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Priority claimed from GBGB9518220.0Aexternal-prioritypatent/GB9518220D0/en
Application filed by Icos CorpfiledCriticalIcos Corp
Publication of MX9801699ApublicationCriticalpatent/MX9801699A/en
Publication of MXPA98001699ApublicationCriticalpatent/MXPA98001699A/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms
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Micro-Organisms Or Cultivation Processes Thereof
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Enzymes And Modification Thereof
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Abstract
This invention relates to a class of checkpoint genes and their polypeptide products which control progression through the cell cycle in eukaryotic cells. In particular this invention relates to Schizosaccharomyces pombe rad3 gene, to its human homologue (ATR) and to their encoded proteins. The invention further relates to assay methods for selecting compounds which modulate the activity of the polypeptide products of these checkpoint genes and the use of the selected compounds in anticancer therapy.
MXPA/A/1998/001699A1995-09-061998-03-03Control point genes of the celu cycle
MXPA98001699A
(en)