant active known in the art such as alcohols, in particular aliphatic monohydric alcohols such as ethanol or propanol, antimicrobial actives such as polyhexamethylenebiguanides for example CosmocilTlí or chlorinated aromatics for example Triclosan ™, non-chemical deodorant assets such as the treatment, bactericides and bacteriostats. The carrier material for the composition of the title according to the invention may also comprise one or more of the volatile carrier fluids, one or more of the non-volatile emollients, and if one or a combination of thickener is required. and / or structuring materials. The carrier material, which includes, where relevant, carrier materials that provide additional properties such as emolliency, can often comprise up to about 90% by weight of the composition, in many cases from 5 to 80% by weight and particularly 10% by weight. up to 70% by weight. Where the composition comprises both hydrophilic and hydrophobic phases, the weight ratio of the two phases is often in the range of 10: 1 to 1:10. The aerosol compositions according to the present invention may be obtained by conveniently introducing a base formulation as described herein, which is free of repellent and at least 0.7 times and often 1.5 to 20 times its weight of repellent within a spray-suitable spray. The antiperspirant or deodorant composition may comprise a mixture of particulate solids or a suspension of solids in a liquid medium, which may be thickened to reduce the rate of segregation or structured to produce a cream (soft solid) or solid. Alternatively The composition may comprise a mixture of constituent liquids, including a solution of an active in a carrier, such composition often taking the form of an oil in water or water in oil emulsion, which may be thickened or gel-like. The carrier material, which may be a fluid or a mixture of fluids, is often selected according to the physical form of the cosmetic composition, for example volatile silicones of low viscosity, low molecular weight hydrocarbons, alcohols with the Except for etansl, and water, and can be selected by those skilled in the art to provide appropriate sensory and physical properties for the product. Volatile silicones are usually selected from cyclic polysiloxanes containing from 3 to 8 dialkyl silicon groups, especially dimeric groups, and particularly from 4 or 5 dimethyl groups with. Other useful volatile silicones may comprise linear or linear units, preferably containing 4 or 5 groups at 1 qui 1 s and 1 oxane, including terminal groups. Low molecular weight liquid hydrocarbons may comprise paraffin oils. Suitable alcohols may comprise monihydric alcohols, such as C3 aliphatic alcohols up to CIO, dihydric alcohols such as glycol or propylene glycol or polyhydric alcohols such as glycerol or sorbitol. The carrier materials can provide additional desirable properties, such as polyhydric alcohols for example glycerol can act as a wetting agent and volatile cytomenes can act as emollients. If used in the composition, the non-volatile emollient may consist of a simple emollient compound or a mixture of emollients, and may typically include fatty alcohols and esters of fatty alcohols, alcohols and esters slightly soluble in water, hydrocarbons, insoluble ethers in water, mineral oils and polyorganosiloxanes, and mixtures thereof. The non-volatile silicones are frequently polyaclysiloxanes, for example the 1-oxime, 1-oxides or 1-oxides having a viscosity above 10 mPa.s, such as up to about 5 × 10 4 mPa.s up to 25 ° C, including 1 ime ti 1 f eni 1 if 1 oxano or ether copolymer of dime ti Ip or 1 i oxy to l ene i.

Aliphatic ester emollients often contain about 12 to 25 carbons, and preferably a substituent containing a chain of at least 2 carbons. Examples include cetyl palmitate, butyl myristate, glyceryl stearate and propylene glycol monolaurate. The composition may comprise a liquid aliphatic ether which can provide emolliency, such as the ethers derived from polyalkylene glycols and a low weight alcohol (for example up to C6), such as pol ip r op i 1 engl i col. { 10-15) butyl ether. The total amount of emollient materials within the composition, which exclude borage oil, is frequently within the range of 1 to 70% by weight. The structuring agent or thickener, when required, is selected according to the product form of the cosmetic composition. The structuring agent or thickener may be organic (numerical or polymeric) or inorganic and is usually chosen depending on the physical nature of the liquid phase that is to be thickened or stretched, such as when it is • hydrophobic or hydrophilic. The amount is usually selected to obtain the desired viscosity or the liquid or cream of the desired strength to penetrate a solid according to the present invention. It can be any of a number of materials, including, for example, waxed structurants for a hydrophobic phase or composition including hydrogenated vegetable oil, hydrogenated castor oil, fatty acids, such as hydroxy acid, beeswax, beeswax. , paraffin wax, microcrystalline waxes, silicone wax, and fatty acids and fatty alcohols such as stearyl alcohol. Polymeric materials for thickening include polymers such as polyamides, hydroxypropyl cellulose, and synthetic or natural gums, such as pyridinium, including agar, agarose, pectin, or guars or mixtures or combinations thereof. An additional class of polymers which is particularly directed to the structuring of an oil phase containing a silicone oil comprises polysiloxane elastomers. Suspending agents such as silica or clays such as bentonite, mon tmo r i 11 on i t a or hectorite, include those available under the trademark Bentona which can also be used to thicken liquid compositions according to the invention.

The composition can be thickened with non-polymeric organic gelatins, including selected dibenzoyl alditols- (eg dibenzoyl sorbitol) or selected n-acylamino derivatives (eg N-acyl glutamide derivatives) or selected hydroxy fatty acids (eg 12-hi acid) dr ox iest ea ri co) or sterols (for example cholesterol) or secondary amides selected by di or tribasic carboxylic acids, (for example 2-dode cy 1-N, N'-dibuti 1 s ucc in imide) by themselves or in combination. The amount of structuring agent or thickener to be employed in the compositions of the invention will depend on the viscosity of a fluid formulation or the hardness amplification of a solid formulation that the producer wishes to achieve. The amount to be employed will vary in practice also depending on the chemical nature of the structuring agent or thickener. In many cases, the amount of structuring agent or thickener will be selected in the range of 0.1 to 20% by weight and particularly 1 to 15% by weight. The composition according to the invention may optionally comprise other ingredients, in addition to those already identified, depending on the nature and form of the finished product. Other ingredients common to the art can also be included in the compositions according to the invention. These include surfactants, fillers, fragrances, preservatives and coloring agents for example. These ingredients are selected according to the physical and chemical form of the composition of the chemical. The surfactants may optionally comprise up to 25%, more commonly up to 5% by weight of the total product, and are particularly useful in formulating antiperspirant or deodorant emulsion compositions for example for use as pump or pellet spray formulations. However for other types of product, it is preferred that the composition contains less than about 8% is weight of surfactants. Nonionic surfactants are particularly preferred. It is often convenient to select a mixture of surfactants, such as one having a comparatively high value of HLB, for example from 8 to 18, and one having a comparatively low value of HLB, for example from 2 to 8, which can introduced into suitable relative proportions to obtain an average HLB value of about 6 to 12. Many suitable non-ionic surfactants are selected from nonionic esters, ethers or amine oxides having an appropriate value of HLB. Many preferred ionic surfactants comprise a 1-oxo-1-alkyl-1-ene molecule, especially a polyoxyethylene molecule, for example from 2 to 80, especially from 5 to 60 oxyethylene units, or possibly with an oxygen content. op i 1 e no, to provide a hydrophilic condition. Other molecules that provide a hydrophilic condition include polyhydric alcohols such as sorbitol or glycerol. The hydrophobic molecule is commonly derived from aliphatic alcohols or acids or amines containing from about 8 to 50 carbons and particularly from 10 to 30 carbons. Examples of suitable nonionic surfactants include ceteareth-10 to -25, cetet-10-25, e s t ert e-10-25, and PEG-15-25 stearate or distearate. Other suitable examples include mono, di or triglycerides of C 10 -C 20 fatty acids. Additional examples include ethers of C18-C22 fatty alcohols of polyethylene oxides (from 8 to 12 EO). Examples of surfactants that typically have a low value of HLB, and often 2 to repeatedly, comprise mono or possibly fatty acid diesters of polyhydric alcohols such as glycerol, sorbitol, erythrocyte or primate, including cetyl, arachidyl and behenyl stearyl. Other examples include monoglycerides of palmitic or stearic acid, sorbitol mono or diesters of myristic, palmitic or stearic acid and monoesters of triethyl ether or stearic acid. The fillers can comprise up to about 20%, more commonly up to 10% of the total product and are usually less expensive than the essential components of the invention; which reduces the total cost. Suitable fillers include aluminum stearate, aluminum tristearate, calcium stearate, talc or finely divided polyethylene, an example of which is ACUMIST B18. Fragrances, when present typically comprise up to about 1% of the total product.

The coloring agents and preservatives can be added as desired. Other optional ingredients are other cosmetics adjuncts conventionally employed in antiperspirant products or deodorants. The ingredients that can optionally be present in the composition of the carrier can conveniently form the balance of the composition. The repellents commonly employed in the aerosol compositions herein comprise hydrocarbons (or much less desirably halohydrides) having a boiling point below 10 ° C and especially those with a boiling point below 0 ° C. . It is especially preferred to employ liquefied hydrocarbon gases and specifically C3 to C4 hydrocarbons, including propane, isopropane, butane, isobutane, pentane and isopentane and mixtures of two or more thereof. The preferred repellents are isobutane, isobutane / isoprone, objectate / pr ope and mixtures of isopropane, isobutane and butane. The composition according to the invention can take any form of a product suitable or adapted for local application of human skin, and is usually contained in a suitable bra or dispenser to allow it to be applied to the skin area, particularly in the armpits, where control of ranspiration and deodorization is required.

Example 1 Twenty healthy male and female volunteers who were between the ages of 18 and 55 were recruited for each trial.

Patch Tests The patches consisted of a divided strip of Al-test units (Finn chambers of 0.8 cm internal diameter) are fixed on top of a wide Scanpor occlusive tape manufactured by Ñor ge sp 1 a s t e r, Norway. Ten compartments were used in these studies to contain the ten test samples.

Test Procedure The protocol adopted for these studies was double-blind, within the type of subject comparison. Twenty volunteer volunteers were conducted per test.

It is a condition of safe clearance of the patch test in the armpit that the panelists have a "rest period" of 3 weeks before a site in the armpit can be repaired.

Protocol The arms were prepared by placing a small amount of Vaseline (White Petroleum Jelly ex Boots) in the lower part of each test chamber, followed by a filter paper on which the test material was dosed. One drop of each test product was dosed back onto a filter paper using a 1.0 ml plastic Pástete pipette supplied by Orme scientific. This constituted an average dose of approximately 0.02g. In the case Jel aerosol product was sprayed directly onto the filter paper (in a ventilated spray booth) and the filter paper was then inserted into the appropriate chamber Finn immediately before patching (the average dose of the aerosol was estimated from the results of 20 filter papers so saturated, the products were randomly put through the patch sites. "The panelists were instructed to keep the patches clean and dry while they are in. The panelists reported on Monday morning of the week. When they had the application of a patch to the clean skin of an inner forearm, these patches remained in place for 24 hours when the panelists were again reported and removed the patch.They returned 6 hours later for evaluation of each one. of the patch sites, the newly prepared patches were applied using the same random distribution of the product. in place for 18 hours, the panelists reported another ez and the patch was removed; again the patches were classified 6 hours later. This r epa rc e and f i ca tion was repeated on Thursday and Friday. A final recovery reading is carried out the following Tuesday morning- that is to say 5 classifications were made in total. The readings six hours after the final removal of the patch were of the greatest interest. A potential issue with this protocol (highlighted during the secure free space process) was "the tape reaction" due to the multiple application and removal of the tape from the same site of the forearm. Therefore the degree of reaction to the tape was also recorded using the same rating scale as that used for the patch sites. The marker for each test was classified according to the Patch Rating Scale.

The marker for each sample was averaged to produce a final marker.

Patch Classification Scale Resul ados The normal statistical analysis showed that sample 2 was significantly milder than sample 1 and that sample 4 was significantly milder than sample 3.

Example 2 The following is an antiperspirant stick formulation according to the invention. It can be done by normal methods known in the art. (1) Comprising 24% AZAG; 1% ESTOL E04DS; 4% Castor Wax; 14% Lorol C 18 deo; 3.2% talc; 1% perfume; and 52.8% DC345 volatile silicone. (2) Comprising 10% AACH; 1% Bentona 38; 1.0% perfume; 13% volatile silicone Q2 1465 and 75% repellent.

E xemployment 3 The following is an antiperspirant aerosol formulation according to the invention. It can be done by normal methods known in the art.

Claims (6)

1. Deodorant or antiperspirant cosmetic composition suitable for local application to human skin comprising: i. an active deodorant or against sweat; ii. a carrier for deodorant or antiperspirant active; and iii. borage seed oil.

2. Composition according to claim 1, characterized in that it comprises from 0.1 to 20% and preferably from 0.5 to 10% by weight of the borage seed oil.

3. Composition according to claim 1 or 2, characterized in that they comprise from 10 to 30% by weight of the active antitoxin agent.

4. Composition according to any preceding claim characterized in that the antiperspirant active contains zirconium.

5. Composition according to any preceding claim characterized in that it comprises a volatile silicone carrier, preferably in an amount of 10 to 70% by weight.

6. Composition according to any preceding claim, characterized in that it comprises a structuring agent or thickener in a concentration sufficient to produce a bar or a r ema.